جست‌وجوی استاد و پژوهشگر

• Epigenetics
• Chromatin Dynamics
• Cell Cycle
• +۴ مورد دیگر

Dr. Valentin Flury is a Research Professor and Group Leader at the Max Planck Institute of Immunobiology & Epigenetics, leading the Valentin Flury Laboratory. His research focuses on understanding how chromatin states are maintained and propagated across the cell cycle, particularly during DNA replication, mitosis, and DNA damage responses. The group employs genomic and proteomic approaches to dissect the mechanisms governing chromatin plasticity and stability in both healthy and diseased states. Research interests include: Epigenetic memory transmission during DNA replication Cell type-specific principles of chromatin restoration Role of signaling in stem cell identity and differentiation Key methodologies include pulse-chase experiments, SCAR/ChOR-seq, iPOND, APEX proteomics, and studies in fission yeast (Schizosaccharomyces pombe) and mouse embryonic stem cells. The lab’s work has significant implications for understanding cancer and other diseases linked to epigenetic dysregulation. Publications highlight breakthroughs in histone recycling mechanisms, parental histone inheritance, and chromatin state dynamics, with a focus on epigenetic memory and cell plasticity. Current efforts aim to develop tools for tracking chromatin changes across cell divisions to identify disease-sensitive stages in epigenome maintenance. No scientific awards or grants are explicitly listed in the provided texts. The lab collaborates widely and maintains an open-positions page for recruitment.

• Neuroscience
• Stem Cell Research
• Neurogenesis
• +۵ مورد دیگر

Prof. Dr. Magdalena Götz is the Director of the Institute of Stem Cell Research at Helmholtz Center Munich and a Professor of Physiological Genomics at Ludwig Maximilian University Munich. Her research focuses on neurogenesis, neural stem cells, and direct neuronal reprogramming of glial cells for brain repair. Education : Dr.rer.nat at Friedrich-Miescher Institute of the Max-Planck Society (1992) Postdoc : National Institute for Medical Research, London (1993-1996) Her research interests span mechanisms of neural stem cell identity, brain development, and reprogramming strategies to convert glia into neurons with up to 90% efficiency in vivo. She pioneered direct neuronal reprogramming prior to induced pluripotent stem cells and discovered key factors like Akna and Hmgb2. Her scientific awards include: Gottfried Wilhelm Leibniz Prize (2007) Advanced ERC Grant (2014, 2020) Roger de Spoelberch Prize (2017) Her recent publications highlight epigenetic remodeling during reprogramming, glial cell heterogeneity, and mitochondrial proteome contributions. These studies, spanning Nature Neuroscience , Science , and Nature Communications , underpin therapeutic strategies for neurodegenerative diseases. She leads the Stem Cell Center at Helmholtz and collaborates with networks like NSC Reconstruct, Synergy, TRR274, and SPP Ferroptosis.

Giacomo Masserdottiمشاهده پروفایل

استاد مدعو

• Direct Reprogramming
• Neuroregeneration
• Cellular Reprogramming
• +۷ مورد دیگر

Giacomo Masserdotti is an Adjunct Professor and Senior Scientist at the Department of Physiological Genomics, Faculty of Medicine, Ludwig-Maximilians-Universität München. He is affiliated with the Graduate School of Systemic Neurosciences (GSN) and conducts cutting-edge research in direct neuronal reprogramming from glial cells and fibroblasts. Research Interests: His work focuses on the molecular mechanisms—transcriptional, proteomic, and metabolic—underlying the direct conversion of astrocytes, OPCs, and fibroblasts into functional neurons. He employs advanced techniques such as primary cultures, transduction, immunofluorescence, RNA-seq (bulk and single-cell), patch-clamp, and 3D bioprinting to develop improved in vitro 3D models that mimic the in vivo environment, aiming to enhance reprogramming efficiency and neuronal subtype specificity while reducing animal use in research. Publication Trends: His recent publications highlight innovations in overcoming metabolic barriers in reprogramming, enhancing mitochondrial function via CRISPR, and understanding heterogeneity in reprogrammed neurons. These works, published in top journals like Cell Stem Cell and Cell Reports , reflect a strong focus on translational neuroscience and regenerative strategies. Scientific Contributions: Dr. Masserdotti plays a key role in advancing glia-to-neuron conversion technologies. His research bridges basic molecular neuroscience with potential therapeutic applications in neurodegenerative diseases. Mentorship and Team: He currently mentors GSN student Fabio Laredo and collaborates closely with Prof. Magdalena Götz, a leading figure in neural stem cell research. His lab integrates molecular biology with systems-level analysis to dissect reprogramming dynamics.

