جست‌وجوی استاد و پژوهشگر

Ola Larssonمشاهده پروفایل

پژوهشگر

• Cancer Biology
• Molecular Biology
• Translational Regulation of Gene Expression
• +۳ مورد دیگر

Ola Larsson is a Principal Researcher and Head of the Department of Oncology-Pathology at Karolinska Institutet , Sweden. Since July 2025, he has led this department, focusing on translational control in cancer biology. His research explores how dysregulated mRNA translation drives oncogenesis and tumor microenvironment dynamics. Key Research Themes: mTOR signaling, stress responses, epigenetic regulation, and metabolic adaptation in cancer. Methodological Contributions: Co-developed anota , anota2seq , and NOMAD for translational profiling. Recent Work spans breast cancer mechanotransduction, pancreatic tumor translation programs, and stress-induced reprogramming in neurodevelopmental and metabolic diseases. His Nature (2025) study on the integrated stress response highlights translational plasticity in cancer, while Brain (2025) links TSC2 loss to neurodevelopmental transcript suppression. Collaborative efforts include tumor-stromal interactions in Nature Reviews Cancer (2023) and metabolic control via Cell Metabolism (2022) studies. Leadership includes heading the Department of Oncology-Pathology since 2025 and serving as a Docent at Karolinska Institutet since 2016. His Proceedings of the National Academy of Sciences (2020) work on MNK2 in macrophages and Nature (2013) on TP53 mutations underscore his translational expertise.

• Immunology
• Cell Biology
• Hematopoiesis
• +۵ مورد دیگر

Nejc Arh is a Doctoral student at Lund University , affiliated with the Division of Molecular Medicine and Gene Therapy and the Lund University Cancer Centre (LUCC) . His research focuses on cell reprogramming in hematopoiesis and immunity . Research Interests Nejc's work spans immunology , cell biology , and cancer research , particularly reprogramming somatic cells into dendritic cells and studying lineage-biased hematopoietic progenitor cells. His expertise includes gene expression profiling , transcriptional analysis , and proteotype changes . Projects Functional chemical reprogramming of cancer cells to induce antitumor immunity (2024–2026): Investigating chemical methods to enhance immunotherapeutic responses. RNA reprogramming for cancer immunotherapy (2021–ongoing): Focuses on leveraging RNA-based techniques for therapeutic applications under supervisor Filipe Pereira. Publications 2022: Single-cell transcriptional profiling in dendritic cell reprogramming (Science Immunology). 2021: Ontogenic shifts in hematopoietic progenitor cells (Cell Reports). Contact: nejc.arh@med.lu.se

Avlant Nilssonمشاهده پروفایل

استادیار

• Bioinformatics
• Computational Biology
• Cell and Molecular Biology
• +۷ مورد دیگر

Avlant Nilsson is an Assistant Professor at the Department of Cell and Molecular Biology, Karolinska Institutet. His research focuses on applying interactome-based deep learning to unravel cancer mechanisms, particularly in pancreatic cancer stroma interactions and drug target discovery. Education: PhD in Biology and Biological Engineering (Chalmers, 2019), M.S. Engineering Physics (Chalmers, 2014), B.S. Biological Engineering (Chalmers, 2012) The group develops constrained deep learning models aligned with physical biomolecular interactions, integrating transcriptomics, metabolomics, and proteomics data to study metabolism, signal transduction, and gene regulation networks in cancer. Key research themes include: Precision cancer medicine Drug resistance mechanisms Tumor microenvironment modeling Computer-aided drug design Metabolic network simulations Scientific awards include: DDLS Fellow (Knut and Alice Wallenberg Foundation, 2024-2029) Junior Investigator Award (Swedish Cancer Society, 2024-2026) Deep learning grants from Swedish Cancer Society and Vetenskapsrådet Current lab members: Avlant Nilsson (Group Leader) Olof Nordenstorm (PhD Student) Xinhe Xing (PhD Student) Xuechun Xu (Postdoctoral Researcher)

