جست‌وجوی استاد و پژوهشگر

Jingsong Zhouمشاهده پروفایل

استاد

• Neuromuscular Diseases
• Striated Muscle Physiology
• Calcium Signaling
• +۴ مورد دیگر

Dr. Jingsong Zhou is a Professor of Kinesiology and Associate Director of the Bone-Muscle Research Center at The University of Texas at Arlington. Her research focuses on neuromuscular diseases, particularly Amyotrophic Lateral Sclerosis (ALS), with expertise in striated muscle physiology, calcium signaling, and mitochondrial dysfunction. She leads the Neuromuscular Diseases Lab, which develops genetic mouse models and molecular probes to study ALS mechanisms. Dr. Zhou’s work has been supported by NIH, MDA, DOD, and the ALS Association. She serves on the NIH SMEP study section and has over 20 years of academic experience, including postdoctoral training at Vanderbilt University College of Medicine and a PhD from Rush University School of Medicine. Education: Postdoctoral Fellow in Pharmacology, Vanderbilt University College of Medicine (2001) PhD in Molecular Biophysics and Physiology, Rush University School of Medicine (1997) Diploma in Medicine, Hunan Medical University (Xiangya Medical School) (1986) Research Interests: Mechanisms of calcium signaling and mitochondrial dysfunction in ALS Role of sarcolemma repair and autophagy in neuromuscular disease progression Development of therapeutic strategies targeting mitochondrial health and membrane integrity Grants and Funding: NIH grants focused on ALS pathogenesis and muscle-bone interactions Support from MDA, DOD, and ALS Association for translational research projects Labs and Teams: Director of the Neuromuscular Diseases Lab at UT Arlington Collaborations in developing mouse models and molecular tools for ALS research

Richard W. Grossمشاهده پروفایل

استاد

• Analytical Chemistry
• Biological Membranes
• Lipidomics
• +۴ مورد دیگر

Dr. Richard W. Gross is Professor of Medicine and Developmental Biology at Washington University School of Medicine and Professor of Chemistry. He holds a PhD from Washington University, MD from New York University Medical School, and BA from Columbia College. His research focuses on the chemical biology of membranes in health and disease, specializing in lipidomics, metabolomics, and membrane signaling. He pioneered shotgun lipidomics technology for direct identification and quantification of lipid molecular species in biological systems. Developed novel shotgun lipidomics technology combining intrasource separation, multidimensional MS, and array analysis Investigates phospholipase regulation and membrane signaling complexes Studies altered lipid metabolism in obesity, diabetes and cardiovascular disease

Jon Olav Vikمشاهده پروفایل

استاد

• Systems Biology
• Computational Biology
• Aquaculture
• +۷ مورد دیگر

Jon Olav Vik is a Professor at the Norwegian University of Life Sciences (NMBU), affiliated with the Department of Mathematical Sciences and Technology within the Faculty of Science and Technology. He leads the DigiSal project—"Towards the Digital Salmon: From a reactive to a pre-emptive research strategy in aquaculture"—funded under the Research Council of Norway’s Digital Life initiative. He is also a lead modeller in the GenoSysFat project, which aims to enhance omega-3 content in farmed salmon through integrated genomics and systems biology approaches. His research spans systems biology , computational physiology , genotype-phenotype modeling , and ecological dynamics . He works at the intersection of biology, mathematics, and computer programming, developing models to understand how genetics, nutrition, and environment interact in fish and ecological systems. His pedagogical focus includes biostatistics and programming in R, and he teaches courses such as STIN100, STIN300, and STAT100. The 15 most recent publications reflect a consistent focus on systems-level understanding in biology, particularly in salmon aquaculture, metabolic regulation, and genotype-phenotype relationships. These works appear in high-impact journals like Nature , Science , PLOS Computational Biology , and Journal of The Royal Society Interface , demonstrating interdisciplinary reach across computational biology, genomics, ecology, and biostatistics. Key themes include metabolic modeling, microbiome stability, lipidome remodeling, and sensitivity analysis in dynamic models. Jon Olav Vik has contributed to major collaborative efforts including the Infrastructure for Systems Biology Europe (ISBE) , where he helped develop frameworks for "modelling as a service." He has also authored book chapters and technical deliverables on systems biology and modeling practices. He actively supervises students and invites master’s thesis candidates with interests in quantitative biology. While no specific awards are listed, his leadership in national and international research projects underscores his scientific impact. His work supports both fundamental science and sustainable aquaculture innovation.

