جست‌وجوی استاد و پژوهشگر

Julia Jellusovaمشاهده پروفایل

استادیار

• Immunology
• B Cell Signaling
• Cell Metabolism
• +۵ مورد دیگر

Prof. Dr. Julia Jellusova is a tenure-track Assistant Professor at the Technical University of Munich (TUM), affiliated with the School of Medicine and the Institute for Clinical Chemistry and Pathobiochemistry. She leads the 'Immune Signaling' research group, focusing on the integration of metabolism and signal transduction in B cells in health and disease. Technical University of Munich, School of Medicine, Institute for Clinical Chemistry and Pathobiochemistry Former junior group leader at Albert Ludwigs University Freiburg Postdoctoral training at Sanford Burnham Prebys Medical Discovery Institute, USA PhD from Friedrich Alexander University Erlangen-Nuremberg Her research centers on immunometabolism, particularly how metabolic programs regulate B cell fate, function, and contribution to autoimmunity and cancer. She investigates signaling pathways such as PI3K, NF-κB, and BAFF-R, and their interplay with metabolic stress, immunoglobulin production, and mitochondrial function. Her work has revealed novel mechanisms by which immunoglobulins influence ER homeostasis and metabolic flexibility independent of their receptor function. The 15 most recent publications highlight a strong trend in B cell immunometabolism, with recurring themes in BAFF signaling, PI3K pathway regulation, metabolic checkpoints (e.g., GSK3), mitochondrial function (e.g., TFAM), and the role of metabolic dysregulation in B cell malignancies. Her articles frequently appear in high-impact journals such as Nature Immunology , PNAS , and Cell Reports , reflecting her leadership in the field. Her scientific awards include: Henriette Herz-Scouting Programme, Alexander von Humboldt Foundation (2022) STS Science Award (2017) Margarete von Wrangell Habilitations Fellowship (2017–2021) Eric Dudl Scholarship Award (2015) Seahorse Travel Award (2015) Arthritis National Research Foundation grant (2013–2014) DFG Research Fellowship (2011–2013) STAEDTLER Foundation Award (2011) Julia Jellusova has secured competitive grants and fellowships throughout her career, including funding from the DFG and Arthritis National Research Foundation. She mentors junior scientists within her research group and has co-authored numerous publications with trainees, indicating an active role in advising. Her research is conducted at TranslaTUM, the Central Institute for Translational Cancer Research at TUM, where her lab investigates metabolic vulnerabilities in malignant B cells to inform new therapeutic strategies. She leads the 'Immune Signaling' working group at TUM, embedded within a collaborative environment at TranslaTUM, focusing on translational cancer research. Her team explores how metabolic stress and signaling context determine B cell fate, with implications for autoimmune diseases and B cell lymphomas.

Andreas Trumppمشاهده پروفایل

استاد

• Hematology
• Stem Cell Biology
• Cancer Progression
• +۳ مورد دیگر

Prof. Dr. Andreas Trumpp is a leading stem cell and cancer researcher at the German Cancer Research Center (DKFZ) and serves as the Managing Director of HI-STEM (Heidelberg Institute for Stem Cell Technology and Experimental Medicine). Since 2008, he has headed the Division of Stem Cells and Cancer, focusing on understanding the molecular mechanisms governing normal and malignant stem cells. His research spans Hematopoietic stem cell dormancy and activation Leukemia stem cell biology Metastasis mechanisms Ferroptosis and cancer metabolism Stem cell niche interactions Single-cell multi-omics in cancer progression Trumpp’s group has made significant contributions to understanding therapy resistance in acute myeloid leukemia (AML) and identified novel mechanisms for targeting cancer stem cells. His lab’s work on the SHATTER-AML project, funded by an ERC Advanced Grant (2022) , aims to develop precision therapies for cancers with structural genetic defects. Scientific accolades include being invited to deliver the Ham-Wasserman Lecture (2022) at the American Society of Hematology (ASH) meeting, a prestigious honor recognizing his global impact in hematology. His alumni include numerous successful researchers transitioning to positions at institutions like Max Planck Institute , TRON-Translational Oncology , and Novartis , reflecting his mentorship role in shaping the next generation of stem cell scientists.

