جست‌وجوی استاد و پژوهشگر

Marilia Cascalhoمشاهده پروفایل

استاد

• Transplantation Immunobiology
• Genetic Susceptibility in Immunopathogenesis
• Novel Immunotherapies
• +۶ مورد دیگر

Marilia Cascalho is a Professor and Vice Chair for Research at the Department of Pathology, Case Western Reserve University School of Medicine. She also serves as a Member of the Immune Oncology Program at the Case Comprehensive Cancer Center. Her academic journey includes MD and PhD degrees from the University of Lisbon and UCSF, respectively, followed by postdoctoral training at the Hagedorn Research Institute and UCSF. Key Appointments : Vice Chair for Research (2024), Richard J. Fasenmyer Professor (2024) Prior Institutions : Mayo Clinic (1999-2008), University of Michigan (2008-2024) Research Interests focus on Immunobiology of organ transplantation Genetic susceptibility in immune-mediated diseases Development of mutable vaccines against viral evolution C3d-based immunotherapies for cancer TACI/TNFRSF13B polymorphisms in immunity Article Trends reveal contributions to transplantation science, B cell immunology, and cancer immunotherapy. Her work spans antibody-mediated immunity , adaptive immune responses , and somatic hypermutation mechanisms , with recent emphasis on piRNA biomarkers in transplant monitoring and metabolic reprogramming for graft survival . Scientific Awards include: Science Magazine Prize for Young Investigators (1999) NIH Grant Support (multiple awards) Gates Foundation Grant US-Israel Bi-National Science Foundation NIH Study Section Memberships Patents and Innovation highlight her inventions in Soluble C3d immunotherapies Mutable vaccine technology B cell repertoire analysis methods T cell diversity modulation Laboratory Focus integrates immunology, genetics, and bioengineering to develop therapies for transplant rejection, autoimmune diseases, and incurable cancers like multiple myeloma.

David Samolsمشاهده پروفایل

استاد

• Acute Phase Response
• C-Reactive Protein (CRP) Biology
• Cytokine Signaling
• +۳ مورد دیگر

Professor David Samols is a leading researcher in the Department of Biochemistry at Case Western Reserve University School of Medicine. With a PhD in Cell Biology from the University of Chicago and postdoctoral training at Roche Institute of Molecular Biology and University of Oregon's Institute of Molecular Biology, his work focuses on the acute phase response and C-reactive protein (CRP) biology. Key research areas: CRP transcriptional regulation, cytokine signaling pathways, transcription factor interactions, inflammatory disease models Methodologies: Transgenic mouse models, Hep3B cell studies, molecular cloning, protein biochemistry Publications demonstrate expertise in CRP's anti-inflammatory properties across septic shock, pulmonary inflammation, and antigen-induced arthritis models. Collaborations with Dr. Irwin Kushner have produced seminal works on CRP's clinical significance and transcriptional mechanisms. Scientific contributions include: Elucidating C/EBPβ's critical role in cytokine responsiveness Discovering indirect NFκB (rel proteins) activation pathways Establishing CRP's in vivo anti-inflammatory effects Advancing understanding of evolutionary conserved biotin enzymes

• RNA Viruses
• Gene Therapy
• siRNA Delivery
• +۷ مورد دیگر

Priti Kumar is an Associate Professor of Infectious Diseases and Microbial Pathogenesis at Yale University School of Medicine , with affiliations in Cancer Immunology, Immunology, and Virology Laboratories. She leads the Yale-UPR Integrated HIV Basic and Clinical Sciences Initiative and directs the Yale Predoctoral Training Program in Virology and BBS Microbiology Track Graduate Admissions. Education: PhD in Immunology (2002) from Indian Institute of Science; Postdoctoral training (2005) at Harvard Medical School. Research Interests: Focus on RNA viruses , gene therapy , and siRNA delivery platforms , particularly for HIV-1, West Nile virus, Japanese encephalitis, dengue, and SARS-CoV-2. Key innovations include transvascular CNS delivery of siRNAs and humanized mouse models for HIV pathogenesis. Recent Work: Her lab explores CRISPR-based HIV cure strategies , picomolar NNRTIs , and metabolic disease interventions using RNA therapeutics. Articles highlight SARS-CoV-2 vaccines, Fc-effector mechanisms, and HIV transmission pathways in macrophages. Collaborations: Key partnerships with Yale labs (Mothes, Saltzman, Anderson) and NIH workshops on humanized mouse models. Her work spans translational medicine , vaccine development , and antiviral pharmacology .

