جست‌وجوی استاد و پژوهشگر

Alea Millsمشاهده پروفایل

استاد

• Cancer Biology
• Aging
• Epigenetics
• +۵ مورد دیگر

Alea Mills is a Professor at Cold Spring Harbor Laboratory, leading the Mills Laboratory and serving as Faculty Head of the Animal Shared Resource within the Cancer Center. She is affiliated with the Cancer Center, the Stanley Institute for Cognitive Genomics, and the Gene Regulation and Inheritance departments. Mills earned her Ph.D. in 1997 from the University of California, Irvine. Her research focuses on the genetic and epigenetic mechanisms underlying cancer, aging, and neurodevelopmental disorders like autism. Central to her work is the study of chromatin regulation and its role in diseases such as glioblastoma, squamous cell carcinoma, and senescence. Key projects include investigating the tumor suppressor gene CHD5, the p63 protein family, and chromatin remodeling complexes in cancer progression. Recent publications highlight advancements in glioblastoma treatment through epigenetic reprogramming, the role of ΔNp63α in cancer stemness, and the impact of chromatin modifiers like BRD8 and EZH2. Mills has also contributed to understanding autism using mouse models of 16p11.2 microdeletion. In 2012, she was honored with the 'Woman of the Year in Health/Medicine' award. Her lab collaborates extensively, with a focus on translating basic research into therapeutic strategies. Current efforts include exploring novel targets for cancer and neurodegenerative diseases, alongside investigating the molecular basis of cellular senescence and aging.

Zhengdong Zhangمشاهده پروفایل

استاد

• Genetics of complex human diseases
• Systems biology
• Aging
• +۵ مورد دیگر

Zhengdong Zhang is a Professor in the Department of Genetics at Albert Einstein College of Medicine. His research focuses on the genetics of aging, Alzheimer's disease, and complex human diseases, combining computational methods with clinical data to uncover genetic mechanisms. His lab develops novel algorithms for genetic analysis, including post-GWAS gene prioritization, Bayesian statistical methods for genomic data, and systems biology approaches. Education details are not explicitly listed, but his professional background includes significant contributions to computational genetics and aging research. Key research areas include method development for genetic analysis, aging-related genetic networks, and disease genetics of Alzheimer's and schizophrenia. His lab has pioneered studies on long-lived species' genomic features, such as naked mole rats and beavers, to understand longevity and disease resistance. Research highlights include identifying rare coding variants linked to schizophrenia risk in 22q11.2 deletion syndrome patients, developing frameworks for Alzheimer's immune pathway analysis, and exploring DNA repair mechanisms in long-lived species. His work emphasizes interdisciplinary approaches integrating data science with clinical insights. Zhengdong Zhang's lab is located in the Michael F. Price Center at Einstein College of Medicine, focusing on translational research to bridge genetic discoveries with clinical applications.

Raffaella Santoroمشاهده پروفایل

استاد

• Epigenetics
• Chromatin Dynamics
• Cancer Biology
• +۵ مورد دیگر

Prof. Raffaella Santoro is a Professor and Principal Investigator at the Department of Molecular Mechanisms of Disease (University of Zurich). She holds a PhD in Biochemistry from the University of Rome La Sapienza and has held research positions at the Hans Knöll Institute (Germany) and ETH Zurich before joining the University of Zurich in 2009. Her laboratory focuses on epigenetic and chromatin regulatory mechanisms in cancer, stem cell pluripotency, and early development, with a particular emphasis on nucleolar function and genome architecture. Key research themes include the role of the nucleolus in repressive chromatin domains, epigenetic alterations in prostate cancer, and the interplay between chromatin and gene expression during development. Her work combines molecular and cell biology with high-throughput genomic approaches, as highlighted in over 100 publications in journals like Molecular Cell, Nature Communications, and EMBO Reports. She leads a dynamic research group comprising PhD students, postdocs, and master’s researchers, and actively recruits talent through the Life Science Zurich Graduate School. Her group collaborates with initiatives such as the NCCR and EMBO, contributing to advancements in epigenetic medicine and cancer biology. Educational Background: PhD in Biochemistry, University of Rome La Sapienza (Italy); Postdoctoral Research at the German Cancer Research Center (Heidelberg, Germany). Research Interests: Chromatin dynamics, nucleolar architecture, epigenetic regulation in cancer and development, prostate cancer heterogeneity, stem cell pluripotency, and spatial genomics. Collaborative efforts include the development of novel methods for 3D chromosome mapping and nucleolar interaction analysis. Scientific Contributions: Pioneering studies on nucleolar heterochromatin formation, the role of BAZ2A in cancer stem cells, and the epigenetic control of melanoma invasiveness. Her lab also explores oxidative stress impacts on early embryonic epigenetic reprogramming and the therapeutic potential of targeting epigenetic modifiers in cancer. Labs & Teams: The Santoro Lab at the University of Zurich integrates interdisciplinary approaches, with ongoing projects funded by ERC, EMBO, and the Swiss National Science Foundation. Current initiatives include modeling prostate cancer heterogeneity and identifying epigenetic biomarkers for disease prognosis.

