Diego Ulisse Pizzagalli

Diego Ulisse Pizzagalli is an independent researcher in Computational Medicine affiliated with the Faculty of Biomedical Sciences at the Università della Svizzera italiana (USI), the Euler Institute, and the Institute for Research in Biomedicine (IRB). He holds roles as a lecturer at USI and teaching assistant, focusing on machine learning in medicine and signal processing. His work bridges immunology and AI, with projects involving wearable device monitoring in chronic diseases and the development of digital biomarkers.

His research focuses on applying artificial intelligence to understand immune responses, tissue remodelling, and chronic diseases. Key areas include trajectory analysis of immune cells using intravital microscopy, predictive models for disease complications, and bioimage analysis. He leads the IMMUNEMAP initiative, an open immunology data platform, and collaborates on hardware prototyping for medical applications.

Pizzagalli’s recent work emphasizes AI-driven medical imaging tools (e.g., CompositIA for CT scans, deep learning in forefoot morphology analysis) and trajectory-based studies of immune cell behavior. His projects integrate clinical data with computational models, such as predicting hospital admissions in chronic liver disease patients using wearable sensors.

He co-leads projects funded by systemsx.ch, Apple Inc., and others. Supervises BSc/MSc students. The Digital Pathophysiology Lab at Euler Institute serves as his primary research base, promoting interdisciplinary collaboration in biomedical imaging, trajectory mining, and wearable sensor development.