Malene Bredal Brohus

Malene Bredal Brohus is an Assistant Professor in Medical Biotechnology at the Department of Chemistry and Bioscience, Faculty of Engineering and Science, Aalborg University, Denmark. Her research focuses on molecular mechanisms related to calmodulin function, calcium signaling, and their implications in cardiac arrhythmias and neurological disorders.

Dr. Brohus's research spans several key areas in molecular and cellular biology:

• Calmodulin structure, function, and pathogenic variants
• Calcium signaling pathways in cardiac and neuronal cells
• Molecular mechanisms of cardiac arrhythmias
• Protein dynamics and stability in disease contexts
• Schizophrenia genetics and calmodulin variants
• Physiological adaptations in hibernating brown bears
• Insulin-like growth factor system adaptations

Her recent publications demonstrate a strong focus on the molecular basis of cardiac arrhythmias, with particular attention to calmodulin variants and their effects on calcium signaling. Her work bridges basic molecular research with clinical implications, notably in understanding how genetic variants can contribute to conditions like Long QT Syndrome. The research also extends to interdisciplinary applications, such as studying physiological adaptations in hibernating bears to understand human metabolic processes. Her work on calmodulin variants in schizophrenia patients represents an important expansion into neuropsychiatric disorders.

Dr. Brohus has been actively involved in high-impact research collaborations, including work that has received significant media attention for its potential to exonerate an Australian woman convicted of killing her children based on genetic evidence. This research has been covered by multiple media outlets internationally and has generated substantial social impact, with the work being shared widely across social media platforms.

Her research is supported through collaborations with international partners and has resulted in numerous datasets, including proteomics data from hibernating brown bears and structural data on calmodulin mutants. She is actively involved in the European Calcium Society, having served as spokesperson for their Junior Board since 2018, demonstrating her commitment to the scientific community and professional development of early-career researchers.