• neurodevelopment
• mental disorders
• brain aneurysms
• +۸ مورد دیگر

Ketu Mishra-Gorur is an Associate Professor in the Department of Neurosurgery at Yale School of Medicine. With a strong background in cell biology and molecular genetics, Dr. Mishra-Gorur has established a significant research program focused on understanding the cellular and molecular mechanisms of brain tumors and vascular disorders. Dr. Mishra-Gorur's educational journey includes: PhD in Cell, Molecular & Developmental Biology from Tufts University MS in Genetics from Purdue University MSc in Microbiology from University of Bombay Postdoctoral Fellowship in Cell Biology at Harvard Medical School/MGH Cancer Center Dr. Mishra-Gorur's research spans multiple areas within neuroscience and oncology, with particular expertise in neurodevelopment and associated disorders, brain aneurysms and tumors, vascular diseases, cancer biology, and therapeutic approaches including drug research and oncolytic viruses. Their work utilizes a variety of in vitro and in vivo approaches, ranging from biochemical and cell-based assays to studying neural development in model organisms and in vivo modeling of tumor growth and metastasis. The research portfolio demonstrates a strong focus on meningioma genomics, with particular interest in TRAF7 mutations, skull-base meningiomas, and genomic variations across racial and ethnic groups. Additional significant work explores brain angiogenesis, intracranial aneurysms, and genetic factors in neurodevelopmental disorders. Dr. Mishra-Gorur has established productive collaborations with several prominent researchers at Yale including: Murat Günel, MD (24 joint publications) Zeynep Erson Omay, PhD (17 joint publications) Kaya Bilguvar, MD, PhD (13 joint publications) Katsuhito Yasuno, PhD (12 joint publications) Sacit Bulent Omay, MD (11 joint publications) Declan McGuone, MD (10 joint publications) Dr. Mishra-Gorur's work has been published in high-impact journals including Nature, Proceedings of the National Academy of Sciences, and Neuro-Oncology, demonstrating the significance and quality of their research contributions to the field of neurosurgery and neuroscience.

Matthew D. Weitzmanمشاهده پروفایل

استاد

• Virology
• Virus Replication
• DNA Damage and Repair
• +۶ مورد دیگر

Matthew D. Weitzman is a Professor of Pathology and Laboratory Medicine at the University of Pennsylvania Perelman School of Medicine and The Children's Hospital of Philadelphia (CHOP). He holds the Arthur Vincent Meigs Endowed Chair in Pediatrics at CHOP and was elected Fellow of the American Academy of Microbiology in 2024. His laboratory is located in the Colket Translational Research Building at CHOP. Dr. Weitzman received his B.Sc. (Honours degree in Genetics) from the University of Leeds, UK (1987) and his Ph.D. in Molecular Virology from Oxford Polytechnic and the Institute of Virology and Environmental Microbiology of the NERC (1991). He completed postdoctoral training as a Fogarty Fellow at NIH (1991-1993) and as a Cystic Fibrosis Foundation Fellow at the University of Pennsylvania Medical Center (1993-1994). His research focuses on the dynamic interactions between viruses and host cells when their genomes are in conflict. He pioneered the study of cellular damage sensing machinery as an intrinsic defense to virus infection, particularly examining how DNA damage responses interact with human DNA viruses. His work revealed that the MRN complex is the mammalian sensor of DNA breaks and viral genomes. His laboratory also studies APOBEC3 proteins and their dual role as antiviral factors and potential contributors to genomic instability and cancer. Analysis of his 15 most recent publications reveals a consistent focus on virus-host interactions, DNA damage responses, and the role of cellular proteins in both defense against viruses and maintenance of genome integrity. His work spans multiple virus families including Adenovirus, Herpes Simplex Virus, and Adeno-Associated Virus, with recent publications exploring biomolecular condensates, viral packaging mechanisms, and the therapeutic implications of APOBEC-mediated mutagenesis in cancer. Natural Environment Research Council (NERC) Graduate Student Scholarship (1984-1987) Young Investigator Award, American Society for Gene Therapy (2004) Foerderer Award, CHOP (2013) CHOP Faculty Mentor Award (2016) Arthur K. Asbury Outstanding Faculty Mentor Award, UPenn (2020) Arthur Vincent Meigs Endowed Chair in Pediatrics (2022-Present) Elected Fellow of the American Academy of Microbiology (2024) Dr. Weitzman has mentored numerous graduate students and postdoctoral fellows, including Amber Abbott and Nick Grams who are listed as graduate students in his laboratory. His lab maintains an interactive and collaborative environment where students and postdocs explore multiple projects including DNA damage responses during virus infection, viral manipulation of host pathways, epigenetic changes during infection, and host restriction factors. His laboratory investigates multiple viruses including Adenovirus (Ad), Herpes Simplex Virus (HSV-1), and Adeno-Associated Virus (AAV), each with different types of DNA genomes that have developed distinct ways of manipulating host defenses. The lab employs an integrated experimental approach combining biochemistry, molecular biology, genetics, and cell biology to probe the dynamic interactions that take place on viral and cellular genomes during infection.