• Thrombosis
• Cardiovascular diseases
• Endothelial cell biology
• +۷ مورد دیگر

Associate Professor Freda Passam is a Clinical Academic Haematologist at Royal Prince Alfred Hospital, University of Sydney, specializing in thrombosis and haemostasis. She leads the Haematology Research Group at the Charles Perkins Centre, focusing on platelet biology, endothelial cell dysfunction, and translational research in cardiovascular diseases. Her work integrates basic science with clinical applications, including developing microfluidic technologies like the Endo-chip for thrombosis diagnosis and therapy screening. Education: MD and PhD in Greece (angiogenesis in Hodgkin’s lymphoma), postdoctoral training at UNSW and Harvard University. Research spans platelet hyperactivity in diabetes, immune thrombosis (e.g., HIT), and thiol isomerase inhibitors as antithrombotics. Collaborates globally with institutions like Harvard and the University of Utah. Research Interests: 1) Platelet biomarkers in diabetes-related cardiovascular risk; 2) Immune thrombosis diagnostics/therapies (e.g., Endo-chip); 3) Bone marrow-on-chip models for thrombopoiesis. Current projects include SEC61B regulation of calcium flux, endothelial thromboinflammation, and ERp5/ERp57 roles in platelet production. Grants: Over $6M in funding from NHMRC, MRFF, NSW Health, and industry partnerships. Notable awards include Sydney Nano Grand Challenge Award (2022) and SLHD VTE Stewardship Award (2020). Advising: Mentors over 6 PhD/master’s students in thrombosis research, emphasizing clinical/research integration. Teaching includes Sydney Medicine curriculum, bedside tutorials, and student engagement in lab activities. Labs/Teams: Haematology Research Group (Charles Perkins Centre), collaborations with Sydney Health Partners, Harvard, and international haematology groups. Develops technologies like the Endo-chip and bone marrow-on-chip models.

Hannah Wunschمشاهده پروفایل

استاد

• Critical Care Medicine
• Anesthesiology
• Sepsis
• +۶ مورد دیگر

Hannah Wunsch is a Professor of Anesthesiology at Weill Cornell Medical College , Cornell University. She serves as an Attending Anesthesiologist at NewYork-Presbyterian/Weill Cornell Medical Center. M.D. from Washington University School of Medicine (2003) M.Sc. from London School of Hygiene and Tropical Medicine (2002) A.B. from Harvard University (1997) Her research focuses on critical care medicine , with particular emphasis on sepsis outcomes , mechanical ventilation practices , opioid use in postoperative and ICU settings , and health services research utilizing large administrative datasets. Key trends in her recent publications include ICU staffing models , opioid prescription patterns , mechanical ventilation strategies , and long-term outcomes after critical illness . She has published extensively in top-tier journals like Critical Care Medicine , JAMA , and The Lancet .

• Cardiac Physiology
• Pharmacology
• Molecular Cardiology
• +۴ مورد دیگر

Ming Lei is a Professor of Physiology and Pharmacology at the University of Oxford. His research focuses on cardiac electrophysiology, signal transduction, and molecular mechanisms of arrhythmias. He leads the Lei Group , also known as the Cardiac Signalling Group , which explores novel therapeutic targets for cardiovascular diseases. Education: BM, MD, D.Phil Professional Recognition: Fellow of the Royal Society of Biology (FRSB) Recent publications highlight his work on: PAK Kinases as targets for arrhythmias Anti-arrhythmic drug classification and clinical applications Isoform-specific glycosylation of ion channels Optical mapping techniques in preclinical cardiac models Stem cell-derived cardiomyocytes for studying atrial function His research trends emphasize molecular mechanisms of cardiac dysfunction, kinase modulation, and advanced imaging methodologies. The Lei Group collaborates on projects involving genetic models (e.g., RyR2 knock-in mice) and cellular interactions (e.g., myofibroblast-cardiomyocyte crosstalk). Key subfields include signal transduction , lysosomal pathways , ion channel regulation , cardiac hypertrophy , electrophysiological imaging , and stem cell applications .

• Sleep Research
• Clinical Neurosciences
• Mental Health
• +۳ مورد دیگر

Simon Kyle is a Professor of Experimental and Clinical Sleep Research at the Nuffield Department of Clinical Neurosciences (NDCN) , University of Oxford. He serves as Programme Director for the Oxford Online Programme in Sleep Medicine and Co-Director of the Experimental and Clinical Sleep Medicine group. He holds affiliations as an Honorary Member of the Department of Psychiatry and a Senior Research Fellow at Somerville College. Education : MA (First Class Hons.), PhD His research focuses on the aetiology and management of sleep disturbance , its interactions with mental health , and implications for neurodegenerative and psychiatric disorders. He investigates interventions like sleep restriction therapy and digital cognitive behavioral therapy (CBT) for insomnia, with work spanning clinical trials, neuroimaging, and population health studies. Recent publications highlight trends in sleep disorders (insomnia, circadian disruption), neurology (white matter integrity), and mental health (depression, emotion regulation). His team employs genome-wide association studies (GWAS), randomized controlled trials, and neuroimaging to advance sleep medicine. Research funding is provided by the NIHR Oxford Health Biomedical Research Centre , Wellcome Trust, and UK government programmes (HTA, PGfAR, EME). Professor Kyle leads the Experimental and Clinical Sleep Medicine research group, contributing to clinical guidelines like the European Insomnia Guideline 2023 .