Rüdiger Kleinمشاهده پروفایل

استاد

• Neuroscience
• Developmental Biology
• Neurodegeneration
• +۷ مورد دیگر

Prof. Dr. Rüdiger Klein is the Director and Head of the Department of Molecules – Signaling – Development at the Max Planck Institute for Biological Intelligence. His research focuses on neuronal circuit formation, cell-cell communication, and neurodegenerative mechanisms using mouse models. Research Areas : Cortex development, amygdala circuits, optogenetics, mouse behavior, neurodegeneration studies Key Techniques : Genetic circuit manipulation, single-cell RNA sequencing, optogenetics, 2-photon calcium imaging Scientific Contributions : His work includes ERC-funded studies on synthetic neurocircuit reconstruction, FLRT protein roles in cortical folding, and amyloid-like aggregate toxicity in Huntington's disease. Advising : Mentored students including Aleksa Petković and Dr. Ylenia Mastrodicasa. Collaborates with Max Planck Institute of Biochemistry departments on proteostasis and neurodegeneration.

George Couplandمشاهده پروفایل

استاد

• Plant Developmental Biology
• Plant Genetics
• Environmental Regulation of Flowering
• +۳ مورد دیگر

George Coupland is a Professor and Director at the Max Planck Institute for Plant Breeding Research , leading the Department of Plant Developmental Biology . His research focuses on the genetic and molecular mechanisms underlying plant reproductive development and perennial life history evolution, primarily in Arabidopsis thaliana and Arabis alpina . Key areas include floral induction networks , environmental signaling integration , and perennial adaptation genomics . 2025 : FD/FDP bZIP interactions in florigen signaling 2024 : Meristem shape-identity coupling 2023 : Urban adaptation in A. thaliana His work combines genetic mapping , confocal imaging , and CRISPR-based functional analysis to dissect regulatory pathways. Articles highlight miRNA dynamics , transcription factor networks , and dormancy-flowering tradeoffs . Collaborations span Andrea Fulgione (population genetics) and Pau Formosa-Jordan (multicellular modeling). Scientific contributions include 2025: FRS (Fellow of the Royal Society) 2021: PLoS Biology publication on miR172 family ResearchGate profiles show over 384 publications and 103,041 reads , emphasizing his leadership in plant developmental biology . The A. alpina model system development enables comparative studies of annual-perennial divergence .

Veit Hornungمشاهده پروفایل

استاد

• Innate Immunity
• Nucleic Acid Sensors
• Inflammasomes
• +۵ مورد دیگر

Professor Veit Hornung is Chair of Immunobiochemistry at the Gene Center and Department of Biochemistry within the Faculty of Medicine at Ludwig Maximilian University of Munich. His laboratory focuses on understanding the molecular mechanisms of innate immune recognition, particularly in the context of nucleic acid sensing and inflammasome biology. Hornung leads a large research group investigating how the immune system distinguishes between self and non-self, with implications for infectious diseases, autoinflammatory disorders, and cancer immunotherapy. Hornung's research spans three primary areas: nucleic acid sensors, inflammasomes, and genome engineering. His work on nucleic acid sensors has elucidated how Toll-like receptors (particularly TLR7 and TLR8) recognize RNA degradation products within endolysosomes, and how the cGAS-STING pathway detects cytosolic DNA. In inflammasome research, his laboratory has made significant contributions to understanding NLRP3, AIM2, and NLRP1 activation mechanisms. His group has also pioneered CRISPR-based genome engineering approaches, developing techniques like SPARCS for spatial cellular phenotype screening. Professor Hornung has received numerous prestigious awards including the Louis-Jeantet Prize (2025), ERC Advanced Grant (2021), William B. Coley Award (2020), Liliane Bettencourt Prize (2018), and the Gottfried Wilhelm Leibniz Prize (2018). He is an EMBO Member and Leopoldina Member, and has been consistently recognized as a Highly Cited Researcher in Immunology. Hornung currently leads multiple major research projects including the ERC Advanced Grant 'ENGINES' focusing on molecular and functional characterization of emerging inflammasomes, and several Collaborative Research Centers including TRR 338 'Lymphocyte Engineering for Therapeutic Synthetic Immunity', TRR 237 'Nucleic Acid Immunity', and SFB 1054 'Control and Plasticity of Cell-Fate Decisions in the Immune System'. His laboratory maintains strong collaborations with other research groups at LMU and internationally.

