جست‌وجوی استاد و پژوهشگر

Timothy J. Nelsonمشاهده پروفایل

دانشیار

• Cardiovascular Regeneration
• Induced Pluripotent Stem Cells (iPSCs)
• Regenerative Medicine
• +۷ مورد دیگر

Timothy J. Nelson, M.D., Ph.D., is an Associate Professor of Medicine and Pharmacology at Mayo Clinic College of Medicine. He holds multiple consulting roles at Mayo Clinic, including in the Division of General Internal Medicine, Department of Internal Medicine, Department of Molecular Pharmacology and Experimental Therapeutics, Division of Pediatric Cardiology, and Department of Cardiovascular Medicine. He is also Director of Research at the NWWI, Mayo Clinic Health System in Eau Claire. Dr. Nelson's research is centered on cardiovascular regeneration using bioengineered induced pluripotent stem cells (iPSCs). His work focuses on modeling degenerative heart diseases such as cardiomyopathy and congenital conditions like hypoplastic left heart syndrome (HLHS) to uncover molecular mechanisms and develop personalized therapies. He uses patient-derived iPSCs to study cardiogenesis, self-renewal pathways, and genotype-phenotype associations, with the goal of translating findings into clinical applications. His recent research spans topics including iPSC-derived cardiomyocyte integration in primates, mitochondrial gene function in HLHS, SARS-CoV-2 cardiotoxicity, and transcriptome analysis in congenital heart disease. His publications reflect a strong emphasis on regenerative medicine, stem cell biology, and translational cardiology. He has led NIH-funded projects, including a study on dysfunctional regeneration in cardiomyopathy. Dr. Nelson is affiliated with key research programs such as the Center for Regenerative Biotherapeutics, the Center for Clinical and Translational Science (CCaTS), and the Todd and Karen Wanek Family Program for Hypoplastic Left Heart Syndrome. His work involves extensive collaboration across disciplines and institutions, supported by a robust network in cardiovascular and regenerative research. Standing member, NIH mentored patient-oriented research program review group (2014–present) He mentors trainees and leads a research team focused on advancing stem cell technology from bench to bedside, aiming to reduce reliance on organ transplantation for heart failure. His lab investigates nuclear reprogramming, cardiac differentiation, and preclinical cell therapy models in porcine and primate systems.

Dana Branzeiمشاهده پروفایل

استاد

• DNA Repair
• Genome Stability
• Replication Stress
• +۳ مورد دیگر

Dana Branzei is a Professor and head of the Department of Biological and Genomic Treatment Approaches at the Research Center One Health within the Faculty of Biology at the University of Duisburg-Essen. She leads a research group investigating DNA repair mechanisms and genome stability. Her work focuses on how cells repair DNA damage, tolerate replication stress, and maintain chromosome integrity through processes integrated with DNA replication machinery (replisome). Her research interests center on molecular mechanisms of DNA damage tolerance, replication fork dynamics, chromosome cohesion, and the role of protein complexes like SMC5/6 in maintaining genome stability. Key areas include error-free DNA repair pathways, SUMOylation in DNA transactions, and the molecular basis of cancer predisposition linked to replication defects. Recent publications (2020-2023) demonstrate strong focus on replication fork protection mechanisms, chromatin remodeling during repair, helicase functions in recombination, and structural analyses of repair complexes. Research consistently bridges fundamental chromosome biology with clinical applications in cancer and neurodegenerative diseases. Scientific Awards: Alexander von Humboldt Professorship (2025) EMBO Membership (2016) FIS grant by Italian Ministry of University and Research (2023) She leads an active research team including postdoctoral fellows, PhD candidates, and master's students. Current lab members focus on replication stress responses, chromatin dynamics, and repair pathway coordination. The laboratory collaborates extensively within the University Alliance Ruhr network.