Rahul Kohliمشاهده پروفایل

دانشیار

• DNA Modifying Enzymes
• Epigenetics
• Antibiotic Resistance
• +۶ مورد دیگر

Rahul Kohli, M.D., Ph.D. is Associate Professor of Medicine and Biochemistry & Biophysics at the University of Pennsylvania's Perelman School of Medicine, Department of Medicine. His laboratory is located in Johnson Pavilion at 3610 Hamilton Walk, Philadelphia, PA. Dr. Kohli's research focuses on DNA modifying enzymes that add complexity to the genome through purposeful mutation and nucleobase modification. His work spans two primary areas: (1) enzymatic deamination, oxidation and methylation of cytosine bases with emphasis on AID/APOBEC DNA deaminases and TET oxygenases; and (2) targeting pathogen pathways that promote evolution and antibiotic resistance, particularly the LexA/RecA axis governing the bacterial SOS response. His lab employs biochemical characterization of enzyme mechanisms, chemical synthesis of enzyme probes, and biological assays spanning bacteriology, immunology, and virology. Analysis of Dr. Kohli's recent publications reveals a strong emphasis on developing novel epigenetic sequencing technologies, understanding TET enzyme mechanisms in cancer and development, engineering hyperactive DNA modifying enzymes for genome editing applications, and targeting bacterial stress responses to combat antibiotic resistance. His work bridges chemical biology, epigenetics, and infectious disease research. Scientific Awards: Benjamin Franklin Medal in Chemistry (2017) Dr. Kohli mentors a robust research team with 15 lab members including graduate students and undergraduate researchers. His work has been supported by multiple grants focused on DNA modification enzymes and their applications in epigenetics and antimicrobial resistance. His research has significant implications for cancer therapy, genome editing technologies, and novel antibiotic development strategies. The Kohli laboratory maintains active collaborations across multiple disciplines, particularly in immunology and cancer research, as evidenced by publications related to CAR-T cell therapy where TET2 disruption enhances therapeutic efficacy.

Mary Lauren Bentonمشاهده پروفایل

استادیار

• Computational Biology
• Gene Regulation
• Biomedical Informatics
• +۳ مورد دیگر

Dr. Mary Lauren Benton is an Assistant Professor in the Department of Computer Science at Baylor University's College of Engineering and Computer Science. She holds a Ph.D. and M.S. in Biomedical Informatics from Vanderbilt University (2020, 2018) and a B.S.I. in Bioinformatics from Baylor University (2015). Education: Ph.D. (Vanderbilt, 2020), M.S. (Vanderbilt, 2018), B.S.I. (Baylor, 2015) Her research focuses on computational biology and gene regulation, particularly how DNA sequences influence genome function and human disease risk through integrated datasets. Recent work explores enhancer-gene interactions, epigenetic mechanisms, and the application of graph neural networks to genomic problems. Selected publications highlight interdisciplinary trends across genomics (e.g., Cis-regulatory landscapes , CTCF motif accessibility ) and computer science (e.g., Dynamic graph attention , Node classification ).