Vlad Cojocaruمشاهده پروفایل

استاد پژوهشی

• Computational Structural Biology
• Molecular Simulations
• DNA recognition by transcription factors
• +۴ مورد دیگر

Vlad Cojocaru is a Research Professor and Group Leader of the Computational Structural Biology project group at the Max Planck Institute for Molecular Biomedicine in Münster, Germany. Since September 2018, he has also served as a Group Leader at the Hubrecht Institute of the Royal Netherlands Academy of Arts and Sciences in Utrecht, The Netherlands. His research group applies state-of-the-art computational methods to investigate biological processes from a physico-chemical perspective, with particular focus on stem cell pluripotency mechanisms. Dr. Cojocaru's research centers on understanding how transcription factors recognize and bind to DNA through computational approaches including structural modeling, biomolecular simulations, and molecular docking. His work examines protein-nucleic acid interactions, protein-membrane interactions, and computer-aided drug discovery. Key research areas include DNA recognition by transcription factors involved in combinatorial control of transcription, cooperativity between transcription factors during DNA binding, and the impact of transcription factor folding on DNA recognition. Analysis of Dr. Cojocaru's recent publications reveals a strong emphasis on chromatin structure and transcription factor dynamics, particularly regarding how pioneer factors like OCT4 interact with nucleosomes. His work combines computational modeling with experimental validation to reveal molecular mechanisms difficult to observe through traditional methods, significantly advancing our understanding of stem cell regulation and chromatin dynamics. PLoS Computational Biology 2011 journal cover feature Biochimica et Biophysica Acta 2007 journal cover feature Nucleic Acids Research 2005 journal cover feature Dr. Cojocaru actively mentors students in computational structural biology and receives funding from prestigious sources including the Max Planck Society and the DFG SPP1356 Priority Program. He utilizes significant computational resources from the Max Planck Society and the PRACE EU initiative. His group welcomes Master's and PhD students interested in pursuing computational biology research, with applications directed to him personally. The Computational Structural Biology group, which includes researchers like Jan Huertas, utilizes what Cojocaru terms a 'computational nanoscope' - a suite of molecular modeling and simulation methods enabling visualization of biomolecular dynamics at atomistic resolution. Their work has produced significant insights into chromatin dynamics, nucleosome breathing, histone tail dynamics, and the structural mechanisms of pioneer transcription factor binding to nucleosomes.

Roland M. Schmidمشاهده پروفایل

استاد

• Pancreatic carcinogenesis
• Molecular oncology
• Gastroenterology
• +۵ مورد دیگر

Prof. Dr. Roland M. Schmid is a Professor of Internal Medicine specializing in Gastroenterology, Hepatology, and Endocrinology at the Technical University of Munich (TUM), where he serves as Director of the Department of Internal Medicine II at Klinikum rechts der Isar. He has held this position since 2002 and previously served as Vice Dean from 2007-2010. From 2018-2023, he was the Spokesperson of the Collaborative Research Center SFB 1321 "Modelling and Targeting Pancreatic Cancer." His educational background includes: 1979-1985: Medical studies at University of Ulm 1987: Dr. med. (summa cum laude) at University of Ulm 1995: Habilitation for Internal Medicine at University of Ulm 2005: Executive EMBA, University of St. Gallen Prof. Schmid's research focuses on understanding the molecular basis of pancreatic carcinogenesis and translating these findings into diagnostic and therapeutic concepts. His laboratory investigates the role of tumor-relevant gene alterations using transgenic and knock-in mouse models. A key focus is on the connection between oxidative stress, chronic inflammatory processes, and tumor development. His team has developed genetic models of chronic pancreatitis to study the significance of chronic inflammation in pancreatic carcinogenesis and to establish preventive and therapeutic approaches. His work also examines tumor survival mechanisms, identifying cellular components essential for tumor maintenance and characterizing their functions at molecular, genetic, and cellular levels. Analysis of Prof. Schmid's recent publications reveals a strong emphasis on pancreatic cancer biology, particularly in understanding metabolic reprogramming, KRAS signaling pathways, tumor microenvironment interactions, and molecular mechanisms of cancer initiation and progression. His research spans from basic molecular mechanisms to translational applications, including personalized oncology approaches using patient-derived organoids. Among his notable recognitions: Heinz Maier Leibnitz Medal, TUM (2008) Merckle Research Prize, University of Ulm (2001) Ludwig Heilmeyer Silver Medal, German Society for Advances in Internal Medicine (1998) Wolf-Boas Prize, German Society for Digestive and Metabolic Diseases (1986) Prof. Schmid actively participates in academic service, serving on the advisory board of the German Cancer Aid and as a member of editorial boards for renowned scientific journals including Gastroenterology and World Journal of Gastroenterology. He leads a research group investigating pancreatic carcinogenesis, working closely with Dr. Henrik Einwächter and a team of researchers including postdocs, medical students, and technical staff. His laboratory, the Working Group of Prof. Dr. Roland M. Schmid and Dr. Henrik Einwächter, focuses on the molecular basis of pancreatic carcinogenesis and tumor survival, with particular attention to the connection between oxidative stress, chronic inflammatory processes, and tumor development. The group utilizes transgenic and knock-in mouse models to study the role of tumor-relevant mutations in pancreatic cancer pathogenesis.