Ron D. Jachimowiczمشاهده پروفایل

دانشیار

• DNA repair
• Genome stability
• Aging
• +۴ مورد دیگر

Ron D. Jachimowicz is a Max Planck Research Group Leader specializing in DNA repair mechanisms and their relationship to aging and cancer development. As a Privatdozent (equivalent to Associate Professor), he leads an independent research group at the Max Planck Institute focused on understanding how DNA repair pathways impact genome stability, aging processes, and cancer progression. His work bridges basic science with clinical applications, particularly in lymphoma research. Dr. Jachimowicz's research centers on the critical relationship between DNA repair mechanisms and aging. His group investigates defects in DNA repair pathways in patients with genome instability syndromes and in patients suffering from mantle cell lymphoma, utilizing an interdisciplinary approach that combines biochemistry, cell biology, computational biology, and mouse genetics. Key research areas include the role of UBQLN4 in DNA repair pathway choice, ATM signaling in DNA damage response, and the connection between genome maintenance defects and age-related diseases. His work has revealed important mechanisms linking DNA repair deficiencies to cancer development, particularly in lymphomas, and has identified potential therapeutic targets for cancer treatment. Analysis of Dr. Jachimowicz's publication record shows a consistent focus on DNA repair mechanisms and their implications for cancer biology. His research demonstrates how defects in DNA repair pathways lead to genome instability, which drives both aging processes and cancer development. Recent publications highlight his work on UBQLN4's role in DNA repair pathway choice, ATM signaling in immune surveillance of lymphoma, and the development of targeted therapies for cancers with specific DNA repair deficiencies. His interdisciplinary approach combines molecular biology, mouse models, and clinical data to translate basic discoveries into potential therapeutic strategies. Scientific Awards: Theodor Frerichs Prize from the German Society for Internal Medicine (DGIM), 2020 Dr. Jachimowicz serves as principal investigator for multiple significant research grants and advises doctoral students in his laboratory. His research is supported by prestigious funding including the German Research Foundation (DFG) Research Unit FOR5504 (2023-2026), Collaborative Research Center SFB1530 (2022-2025), and the Research Network CANTAR from the Ministry of Culture and Science of North Rhine-Westphalia (2022-2026). He also serves as co-speaker for the Else Kröner Research College on Clonal Evolution in Cancer. His doctoral student Julia Hansen received a scholarship from the German Academic Scholarship Foundation in 2022. Dr. Jachimowicz leads a dynamic research laboratory focused on DNA repair mechanisms and their relationship to aging and cancer. His group employs a comprehensive interdisciplinary approach that integrates biochemical, cellular, computational, and genetic techniques to investigate how defects in DNA repair pathways contribute to genome instability syndromes and cancer development. The lab's work has particular relevance for understanding mantle cell lymphoma and developing targeted therapeutic interventions based on DNA repair deficiencies.

• Molecular Oncology
• Cancer Therapeutics
• Genetic Abnormalities in Tumors
• +۳ مورد دیگر

Professor John Lunec, based at Newcastle University 's Faculty of Medical Sciences , is a leading researcher in Molecular Oncology with over 30 years of publications focusing on the p53 tumor suppressor pathway and its interactions with oncogenic proteins like MDM2 . His work spans Cancer Therapeutics Development Genomic Instability in Tumors Drug Resistance Mechanisms RNA Splicing and Retrotransposon Biology Current research emphasizes MDM2-p53 interaction inhibitors for hematologic malignancies and sarcomas, with recent breakthroughs in Siremadlin and ASTX295 drug development Identification of SF3B1 resistance biomarkers Combination strategies with PARP and WEE1 inhibitors Key collaborations exist with Professor Nicola Curtin , Professor Deborah Tweddle , and Professor Herbie Newell , with funding evident through multiple clinical trials and laboratory studies. His work has significantly impacted neuroblastoma and ovarian cancer research, establishing frameworks for Drug sensitivity assays Genotype-phenotype correlations Translational medicine applications

Jean Krutmannمشاهده پروفایل

استاد

• Molecular Aging Research
• Environmental Medicine
• DNA Repair Deficiency Syndromes
• +۳ مورد دیگر

