معرفی
Nicolas Wolff is a researcher at the Pasteur Institute, focusing on structural and molecular biology with a strong emphasis on host-pathogen interactions. He leads projects such as Cell-Free System Development and Structural and functional impacts of ADGRV1 variants, often collaborating across disciplines like Neuroscience and Virology.
His research explores PDZ domain interactions in diseases like Usher syndrome (hearing and vision loss) and viral infections (SARS-CoV-2, Rabies, West Nile). Notably, he investigates how viral proteins hijack host PDZ-containing proteins to disrupt cellular functions, as seen in his 2025 study on SARS-CoV-2 envelope protein mechanisms.
- Key publications (2021–2025) cover structural analyses of viral proteins, functional studies of PDZ-PBM binding, and phylogenetic investigations of protein domains.
- Teaching includes courses like Protein Structure and Function and Biochemistry of Proteins, reflecting his expertise in molecular mechanisms.
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