جست‌وجوی استاد و پژوهشگر

• Cancer Immunotherapy
• Gene Editing (CRISPR)
• Vaccine Development
• +۳ مورد دیگر

Lei Peng is an Associate Research Scientist in the Department of Genetics at Yale University School of Medicine. Their research focuses on advancing cancer immunotherapy, particularly through CRISPR-based genetic screens and engineering of immune cells like CAR-NK and CAR-T cells. Peng has contributed to breakthroughs in viral vaccine development, including Omicron-specific mRNA vaccines and monoclonal antibody generation. Their work integrates cutting-edge gene editing technologies with immunological insights to address challenges in cancer treatment and infectious diseases. Key collaborations include projects with Paul Renauer and Sidi Chen, targeting genetic checkpoints in NK cells and SARS-CoV-2 variant-specific immunity. Research interests span molecular virology, gene delivery systems (AAV/Sleeping Beauty), and structural biology of antibodies. Peng's studies often bridge basic science with translational applications, aiming to enhance therapeutic efficacy through systems-level approaches. Publications highlight innovations in CRISPR screens for cancer resistance mechanisms, cryo-EM structural analysis of antiviral antibodies, and multiplexed mRNA vaccine strategies. While no awards are explicitly listed, their contributions to high-impact journals like Nature Biotechnology reflect significant scholarly recognition.

• Molecular Embryology
• Cell Biology
• Focal Adhesion Proteins
• +۵ مورد دیگر

Paris Skourides is a Professor at the Department of Biological Sciences , part of the School of Natural and Applied Sciences at the University of Cyprus . His research focuses on the molecular and cellular mechanisms underlying tissue morphogenesis and neural tube closure in vertebrates, particularly using the Xenopus laevis model organism. He also develops advanced imaging techniques using quantum dot nanocrystals and investigates the role of focal adhesion proteins in embryonic development and disease. Education PhD (1998-2004), The Rockefeller University: Morphogenetic Movements during Xenopus Gastrulation and Development of Biocompatible Quantum Dots BA Biochemistry (1994-1997), Brandeis University: Summa Cum Laude and Highest Honors in Biochemistry Research Interests include: Elucidating molecular mechanisms of vertebrate body plan formation Developing quantum dot-based imaging methods for morphogenesis studies Investigating focal adhesion proteins' roles in ciliogenesis and tissue mechanics Studying mechanotransduction pathways in embryonic development Creating high-throughput mucociliary flow assays for ciliopathy research His scientific contributions include the Marie Skłodowska-Curie Individual Fellowship. The Skourides Lab employs interdisciplinary approaches combining live imaging, 4D cell tracking, optogenetics, and molecular dynamics simulations to study: Ciliary adhesion complex formation Integrin-FAK signaling in spindle orientation Calcium signaling in apical constriction Quantum dot applications in developmental biology

Rafael Giraldoمشاهده پروفایل

استاد پژوهشی

• Microbiology
• Biochemistry and Molecular Biology
• Structural Biology and Biophysics
• +۷ مورد دیگر

Rafael Giraldo is a National Centre for Biotechnology (CNB-CSIC) Research Professor in the Department of Microbial Biotechnology since 2019. His career spans over three decades at the Centro de Investigaciones Biológicas (CIB-CSIC) , where he held progressively senior roles from 1995-2018. Current affiliation: CNB-CSIC (2019-) Previous roles: CIB-CSIC (1995-2018) Academic memberships: SEBBM, SBE, SEM (Vice-President 2015-), ASM, ISPB His research focuses on: Structural & functional biology of DNA replication proteins Amyloid proteinopathies in bacterial models Synthetic biology applications for protein assembly Optogenetics control of protein aggregation Recent publications demonstrate his pioneering work in: Engineering bacterial amyloids (2021-2024) Elucidating DNA replication mechanisms (2023) Developing synthetic prionoid systems (2016-2020) Scientific recognition includes: Fellow, Academia Europaea (2010) Corresponding Fellow, Spanish Royal Academy of Pharmacy (2023) Member, CSIC Research Ethics Committee (2018-2020) His Laboratory of Synthetic Bacterial Amyloids explores protein conformational dynamics using: Cell-free expression systems Cytomimetic lipid vesicles Structural methods (NMR, EM, AFM)