• Mycology
• Molecular Biology
• Genomics
• +۶ مورد دیگر

Joseph Strauss is a Full Professor at the University of Natural Resources and Life Sciences Vienna (BOKU), leading the Institute of Microbial Genetics. With a career spanning over three decades, he has focused on fungal genetics, epigenetics, and bioactive metabolite discovery, particularly in filamentous fungi and pathogens. His work bridges fundamental research with applications in agriculture, medicine, and environmental biotechnology. Research Focus: Epigenetic regulation of fungal secondary metabolism, chromatin dynamics, bioactive compounds, nitrate signaling, and microbial interactions. Projects: Leads multiple grants from Austrian Science Fund (FWF), European Commission, and industry partners, including studies on chromatin engineering, fungal biotechnology, and toxin biosynthesis. His recent publications highlight advancements in chromatin proteomics, fungal pathogenicity, and novel bioactive molecules like luteapyrone and rasfonin. Articles emphasize broad disciplines such as Fungal Genetics, Epigenetics, and Natural Product Discovery, with subfields including secondary metabolite clusters, histone modifications, and stress response mechanisms. Scientific Awards: 2021 - Keratinophyton straussii fungal species named after him 1999 - START Preis 1995 - EMBO Stipendium 1994 - OTTO LOEWI Stipendium He has supervised over 69 theses and contributed to 186 publications, reflecting his leadership in fungal genomics and its applications. Projects like 'Bioaktive Mikrobielle Metaboliten' and 'TASSMATA' underscore his commitment to translating research into sustainable solutions.

Rui Guoمشاهده پروفایل

استادیار

• Epstein-Barr Virus (EBV) Pathogenesis
• Viral Oncology
• Cancer Metabolism
• +۵ مورد دیگر

Rui Guo is an Assistant Professor at Tufts University School of Medicine, affiliated with the Department of Molecular Biology and Microbiology. Their research focuses on Epstein-Barr Virus (EBV) pathogenesis, particularly its role in cancers like Burkitt lymphoma and mechanisms for developing targeted therapies. Doctor of Philosophy (2018), Kansas State University Master of Science (2013) and Bachelor of Science (2010), Yangzhou University Research interests include EBV-driven metabolic vulnerabilities in B-cells, with a focus on methyl group metabolism, mitochondrial remodeling, and lipid dynamics. Their work aims to improve cancer treatments by targeting viral dependencies. Recent publications highlight discoveries in EBV's manipulation of cardiolipin synthesis , methionine metabolism , and lysosomal iron reduction in Burkitt lymphoma. Techniques include transcriptomics , metabolomics , and CRISPR/Cas9 screening . Scientific recognition includes: National Institutes of Health Grant (2022-2026) for Epstein-Barr Virus epigenetic research

Steven J Jonesمشاهده پروفایل

استاد

• Bioinformatics
• Gene Expression
• Gene Regulation
• +۷ مورد دیگر

Dr. Steven J. Jones is a Professor in the Department of Medical Genetics at the University of British Columbia (UBC) and Associate Director/Head of Bioinformatics at the Genome Sciences Centre, BC Cancer Research Centre. He serves as Director of the CIHR/MSFHR Bioinformatics Training Program and the UBC Bioinformatics Graduate Program, with associate memberships at the Peter Wall Institute for Advanced Studies and Michael Smith Laboratories. Dr. Jones' research focuses on computational genomics and cancer bioinformatics , analyzing mutational landscapes and epigenetic targets in oncology. His work includes next-generation sequencing , structural variant detection , and long-read sequencing applications for resolving complex genomic architectures. He has extensive experience with transcriptome analysis , gene regulation , and comparative genomics across diverse organisms including C. elegans , conifers, and human pathogens. His 15 most recent publications highlight expertise in long-read sequencing for cancer genomics , imprinting disorders , and structural variation analysis. Key contributions include developing the Circos visualization tool for comparative genomics and pioneering bioinformatics approaches for epigenetic modifier discovery in oncology. Scientific Awards : Spencer Award for IT innovation (2005) 2007 Medical Genetics teaching award (UBC) 2011 Fellow of the Royal Society of Canada 2012 UBC Killam teaching prize 2014 Distinguished Achievement Award (UBC Faculty of Medicine) 2014 Fellow of the Canadian Academy of Health Sciences Clarivate Analytics Highly Cited Researcher (2016, 2018) Dr. Jones actively advises graduate students and serves as a data analysis center for the Canadian Epigenetics, Environment and Health Research Consortium (CEEHRC). He co-founded Ifowonco Bioinformatics Inc. and Alamya Health, PBC, and consults for Apotheca Systems Inc.

