جستجوی استاد راهنمای دانشگاهی

Michael Toft Overgaard is a Professor at Aalborg University's Department of Chemistry and Bioscience, affiliated with The Faculty of Engineering and Science. His research focuses on protein science, with particular emphasis on calmodulin mutations linked to cardiac arrhythmias, hibernation physiology in brown bears, and functional peptide characterization. Key projects include investigations into calmodulinopathy mechanisms (funded by the Danish Cardiovascular Academy) and protein valorization through enzymatic hydrolysis (Novo Nordisk Foundation). Notable contributions include identifying calmodulin mutations' effects on neuronal and cardiac function, and elucidating metabolic adaptations in hibernating bears. Recent publications (2023-2025) address calmodulin's role in arrhythmias, hibernation endocrinology, and peptide-based emulsifiers. His work impacts forensic genetics, as seen in the re-evaluation of the Australian infanticide case involving calmodulin mutations. Collaborations span proteomics, cardiovascular research, and wildlife biology, with datasets deposited in PRIDE and Zenodo. Professional activities include external examinations and advisory roles in protein innovation.

• Protein engineering
• Recombinant protein production
• Proteomics
• +۴ مورد دیگر

Helene Halkjær Jensen is a Tenure Track Assistant Professor in the Department of Chemistry and Bioscience within The Faculty of Engineering and Science at Aalborg University, Denmark. Her research focuses on neuronal cell biology, specifically investigating how disruptions in neuronal calcium signaling contribute to neuropsychiatric disorders. Education: PhD in Molecular Cell Biology from Aarhus University (awarded November 9, 2017) MSc in Molecular Biology from Aarhus University (awarded July 1, 2015) Dr. Jensen's research primarily centers on calmodulin mutations and their effects on calcium signaling pathways. Her work explores how these disruptions can lead to neuropsychiatric disorders and cardiac arrhythmias. She employs advanced techniques including photoactivated localization microscopy to study membrane nanodomains and calcium channel regulation. Her research has significant implications for understanding conditions like schizophrenia and neurological symptoms associated with calmodulinopathies. Analysis of her recent publications reveals a strong focus on the intersection of neuroscience, molecular biology, and genetics, particularly examining how calmodulin mutations affect neuronal voltage-gated calcium channels. Her work spans basic molecular mechanisms through to clinical implications, with several publications addressing the real-world impact of genetic research on legal cases involving sudden infant death. Scientific Awards: Talent Award, Science & Technology, Aarhus University (2018) Best oral presentation (2015) Dr. Jensen has been actively involved in research projects, including the current project "Human calmodulin mutations at the heart of neurodevelopment" (2025-2028) where she serves as Principal Investigator. She has also engaged in numerous outreach activities, including guest lectures and conference organization, particularly for the European Calcium Society Junior Meetings. Her work has received significant media attention, especially regarding the implications of calmodulin research for legal cases involving infant deaths. Dr. Jensen's research has generated considerable impact, particularly her work on how calmodulin mutations can explain cases previously attributed to infanticide. This research has been featured in multiple media outlets and has contributed to the exoneration of individuals convicted of killing their children based on new genetic evidence.

• Neuronal Calcium Signaling
• Calmodulin Mutations
• Voltage-Gated Calcium Channels
• +۵ مورد دیگر

Malene Bredal Brohus is an Assistant Professor in Medical Biotechnology at the Department of Chemistry and Bioscience, Faculty of Engineering and Science, Aalborg University, Denmark. Her research focuses on molecular mechanisms related to calmodulin function, calcium signaling, and their implications in cardiac arrhythmias and neurological disorders. Dr. Brohus's research spans several key areas in molecular and cellular biology: Calmodulin structure, function, and pathogenic variants Calcium signaling pathways in cardiac and neuronal cells Molecular mechanisms of cardiac arrhythmias Protein dynamics and stability in disease contexts Schizophrenia genetics and calmodulin variants Physiological adaptations in hibernating brown bears Insulin-like growth factor system adaptations Her recent publications demonstrate a strong focus on the molecular basis of cardiac arrhythmias, with particular attention to calmodulin variants and their effects on calcium signaling. Her work bridges basic molecular research with clinical implications, notably in understanding how genetic variants can contribute to conditions like Long QT Syndrome. The research also extends to interdisciplinary applications, such as studying physiological adaptations in hibernating bears to understand human metabolic processes. Her work on calmodulin variants in schizophrenia patients represents an important expansion into neuropsychiatric disorders. Dr. Brohus has been actively involved in high-impact research collaborations, including work that has received significant media attention for its potential to exonerate an Australian woman convicted of killing her children based on genetic evidence. This research has been covered by multiple media outlets internationally and has generated substantial social impact, with the work being shared widely across social media platforms. Her research is supported through collaborations with international partners and has resulted in numerous datasets, including proteomics data from hibernating brown bears and structural data on calmodulin mutants. She is actively involved in the European Calcium Society, having served as spokesperson for their Junior Board since 2018, demonstrating her commitment to the scientific community and professional development of early-career researchers.