• Molecular Neuroscience
• Developmental Neuroscience
• Stem Cell Biology
• +۴ مورد دیگر

Magdalena Götz is a Professor at Ludwig-Maximilians-Universität München and Director of the Institute of Stem Cell Research at Helmholtz Munich. She leads the Stem Cell Center Department and Neural Stem Cells research group, focusing on molecular mechanisms of neurogenesis and direct neuronal reprogramming. Chair of Physiological Genomics, LMU Biomedical Center Director, Institute of Stem Cell Research Head, Stem Cell Center Department Head, Neural Stem Cells Research Group Her research in molecular & developmental neuroscience explores neural stem cells, neurogenesis, brain injury repair, and direct neuronal reprogramming. Key discoveries include identifying radial glial cells as neural stem cells and pioneering glia-to-neuron conversion for brain repair. Recent work examines epigenetic remodeling, centrosome proteins, and human neural stem cell proteomics. Articles highlight advancements in neurogenesis mechanisms and therapeutic applications for brain injuries. Honors & Awards Gottfried Wilhelm Leibniz Prize (2007) Advanced ERC Grant (2014, 2020) Roger de Spoelberch Prize (2017) She mentors numerous PhD students and collaborates with institutions like GSN Scientific Board and Synergy Cluster. Her work bridges developmental biology with regenerative medicine, offering new hope for neurodegenerative diseases.

Edda Schulzمشاهده پروفایل

استاد

• X-chromosome inactivation
• Epigenetics
• Gene regulation
• +۵ مورد دیگر

Dr. Edda Schulz is a Lise Meitner Group Leader and Research Group Leader at the Max Planck Institute for Molecular Genetics in Berlin, where she leads an active research laboratory focused on epigenetic regulation and chromosome biology. She has been in this position since 2020, following five years as a Max Planck Research Group Leader at the same institution. Dr. Schulz received her PhD from Humboldt Universität und Deutsches Rheumaforschungszentrum in Berlin, where she worked with Professors Thomas Höfer and Andreas Radbruch, and completed postdoctoral training at Institut Curie in Paris with Professor Edith Heard. Her research program centers on X-chromosome inactivation, epigenetic regulation, and gene expression dynamics. Dr. Schulz employs cutting-edge approaches including CRISPR screening, quantitative modeling, and single-cell genomics to investigate how cells establish and maintain epigenetic states during development. Her lab has developed innovative tools like CasTuner for precise gene expression modulation and has made significant contributions to understanding how transcription factors and cis-regulatory elements coordinate Xist expression during early embryonic development. Analysis of her recent publications reveals a strong focus on the molecular mechanisms of X-chromosome inactivation, with particular emphasis on cis-regulatory architecture, chromatin topology changes, and the role of transcription factor networks. Her work bridges quantitative biology with molecular genetics, often incorporating mathematical modeling to understand gene regulatory networks. The lab's research has important implications for understanding developmental disorders, stem cell biology, and epigenetic inheritance. EMBO Young Investigator (2022) ERC Starting Grant (2020) HFSP Career Development Award (2018) HFSP Long-Term Fellowship (2010-2014) Young Female Scientist Award for PhD thesis (2011) Avrion Mitchison Price for Rheumatology (2010) MTZ-Award for Medical Systems Biology for PhD thesis (2010) Dr. Schulz actively mentors PhD students and postdoctoral researchers, with several successful thesis defenses documented in her lab news. She has secured competitive funding including an ERC Starting Grant and serves on the review board of the German Research Foundation (DFG). Her lab collaborates with multiple international groups and she co-organized the 2023 EMBO Workshop on X-chromosome inactivation. The Schulz Lab maintains a dynamic research environment with regular retreats, workshops, and collaborative projects, as evidenced by their active news updates through 2025.