Yoon Seok Kimمشاهده پروفایل

پژوهشگر ارشد

• Optogenetics
• Structural Biology
• Neuroscience
• +۳ مورد دیگر

Dr. Yoon Seok Kim is a Postdoctoral Fellow at Stanford University’s Department of Bioengineering, focusing on structural and mechanistic studies of light-gated ion channels. He earned his Ph.D. in Bioengineering at Stanford, mentored by Drs. Karl Deisseroth and Brian Kobilka, with research centered on ion channel selectivity and optogenetic applications. Education: Ph.D. in Bioengineering, Stanford University Dr. Kim’s research spans Optogenetics , Structural Biology , and Neuroscience , particularly the molecular mechanisms of ion channels in neural and glioma contexts. His work includes structural analysis of potassium-selective channelrhodopsins and synaptic mechanisms in neurodegenerative diseases. Recent publications highlight interdisciplinary trends, merging Neuroscience , Molecular Biology , and Bioengineering , with subfields like diffuse midline gliomas , dopamine neuron resilience , and machine learning in protein engineering . His studies often integrate advanced imaging and optogenetic tools.

• Biomedical Engineering
• Microfluidics
• Tissue Engineering
• +۴ مورد دیگر

Yi-Chin Toh is a Professor in the Faculty of Engineering at Queensland University of Technology (QUT), leading the Micro Tissue Engineering Lab. She holds an ARC Future Fellowship and has held prior roles as an Assistant Professor at the National University of Singapore. Her expertise lies in microfluidic tissue models for drug testing and organ-on-a-chip technologies. She earned her B.Eng. (2001) and Ph.D. (2008) in Bioengineering from National University of Singapore, followed by postdoctoral training at MIT and A*STAR. Her research focuses on advancing alternative animal-free technologies, with notable contributions to multi-organ microfluidic platforms and 3D bioprinted tissue models. She has published over 70 peer-reviewed articles, secured eight patents, and received accolades like the 2022 Lab on a Chip Pioneers in Miniaturization Award and 2019 Global 3R Award. She holds editorial roles in journals like Biomicrofluidics and contributes to conferences such as MicroTAS. Key research areas include mechanobiology modeling, hepatic-microbiome interactions, and AI-driven single-cell analysis. Her lab’s work bridges academia and industry, emphasizing translational applications in drug safety and toxicology. Current projects include modular microfluidic platforms for multi-organ interactions and FDA-regulatory compliant non-animal testing systems. Education: B.Eng in Chemical Engineering, National University of Singapore (2001) Ph.D. in Bioengineering, National University of Singapore (2008) Awards & Leadership: Lab on a Chip Lectureship (2022), Global 3R Award (2019), ARC College of Experts member, and leadership roles in MicroTAS conferences. She also leads the ARC Training Centre for Cell and Tissue Engineering Technologies.

• Metabolic Disorders
• Mitochondrial Biology
• Endocrinology
• +۳ مورد دیگر

Sylvie Dufour is an Associate Research Scientist in the Department of Endocrinology at Yale School of Medicine, part of Yale University. Her research focuses on metabolic disorders, mitochondrial dysfunction, and insulin resistance, with a particular emphasis on liver and muscle metabolism in diabetes and fatty liver disease. She collaborates closely with prominent researchers like Gerald I. Shulman and Kitt Petersen. Key research themes include the role of glucagon in hepatic mitochondrial oxidation, the impact of genetic variants (e.g., PNPLA3 I148M) on lipid metabolism, and interventions like carbohydrate restriction or SGLT2 inhibitors to reverse metabolic dysfunction. Her work bridges basic science and clinical translation, addressing mechanisms underlying insulin resistance, hepatic steatosis, and cardiometabolic risk. Publications span topics such as mitochondrial protonophore therapies, ketogenesis modulation, and the effects of burosumab on muscle function. Her studies frequently employ human and animal models to elucidate metabolic pathways and therapeutic targets.