• Stem Cell Biology
• Cell Biology
• Developmental Biology
• +۵ مورد دیگر

Anika Böttcher serves as Group Leader of the Intestinal Stem Cell Research group at the Institute of Diabetes and Regeneration Research (IDR), Helmholtz Munich, Germany, a position she has held since 2016. Her work bridges cell biology, developmental mechanisms, and metabolic disease research with a focus on therapeutic applications for diabetes and obesity. Her academic foundation includes a Diploma in Biology from the University of Jena (Germany) and University of Lund (Sweden), followed by a PhD at the Max Planck Institute of Biochemistry under Reinhard Fässler investigating integrin signaling in kidney development. She completed postdoctoral training at Helmholtz Munich with Heiko Lickert, studying Wnt/Planar Cell Polarity signaling in gut development. Böttcher's research centers on deciphering how biomechanical signals govern intestinal stem cell fate decisions, particularly in enteroendocrine lineage formation. Her team employs single-cell genomics, mouse models of diet-induced obesity, and molecular techniques to uncover mechanisms linking gut dysfunction to metabolic disorders. Key interests include stem cell plasticity, cellular polarity, and the role of specific enteroendocrine cell subsets in obesity pathogenesis. Analysis of her publication record reveals consistent focus on intestinal stem cell regulation in metabolic disease contexts, with increasing emphasis on single-cell resolution of cellular heterogeneity and diet-induced molecular reprogramming since 2017. Her work demonstrates how obesogenic diets alter stem cell identity through PPAR signaling and insulin pathways, directly linking gut maladaptation to systemic metabolic syndrome. Her scientific recognition includes: Transregional Collaborative Research Centre 127 (2020-2024) German Center for Diabetes Research (DZD) funding (2018-2019) Max Planck Junior Research Award (2010) Rupert Timpl Award from the International Society for Matrix Biology (2010) As group leader, Böttcher directs research supported by major grants from the DFG and DZD, with collaborative projects spanning diabetes mechanism elucidation to therapeutic development. Her team maintains active partnerships with the German Center for Diabetes Research and participates in transregional consortia focused on regenerative approaches. The Intestinal Stem Cell Research group operates within Helmholtz Munich's IDR facility, utilizing advanced genomic, imaging, and mouse phenotyping platforms. Their work connects fundamental stem cell biology with translational applications, particularly in developing gut-based interventions for metabolic disorders through manipulation of enteroendocrine cell differentiation.

Stefan H. Strickerمشاهده پروفایل

استاد

• Epigenetics
• Chromatin Dynamics
• Transcriptional Reprogramming
• +۶ مورد دیگر

Professor Stefan H. Stricker is a W2 Professor of Reprogramming and Regeneration in the Department of Physiological Genomics at the Medical Faculty of Ludwig-Maximilians-University Munich. He leads Project A35 focused on 'Functional analysis and targeted manipulation of chromatin dynamics on mammalian noncoding regions' as part of the CRC 1064 research program. His laboratory is situated within the Biomedical Center (BMC) in Martinsried, which integrates natural sciences with clinical applications to study cell development and plasticity. Professor Stricker's research focuses on epigenetic regulation and cellular reprogramming, particularly investigating how chromatin dynamics can be manipulated to enable cell fate transitions. His work bridges molecular biology with regenerative medicine applications, with significant emphasis on neural lineage development and CRISPR-based technologies for epigenome editing. Recent publications demonstrate his expertise in transcriptional engineering and overcoming epigenetic barriers during cell reprogramming processes. His selected publications from 2019-2021 reveal a strong research trajectory in epigenetics and cellular reprogramming, with articles appearing in high-impact journals including Nature Communications, Cell Stem Cell, and Physiological Reviews. These works collectively explore the intersection of CRISPR technology, epigenetic regulation, and cellular plasticity with implications for regenerative medicine. Kitty Cookson award (2013) EMBO Long-term Fellowship (2009) B.I.F. Böhringer Ingelheim Fonds Scholarship (2005) As an active member of the Graduate School for Systemic Neurosciences since 2016, Professor Stricker supervises graduate students and contributes to academic training. His laboratory benefits from collaborations through the International Training Network (ITN) Nanostem and the Helmholtz@epigenetics committee, providing students with interdisciplinary research opportunities and access to state-of-the-art core facilities at the Biomedical Center.