May Sin Keمشاهده پروفایل

پژوهشگر ارشد

• Immunotherapy
• Cancer Biology
• Immunogenetics
• +۳ مورد دیگر

Dr. May Sin Ke is a Junior Research Fellow and Postdoctoral Researcher in the Department of Oncology at the University of Oxford's Old Road Campus. Her research focuses on immunotherapy in cancer, particularly leveraging bispecific monoclonal antibodies for colorectal cancer and adenocarcinomas. She specializes in developing biological assays to model cancer biology and identify therapeutic targets. Her doctoral work at Oxford explored tumour heterogeneity in triple-negative breast cancer under hypoxic conditions using single-cell sequencing. During her BSc at the University of Tsukuba, Japan, she developed 3D spheroid models of dermal papilla cells for hair growth screening. Key research interests include tumour heterogeneity, hypoxia-driven cancer mechanisms, and translational applications of 3D cell culture models. Her recent publications emphasize single-cell technologies and their challenges in understanding cellular diversity in oncology. No scientific awards are listed in the provided text. Her work contributes to therapeutic target discovery through advanced cellular and molecular approaches.

• Cellular Signalling
• Phosphoinositide Biology
• Nuclear Functions
• +۵ مورد دیگر

Professor Nullin Divecha is a faculty member at the University of Southampton, specializing in Cellular Signalling research. His work focuses on phosphoinositide biology, nuclear functions, and their roles in immunology, cancer, and neurodegenerative diseases. He leads projects funded by the Biotechnology & Biological Sciences Research Council (BBSRC) and Alzheimer’s Research UK, investigating mechanisms such as nuclear phosphoinositide regulation, mechanoresponsive signaling pathways, and tau protein secretion. Current PhD students under his supervision include Sonakshi Gehlot and Lee Morgan. His research explores interdisciplinary areas including epigenetic signaling, T-cell regulation, and viral inactivation strategies. Recent studies highlight contributions to understanding SARS-CoV-2 inactivation via UVC laser radiation, tau protein dynamics in Alzheimer’s, and mechanoresponsive nuclear softening. Divecha collaborates with international teams and publishes in top journals like Nature Communications , PNAS , and Biomolecules . Research interests span from basic molecular mechanisms to translational applications in disease treatment, with active projects targeting acute myeloid leukemia and immunotherapy advancements. His lab integrates proteomics, biophysics, and pharmacology to uncover novel therapeutic strategies.

Wanhe Liمشاهده پروفایل

استادیار

• Neurobiology
• Circadian Rhythms
• Sleep Regulation
• +۴ مورد دیگر

Wanhe Li is an Assistant Professor at Texas A&M University and a CPRIT Scholar in Cancer Research. His lab investigates the neurobiological mechanisms linking chronic social isolation, stress, sleep disruption, and metabolic changes using Drosophila models. He joined Texas A&M in 2022. Education: B.S. Biological Sciences from Nankai University (2004), Ph.D. in Molecular and Cellular Biology from Stony Brook University (2011, joint with Cold Spring Harbor Laboratory), and postdoctoral training at The Rockefeller University. Research focuses on neural circuits regulating sleep/wake cycles, circadian rhythms, and metabolic responses to social isolation. Key discoveries include how chronic isolation mimics starvation signals in Drosophila , leading to sleep loss and hyperphagia. This work bridges animal models to human conditions like loneliness-associated metabolic disorders and chronic illness progression. Publications highlight translational research in stress neurobiology, circadian regulation, and neurodegenerative mechanisms. Major funding includes CPRIT support for studying cancer-related chronic stress pathways. Labs/Teams: Directs the Li Lab, advancing genetically tractable models to study stress and chronic disease interactions.

Ali Tavassoliمشاهده پروفایل

استاد

• Chemical Biology
• Drug Discovery
• Protein-Protein Interactions
• +۳ مورد دیگر

Ali Tavassoli is a Professor of Chemical Biology at the University of Southampton's School of Chemistry and serves as Chief Scientific Officer at Curve Therapeutics, a VC-backed spin-out from his lab. He leads an interdisciplinary team focused on developing chemical tools to elucidate protein-protein interactions and advance therapeutic discovery. His research bridges synthetic chemistry and biology, with applications in cancer and metabolic disease. Tavassoli holds RSC Fellow status and has led roles in the Royal Society of Chemistry's Chemical Biology divisions. Education & Career: BSc Chemistry, University of Bristol PhD in Synthetic Organic Chemistry, University of Reading Postdoctoral Fellowships: University of Sussex and Penn State University Joined University of Southampton as Lecturer in 2006, promoted to Reader (2011) and Professor (2015) Research Interests: Chemical biology approaches to target protein interactions, hypoxia signaling in cancer, cyclic peptide therapeutics, and synthetic organic chemistry. His work combines molecular design with biological validation to address unmet clinical needs. Key Projects: MRC-funded studies on hypoxia-driven drug discovery EPSRC project on semi-biotic immune systems Cancer Research UK grants for HIF pathway inhibitors Awards: European Young Chemist Medal (2008) RSC Protein & Peptide Science Award (2017) European Peptide Society's Leonidas Zervas Award (2020) Professional Activities: Editorial board member for RSC Chemical Biology , former Chair of RSC Chemical Biology divisions, and inventor of SICLOPPS screening technology. His lab actively collaborates with industry and academia to translate discoveries into therapies.