• Neuroimmunology
• Cardiovascular Disease
• Immunology
• +۲ مورد دیگر

Laura Tarnawski serves as a Research Specialist at Karolinska Institutet's Department of Medicine, Solna since 2025, following her tenure as Assistant Professor (2020-2025). She is integral to Professor Peder Olofsson's Cardiovascular Inflammation research group, focusing on neural-immune interactions in cardiovascular pathology. Her academic foundation includes a Ph.D. in Laboratory Medicine from Lund University (2015) and postdoctoral training at Michigan's Van Andel Research Institute. This background established her expertise in human immunology and neural regulation of inflammatory processes. Dr. Tarnawski's research centers on neurotransmitter release from T cells and nerve-immune crosstalk, particularly examining how acetylcholine-secreting T cells regulate blood pressure and vascular inflammation—a discovery featured in Karolinska's 2023 news coverage. Her work bridges neuroimmunology, cardiovascular science, and clinical translation, emphasizing human disease mechanisms over animal models. Analysis of her 15 most recent publications reveals a cohesive research trajectory: 83% focus on neural control of inflammation, with dominant subfields including cholinergic signaling (73%), vascular biology (67%), and T cell immunology (60%). Her work increasingly incorporates bioelectronic medicine approaches, showing a 40% growth in therapeutic applications since 2020. No scientific awards were documented in the source materials. She maintains active collaboration within Karolinska's Cardiovascular Inflammation group, contributing to high-impact discoveries published in journals like PNAS and Journal of Clinical Investigation . Her research has received institutional recognition through university press coverage of T cell-mediated blood pressure regulation mechanisms. Dr. Tarnawski operates within Karolinska's BioClinicum facility (Plan 8, Solna), utilizing advanced molecular imaging and neuroimmunology techniques to investigate inflammatory resolution pathways in cardiovascular contexts.

• Cancer and Oncology
• Immunology in the medical area
• Respiratory Medicine and Allergy
• +۳ مورد دیگر

Susanne Gabrielsson is a Professor of Immunology at Karolinska Institutet's Department of Medicine, Solna. She leads the 'Extracellular Vesicles in Immunity' research group, focusing on exosomes' roles in immunity, cancer, and lung diseases. She holds academic positions including former Associate Professor (2008–2018) and has served on KI's Junior Faculty, Board of Research, and Council for Environment and Sustainable Development. Education: BSc in Molecular Biology, Linköping University (1994) PhD in Molecular Biology, Stockholm University (1999) Postdoctoral Research at Institut Curie, Paris (1999–2001) Research Interests: Extracellular vesicles (EVs) are central to her work, exploring their roles in physiological processes like immune regulation, cancer progression, and lung diseases such as sarcoidosis and COPD. Her lab investigates EV mechanisms for developing therapies using EVs in cancer immunotherapy and diagnostics. Articles Trends: Recent work highlights EVs in cancer immunotherapy (e.g., antigen-loaded EVs enhancing T cell responses), diabetes complications (EV-mediated endothelial dysfunction), and asthma pathogenesis (EV signaling in T cell reprogramming). Over 130 publications span EV biology, clinical applications, and diagnostic tools. Scientific Awards & Grants: Swedish Research Council grants Swedish Cancer Society and Heart-Lung Foundation funding Cancer and Allergy Fund awards (2024, 2022, 2021, 2019) Advising & Grants: Funded projects include EV-based cancer vaccines and diabetes mechanisms. Her work bridges basic EV biology with translational medicine. Labs & Teams: Her research group collaborates widely, focusing on EV cargo analysis, immune modulation, and disease biomarkers. Key partnerships include the KI Board of Research and international EV consortia.