Jill Dowenمشاهده پروفایل

استاد

• Gene Regulation
• Chromosome Structure
• Genome Organization
• +۷ مورد دیگر

Jill Dowen is a Professor in the Department of Genetics at the University of North Carolina at Chapel Hill, focusing on the interplay between genome organization and gene expression. Her lab investigates how DNA looping influences cellular identity during development and disease, utilizing embryonic stem cells, cancer cells, and functional genomics approaches. Research interests include: Chromatin structure and transcriptional regulation 3D genome architecture in disease contexts Role of cohesin and Polycomb complexes in gene expression Histone modifications and their impact on chromatin dynamics Her recent publications highlight advancements in understanding cohesin's regulatory mechanisms, histone acetylation's role in MLL complex function, and Polycomb repressive complex interactions with lncRNA. The lab actively trains scientists and accepts applications for postdoctoral and graduate positions through the UNC BBSP PhD Program.

Laurie A. Boyerمشاهده پروفایل

استاد

• Developmental Biology
• Cardiovascular Biology
• Chromatin Remodeling
• +۴ مورد دیگر

Laurie A. Boyer is a Professor of Biology and Biological Engineering at the Massachusetts Institute of Technology (MIT), affiliated with the Koch Biology Building. She serves as Co-Undergraduate Officer and leads research on gene regulatory mechanisms in heart development and regeneration using embryonic stem cells and mouse models. Her work integrates genomic, genetic, biochemical, and cell biological approaches to understand chromatin dynamics and lineage commitment, with applications in cardiac tissue engineering and regeneration. Education: PhD, 2001, University of Massachusetts Medical School BS, 1990, Biomedical Science, Framingham State University Research Interests: Dr. Boyer’s research focuses on the interplay between chromatin remodeling, epigenetic regulation, and transcriptional networks that drive heart development. She investigates how ATP-dependent chromatin remodelers influence lineage specification and explores methods to stimulate cardiac regeneration. Her lab combines advanced genomic techniques with tissue engineering to model 3D cardiac architecture, aiming to uncover regulatory circuits underlying normal and diseased heart development. Publications: Her recent work includes breakthroughs in high-throughput expansion microscopy for scalable super-resolution imaging, metabolic modulation of mesenchymal stem cells for cartilage repair, and the role of long noncoding RNAs like Braveheart in cardiovascular lineage commitment. These studies span molecular mechanisms of chromatin dynamics to translational applications in regenerative medicine. Awards & Honors: Pew Scholars Award in the Biomedical Sciences (2008) Smith Family Award for Excellence in Biomedical Science (2009) Scientific American World’s 50 Top Leaders in Research (2006) Irvin and Helen Sizer Career Development Award (2012) Grants & Collaborations: Dr. Boyer oversees grants from organizations like the NIH and American Heart Association. She collaborates with teams on interdisciplinary projects, including tissue engineering and stem cell therapies. Her lab also develops innovative microscopy techniques to advance cellular imaging scalability. Labs & Teams: Her laboratory at MIT’s Koch Institute integrates computational biology, bioengineering, and molecular biology. The lab focuses on translating fundamental discoveries into clinical applications for heart disease and regeneration.