• Exercise Physiology
• Cardiovascular Physiology
• Sports Science
• +۳ مورد دیگر

Dr. Ole Kemi is a Senior Lecturer at the University of Glasgow's School of Cardiovascular and Metabolic Health. His interdisciplinary research focuses on the effects of exercise and exercise training on cardiovascular physiology, employing experimental models and human studies to investigate cellular mechanisms in health and disease. He holds a BSc in Medicine and Sports Science from the University of Tromsø, an MSc from the Norwegian University of Science and Technology, and a PhD in Molecular Medicine. His research integrates sports science, molecular medicine, and physiology to explore: Intensity-dependent benefits of exercise in cardiac recovery and adaptation Cellular determinants of cardiovascular performance using advanced microscopy and biochemical assays Performance optimization in elite athletes and clinical populations Physiological adaptations in rock climbing and mountaineering Recent publications demonstrate strong trends in exercise physiology innovation, including novel in vitro cardiac models, sports performance analytics, and educational methodology. His work consistently emphasizes the therapeutic potential of exercise in reversing cardiac dysfunction and improving clinical outcomes. He teaches cellular physiology, exercise biology, and sports science across undergraduate and postgraduate programs, while supervising research students in projects spanning from lactate metabolism to climbing biomechanics. His laboratory employs physiological measurements, molecular assays, and performance testing to advance understanding of human physical capacity.

Scott Manalisمشاهده پروفایل

استاد

• Cancer Biology
• Precision Medicine
• Single-Cell Analysis
• +۵ مورد دیگر

Scott Manalis is the David H. Koch (1962) Professor of Engineering at MIT, holding dual appointments in Biological Engineering and Mechanical Engineering. He serves as Associate Department Head of Biological Engineering and is a member of the MIT Center for Precision Cancer Medicine, Ludwig Center at MIT, and the Broad Institute. His lab develops precision measurement technologies for single-cell analysis, focusing on biophysical properties relevant to cancer and immune cell dynamics. Key innovations include the suspended microchannel resonator for cell mass measurement and high-throughput density profiling. Education: B.S. in Physics from UC Santa Barbara; Ph.D. in Applied Physics from Stanford University. He founded Travera and Affinity Biosensors to commercialize his lab's technologies. His research spans precision medicine, microfluidic device engineering, and environmental microbiology. Notable achievements include predicting cancer drug responses through single-cell mass dynamics and revealing biophysical changes during cell division. Research emphasizes functional assays for personalized medicine, with a focus on metastasis, immune cell profiling, and minimal residual disease. Over 100 publications highlight his interdisciplinary approach, integrating engineering, biology, and clinical science. Administrative support is provided by Mariann Murray (mariann@mit.edu). His lab’s work has been featured in MIT News and Nature Biomedical Engineering. Students and alumni include pioneers in biotechnology, academia, and industry, such as Rob Kimmerling (Co-founder, Travera) and Marcio von Muhlen (Co-founder, Turboprop). Current lab members include postdocs and graduate students working on projects ranging from CAR-T cell optimization to AAV gene therapy characterization. Collaborations with Dana-Farber Cancer Institute and Broad Institute underscore translational impact.