Prof. Dr. Jean Krutmann leads the Molecular Aging Research group at the Leibniz Research Institute for Environmental Medicine in Düsseldorf. His research focuses on environmentally-induced skin aging , DNA repair deficiency syndromes (Xeroderma pigmentosum, Cockayne syndrome), and air pollution effects on skin . Key projects include DFG FOR5489 exploring AHR-retinoid crosstalk and RTG 2624 developing biostatistical toxicology methods. Research Themes Mitochondrial DNA repair mechanisms Particulate matter dermatotoxicity Cutaneous exposome characterization 3D organoid modeling for UVB responses International environmental health collaborations (India, China) Key Discoveries ICAM-1 regulation in UV-damaged cells Ectoine-based lung disease prevention Near-infrared radiation's role in wrinkle formation Two microbiota cutotypes in Han Chinese AHR as UVB radiation target Collaborations Prof. Klaus Unfried (ectoine research) WG Esser, Schikowski, Schins International dermatology experts (Henry Lim, Akimichi Morita) Core Unit GEMD (iPSC organoids) Training & Leadership : Coordinates DFG research units FOR5489 and RTG 2624 . Supervises PhD student Jennifer Schindler and postdocs. Publications span J. Exp. Med , Nature Cell Biology , and Environmental International .

Steve Murrayمشاهده پروفایل

استاد

• Developmental Biology
• Genetics
• CRISPR/Cas9
• +۴ مورد دیگر

Steve Murray is a Professor and Senior Director at Genetic Resource Science , affiliated with the Graduate School of Biomedical Science and Engineering at the University of Maine. His research focuses on developmental mechanisms of morphogenesis and structural birth defects using CRISPR/Cas9 modeling, large-scale mutagenesis programs, and mouse genetic resources. Research Interests Murray's work spans: CRISPR/Cas9 for functional genomics Mouse models of human disease Embryonic morphogenesis and gene function Genetic drivers of behavioral and developmental traits Resource development for the scientific community His recent publications emphasize mouse mutagenesis programs (KOMP2), genome editing applications, and collaborations in developmental biology and immunology. Articles highlight interdisciplinary approaches to understanding genetic pathways, inflammation, and therapeutic interventions in rare disease models. Laboratory & Collaborations Murray leads initiatives at The Jackson Laboratory and contributes to international consortia like the International Mouse Phenotyping Consortium . His lab develops tools such as CrePortal.org for conditional mutagenesis and participates in large-scale phenotyping efforts.

Daylon Jamesمشاهده پروفایل

استادیار

• Stem Cell Biology
• Regenerative Medicine
• Reproductive Endocrinology
• +۲ مورد دیگر

Daylon James is an Assistant Professor in Stem Cell Biology at Weill Cornell Medicine , where he serves as Director of the Reproductive Endocrinology Laboratory and Manager of the Tri-Institutional Stem Cell Derivation Laboratory . His research program focuses on regenerative medicine and cell-based therapies for infertility , leveraging expertise in stem cell biology and xenograft models. PhD: The Rockefeller University Postdoctoral Training: Weill Cornell Medical College Research interests include: Stem cell differentiation for vascular and ovarian tissue regeneration Modified RNA delivery systems for fertility preservation Xenograft models in reproductive endocrinology Lipid metabolism in pluripotent stem cells Angiogenic and paracrine mechanisms for graft survival His publications reveal a focus on ovarian reserve disorders , anti-Müllerian hormone (AMH) applications , and endothelial cell engineering , with recent work exploring JAK inhibition for chemotherapy protection and cytoskeletal regulation in oocyte maturation. Labs and teams: Reproductive Endocrinology Laboratory Tri-Institutional Stem Cell Derivation Laboratory

Elizabeth O’Hareمشاهده پروفایل

دانشیار بالینی

• General biology
• Genetics (molecular and developmental)
• Biotechnology
• +۱ مورد دیگر