• Stem Cell Research
• Embryonic Development
• Biomedical Engineering
• +۳ مورد دیگر

Gloryn Chia is an Assistant Professor at the National University of Singapore, affiliated with the Department of Pharmacy. Her career spans roles as a Senior Scientist at Merck Sharp and Dohme (2018–present), a Research Fellow at Bioprocessing Technology Institute (2016–2018), and a Postdoctoral Fellow at Columbia University (2013–2016). Ph.D. in Physiology, Development and Neuroscience from the University of Cambridge (2009–2013) B.Sc. from the National University of Singapore (2003–2007) Her research focuses on stem cell biology, embryonic development, and biomedical engineering, particularly on iPSC-derived red blood cells and antigen presentation . Key contributions include studies on Oct4 regulation, genomic instability during reprogramming, and mechanisms of embryonic aneuploidy. Recent publications highlight advancements in cancer neoantigen discovery, in vitro red blood cell generation, and transcriptional networks governing pluripotency. She secured a grant from the National Medical Research Council for engineering iPSC-derived red blood cells for antigen presentation to CD8+ T cells.

• Epigenetics
• Cancer Biology
• Neuroscience
• +۵ مورد دیگر

Derrick Ong is an Assistant Professor at the Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore (NUS). His academic career spans roles in research, editorial contributions, and grant-funded projects focused on cancer biology and epigenetics. Education: Ph.D. in Molecular Medicine (2011), Scripps Research Institute M.S. in Biological Sciences (2004), NUS B.S. (First Class Honors) in Chemistry & Biological Sciences (2003), NUS Research interests center on epigenetic regulation in cancer, particularly glioblastoma, with a focus on chromatin dynamics, metabolic stress, and redox biology. His work bridges molecular medicine with translational oncology. Recent publications highlight advancements in glioblastoma stemness, chromatin topology, nanoparticle-based therapies, and telomere biology. Key themes include epigenetic plasticity, mitochondrial dysfunction, and therapeutic vulnerabilities. Scientific Awards: NRF Fellowship (Singapore) Yong Loo Lin School of Medicine Research Excellence Award (2023) Active in peer review for journals like Advanced Science, Cell Death & Disease, and Oncogene. Leads grants from NUS, NUS Center for Cancer Research, and Singapore's Ministry of Education.

• Epigenetics
• Cellular Reprogramming
• Developmental Biology
• +۳ مورد دیگر

Dr. Eva Hörmanseder is a Group Leader at Helmholtz Munich, leading the Hörmanseder Lab within the Institute of Epigenetics and Stem Cells (IES). Her research focuses on understanding epigenetic mechanisms that stabilize cell identity and inhibit reprogramming, particularly during somatic cell nuclear transfer (SCNT). She investigates how vertebrate eggs can erase cellular memory to reprogram somatic nuclei into totipotent states, with implications for regenerative medicine. Her work emphasizes histone modifications like H3K4 methylation as barriers to reprogramming. Her lab combines SCNT with multi-omics approaches to study three main areas: Epigenetic Memory: How differentiated cells retain identity Reprogramming to Totipotency: Mechanisms enabling nuclear transfer embryos Barriers for Cell Fate Changes: Overcoming resistance in nuclear transfer Recent work highlights her lab’s efforts to improve reprogramming efficiency by manipulating epigenetic barriers. Collaborations within the IES and Helmholtz Munich provide a multidisciplinary environment for advancing stem cell and epigenetic research. Students Marco Stock, Meghana Oak, and Ana Janeva contribute to these efforts, focusing on computational biology, chromatin dynamics, and developmental epigenetics. Key publications include breakthroughs in understanding H3K4 methylation’s role in cellular memory and the application of targeted DamID technology for histone modification analysis. Her findings bridge basic science and therapeutic potential in regenerative medicine.