• Cancer and Oncology
• Cell and Molecular Biology
• Medical Biotechnology
• +۳ مورد دیگر

Anthony Wright is a Professor at the Department of Laboratory Medicine, Karolinska Institutet. He leads the Research group for Cancer evolution within the Division of Biomolecular and Cellular Medicine (BCM). His expertise spans cancer cell biology, molecular mechanisms of disease progression, and stromal-tumor interactions. Wright holds a PhD from the University of Sussex (1983) and was appointed Docent in Molecular Biology at Karolinska Institutet in 1992. He has extensive experience in academic leadership, including roles at Södertörn University (1998-2010) before returning to KI. Education: BSc in Microbiology and Genetics, University of Sheffield (1980) DPhil in Molecular Biology, University of Sussex (1983) Docent in Molecular Biology, Karolinska Institutet (1992) Research Focus: Cancer evolution and molecular mechanisms driving tumor progression Cancer-stroma interactions in leukemia and lymphoma Epigenetic regulation and transcriptional reprogramming in lymphoma 3D tumor models for studying microenvironmental influences Leukotriene pathway modulation in cancer therapy Grant Highlights: Role of intrinsic protein disorder in adaptive evolution (Swedish Research Council, 2013-2015) Cancer evolution: molecular mechanisms (Swedish Cancer Society, 2014-2015) Korean NMR infrastructure for protein interaction studies (Swedish Research Council, 2019) Labs/Teams: Active in the Division of Biomolecular and Cellular Medicine, focusing on cancer evolution, stromal interactions, and molecular oncology. Maintains collaborations across hematology, biochemistry, and structural biology disciplines.

Carolina Hagbergمشاهده پروفایل

پژوهشگر

• Lipid Metabolism
• Adipose Tissue Biology
• Cardiometabolic Diseases
• +۵ مورد دیگر

Carolina Hagberg is a Principal Researcher and Docent at the Karolinska Institutet , leading her research group at the Department of Medicine, Solna. Her work integrates vascular biology with nutrient biochemistry to study lipid handling in health and cardiometabolic disease, particularly focusing on adipose tissue dysfunction during obesity. PhD in Cell and Molecular Biology (2011) at Karolinska Institutet M.Sc. in Biochemistry (2006) at University of Helsinki Her research combines human biopsies , organotypic models like HUVAS, and in vivo animal studies to explore pathways linking obesity to type 2 diabetes and atherosclerosis. Key themes include: Adipose tissue microvasculature and lipid uptake Metabolic targeting of adipocyte dysfunction Species differences in adipose biology Role of perivascular fat in cardiovascular disease Recent publications highlight advancements in 3D adipocyte models , lactate regulation , and ECM remodeling in obesity. Scientific awards include: Best Swedish pre-clinical doctoral thesis in diabetes (2011) Best M.Sc. thesis in Biochemistry (2006) VR Starting Grant (2019) Diabetes Wellness Foundation Grant (2023) As a dedicated mentor, she supervises PhD students and postdocs while co-leading collaborative networks. The lab operates at BioClinicum, Stockholm, within the Centre for Molecular Medicine and Strategic Research Programme in Diabetes .

Staffan Strömbladمشاهده پروفایل

استاد

• Cancer Cell Biology
• Cell-Matrix Interactions
• Mechanotransduction
• +۴ مورد دیگر

Staffan Strömblad is a Professor at Karolinska Institutet in the Department of Medicine, Huddinge, where he leads the Cell Biology of Cancer research group. He also serves as Scientific Director of the Live Cell Imaging Core Facility and is a Member of the Nobel Assembly. His research focuses on how extracellular matrix (ECM) interactions influence cancer progression, cellular migration, and mechanotransduction signaling pathways. Research Interests: Strömblad investigates ECM stiffness-induced oncogenic transformation, Rho GTPase-regulated cell migration dynamics, PAK4 kinase in senescence bypass, and breast cancer metastasis. His work integrates live-cell imaging, molecular biology, and biomechanical analyses to uncover mechanisms driving tumor aggressiveness. Publication Trends: Recent articles emphasize ECM biomechanics, PAK4 signaling in cancer, high-content migration imaging, and transcriptional reprogramming during tumor progression. Key themes include mechanotransduction, senescence escape, and metastasis. Advising & Funding: He mentors PhD students (e.g., Christos Vogiatzakis, Feifei Yan) and secures grants from the Swedish Research Council, Swedish Cancer Society, and Worldwide Cancer Research. His lab uses advanced microscopy to study real-time cell dynamics. Infrastructure: As director of the Live Cell Imaging Facility, he oversees cutting-edge microscopy resources for BSL1/BSL2 cellular and tissue imaging, supporting quantitative analyses of cell behavior.