Elizabeth O’Hare is a Clinical Associate Professor at the Department of Biological Sciences , Towson University. Her academic journey includes a B.S. in Molecular Genetics/Plant Biotechnology from the University of Illinois at Urbana-Champaign, a Ph.D. in Genetics from the University of California Davis, and a Postdoctoral Fellowship at the University of Maryland School of Medicine focusing on the genetic etiology of complex traits. Education B.S. in Molecular Genetics/Plant Biotechnology, University of Illinois at Urbana-Champaign Ph.D. in Genetics, University of California Davis Postdoctoral Fellowship in Genetic Etiology of Complex Traits, University of Maryland School of Medicine Her research expertise spans Molecular and Developmental Genetics , Biotechnology , and Model Organisms (zebrafish and chick) , with a focus on understanding genetic mechanisms underlying human diseases and developmental disorders. She has contributed to studies on craniofacial-limb syndromes, lipid metabolism, β-cell mass deficits, and telomere biology. Dr. O’Hare teaches courses such as Introductory Biology for Health Professions , Biotechnology , and Applied Biotechnology , emphasizing active learning and interdisciplinary connections. Her publications highlight collaborations with institutions like the University of California Davis, University of Maryland School of Medicine, and Towson University, addressing topics in genetics, medicine, and developmental biology. While no explicit scientific awards are listed, her work on genetic etiology and contributions to journals like Journals of Heredity , Circulation , and Hepatology underscores her academic impact. She utilizes zebrafish and chick models to bridge molecular genetics with human health applications.

Jhih-Rong Linمشاهده پروفایل

عضو هیئت علمی

• Genetics
• Genomics
• Aging and Longevity
• +۳ مورد دیگر

Jhih-Rong Lin is a Research Assistant Professor in the Department of Genetics at Albert Einstein College of Medicine. His research focuses on understanding the genetic and genomic mechanisms underlying complex human diseases, particularly neurodegenerative disorders, longevity, and developmental syndromes. He employs computational and systems biology approaches to analyze genomic data, identify disease risk genes, and model genetic pathways. Key research themes include: Genetic variants associated with aging and neurodegeneration (e.g., Alzheimer’s disease, schizophrenia) Post-GWAS analysis for disease gene prioritization (e.g., using tools like PGA) Evolutionary genomics of longevity (e.g., studies on beaver genomes) Epigenetic regulation in cancer progression and development Lin’s work bridges computational methods with experimental validation, contributing to drug discovery for aging-related conditions and improving understanding of genetic modifiers in syndromic disorders. His recent publications highlight discoveries in rare variant analysis, polygenic risk prediction, and systems-level aging mechanisms.

Alan D. D'Andreaمشاهده پروفایل

استاد

• DNA Repair
• Cancer Genetics
• Fanconi Anemia
• +۱ مورد دیگر

Dr. Alan D. D'Andrea is the Fuller-American Cancer Society Professor of Radiation Oncology at Harvard Medical School and Director of both the Susan F. Smith Center for Women's Cancers and the Center for DNA Damage and Repair at Dana-Farber Cancer Institute. An internationally recognized leader in DNA repair mechanisms, his research focuses on Fanconi anemia and cancer susceptibility syndromes. D'Andrea cloned the erythropoietin receptor and identified key DNA repair pathway components defective in Fanconi anemia. His laboratory develops synthetic lethal approaches targeting DNA repair deficiencies in cancers, discovering POLQ and USP1 inhibitors that overcome PARP inhibitor resistance. Honors include election to National Academy of Sciences, National Academy of Medicine, and American Association for Cancer Research Academy. As director of premier research centers, D'Andrea oversees translational programs in women's cancers and DNA repair targeting. His work bridges basic discovery in chromosome instability with therapeutic development for treatment-resistant cancers.