• Calmodulin Research
• Calcium Signaling
• Cardiac Arrhythmias
• +۵ مورد دیگر

Steffan Noe Niikanoff Christiansen serves as a Postdoctoral Researcher at the Department of Health Science and Technology within the Faculty of Medicine at Aalborg University, Denmark. His research program focuses on elucidating the genetic and epigenetic mechanisms underlying sudden cardiac death in young individuals, with particular emphasis on calmodulinopathies and DNA methylation patterns in cardiac tissues. His academic credentials include: PhD in Oral Sciences, Forensic Medicine and Bioanthropology from the University of Copenhagen (2017-2022) MSc in Molecular Medicine from Aarhus University (2014-2016) BSc in Molecular Medicine from Aarhus University (2011-2014) Christiansen's research integrates molecular cardiology with forensic applications, investigating how DNA and RNA variations contribute to cardiac arrhythmias and sudden death. His work addresses critical challenges in variant interpretation by examining calmodulin gene mutations (CALM1/CALM2/CALM3) and epigenetic modifications, particularly DNA methylation alterations in cardiac development and postmortem tissues. This research has significant implications for improving genetic testing accuracy and risk stratification in clinical and forensic contexts. Analysis of his publication trajectory reveals a pronounced methodological focus on epigenetic techniques, with increasing specialization in cardiac methylation patterns since 2021. His recent work demonstrates sophisticated integration of genomic technologies across cardiac and neurological contexts, consistently bridging basic science with clinical applications through advanced bioinformatics approaches. As Principal Investigator of the Danish Cardiovascular Academy project "The Deadly, the Deleterious, and the Dangerous – Decoding the Differential Pathogenicity among CALM1, CALM2, and CALM3" (2024-2026), Christiansen leads a multi-institutional collaboration investigating calmodulin variant pathogenicity. This project involves key partners including the University of Copenhagen and international experts in cardiac genetics. He actively contributes to methodological advancement through tools like the "Snpbeadchip" R package for genomic analysis, while maintaining active collaborations across Danish research institutions as evidenced by his network map showing extensive domestic and international connections.

• Genetics
• Cardiology
• Molecular Biology
• +۵ مورد دیگر

Professor Torben Moos is a leading academic at Aalborg University's Department of Health Science and Technology under The Faculty of Medicine, where he also serves as Head of Research Group. His work focuses on neurobiological research and drug delivery, with a strong emphasis on the blood-brain barrier, neurodegenerative diseases, and iron metabolism. Moos has been actively involved in projects like 'Targeteret terapi i den hypoksiske og inflammerede blod-hjerne barriere' and 'Epigenetisk regulering af ferroportin i den neurovaskulære enhed,' supported by grants from Aase og Ejnar Danielsens Fond and Scleroseforeningen. Research Interests: His research spans diverse areas including Niemann-Pick disease therapies, chronic neurodegeneration, gene therapy strategies, and iron homeostasis in neurological contexts. He has pioneered work on transferrin receptor-targeted drug delivery systems and vascular changes in neurodegenerative conditions. His lab's innovations include using AAV vectors for brain endothelial gene therapy and exploring calmodulin variants in schizophrenia. Publications & Media: With over 166 publications (2025), Moos' work bridges basic science and clinical applications. Recent trends show focus on gene therapy efficacy, BBB-targeted therapies, and biomarker identification. Media highlights include coverage of microplastic infiltration into the brain and iron deficiency treatment in pregnancy. Advising & Grants: Supervised 6 PhD students and secured funding for projects addressing neurovascular unit dysfunction and therapeutic delivery. Collaborations span institutions globally, emphasizing translational research. Labs & Teams: Leads the Neurobiological Research and Drug Delivery group at Neuroboost, fostering interdisciplinary approaches to CNS drug delivery and BBB biology. Active in both experimental and clinical translational research.

• Neurobiology
• Blood-Brain Barrier
• Neurodegenerative Diseases
• +۷ مورد دیگر

Morten Grunnet serves as an Adjunct Professor in the Department of Drug Design and Pharmacology within the Faculty of Health and Medical Sciences at the University of Copenhagen. His primary professional affiliation appears to be with Lundbeck pharmaceutical company, where he maintains his professional email address (MGRU@lundbeck.com), while contributing academic expertise through his university affiliation. His research focuses on cardiac physiology with particular emphasis on ion channels that regulate electrical activity in the heart. Dr. Grunnet's primary research interests center on cardiac ion channels, particularly potassium channels including KCa2 (SK channels) and KV11.1, and their role in cardiac electrophysiology and arrhythmias. His work investigates how modulation of these channels affects cardiac function, with specific applications in atrial fibrillation treatment and safety pharmacology. He employs sophisticated animal models, primarily porcine and rabbit systems, to study cardiac electrophysiology under various pathological conditions including myocardial infarction and induced arrhythmias. Analysis of his recent publications (2019-2025) reveals a consistent research trajectory focused on developing and testing novel antiarrhythmic therapies targeting specific potassium channels. His work demonstrates particular expertise in translational research, moving from basic ion channel physiology to clinical applications, with multiple publications describing phase 1 and phase 2 clinical trials of novel compounds like AP30663. His research frequently examines the balance between therapeutic efficacy and potential pro-arrhythmic risks of channel-modulating drugs. Dr. Grunnet maintains an active research profile with 113 documented research outputs. His work shows significant collaborative activity, particularly with researchers including Bentzen B.H., Diness J.G., and Holst A.G. His publications appear in high-impact journals including Nature Medicine, British Journal of Clinical Pharmacology, and Frontiers in Pharmacology, indicating recognition of his contributions to the field of cardiac pharmacology and electrophysiology.

• Cardiovascular Diseases
• Heart Physiology
• Ion Channels
• +۲ مورد دیگر