Michael Siewekeمشاهده پروفایل

استاد

• Stem Cell Biology
• Macrophage Immunology
• Hematopoietic Stem Cells
• +۳ مورد دیگر

Prof. Dr. Michael Sieweke is Alexander von Humboldt Professor and Group Leader at the Center for Regenerative Therapies Dresden (CRTD), Technische Universität Dresden. He maintains joint leadership of the Helmholtz-INSERM Research Unit between Centre d'Immunologie de Marseille-Luminy (France) and Max-Delbrück Center Berlin. His career includes positions as Directeur de Recherche at CNRS, Staff Scientist at EMBL, and postdoctoral training at EMBL. His research bridges immunology and stem cell science, focusing on: Molecular mechanisms of macrophage differentiation from hematopoietic stem cells Self-renewal capabilities of mature macrophages via embryonic stem cell gene networks Development of macrophage-based cellular therapies for regenerative medicine His 15+ major awards include: Alexander von Humboldt Professorship (2018) CNRS Silver Medal (2017) ERC Advanced Grant (2016) Prix AXA (2010) EMBO Fellowship (1992) The lab actively recruits PhD candidates through Dresden International Graduate School for Biomedicine and Bioengineering (DIGS-BB), emphasizing macrophage biology and regenerative therapy development.

• Epigenetics
• Stem Cell Research
• Molecular Biology
• +۴ مورد دیگر

Professor Konstantinos Anastassiadis is a faculty member at Dresden University of Technology, based at the Biotechnology Center (Biotec) within the Center for Molecular and Cellular Bioengineering (CMCB) in Dresden, Germany. His research focuses on epigenetic regulation in stem cell differentiation and blood cell development. His primary research interests encompass: Epigenetic control of cellular reprogramming through chromatin modifications Gender-specific functions of H3K27 demethylases (UTX/KDM6A and UTY/KDM6C) in hematopoiesis Molecular networks governing lineage specification in mesenchymal stromal cells Pluripotency regulation via histone methylation mechanisms His work bridges molecular bioengineering and regenerative medicine, with emphasis on epigenetic drivers of cell fate decisions. Dr. Anastassiadis secured competitive funding through multiple German Research Foundation (DFG) programs: As Principal Investigator: "The role of chromatin modifications in the efficiency of reprogramming" (Priority Program) and "Gender differences of H3K27 demethylases in hematopoiesis" (Material Grant) As Sub-Project Manager: "Conditional immortalization of embryonic mouse cells" and "Molecular networks in bone marrow stromal cells" (Collaborative Research Centers) As Key Collaborator: "Regulation of pluripotency by histone methylation" (Priority Program) These completed projects demonstrate sustained expertise in epigenetic mechanisms across developmental biology contexts. He conducts research within TU Dresden's Biotechnology Center (Biotec), an interdisciplinary hub for molecular and cellular bioengineering that integrates advanced technologies for biomedical discovery.