Karla Rodgersمشاهده پروفایل

استاد

• Immunology
• Molecular Biology
• Genetics
• +۳ مورد دیگر

Dr. Karla Rodgers is a Professor in the Department of Microbiology and Immunology at the University of Oklahoma Health Sciences Center. Her research focuses on understanding mechanisms regulating V(D)J recombination and its role in adaptive immunity. She holds a PhD from the University of Illinois, Urbana-Champaign, and has prior research experience at Yale University. Her research interests include: Molecular basis of antigen receptor gene diversification RAG1/RAG2 protein complex regulation DNA repair mechanisms during lymphocyte development Genetic defects causing immunodeficiency Her lab uses advanced techniques such as high-throughput recombination assays to study recombination signal sequence (RSS) specificity and investigates nuclear dynamics of RAG proteins under DNA damage conditions. Current lab personnel include graduate students Justin Harris and Cooper McKinney, and research technician John Ngo. Notable research directions include: Quantitative analysis of RSS sequence determinants DDR pathway interactions with V(D)J recombination Risk assessment of off-target RAG activity in leukemogenesis Dr. Rodgers has maintained an NIH-funded research program for over 15 years, with publications in leading journals such as Nucleic Acids Research and Immunobiology . Her work bridges basic immunology with clinical implications for immunodeficiency and cancer.

• Hematology
• DNA Repair
• Cell Biology
• +۴ مورد دیگر

Ashley Kamimae-Lanning is a Senior Research Fellow at the MRC Weatherall Institute of Molecular Medicine (WIMM), University of Oxford, within the Radcliffe Department of Medicine. Her research focuses on cellular defense mechanisms against aldehydes, particularly their effects on hematopoietic stem cells and DNA repair pathways in Fanconi anemia. She completed her PhD at Oregon Health & Science University under Peter Kurre, investigating prenatal defects in hematopoietic stem cells. Her work bridges developmental biology and genetics, exploring how endogenous aldehydes contribute to DNA damage and hematopoietic failure. Collaborations include work with Dr. Daniel Marks on metabolic programming of fetal liver hematopoiesis and the Patel Lab on 'two-tier protection' mechanisms against genotoxic aldehydes. Recent studies highlight aldehyde-induced stem cell aging and carcinogenesis risks in FA patients. Key publications include groundbreaking work on formaldehyde toxicity in hematopoietic stem cells and dual aldehyde clearance systems in mice/humans. She advises DPhil students like Xinran Huang and received the Sir Andrew McMichael Medal for mentorship. Her lab integrates molecular, cellular, and genetic approaches to understand metabolic-DNA repair interactions in disease contexts.

Fabio Candottiمشاهده پروفایل

استاد

• Immunodeficiency
• Gene Therapy
• Pediatrics
• +۷ مورد دیگر

Fabio Candotti is a full professor at the University of Lausanne (UNIL) in the Faculty of Biology and Medicine and serves as head physician in the Department of Immunology and Allergology at the Lausanne University Hospital (CHUV). A world-renowned expert in immunodeficiency, pediatrics, and gene therapy, he has held academic and research leadership roles in both the United States and Europe, including a long tenure at the National Institutes of Health (NIH). Born: 1962, Italian nationality Education: MD, University of Brescia (1987); specialization in pediatrics (University of Pavia) and immunology/allergology (Brescia) Postdoctoral training: National Institutes of Health (NIH), USA (1992) Academic appointments: Associate Professor at UNIL (2014), promoted to Full Professor (2022) Prior roles: Senior Investigator and Head of Immune Diseases Section, NHGRI/NIH; Head, NIH Gene Therapy Interest Group His research and clinical work focus on primary immunodeficiencies, particularly adenosine deaminase deficiency (ADA) and Wiskott-Aldrich syndrome (WAS). He investigates the molecular and cellular mechanisms underlying immune dysregulation, autoimmunity, and metabolic defects in these disorders. His work has revealed how high adenosine levels and DNA repair deficiencies contribute to inflammatory, fibrogenic, and oncogenic processes in ADA-deficient patients. Using murine models, he has advanced understanding of autoimmune complications in WAS. A major focus of his work is the development and application of gene therapy strategies, including viral vector-based tools and transgenesis, for curative treatments. The trends in his recent publications highlight sustained leadership in translational immunology and gene therapy, with recurring themes in immune reconstitution, metabolic consequences of immunodeficiency, long-term patient outcomes, and innovative therapeutic design. His work bridges basic science and clinical application, emphasizing durable correction of immune function and quality of life. He has received multiple scientific awards, including: National Institutes of Health Award of Merit (1999, 2006) National Human Genome Research Institute Service Award (2002) US Government Service Award (2003, 2008) Best Docs in Northern Virginia (2009) Candotti is actively involved in medical education, having taught at Metropolitan Washington D.C. Medical Genetics since 2004 and contributed to numerous fellowship and residency training programs in immunology and hematology. He is an adjunct member of the Graduate Faculty at the University of Medicine and Dentistry of New Jersey. He also contributes to the scientific community through editorial roles in journals such as Clinical and Translational Science , The Open Gene Therapy Journal , Frontiers in Primary Immunodeficiencies , and Journal of Clinical Immunology . He is a member of the Italian Society of Pediatric Allergology and Immunology, the American Society for Gene Therapy, and the European Society for Immunodeficiencies. His work is supported by long-term patient cohorts and clinical studies aimed at developing new drugs and gene-based therapies. He leads a research team focused on advancing gene therapy for monogenic immune disorders, with a vision of translating laboratory discoveries into safe and effective clinical applications.

