Jean Krutmann

Prof. Dr. Jean Krutmann leads the Molecular Aging Research group at the Leibniz Research Institute for Environmental Medicine in Düsseldorf. His research focuses on environmentally-induced skin aging, DNA repair deficiency syndromes (Xeroderma pigmentosum, Cockayne syndrome), and air pollution effects on skin. Key projects include DFG FOR5489 exploring AHR-retinoid crosstalk and RTG 2624 developing biostatistical toxicology methods.

• Research Themes
  • Mitochondrial DNA repair mechanisms
  • Particulate matter dermatotoxicity
  • Cutaneous exposome characterization
  • 3D organoid modeling for UVB responses
  • International environmental health collaborations (India, China)
• Key Discoveries
  • ICAM-1 regulation in UV-damaged cells
  • Ectoine-based lung disease prevention
  • Near-infrared radiation's role in wrinkle formation
  • Two microbiota cutotypes in Han Chinese
  • AHR as UVB radiation target
• Collaborations
  • Prof. Klaus Unfried (ectoine research)
  • WG Esser, Schikowski, Schins
  • International dermatology experts (Henry Lim, Akimichi Morita)
  • Core Unit GEMD (iPSC organoids)

Training & Leadership: Coordinates DFG research units FOR5489 and RTG 2624. Supervises PhD student Jennifer Schindler and postdocs. Publications span J. Exp. Med, Nature Cell Biology, and Environmental International.