Robert A. Weinbergمشاهده پروفایل

استاد

• Cancer Biology
• Cancer Metastasis
• Cancer Stem Cells
• +۳ مورد دیگر

Robert A. Weinberg is the Daniel K. Ludwig Professor for Cancer Research and a Core Member at the Whitehead Institute for Biomedical Research, affiliated with MIT. His research focuses on cancer metastasis, cancer stem cells, and molecular mechanisms underlying epithelial-mesenchymal transition (EMT). He holds a PhD (1969) and SB in Biology (1964) from MIT. Educations: PhD in Biology, MIT, 1969 SB in Biology, MIT, 1964 Research Interests: His work investigates how cancer cells metastasize, the role of EMT in cancer stem cell properties, and molecular regulators of metastasis. Key areas include understanding tumor microenvironment interactions, immunosuppressive mechanisms in breast carcinomas, and therapeutic resistance. Recent Publications Trends: Recent studies emphasize EMT's role in metastasis, cancer stem cell plasticity, and developing immunotherapies for ovarian cancer. He has identified critical genes (e.g., Twist, p63/p73) and pathways (e.g., GLIS2 signaling) driving metastatic colonization and therapeutic resistance. Awards & Honors: Japan Prize (2021) Salk Institute Medal (2016) Breakthrough Prize in Life Sciences (2013) Wolf Prize (2004) National Medal of Science (1997) Member of the National Academy of Sciences (1985) Advising & Grants: He has mentored numerous researchers and led grants focused on EMT, cancer stem cells, and metastasis. His work bridges molecular oncology with clinical applications in combination immunotherapy and targeted therapies. Labs & Collaborations: Led the Whitehead Institute's cancer biology group, collaborating on projects like genetically defined mouse models for ovarian cancer and CRISPR-based screens to identify metastasis regulators.

Diego Ulisse Pizzagalliمشاهده پروفایل

پژوهشگر

• Computational Medicine
• Immunology
• Machine Learning
• +۵ مورد دیگر

Diego Ulisse Pizzagalli is an independent researcher in Computational Medicine affiliated with the Faculty of Biomedical Sciences at the Università della Svizzera italiana (USI), the Euler Institute, and the Institute for Research in Biomedicine (IRB). He holds roles as a lecturer at USI and teaching assistant, focusing on machine learning in medicine and signal processing. His work bridges immunology and AI, with projects involving wearable device monitoring in chronic diseases and the development of digital biomarkers. His research focuses on applying artificial intelligence to understand immune responses, tissue remodelling, and chronic diseases. Key areas include trajectory analysis of immune cells using intravital microscopy, predictive models for disease complications, and bioimage analysis. He leads the IMMUNEMAP initiative, an open immunology data platform, and collaborates on hardware prototyping for medical applications. Pizzagalli’s recent work emphasizes AI-driven medical imaging tools (e.g., CompositIA for CT scans, deep learning in forefoot morphology analysis) and trajectory-based studies of immune cell behavior. His projects integrate clinical data with computational models, such as predicting hospital admissions in chronic liver disease patients using wearable sensors. He co-leads projects funded by systemsx.ch, Apple Inc., and others. Supervises BSc/MSc students. The Digital Pathophysiology Lab at Euler Institute serves as his primary research base, promoting interdisciplinary collaboration in biomedical imaging, trajectory mining, and wearable sensor development.

Alex Cheongمشاهده پروفایل

مدرس ارشد

• Transcription Factors
• Gene Expression Regulation
• Hypoxia
• +۵ مورد دیگر

Alex Cheong is a Senior Lecturer at Aston University, affiliated with the Pharmacology & Translational Neuroscience Research Group (PTNRG) within the College of Health and Life Sciences. He holds a PhD in Pharmacology from the University of Leeds (2001) and a BSc in Pharmacology from University College London (1997). His research focuses on transcription factor regulation of gene expression, particularly in hypoxic environments, employing novel techniques like the secreted Gaussia luciferase method. He has explored crosstalk between HIF and NFκB during hypoxia and developed mathematical models of HIF pathways. Teaching responsibilities include coordinating the Pharmacology PH2501 module and directing the MSc Advanced Clinical Practice Programme. Professional memberships include the Physiological Society and American Society for Biochemistry and Molecular Biology. He serves as an external examiner at Lincoln University and the University of Reading. Research interests span cellular adaptation to hypoxia, inflammatory diseases, cancer, and ageing, combining mathematical modelling with experimental biology. Recent work includes studies on lifespan regulation in C. elegans and fibrosis mechanisms in intestinal inflammation. His lab offers PhD projects for non-EU students, partly funded by the Overseas Research Scholarship.

