Valentin Flury

Dr. Valentin Flury is a Research Professor and Group Leader at the Max Planck Institute of Immunobiology & Epigenetics, leading the Valentin Flury Laboratory. His research focuses on understanding how chromatin states are maintained and propagated across the cell cycle, particularly during DNA replication, mitosis, and DNA damage responses. The group employs genomic and proteomic approaches to dissect the mechanisms governing chromatin plasticity and stability in both healthy and diseased states.

Research interests include:

• Epigenetic memory transmission during DNA replication
• Cell type-specific principles of chromatin restoration
• Role of signaling in stem cell identity and differentiation

Key methodologies include pulse-chase experiments, SCAR/ChOR-seq, iPOND, APEX proteomics, and studies in fission yeast (Schizosaccharomyces pombe) and mouse embryonic stem cells. The lab’s work has significant implications for understanding cancer and other diseases linked to epigenetic dysregulation.

Publications highlight breakthroughs in histone recycling mechanisms, parental histone inheritance, and chromatin state dynamics, with a focus on epigenetic memory and cell plasticity. Current efforts aim to develop tools for tracking chromatin changes across cell divisions to identify disease-sensitive stages in epigenome maintenance.

No scientific awards or grants are explicitly listed in the provided texts. The lab collaborates widely and maintains an open-positions page for recruitment.