Anja Grothمشاهده پروفایل

استاد

• Molecular Cell Biology
• Epigenetics
• DNA Repair
• +۳ مورد دیگر

Anja Groth, 43 years old, is a full professor at the Biotech Research and Innovation Centre (BRIC) under the University of Copenhagen's Faculty of Health Sciences. Her research centers on molecular cell biology, epigenetics, DNA repair, and genome stability, with significant contributions to understanding how cells maintain functional memory during division—a critical process for both human development and cancer progression. Education: MSc in Biochemistry, University of Copenhagen PhD in Cancer Biology, University of Copenhagen (2004) Postdoc at Institut Curie, Paris (3 years) Her groundbreaking work on DNA repair mechanisms revealed a protein critical for cancer cell survival through error-free DNA repair. This discovery is paving the way for novel cancer therapies that block this protein. Using advanced molecular biology and interdisciplinary collaboration, she has published in top journals like Nature and secured two major ERC grants. Key Research Themes: Epigenetic memory and chromatin replication DNA damage repair pathways Histone dynamics and inheritance Replication fork stability Protein networks in genome maintenance Articles show a consistent focus on histone chaperones, ubiquitination pathways, and chromatin assembly factors. Her 2016 discovery of H4K20me0 marks and the TONSL–MMS22L complex has had lasting impacts on DNA repair research. Awards & Grants: EliteForsk Award (2018) EMBO Investigator Heirloom Award for Women Scientist Leaders ERC Starting Grant ERC Consolidator Grant As leader of a diverse research group of 15 international scientists (primarily women), Groth emphasizes collaborative innovation and trust-building in scientific environments. She advocates for sustainable lab practices and flexible research strategies that allow unexpected discoveries.

Michelle Brownمشاهده پروفایل

پژوهشگر

• DNA Repair Pathways
• Chemotherapy Resistance
• Ovarian Cancer
• +۵ مورد دیگر

Dr Michelle Wong-Brown is a Researcher at the University of Newcastle's School of Medicine and Public Health , affiliated with the Centre for Drug Repurposing and Medicines Research (CDRMR) and Hunter Medical Research Institute (HMRI) . Her work focuses on DNA repair pathways in chemoresistant cancers , particularly high-grade serous ovarian cancer , with emphasis on homologous recombination deficiency and drug repurposing strategies. PhD in Biomedical Sciences (University of Newcastle) HMRI Karen Brown Breast Cancer Travel Award recipient (2014) Active in clinical trial development for novel drug combinations Her research bridges genomic instability , epigenetic regulation , and translational oncology , with significant contributions to familial breast cancer genetic testing and ovarian cancer prognostic markers . Current projects include PARP-targeted therapies and immune checkpoint priming in resistant cancers. Scientific awards and grants include: NSW Regional Cancer Research Network Fellowship (2025) Australian Program for Drug Repurposing (MRFF $2.8M grant, 2020) Hunter Medical Research Institute grants (2014-2024) She supervises multiple PhD students in drug repurposing and cancer epigenetics , collaborating with international researchers across 14 countries.