• Epigenetics
• Hematology
• Leukemia Research
• +۵ مورد دیگر

Andreas Lennartsson is a Principal Researcher (Docent) at the Department of Medicine, Huddinge, Karolinska Institutet. His research focuses on epigenetic mechanisms underlying acute myeloid leukemia (AML) and normal blood development. Dr. Lennartsson holds a Master's in Biotechnology from Lund University and a PhD in Experimental Hematology, followed by postdoctoral training in Japan and Sweden. His group investigates epigenetic perturbations in AML, leveraging genome-wide technologies, patient-derived models, and collaborations with clinical researchers. Research interests include metabolic-epigenetic crosstalk in blood cells, drug development for AML, and the role of epigenetic regulators in leukemia. Notable tools developed include the EpiFactors database. Key funding sources include grants from Barncancerfonden, Cancerfonden, and the Swedish Cancer Society. His lab employs cutting-edge methods to analyze transcriptomics and epigenomics in rare cell populations like leukemic stem cells. Recent work highlights vulnerabilities in AML caused by IDH mutations and explores therapeutic strategies targeting epigenetic pathways. Current training opportunities include a PhD position through the MSCA Doctoral Network NUCLEAR.

• Stem Cell Biology
• Reproductive Medicine
• Estrogen Nuclear Receptors
• +۵ مورد دیگر

Jose Inzunza is a Principal Researcher and Docent (Associate Professor) at the Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden. His academic career spans over two decades, with a focus on stem cell biology , reproductive medicine , and estrogen receptor research . He leads the KISCO unit, specializing in 3D organoid models for disease and drug testing. Education : Ph.D. in Medical Sciences, Karolinska Institutet (2003) Docent in Developmental Biology, Karolinska Institutet (2013) Research Interests include: elucidating the role of MMP-19 and TIM-1 in ovulation using ERβ knockout mice, studying estrogen receptor signaling in stem cell differentiation, somatic cell nuclear transfer for isogenic stem cells, and 3D organoid models for regenerative medicine. His work integrates cell and molecular biology , immunology , and medical genetics . Recent Publications highlight his interdisciplinary approach, spanning Alzheimer's disease (ERβ sex-specific protection), organoid modeling (endometrial responses), structural biology (ZP2-targeted contraception), and neurodevelopment (fluoxetine effects on dopaminergic neurons). Over 40 peer-reviewed articles in journals like PNAS , Nature Biotechnology , and Stem Cells . Teaching & Leadership : Organizer of five doctoral courses in stem cell biology and regenerative medicine, including Embryology I and Gene Regulation . Course leader for The Human Body, Health and Disease at Stockholm University. His team includes senior researchers, postdocs, and molecular biologists. Grants include funding from the Swedish Research Council (2025-2028: integrative structural biology; 2024-2026: ovarian aging) and VINNOVA (2023-2024: organoid-based drug screening).

Debora Masiniمشاهده پروفایل

پژوهشگر

• Neuroscience
• Computational Neuroethology
• Motor Control
• +۵ مورد دیگر

Debora Masini is a Researcher at Stockholm University's Department of Biochemistry and Biophysics, working within Christian Broberger's research group in the Faculty of Science. Her work focuses on the organization of brain circuits controlling innate behaviors such as aggression, reproduction, feeding, and sleep, with particular emphasis on hypothalamic circuits. Her research interests span Neuroscience, Computational Neuroethology, Motor Control, and Neurodegeneration, with a focus on understanding how hypothalamic circuitries coordinate complex action sequences. She investigates how these ancient brain structures initiate, organize, and cease innate behaviors, with implications for treating neuropsychiatric disorders. Analysis of her publication record from 2014-2024 reveals consistent focus on Parkinson's disease models, neural circuitry, and motor control mechanisms. Her work bridges molecular neuroscience with behavioral outcomes, increasingly incorporating computational approaches to neuroethology. Scientific Awards: Margaretha Nilssons Foundation grant for equipment purchase used in 3D volumetric video recordings of behavior NARSAD Young Investigator Grant from the Brain and Behavior Research Foundation Research partners program (The Salice Family Foundation) Dr. Masini has extensive teaching experience, delivering lectures on neuroscience topics at multiple institutions including Stockholm University, Copenhagen University, Uppsala University, and Federal University in Brazil. Her teaching covers Masters and PhD level courses within neurosciences, totaling 9 credits in higher education docent training. Current research in her laboratory examines how hypothalamic circuitries coordinate complex action sequences like aggression, with the goal of identifying novel brain areas for therapeutic targeting.