Albert Keungمشاهده پروفایل

دانشیار

• Synthetic Biology
• Neural Engineering
• Stem Cell Engineering
• +۳ مورد دیگر

Albert Keung is an Associate Professor in the Department of Chemical and Biomolecular Engineering at North Carolina State University, holding titles of University Faculty Scholar and Goodnight Distinguished Scholar. His research integrates engineering, biology, and physics to develop molecular technologies for understanding and manipulating chromatin dynamics. Key focuses include synthetic biology platforms for epigenetic control, stem cell engineering for neuroepigenetic disorders, and DNA-based information storage systems. His lab develops tools to study chromatin biochemistry and 3D structure, enabling insights into disease mechanisms and applications like antibody production and cancer therapies. Notable achievements include the 2023 Langer Prize for innovations in DNA data storage and pioneering work on epigenetic editing systems. The Keung Lab also explores neuroepigenetic models using human cerebral organoids and synthetic biology approaches to decode gene regulation. Research interests span from foundational epigenetic mechanisms to applied technologies, with over 50 peer-reviewed articles. His work bridges fundamental science and translational applications, addressing challenges in biotechnology, medicine, and data storage. Current projects emphasize scalable DNA storage systems, synthetic epigenetic circuits, and mechanistic studies of UBE3A-related disorders. Academic contributions include an NSF CAREER Award (2022) and leadership in the Synthetic Biology community. The lab collaborates across disciplines, leveraging engineering principles to solve complex biological problems. Education and training initiatives emphasize training the next generation of bioengineers through interdisciplinary research programs.

Tuğba Bağcı Önderمشاهده پروفایل

استاد

• Brain Tumors
• Molecular Oncology
• Apoptosis Mechanisms
• +۳ مورد دیگر

Tuğba Bağcı Önder is a Professor in the Medical Biology department at Koç University's Graduate School of Health Sciences. Her work focuses on brain tumors, tumor cell apoptosis, and neural stem cells. She earned her PhD from Tufts University (2008) and Bachelor's from Bilkent University (2002). Key Research Areas : Brain Tumors, Molecular Mechanisms of Apoptosis, Neural Stem Cells Awards : BAGEP Award (2014), UNESCO-L’oreal Women in Science (2013) Her recent publications highlight epigenetic vulnerabilities in glioblastoma, prostate cancer, and breast cancer, with a focus on chromatin modifiers like BRPF1, KDM6A/B, and SWI/SNF dependencies. Therapeutic approaches include CRISPR screening, histone demethylase inhibition, and engineered stem cells. Scientific Awards BAGEP Award (2014) UNESCO-L’oreal for Women in Science in Turkey (2013)

Johannes C. Hellmuthمشاهده پروفایل

پژوهشگر

• Non-Coding Cancer Biology
• Super-Enhancer Regulation
• CRISPRi Screening
• +۳ مورد دیگر

Dr. Johannes C. Hellmuth leads the DKTK Junior Clinical Cooperation Unit for Non-Coding Cancer Biology at the Ludwig Maximilian University of Munich (LMU Klinikum), affiliated with the Department of Pathology under the School of Medicine. His research focuses on exploiting vulnerabilities in the non-coding genome of cancer cells, particularly through super-enhancer analysis and CRISPRi screening. Research Interests: Functional interrogation of the non-coding genome Super-enhancer proteomes in oncogenesis Transcriptional condensates as therapeutic targets Non-invasive super-enhancer diagnostics Publication Trends: Recent work spans epigenetic regulation in lymphomas, super-enhancer dependencies in cancer, and chromatin dynamics during immune cell differentiation, with a focus on integrating omics data for personalized therapies.

Mary Lauren Bentonمشاهده پروفایل

استادیار

• Computational Biology
• Gene Regulation
• Biomedical Informatics
• +۳ مورد دیگر

Dr. Mary Lauren Benton is an Assistant Professor in the Department of Computer Science at Baylor University's College of Engineering and Computer Science. She holds a Ph.D. and M.S. in Biomedical Informatics from Vanderbilt University (2020, 2018) and a B.S.I. in Bioinformatics from Baylor University (2015). Education: Ph.D. (Vanderbilt, 2020), M.S. (Vanderbilt, 2018), B.S.I. (Baylor, 2015) Her research focuses on computational biology and gene regulation, particularly how DNA sequences influence genome function and human disease risk through integrated datasets. Recent work explores enhancer-gene interactions, epigenetic mechanisms, and the application of graph neural networks to genomic problems. Selected publications highlight interdisciplinary trends across genomics (e.g., Cis-regulatory landscapes , CTCF motif accessibility ) and computer science (e.g., Dynamic graph attention , Node classification ).