• Immunology
• Systems Biology
• Single-Cell Omics
• +۳ مورد دیگر

Dr. Tal Pecht is a Junior Group Leader at the LIMES-Institute , affiliated with the ImmunoSensation2 Excellence Cluster and the German Center for Neurodegenerative Diseases (DZNE) at the University of Bonn. Her research in the Transdisciplinary Research Area Life and Health focuses on understanding immune-metabolic sex differences through systems biology approaches. Her work investigates how endocrine and metabolic fluctuations shape the female immune system, particularly in conditions like obesity and insulin resistance. Using collaborations in Tanzania and Germany, she integrates transcriptome, metabolome, and proteome data to characterize immune-metabolic interactions through advanced bioinformatics tools. Key article trends reveal her expertise in Single-cell omics for immune profiling Environmental and dietary impacts on inflammation Sex-specific disease mechanisms Translational immunometabolism Cross-continental health disparities Systems biology of immune-endocrine interactions Dr. Pecht leads the FemmunityX research team , contributing to transdisciplinary projects through Bonn Technology Campus resources and participating in TRA Life and Health initiatives .

Mauricio Rocha-Martinsمشاهده پروفایل

پژوهشگر

• Developmental Biology
• Cellular Plasticity
• Neuroscience
• +۳ مورد دیگر

Dr. Mauricio Rocha-Martins is a Researcher at the Max Planck Institute for Molecular Biomedicine in Münster, Germany, leading the Rocha Lab focused on Embryo Self-Correction . His work investigates how embryos overcome genetic and environmental stressors to develop functional organs, emphasizing developmental robustness, cellular plasticity, and nervous system development. Affiliations: Max Planck Institute for Molecular Biomedicine Role: Lab Head (Rocha Lab) and Supervisor in the CiM-IMPRS Graduate Programme Methodologies: Live imaging of in vivo systems, organoids, CRISPR genetics, light-sheet microscopy, and deep-learning image restoration Research Interests: His lab explores mechanisms enabling embryos to recover from developmental defects using advanced imaging and molecular profiling. Key areas include: Cellular cooperation under stress Regeneration of tissue organization Biophysical and molecular dynamics in repair processes Scientific Contributions: Publications span retinal development, neuronal migration, and imaging innovations. Recent work (2023-2025) highlights novel insights into progenitor cell behavior, neurogenic signaling, and stress adaptation in embryonic systems. Lab & Team: The Rocha Lab combines experimental and computational approaches, collaborating with the Cells in Motion initiative. Their work bridges basic research with potential applications in regenerative medicine and developmental disorder modeling.

• Cell Biology
• Developmental Biology
• Systems Biology
• +۵ مورد دیگر

Dr. Antonio Scialdone is a Group Leader at Helmholtz Zentrum München, leading the Scialdone Lab within the Stem Cell Center and Epigenetics research groups. His research focuses on understanding molecular mechanisms of cell identity changes through single-cell and spatial omics analysis combined with physical modeling. He holds a PhD in Physics from the University of Naples Federico II, followed by postdoctoral work in the UK. Key research areas include embryo patterning, cell competition, cell migration, and olfactory neuron spatial organization. Education: PhD in Fundamental and Applied Physics, University of Naples Federico II (Italy) Bachelor’s degree in Physics, University of Naples Federico II Postdoctoral positions at John Innes Centre (UK), EMBL-EBI, and Wellcome Trust Sanger Institute Research Interests: Decoding principles of cellular plasticity at single-cell and inter-cellular levels Role of cellular communication in collective decisions (e.g., embryo axis formation, cell competition) Applications in developmental biology, cancer, and aging Recent Work Highlights: Studies on stem cell reprogramming heterogeneity and somatic cell memory Identification of molecular underpinnings of primordial germ cell development Development of algorithms for gene regulatory network inference (CIARA, Topological Benchmarking) Advising and Lab Team: Supervises doctoral researchers Marco Stock, Gabriele Lubatti, and Veronica Finazzi Collaborates with experimental labs to integrate computational models with biological data Labs and Affiliations: Part of Epigenetics@Helmholtz Munich Location: Building 90, Großhadern Campus