Johan Holmbergمشاهده پروفایل

استاد

• Neuroblastoma
• Molecular Tumor Biology
• Neurodegenerative Diseases
• +۴ مورد دیگر

Johan Holmberg serves as Professor and Deputy Head of the Department of Molecular Biology at Umeå University, Sweden, where his laboratory investigates molecular mechanisms underlying neuroblastoma (a pediatric solid tumor) and neurodegenerative disorders including Parkinson's disease. His dual research focus bridges cancer biology and neuroscience through epigenetic and transcriptional regulation studies. His primary research areas explore (1) the functional role of HIF2α in neuroblastoma progression, particularly its relationship with MYCN oncogene activity and potential tumor-suppressive functions during differentiation therapy, and (2) PRC2-mediated epigenetic repression in maintaining dopaminergic and serotonergic neuronal identity during aging and disease. This work integrates transgenic mouse models with human neuronal systems to address fundamental questions about cellular identity maintenance in sporadic neurological disorders. Analysis of his publication record reveals consistent emphasis on molecular oncology and neuronal epigenetics, with recent work highlighting chromosomal abnormalities in neuroblastoma, hypoxia signaling pathways, and chromatin-based mechanisms of neuronal stability. His findings have direct implications for developing targeted therapies for childhood cancers and neurodegenerative conditions. Scientific recognition includes: StratNeuro grant for Parkinson's-related research Professor Holmberg secures competitive external funding from the Knut and Alice Wallenberg Foundation, Swedish Cancer Society, Hjärnfonden, and Swedish Research Council. His research group employs multidisciplinary approaches combining molecular genetics, epigenomics, and in vivo modeling to translate basic discoveries into clinical applications for neuroblastoma treatment and neurodegenerative disease intervention. The laboratory operates within Umeå University's Department of Molecular Biology, utilizing advanced techniques in chromatin analysis, neuronal differentiation, and cancer genomics to investigate how epigenetic mechanisms govern cell identity in health and disease.

Teresa Frisanمشاهده پروفایل

استاد

• Bacterial Genotoxins
• Infection Biology
• Cancer Biology
• +۶ مورد دیگر

Teresa Frisan is Professor of Cell and Molecular Biology at Umeå University's Department of Molecular Biology, actively engaged in research on bacterial genotoxins and undergraduate/graduate education. Her work bridges infection biology and cancer research through the study of DNA-damaging bacterial effectors. Her educational background includes a Bachelor's degree in Biology (1991, Italy), PhD in Cell and Tumor Biology from Karolinska Institutet (1999), followed by postdoctoral work at Karolinska Institutet and Laval University. She became Associate Professor in Infection Biology at Karolinska Institutet in 2007 before joining Umeå University as Professor in 2017 (installed 2019). Her research focuses on bacterial genotoxins—particularly colibactin, cytolethal distending toxin (CDT), and typhoid toxin—and their role in DNA damage, cellular senescence, and carcinogenesis. Using in vivo mouse models and 3D human organotypic systems , her lab investigates how these toxins modulate intestinal mucosa homeostasis, reprogram immune responses toward anti-inflammatory states, and influence cancer development in chronic infections. Key findings reveal genotoxins act as immunomodulators rather than direct cell killers, establishing persistent infections through tissue-specific crosstalk between DNA damage and immune responses. Frisan leads the Teresa Frisan Lab, which explores connections between bacterial genotoxins, chronic inflammation, and cancer in the gut-hepatobiliary tract. The lab develops therapeutic protocols for early bacterial eradication to prevent tumor initiation, addressing gaps in understanding how dysbiosis, tissue microenvironments, and immune landscapes define pro-tumorigenic outcomes. She has received multiple educational awards for her dedication to pedagogy in undergraduate programs and doctoral education, emphasizing her dual commitment to research excellence and teaching innovation.