• Pathology
• Medical Imaging
• Machine Learning
• +۷ مورد دیگر

Bri Jackson is a Lecturer in the Department of Foreign Language at Virginia Commonwealth University. While his formal academic role is in language education, his research focuses on advanced computational methods in pathology, including machine learning applications for cancer diagnosis, virtual immunohistochemistry, and digital pathology tools. His work spans histopathological analysis, immuno-oncology, and biomedical imaging. Jackson's research has led to the development of innovative algorithms for virtual diagnostic companion tools, foundation models for whole slide image analysis, and benchmarks for cervical cytology classification. His publications emphasize precision oncology, including biomarker multiplexing, molecular response prediction, and AI-driven histopathological interpretation. Key areas include non-small cell lung cancer, esophageal adenocarcinoma, and splenic involvement in pancreatic cancer prognosis. He has also explored educational challenges in pathology residency programs during the pandemic, viral epidemiology, and rare congenital disorders involving multiple organ systems. Jackson's work bridges computational biology with clinical diagnostics, though no scientific awards or student advisement details are mentioned in the available data.

Rosalyn Fergusonمشاهده پروفایل

مدرس

• Medical Education
• Anatomy and Physiology Education
• Genomic Medicine Education
• +۳ مورد دیگر

Rosalyn Ferguson is a University Teacher at the School of Allied Health Professions, Nursing and Midwifery, University of Sheffield, where she has taught Anatomy, Physiology, and Cell Biology across health-related programs since 2020. Her role encompasses curriculum leadership and pedagogical innovation in nursing and allied health education. Her academic credentials include: BSc Microbiology (Hons), University of Edinburgh MSc Clinical Medicine (Haematology), Queen’s University Belfast PhD in Cell Biology, Queen’s University Belfast Postgraduate Certificate in Education (PGCE), Queen’s University Belfast Dr. Ferguson's research centers on medical education pedagogy, with current projects standardizing Anatomy and Physiology teaching for nursing students and developing digital genomic medicine resources. She pioneers interactive software and online platforms to create flexible, cross-program educational materials that address critical gaps in allied health training. Her publication trajectory reveals a strategic shift from cancer biology (2010-2013), where she investigated metabolic disorder-cancer links through molecular mechanisms, to contemporary educational scholarship focused on quality assurance frameworks like the SAFE-A&P database. This evolution underscores her commitment to transforming healthcare education through evidence-based teaching standardization.

Gaurav Bhardwajمشاهده پروفایل

استادیار

• Computational Peptide Design
• Drug Discovery
• Structural Biology
• +۴ مورد دیگر

Gaurav Bhardwaj is an Assistant Professor in the Department of Medicinal Chemistry at the University of Washington School of Pharmacy. He is affiliated with the Institute for Protein Design and leads the Bhardwaj Lab, focusing on computational and experimental tools for peptide-based therapeutics. Education: B.Tech in Biotechnology, GGS Indraprastha University, Delhi PhD in Integrative Biosciences, Pennsylvania State University Postdoctoral work at University of California, Davis and University of Washington, Seattle His research spans computational peptide design , structural biology , and drug discovery , targeting challenges in membrane permeability , oral bioavailability , and blood-brain barrier traversal . Current projects address antibiotic resistance, chronic pain, and neurodegenerative disorders. Recent publications highlight de novo macrocycle design , AlphaFold-based modeling , and cyclic peptide libraries , emphasizing computational methods and deep learning applications in drug design. His work integrates molecular biophysics and structural validation to enhance therapeutic efficacy. The Bhardwaj Lab promotes diversity and offers opportunities for undergraduate researchers, graduate students, postdoctoral fellows, and technicians, with a focus on interdisciplinary collaboration at the interface of chemistry, biology, and computational sciences.