• Genomics
• Epigenetics
• Systems Biology
• +۷ مورد دیگر

Gary Hon is an Assistant Professor at the University of Texas Southwestern Medical Center (UTSW), jointly affiliated with the Cecil H. and Ida Green Center for Reproductive Biology Sciences and the Lyda Hill Department of Bioinformatics. His research lies at the intersection of genomics, epigenetics, and systems biology, with a focus on decoding the regulatory complexity of the human genome. His research interests include: Understanding the molecular basis of cell state for applications in regenerative medicine Elucidating how non-coding genetic variants contribute to development and disease Developing integrative techniques combining gene regulation, epigenetics, genome engineering, and single-cell genomics Advancing bioinformatics tools for analyzing chromatin and transcriptional regulation The trends across his recent publications reveal a strong emphasis on enhancer biology, epigenetic modifications (especially 5mC and 5hmC), single-cell functional genomics, and the development of novel molecular tools such as in situ chromatin capture and combinatorial perturbation assays. His work frequently leverages CRISPR-based technologies and high-throughput sequencing to dissect gene regulatory networks. Dr. Hon has received significant recognition for his innovative research, including: CPRIT Scholar NIH Director’s New Innovator Award Dr. Hon leads the Hon Lab, which actively develops and applies systems-level approaches to study genome regulation. His collaborative research involves advising graduate students and postdoctoral fellows, many of whom appear as co-authors on his publications. While specific grant details are not listed, his prestigious awards suggest substantial federal and state funding support for his high-impact, interdisciplinary research program.

Tuncay Baubecمشاهده پروفایل

استاد

• Epigenetics
• Functional Genomics
• Molecular Biology
• +۶ مورد دیگر

Prof. Tuncay Baubec is a Professor and Chair of Genome Biology & Epigenetics at the Department of Biology, Utrecht University. He holds a PhD in Genetics from the University of Vienna and has held academic positions at the University of Zurich and the Friedrich Miescher Institute. His research focuses on epigenetic mechanisms, chromatin dynamics, and gene regulation, with a particular emphasis on DNA methylation and histone modifications. Education: PhD in Genetics (2009, University of Vienna), MSc in Molecular Medicine (2004–2009), BSc in Biology (2000–2003). Research interests include understanding how chromatin modifiers and DNA methylation regulate gene expression in development and disease. Key areas: epigenetic bistability at imprinting control regions, engineering CRISPR-based tools for gene silencing, and studying the impact of DNA damage on genome stability. His work has led to over 40 peer-reviewed publications, including high-impact studies in Nature Genetics , Nature Biotechnology , and Molecular Cell . Recent findings explore histone mark interactions, DNA repair mechanisms, and the role of SETD2 in cell size regulation. Awards: NWO VICI Grant (2023), ERC Consolidator Grant (2020), EMBO Young Investigator (2019). Baubec leads the Baubec Lab, which investigates epigenetic networks in health and disease, collaborating with institutions worldwide. Current projects include developing novel epigenome-editing tools and studying epigenetic drivers of cancer and neurodegenerative disorders.

Bluma Leschمشاهده پروفایل

دانشیار

• Transcriptional Regulation
• Epigenetics
• Evolutionary Biology
• +۳ مورد دیگر

Bluma Lesch is an Associate Professor of Genetics and of Obstetrics, Gynecology, and Reproductive Sciences at Yale University. She earned her B.S. from Yale (2003), Ph.D. from Rockefeller University (2010), and M.D. from Weill Cornell (2011). Her postdoctoral training at the Whitehead Institute (2011–2017) focused on epigenetic mechanisms in germ cells. She joined Yale faculty in 2017, receiving notable awards like the Pew Biomedical Scholar (2021) and Searle Scholar (2019) recognitions. Lesch’s research integrates genetics, epigenetics, and evolutionary biology to study transcriptional regulation in germ cells and its implications for development and disease. Key areas include gene regulatory evolution, transgenerational epigenetic inheritance, and chromatin dynamics in spermatogenesis. Her work bridges molecular mechanisms with organismal and evolutionary scales, leveraging both experimental and computational approaches. Recent publications highlight studies on mastitis hub genes, cattle DGAT gene families, and myelin-microbe interactions in multiple sclerosis. She collaborates with researchers like Gunter Wagner and Stephanie Halene, advancing interdisciplinary projects in reproductive and developmental genomics. Lesch holds grants including the Burroughs Wellcome Career Award (2015) and leads the Whisk Cup Streamline Lab at Yale, focusing on epigenetic and chromatin regulation in germ cell biology. Her lab explores evolutionary innovations in germline biology and human-specific epigenomic states, contributing to our understanding of transgenerational inheritance and disease mechanisms.