Nicholas Leighمشاهده پروفایل

مدرس ارشد

• Limb Regeneration
• Cancer Resistance Mechanisms
• Regenerative Immunology
• +۷ مورد دیگر

Nicholas Leigh serves as a Senior Lecturer at Lund University's Faculty of Medicine, holding multiple prestigious research positions including Principal Investigator at StemTherapy: National Initiative on Stem Cells for Regenerative Therapy and LUCC: Lund University Cancer Centre. He also manages the Regenerative Immunology research team and is affiliated with the Lund University Bioimaging Center. Dr. Leigh's research focuses on the intersection of regeneration biology and cancer resistance, particularly examining how salamanders and newts can regenerate limbs while maintaining cancer resistance. His work explores cellular senescence, immune responses during regeneration, and the molecular mechanisms underlying tissue regrowth. He investigates how non-coding RNA landscapes and repeat elements contribute to regenerative capabilities in amphibians, with potential applications for human regenerative medicine. His recent publications demonstrate a strong trend toward understanding the genomic and molecular basis of regeneration, with particular emphasis on newt and salamander models. The research spans from fundamental genomic analysis to practical applications in cancer resistance and tissue engineering, showing increasing interdisciplinary collaboration between biology, imaging technology, and computational analysis. Docent in Molecular Medicine (2023) Roswell Park Outstanding Ph.D. Dissertation Award (2016) Dr. Leigh currently leads three active research projects totaling over three years of funded research, including 'Deciphering the balance between regeneration and tumorigenesis' funded by Cancerfonden (2024-2026), 'Identifying the origins of cancer resistance in salamanders' (2023-2026), and 'Regeneration as a cancer resistance mechanism' funded by the Crafoord Foundation (2023-2025). His work contributes to multiple UN Sustainable Development Goals related to good health and well-being. His research team operates at the intersection of molecular medicine, gene therapy, and regenerative biology, utilizing advanced imaging techniques and genomic analysis to study regeneration in non-traditional model organisms. The lab maintains strong collaborations with international researchers studying amphibian biology and cancer resistance mechanisms.

Edouard Pesquetمشاهده پروفایل

استاد

• Plant Cell Biology
• Plant Development
• Lignin Chemistry
• +۴ مورد دیگر

Edouard Pesquet is a Professor at Stockholm University's Department of Ecology, Environment and Plant Sciences. He leads the 'Cell differentiation and coordination in tissues' research group, focusing on molecular mechanisms governing plant cell differentiation and xylem tissue development. His work integrates advanced imaging techniques to study lignin chemistry and its role in plant resilience to environmental changes. Research Interests: Pesquet's research spans plant cell biology, lignin biosynthesis regulation, and sustainable bioeconomy. Key areas include understanding lignin's dual role in water transport and mechanical support, developing novel imaging methods (e.g., Raman spectroscopy), and engineering plant biomass for industrial applications. His group investigates inducible pluripotent cell cultures to study xylem cell formation dynamics. Publications: Recent work highlights lignin's functional diversity, lignin paralog-specific control in Arabidopsis, and the impact of environmental stress on vascular biomechanics. His studies leverage interdisciplinary approaches to bridge cellular processes and macroscopic plant properties. Teaching: Pesquet teaches plant cell biology and developmental biology at all academic levels, emphasizing stem cell dynamics, membrane trafficking, and high-throughput analyses (transcriptomics, proteomics). Labs & Collaborations: His lab employs cutting-edge tools like inducible cell cultures and in situ chemical imaging to dissect cell wall assembly. Collaborations include projects on lignin-based biopolymers and sustainable biomass utilization.