Bill Faquinمشاهده پروفایل

استاد

• Cytopathology
• Head and Neck Pathology
• Thyroid Pathology
• +۵ مورد دیگر

Bill Faquin, MD, PhD is a Professor of Pathology at Harvard Medical School and serves as a Pathologist at Massachusetts General Hospital with subspecialty expertise in Head and Neck Pathology & Cytopathology. He is a key member of the Head & Neck and Endocrine Pathology Division at Massachusetts General Hospital, which handles over 10,000 surgical cases annually and accounts for more than 10% of the MGH Pathology Service case volume. Dr. Faquin is also affiliated with the Center for Head and Neck Cancers at the Massachusetts General Hospital Cancer Center. Dr. Faquin completed his medical education at Harvard Medical School, followed by residency and fellowship training at Brigham and Women's Hospital. He is board certified in Cytopathology and Anatomic Pathology by the American Board of Pathology. His clinical practice focuses on cytopathology (particularly fine-needle aspiration cytology) and head and neck pathology, with special expertise in thyroid and salivary gland neoplasms. Dr. Faquin's research combines expertise in cytopathology and head and neck pathology to investigate key issues in the carcinogenesis of head and neck and thyroid neoplasia. His translational research focuses on the detection, diagnosis, and prognostication of cancers involving the thyroid and salivary glands, squamous cell carcinomas of the oropharynx, and tumors of the jaws and oral cavity. Recent publications demonstrate his leadership in genomic analysis of thyroid carcinoma, molecular diagnostics, and consensus guidelines for mutational testing in thyroid cancer. His work shows a consistent trajectory toward integrating molecular pathology with traditional diagnostic approaches to improve cancer classification and treatment. Among his notable achievements, Dr. Faquin serves as Editor-in-Chief of Cancer Cytopathology, the premier cytology journal, and is the primary author of the Milan System for Reporting of Salivary Gland Cytopathology, which has become a standard reference in the field. These contributions represent significant recognition of his expertise and leadership in cytopathology. As an educator, Dr. Faquin participates in the training of pathology residents and fellows at Harvard Medical School and Massachusetts General Hospital. He is involved in the Head & Neck and Endocrine Fellowship program, which prepares pathologists for academic and clinical leadership roles. His mentorship has contributed to the development of pathologists who have gone on to faculty positions at leading institutions worldwide including the University of Chicago, Mayo Clinic, UCLA, and Harvard Medical School. Dr. Faquin collaborates extensively with the Head & Neck and Endocrine Pathology Division, which includes weekly Head & Neck Pathology Staff Conferences, Head & Neck Tumor Boards, and participation in Endocrine Oncology Conferences. His work bridges clinical practice, research, and education in head and neck pathology, contributing significantly to advances in diagnostic approaches and cancer management.

Mariya Logachevaمشاهده پروفایل

دانشیار

• Plant Genomics
• Non-photosynthetic Plants Genomics
• Invasive Plants Genomics
• +۳ مورد دیگر

Mariya Logacheva is an Associate Professor at the Skolkovo Institute of Science and Technology, where she leads a research group at the Center for Molecular and Cellular Biology. Her work focuses on understanding plant genome dynamics with applications to both fundamental and practical aspects of plant biology. Dr. Logacheva's primary research interests include: Genomics of non-photosynthetic plants Genomics of invasive plants Buckwheat genomics and mapping genes for agriculturally important traits Her research addresses the enormous complexity of plant genomes characterized by segmental and whole-genome duplications, as well as the activity of transposable elements. She employs high-throughput sequencing approaches to study genome evolution in challenging plant systems, particularly mycoheterotrophic species that have undergone significant genome reduction. Dr. Logacheva's publication record shows consistent contributions to plant genomics, with recent work spanning from 2015 to 2022. Her research demonstrates interdisciplinary connections between molecular biology, evolutionary studies, and practical agricultural applications, particularly in buckwheat genomics. She actively collaborates with international researchers from institutions across Russia, Czech Republic, Netherlands, Thailand, and Japan, reflecting the global nature of contemporary genomic research.