Gregory Dickمشاهده پروفایل

استاد پژوهشی

• Coronary Circulation
• Ion Channel Physiology
• Vascular Tone Regulation
• +۳ مورد دیگر

Gregory Dick, PhD, is a Research Professor in the Department of Physiology & Anatomy at the University of North Texas Health Science Center's College of Biomedical and Translational Sciences. His research focuses on ion channel regulation in coronary arteries, particularly how potassium channels control vascular tone under normal and pathological conditions (e.g., obesity, diabetes). He has led multiple NIH-funded projects exploring coronary vascular dysfunction and metabolic signaling. Education: Bachelor of Science in Physiology, Oklahoma State University Doctor of Philosophy in Physiology, University of Missouri Research Interests: Electro-metabolic signaling in coronary vasodilation Role of K+ channels in coronary blood flow regulation Impact of metabolic syndrome and obesity on cardiovascular health Vascular smooth muscle plasticity in disease states Key Projects (2024–2026): Role of potassium as a coronary metabolic vasodilator (Principal Investigator) Disentangling the Mechanisms of Coronary Dysfunction (Co-Investigator) Grants & Funding: NIH R01 Grant: Mineralocorticoid Receptor-Dependent Coronary Vascular Dysfunction in Obesity Multiple collaborative grants with University of Michigan and University of Missouri Collaborations: Active partnerships with institutions studying coronary autoregulation, metabolic syndrome, and swine models of cardiovascular disease.

Bumsoo Ahnمشاهده پروفایل

استادیار

• Mitochondria
• Aging
• Muscle
• +۱۲ مورد دیگر

Bumsoo Ahn, PhD, is an Assistant Professor in the Department of Gerontology and Geriatric Medicine at Wake Forest University School of Medicine. He is also affiliated with the Wake Forest Institute for Regenerative Medicine, Center for Redox Biology and Medicine, Sticht Center for Healthy Aging and Alzheimer’s Prevention, Cardiovascular Sciences Center, Comprehensive Cancer Center, Center for Precision Medicine, and the Center for Vaccines at the Extremes of Aging. His educational background includes a BS from Yonsei University (2004), an MS from the University of North Carolina at Chapel Hill (2011), and a PhD from the University of Florida (2015). Dr. Ahn's research focuses on the mechanisms of muscle aging and wasting, particularly sarcopenia and cancer cachexia. His work emphasizes mitochondrial redox biology, oxidative stress, and the role of reactive oxygen species in muscle dysfunction. He employs transgenic mouse models to investigate causal relationships and test potential interventions, including unacylated ghrelin. His research spans molecular, cellular, and physiological levels, aiming to extend active and functional lifespans. His recent publications highlight investigations into mitochondrial hydrogen peroxide scavenging, SERCA activity restoration, neuronal SOD1 expression, and pharmacological protection against diaphragm dysfunction. These studies reflect a strong interdisciplinary focus on redox biology, muscle physiology, aging, and translational therapeutics. Scientific Awards: No awards listed in the provided text. Dr. Ahn contributes to graduate education through the Molecular Medicine and Translational Science PhD program and the Integrative Physiology and Pharmacology PhD program. His laboratory operates at the intersection of aging, regenerative medicine, and redox biology, engaging in collaborative research with multiple centers. While specific grants are not mentioned, his affiliations suggest involvement in federally and institutionally funded research initiatives focused on healthy aging and disease mitigation. The Ahn Lab investigates mitochondrial redox biology and muscle contractile properties in the context of aging and chronic diseases, utilizing animal models to identify therapeutic strategies for preserving muscle function.

Elizabeth Lipkeمشاهده پروفایل

استاد

• Tissue Engineering
• Cancer Research
• Cardiac Tissue Engineering
• +۵ مورد دیگر

Dr. Elizabeth Lipke is the Mary and John H. Sanders Professor of Chemical Engineering at Auburn University’s Samuel Ginn College of Engineering. Her lab focuses on tissue engineering, particularly in cancer and cardiovascular systems, with a focus on 3D in vitro models for drug screening and disease mechanisms. She leads interdisciplinary research combining biomaterials, microfluidics, and stem cell technologies to model complex biological systems. Education & Affiliations: PhD in Chemical Engineering (assumed based on role) Director of the Lipke Lab at Auburn University Collaborator with Dr. Arnold (cancer biology) and Dr. Mistriotis (biomedical engineering) Research Interests: Engineered cancer models to study obesity-related colorectal cancer progression Cardiac tissue engineering using pluripotent stem cells Microfluidic platforms for scalable production of hydrogel microspheres Drug efficacy testing in vascularized tumor models Awards & Recognition: 2024 AIMBE College of Fellows Inductee (top 2% in medical/biological engineering) NSF Grant ($621,934) for cardiac tissue manufacturing research (2018) Alabama Launchpad $25,000 award for Vivosphere technology (2023) Lab Highlights: Developed tumor-mimetic microvascular platforms for anti-cancer drug screening Engineered insulin-sensitive/insulin-resistant colorectal cancer models Pioneered scalable production of cardiac tissue microspheres from hiPSCs Grants & Funding: NSF RECODE Grant (2021) LAUNCH Innovation Grant (2023) Labs/Teams: Lipke Lab at Auburn University Collaborations with Arnold Lab (cancer biology) and Mistriotis Lab (biomedical engineering)

