معرفی
Ashley Kamimae-Lanning is a Senior Research Fellow at the MRC Weatherall Institute of Molecular Medicine (WIMM), University of Oxford, within the Radcliffe Department of Medicine. Her research focuses on cellular defense mechanisms against aldehydes, particularly their effects on hematopoietic stem cells and DNA repair pathways in Fanconi anemia. She completed her PhD at Oregon Health & Science University under Peter Kurre, investigating prenatal defects in hematopoietic stem cells.
Her work bridges developmental biology and genetics, exploring how endogenous aldehydes contribute to DNA damage and hematopoietic failure. Collaborations include work with Dr. Daniel Marks on metabolic programming of fetal liver hematopoiesis and the Patel Lab on 'two-tier protection' mechanisms against genotoxic aldehydes. Recent studies highlight aldehyde-induced stem cell aging and carcinogenesis risks in FA patients.
Key publications include groundbreaking work on formaldehyde toxicity in hematopoietic stem cells and dual aldehyde clearance systems in mice/humans. She advises DPhil students like Xinran Huang and received the Sir Andrew McMichael Medal for mentorship. Her lab integrates molecular, cellular, and genetic approaches to understand metabolic-DNA repair interactions in disease contexts.