Nikhil Joshiمشاهده پروفایل

دانشیار

• Tumor Immunology
• Cancer Immunotherapy
• T cell biology
• +۷ مورد دیگر

Nikhil Joshi, PhD is an Associate Professor with Tenure in the Department of Immunobiology at Yale School of Medicine. He serves as Co-leader of the Cancer Immunology Program at Yale Cancer Center and maintains affiliations with multiple Yale research initiatives including the Yale Center for Immuno-Oncology, Human and Translational Immunology Program, and Immunology Liver Center. His research focuses on understanding immune cell interactions with developing tumors, particularly investigating how T cell subtypes function in the tumor microenvironment using complex mouse models. The Joshi Lab combines advanced genetic modeling with immunologic techniques to address fundamental questions in tumor immunology. Analysis of recent publications (2022-2025) reveals a strong focus on T cell biology in cancer, with particular emphasis on T cell exhaustion mechanisms, immunoediting processes, tertiary lymphoid structures, and metabolic influences on tumor immunity. His work spans both basic immunological mechanisms and translational applications for cancer immunotherapy. Class of 1961 Cancer Research Award, Yale Cancer Center (2023) Basic Science Research Prize, Yale Cancer Center (2023) Young Investigators in Cancer Research, Pershing Square Sohn Prize (2022) Emerging Leader Award, Mark Foundation (2022) James B. Dougherty MD Award, Lung Cancer Research Foundation (2021) Professor Joshi maintains active research funding as evidenced by his substantial publication record in high-impact journals. His lab trains numerous students and postdocs, with frequent collaborators including Kelli Connolly, Gena Gora Foster, and Eric Fagerberg. The lab participates in multiple interdisciplinary initiatives at Yale, providing students with opportunities to work at the intersection of immunology, cancer biology, and computational approaches. The Joshi Laboratory focuses on engineering models to decode T-cell immunity in cancer, with research spanning tumor differentiation, T cell fate in cancer and health, and mechanisms of action for immune cells in tumor development and suppression.

• Epigenetics
• Genome Biology
• Embryonic Development
• +۷ مورد دیگر

Zachary Smith is an Assistant Professor (Adjunct) in the Department of Genetics at Yale School of Medicine, with additional affiliations at the Yale Stem Cell Center, Center for RNA Science and Medicine, and the Genomics, Genetics, and Epigenetics program. His research focuses on epigenetic regulation during mammalian development. Dr. Smith received his B.S. in Biology from M.I.T. in 2008 and his Ph.D. in Biology from Harvard University in 2019. His doctoral work focused on applying cutting-edge genomic technologies to understand chromatin dynamics during mammalian development. He joined the Yale Stem Cell Center and Department of Genetics as an Assistant Professor in September 2020. Dr. Smith's research program investigates three critical developmental processes: fertilization, implantation, and gastrulation. His lab seeks to understand how the genome is reconstructed after fertilization, how distinct epigenetic states are established in embryonic versus extraembryonic lineages, and how chromatin regulators orchestrate the complex process of gastrulation. They employ advanced genomic techniques including single-cell sequencing, Cas9-mediated genome editing, and novel molecular recording technologies. His recent publications highlight significant contributions to understanding DNA methylation dynamics in development and disease, X-chromosome biology, and the development of innovative genomic technologies. Dr. Smith's work bridges fundamental developmental biology with potential applications to understanding developmental disorders and cancer. Epigenetic regulation of mammalian development Chromatin dynamics during embryogenesis DNA methylation reprogramming Single-cell genomic analysis Novel molecular recording technologies Dr. Smith's lab collaborates extensively with researchers at Yale and other institutions, including Michael Caplan, Berna Sozen, and Biff Forbush. His interdisciplinary approach combines expertise in genetics, developmental biology, and technology development to address fundamental questions about how epigenetic mechanisms shape development. Students and postdocs in Dr. Smith's lab have opportunities to work at the forefront of developmental epigenetics, gaining expertise in both experimental and computational approaches to studying genome regulation during development.

• Stem Cell Differentiation
• Toxicology
• Hepatocyte Biology
• +۲ مورد دیگر

Dr. David Feuerborn is a Researcher at the Leibniz Research Centre for Working Environment and Human Factors (IFADO) in Dortmund, Germany, within the Toxicology department's Regulatory Networks of Stem Cell Differentiation group. His work focuses on modeling stem cell differentiation into hepatocyte-like cells for toxicology applications, with contact details feuerborn@ifado.de and +49 231 1084-344. His research centers on regulatory mechanisms in stem cell differentiation, particularly hepatocyte development influenced by environmental toxins like bisphenols. He employs genome-wide expression profiling and bioinformatic analysis to study transcription factors (HNF4α, FXR) and cellular responses to toxicants, bridging stem cell biology and toxicology. Analysis of his 2018-2022 publications reveals consistent use of iPSC-derived hepatocyte models to assess compound toxicity, with increasing integration of single-cell genomics and computational methods. Key trends include characterizing hybrid cell states, dissecting endocrine disruptor effects, and developing predictive frameworks for transcription factor activity. As part of IFADO's Regulatory Networks of Stem Cell Differentiation team, he collaborates on projects examining molecular pathways governing cell fate decisions in toxicological contexts, contributing to stem cell-based testing methodologies for drug development and safety assessment.