• Drug Metabolism
• Pharmaceutical Sciences
• Mass Spectrometry
• +۴ مورد دیگر

Ala F. Nassar, PhD, is a Senior Research Scientist and faculty member at Yale University's School of Medicine. With over 25 years of experience in drug metabolism and preclinical drug development, he has held leadership roles in academia and industry. His expertise spans ADME-Tox studies, mass spectrometry, and bioanalytical chemistry. Nassar leads the Chen Lab, focusing on advancing drug design through structural modifications and leveraging cutting-edge technologies like mass cytometry for single-cell analysis in cancer research. Education: Postdoctoral training at UCONN in Pharmacology, PhD in Bioanalytical/Drug Metabolism from UCONN, and Visiting Scientist roles at Kyushu and Nagasaki Universities. He has taught advanced courses in mass spectrometry and drug metabolism at institutions like Brandeis University and the University of Connecticut. Research Interests: His work emphasizes optimizing drug candidates' pharmacokinetic parameters, minimizing toxicity via structural alerts, and applying mass spectrometry for metabolite identification. Current projects include lipid metabolism in cancer, immune cell subset analysis, and developing clinical tools for cellular profiling using mass cytometry. Key Achievements: Editor of major drug metabolism handbooks, guest editor for Metabolites , and inventor with over 100 peer-reviewed articles and patents. His Laromustine ADME-Tox studies significantly advanced clinical understanding of this anticancer agent. Awards include the Battelle R&D Fellowship and the Nat & Frances Sadow Scholarship. Professional Contributions: Serves on editorial boards, including Journal of Drug Metabolism Letters and Metabolites . Active in public service as a science fair judge and collaborates with industry on drug development.

• Proteomics
• Mass Spectrometry
• Biomarker Discovery
• +۴ مورد دیگر

Dr. Kenneth Williams is a Professor (Adjunct) of Research in Molecular Biophysics and Biochemistry at Yale University, affiliated with the Yale School of Medicine. He is the Founder of the W.M. Keck Foundation Biotechnology Resource Laboratory and Co-Director of the Yale/NIDA Neuroproteomics Center. His research focuses on proteomics, mass spectrometry technologies, and biomarker discovery for diseases like cancer and addiction. Williams earned his B.S. in Chemistry from Boston University (1971) and his Ph.D. in Biochemistry from the University of Vermont (1976). He completed postdoctoral training at Yale in Molecular Biophysics and Biochemistry. His work includes developing targeted proteomic assays for kidney transplant recovery and ovarian cancer diagnostics, leveraging advanced mass spectrometry techniques. He has held leadership roles in organizations like the Association of Biomolecular Resource Facilities (ABRF) and secured major NIH grants for proteomics initiatives. Education: B.S., Chemistry, Boston University, 1971 Ph.D., Biochemistry, University of Vermont, 1976 Key Research Areas: Neuroproteomics and addiction mechanisms Proteomic biomarkers for kidney and ovarian diseases High-throughput proteomics technologies Affiliations: Yale/NIDA Neuroproteomics Center (Co-Director since 2015) Keck Biotechnology Resource Laboratory (Founder since 1980) Grants & Recognition: NIH/NIDA Neuroproteomics Center funding (since 2004) ABRF Executive Board member (1988–present) His research integrates proteomics with clinical applications, emphasizing translational medicine and technological innovation. Collaborators include experts in neuroscience, oncology, and bioinformatics. Current projects explore single-cell proteomics and biomarker validation for early disease detection.

Javier Apfeldمشاهده پروفایل

دانشیار

• Cellular Redox Chemistry
• Multicellular Aging
• Neuronal Biology
• +۳ مورد دیگر

Javier Apfeld is an Associate Professor of Biology at Northeastern University’s College of Science, leading the Apfeld Lab. His research focuses on cellular redox chemistry and multicellular aging in the nematode C. elegans, particularly investigating how oxidative stress impacts tissue function and aging-related diseases. His work integrates molecular biology, live imaging, and systems biology approaches to study redox regulation across molecular, cellular, and organismal levels. Research interests include neuronal biology, protein oxidation dynamics, and lifespan regulation. He employs CRISPR-Cas9 genome editing and genetically encoded biosensors for real-time protein oxidation monitoring in live organisms. Key themes include environmental stress responses, microbiome interactions, and the neuroendocrine control of survival strategies in C. elegans. Publications highlight studies on temperature-dependent stress defenses, toxin avoidance mechanisms, and the role of HSF-1 in peroxide stress protection. His lab also explores translational applications of C. elegans models for understanding human diseases like Parkinson’s and diabetes. No specific awards are listed, but his work has been featured in media articles discussing aging biology and organismal stress adaptation. Advising and grants are not explicitly detailed in the provided text, though his lab’s collaborative projects suggest involvement in experiential learning initiatives. The Apfeld Lab is located in the Mugar Life Sciences Building (134 MU), Boston.