Andrew Braunمشاهده پروفایل

استاد

• KCa Channels
• Nitric Oxide
• Calcium Signaling
• +۷ مورد دیگر

Andrew Braun is a Professor at the University of Calgary, affiliated with the Libin, Hotchkiss Brain Institute, and Snyder Institute. His research focuses on vascular physiology, particularly the role of potassium channels in regulating blood flow and pressure, with applications in diabetes and neurodegenerative diseases. He utilizes advanced techniques like patch clamping and arterial pressure myography. His work explores KCa channels , nitric oxide signaling , and calcium dynamics in vascular cells, aiming to develop novel therapies for endothelial dysfunction. He investigates how these channels affect myogenic tone , vasodilation , and coronary circulation in diseased states such as Type 2 Diabetes and Alzheimer's. The 15 most recent publications highlight his focus on pharmacological targeting of KCa channels to treat vascular complications in diabetes, aging, and atherosclerosis. Key subfields include platelet aggregation , genetic mutations in IP3 receptors , glycation effects on vascular function , and sex-dependent cerebrovascular defects . Contact information: Email abraun@ucalgary.ca. Administrative Assistant: Theresea Connolly (tconnoll@ucalgary.ca, 403-220-3018).

Xi-Long Zhengمشاهده پروفایل

استاد

• Vascular Smooth Muscle Biology
• Atherosclerosis
• Vascular Disease Mechanisms
• +۴ مورد دیگر

Xi-Long Zheng is a tenured Professor in the Department of Biochemistry and Molecular Biology and Department of Physiology and Pharmacology at the Cumming School of Medicine, University of Calgary. He holds additional appointments as a Member of the Libin Cardiovascular Institute and Associate Member of both the Snyder Institute for Chronic Diseases and Arnie Charbonneau Cancer Institute. His research focuses on vascular smooth muscle biology and its role in cardiovascular diseases. Doctor of Medicine, Hunan Medical University (1986) M.S. in Pharmacology, Hunan Medical University (1989) Doctor of Philosophy in Pharmacology, University of Calgary (1997) Dr. Zheng's research centers on vascular smooth muscle cell differentiation, proliferation, and phenotypic switching in vascular diseases. His laboratory investigates mechanisms of vascular smooth muscle dedifferentiation in atherosclerosis, abdominal aortic aneurysms, and vascular stiffness. Current work explores ferroptosis, epigenetic regulation (particularly BRD4), and PCSK9 functions in vascular pathologies. His studies integrate molecular, cellular, and in vivo approaches to identify novel therapeutic targets for cardiovascular diseases. Analysis of his recent publications reveals strong emphasis on cell death mechanisms (ferroptosis, cuproptosis), epigenetic regulation, lipid metabolism, and immune-vascular interactions in atherosclerosis. His work demonstrates increasing focus on translational applications targeting vascular smooth muscle phenotypic switching and plaque stability. Alberta Innovates ‒ Health Solutions Senior Scholar Award (2008-2015) Heart & Stroke Foundation New Investigator Award (2001-2006) CIHR/Hypertension Society Scholarship Award (2001-2004) Heart & Stroke Foundation Fellowship Award (1999-2001) AHFMR Independent Investigator Award (2008) Dr. Zheng serves on grant panels for Canadian Institutes of Health Research and Heart and Stroke Foundation of Canada. He is an editorial board member for Biochemical Journal and other scholarly publications. His laboratory receives funding from CIHR and NSERC for projects including smooth muscle PCSK9 in abdominal aortic aneurysm pathogenesis, smooth muscle autophagy in vascular aging, and epigenetic regulation of smooth muscle plasticity. The Zheng Lab investigates vascular smooth muscle functions across multiple organ systems including blood vessels, gastrointestinal tract, bladder, and uterus. His research has established critical mechanisms in vascular smooth muscle differentiation and cell cycle regulation, contributing over 100 peer-reviewed publications in high-impact journals including PNAS, ATVB, Diabetologia, JBC, and Hypertension.