• Stem Cell Research
• Pluripotency
• Developmental Biology
• +۳ مورد دیگر

Professor Hans Schöler is a leading stem cell biologist and Director of the Max Planck Institute for Molecular Biomedicine in Münster, Germany. He holds simultaneous academic roles as Professor at the Medical Faculty of the University of Münster, Distinguished Professor at UNIST (Ulsan National Institute of Science and Technology) and Konkuk University in South Korea, as well as Adjunct Professorships at the University of Pennsylvania and Hannover Medical School. His research focuses on pluripotency mechanisms, stem cell reprogramming, and organoid modeling for regenerative medicine. Key affiliations include leadership roles in the ISSCR (International Society for Stem Cell Research) Board since 2015, and active participation in the Cells-in-Motion (CiM) Cluster of Excellence. Dr. Schöler’s work bridges basic research and clinical translation, emphasizing ethical communication of stem cell research to the public and policymakers. Research interests span molecular regulation of pluripotency (Oct4/Sox2 networks), organoid-based disease modeling, and epigenetic reprogramming strategies. Recent work explores applications in neurodegenerative diseases (e.g., Parkinson’s, frontotemporal dementia) and liver fibrosis through organoid systems. His contributions have advanced methodologies for induced pluripotent stem cell (iPSC) generation, somatic cell reprogramming, and high-throughput organoid screening platforms integrated with AI analysis. He remains a vocal advocate for responsible science communication and public education about stem cell technologies.

• Immunology
• Cell Biology
• Metabolism
• +۱ مورد دیگر

Dr. Angelika Rambold is a Research Professor and Group Leader at the Max Planck Institute of Immunobiology and Epigenetics, leading the Metabolic Organelle Networks in Immunology lab. Her multidisciplinary research combines cell biology and immunology to understand how organelles regulate immune cell functions, with applications in autoimmune disorders and metabolic diseases. Her investigations focus on organelle dynamics in immune cells, employing advanced imaging and omics technologies. Key interests include metabolic regulation of immune responses, mitochondrial function in inflammation, and organelle communication networks. Research trends show consistent focus on immunometabolism, cellular organelle interactions, and developing novel imaging techniques to track immune cell behavior in physiological and pathological conditions. Dr. Rambold leads an interdisciplinary team exploring how metabolic reprogramming of organelles influences immune cell fate decisions, supported by international collaborations and institutional funding.

Nicola Iovinoمشاهده پروفایل

استاد پژوهشی

• Epigenetics
• Developmental Biology
• Chromatin Regulation
• +۳ مورد دیگر

Dr. Nicola Iovino is a Senior Group Leader & Director at the Max Planck Institute of Immunobiology & Epigenetics, leading the Developmental Epigenetics Laboratory . His research focuses on unraveling mechanisms governing epigenetic reprogramming in gametes, germline inheritance, and de novo epigenome establishment in Drosophila embryos. The lab employs cutting-edge genomic and molecular approaches to study chromatin regulation during early embryogenesis, with implications for translational research in vertebrate models. Key research interests include histone modifications (e.g., H3K9 methylation, H3K27me3), 3D genome architecture, and the role of histone variants like H2A.Z. His work bridges basic science and potential applications in understanding embryonic development and genetic disorders. Collaborations involve interdisciplinary teams, as evidenced by co-authored studies in high-impact journals like Nature , Science , and Developmental Cell . Articles highlight advancements in understanding zygotic genome activation, maternal-to-zygotic transition, and HP1-driven genome reorganization. No scientific awards are explicitly mentioned in the provided texts. The lab actively engages in social media via @Iovino_Lab and maintains a focus on open collaboration and innovation.