Xiao Dongمشاهده پروفایل

استادیار

• Aging
• Genetics
• Cell Biology
• +۴ مورد دیگر

Xiao Dong is an Assistant Professor at the University of Minnesota in the Genetics, Cell Biology and Development (TMED) department. Their research focuses on aging biology, somatic mutations, and cancer mechanisms, with significant contributions to understanding cellular senescence and its therapeutic implications. Research Interests: Aging and longevity mechanisms Genetic variants in age-related diseases Senolytic drug discovery Computational biology applications Recent Publications highlight advancements in: Machine learning for transcriptome analysis Somatic mutation profiling via single-cell sequencing Senomorphic microRNA identification TREM2 macrophage roles in metabolic liver disease Current collaborative projects include: Genetic variant-based drug discovery (NIH-funded) Cardiovascular regeneration with pioneer factors Exogenic organ development in gene-edited pigs

Jessica Haywardمشاهده پروفایل

پژوهشگر

• Veterinary Genetics
• Canine Genetics
• Feline Genetics
• +۵ مورد دیگر

Jessica Hayward is a Senior Research Associate in the Department of Biomedical Sciences at Cornell University's College of Veterinary Medicine. Her research focuses on veterinary genetics, particularly canine, feline, and equine species, using genomic approaches to understand disease traits and develop non-invasive biomarkers. She is affiliated with the Cornell Veterinary Biobank and the Center for Vertebrate Genomics. PhD in Biological Sciences from the University of Auckland (2009) Postdoctoral work at Cornell University (Canine Influenza Virus, later shifting to canine genetics) Her research spans veterinary genetics, bioinformatics, and biomarker development. Key projects include genome-wide association studies for glaucoma, deafness, and cancer in companion animals, alongside developing animal variant classification guidelines. She contributes to computational genomics by improving genotype imputation methods. Recent publications highlight her work on gastric cancer in dogs (2025), variant classification frameworks (2024), and orthopedic trait mapping (2023-2016). Her studies often integrate comparative medicine approaches, linking animal models to human health insights.

• Mathematical Biology
• Ecology
• Cancer Biology
• +۷ مورد دیگر

Fred Adler is a Professor at the School of Biological Sciences and Mathematics at the University of Utah, where he has held joint appointments since 2004. He currently serves as the Director of the School of Biological Sciences, leading one of the university's key academic units. His interdisciplinary work bridges mathematical theory with biological applications across multiple scales of organization. Dr. Adler's educational background includes: BA in Mathematics from Harvard-Radcliffe College (1984) PhD in Applied Mathematics from Cornell University (1991) He completed postdoctoral training in Zoology at the University of California, Davis, focusing on population biology. As a mathematical biologist, Adler's research spans urban, behavioral, evolutionary, and community ecology to cell biology, immunology, epidemiology, and cancer biology. He develops "appropriately simple models to understand the evolution and function of self-organized systems across the full range of biological scales." His work connects theoretical frameworks with empirical data to address pressing questions in both basic and applied biology, with particular emphasis on complex systems where emergent properties arise from interactions among components. His scholarly output demonstrates a clear trend toward increasingly interdisciplinary work that bridges traditional boundaries between mathematical theory and biomedical applications. Recent publications focus on cancer biology, particularly modeling tumor microenvironments, therapy resistance mechanisms, and immune interactions. His work also addresses ecological dynamics, antibiotic resistance, and the mathematical foundations of learning and decision-making in biological systems. Adler has received numerous honors and awards for his contributions to science and education: John Jungck Prize for Excellence in Education (2024) from the Society for Mathematical Biology Fellow of the Ecological Society of America (2018) Fellow of the Society for Mathematical Biology (2017) College of Science Professorship at the University of Utah (2012) Distinguished Mentor award from the University of Utah (2009) Dr. Adler has secured substantial research funding from diverse sources including NIH, US Army, Burroughs Wellcome Fund, and various foundations. His current grants focus on breast cancer mechanisms, antibiotic resistance, and complex systems biology. As an educator, he has developed innovative courses bridging mathematics and biology, including Calculus for Life Scientists and Mathematical Modeling in Biology. He has mentored numerous graduate students, as evidenced by his regular teaching of thesis research courses. His leadership extends to directing the Center for Quantitative Biology and serving as President of the Society for Mathematical Biology. Adler leads research groups focused on mathematical biology, with particular emphasis on cancer systems biology and ecological modeling. His teams bring together mathematicians, biologists, and clinicians to develop models that capture essential features of complex biological systems while remaining analytically tractable. Current projects involve creating "medical digital twins" for immunology applications and developing evolutionary models of cancer therapy resistance.