جست‌وجوی استاد و پژوهشگر

• Structural Biology
• Parasitology
• Cysteine Peptidases
• +۳ مورد دیگر

Karen McLuskey is a Research Associate in the Department of Molecular Biosciences at the University of Glasgow, College of Medical, Veterinary and Life Sciences. Her work focuses on structural biology and enzymology within parasitic organisms. 2010-2014: Wellcome Trust Grant for structural and activity studies of trypanosomatid metacaspases Research Interests: McLuskey's research spans structural biology, parasitology, and cysteine peptidase studies, particularly in trypanosomatid pathogens like Leishmania and Trypanosoma. Her publications demonstrate expertise in protein crystallography, enzymatic activity analysis, and membrane protein purification techniques. Publication Trends: Recent work (2024) examines TORC1 as a nutrient-regulated regulator in Leishmania, while earlier studies focus on metacaspase structures, cysteine peptidases, and high-throughput methodologies for protein analysis. Themes include parasite biology, structural enzymology, and microbiome interactions. Scientific Contributions: Crystal structure determination of key parasitic enzymes Development of high-throughput protein purification protocols Metabolite activity ranking algorithms Labs & Collaborations: McLuskey collaborates closely with Jeremy Mottram's research group, focusing on parasitic disease mechanisms and structural characterization of virulence factors.

• Inherited Cardiomyopathies
• Cardiovascular Genetics
• Molecular Mechanisms of Heart Disease
• +۵ مورد دیگر

Paul Robinson is a Senior Postdoctoral Researcher at the University of Oxford's Radcliffe Department of Medicine (Cardiovascular Division), based at the British Heart Foundation Centre for Research Excellence Laboratories in the John Radcliffe Hospital. He operates within the Watkins Group (Inherited Heart Muscle Disease) and Redwood Group (Cardiac Contractility), focusing on translational cardiovascular research. His academic foundation includes a BSc (Hons) in Medical Biochemistry from Royal Holloway College London and a DPhil in Clinical Medicine from Exeter College, Oxford. With over 20 years of specialized research experience, he bridges molecular mechanisms with clinical manifestations of cardiac disease. Robinson's research centers on how genetic mutations in sarcomeric proteins cause hypertrophic (HCM) and dilated (DCM) cardiomyopathies. He employs recombinant protein systems, biophysical assays, and advanced cardiomyocyte models to investigate altered contractility, calcium handling dysregulation, and pathological signaling cascades. His work established critical links between myofilament calcium buffering defects and disease progression, revealing how thin filament mutations disrupt cellular homeostasis. Current efforts focus on developing genetically encoded calcium sensors and identifying therapeutic compounds to restore contractile balance. His publication record (2007-2023) demonstrates consistent focus on molecular cardiomyopathy mechanisms, with recent work emphasizing calcium imaging innovations and mutation-specific pathophysiological pathways. Key studies revealed opposing effects of HCM/DCM mutations on calcium affinity and identified NFAT/Akt signaling activation as a consequence of contractile dysfunction. As a core member of the CureHeart project—awarded the British Heart Foundation's £30 million Big Beat Challenge—Robinson contributes to developing gene-editing therapies for inherited cardiomyopathies. His laboratory work integrates with international collaborations featured in high-impact journals including Nature, Journal of Biological Chemistry, and American Journal of Physiology. His research groups utilize cutting-edge facilities for protein biochemistry, cellular electrophysiology, and stem cell-derived cardiomyocyte models. Recent initiatives include CalTrack software for automated calcium transient analysis and investigations into paracrine signaling pathways in cardiac fibrosis, positioning his work at the frontier of precision cardiovascular medicine.

Kai Erdmannمشاهده پروفایل

مدرس ارشد

• Molecular Cell Biology
• Mechanobiology
• Mechanotransduction
• +۶ مورد دیگر

Dr Kai Erdmann is a Senior Lecturer in Molecular Cell Biology at the School of Biosciences, The University of Sheffield, where he has been employed since 2012. His academic career includes leading his research group at Ruhr-University Bochum (2006-2012) and postdoctoral work at Yale University School of Medicine (2005-2006). He obtained his PhD at Ruhr-University Bochum (1993-1996) and was a Feodor Lynen Fellow (2003-2005). Dr Erdmann's research focuses on molecular and cellular mechanobiology , particularly how mechanical cues regulate mechanotransduction pathways and membrane trafficking in disease contexts like fibrosis and cancer. His work has pioneered using YAP as a model mechanotransducer to identify novel proteins involved in stiffness sensing. Key studies include the role of Fas/CD95 endocytosis in apoptosis regulation and mechanical control of alternative splicing factors . He has published extensively in journals like Nature Communications and EMBO Journal while coordinating the Marie Curie ITN TRANSPOL and collaborating with institutions like Yale University and TU Dresden. Scientific awards include the Feodor Lynen Fellowship (Alexander von Humboldt Foundation, 2003-2005) Eurotrans-Bio Award (2011, consortium) His research is funded by DFG and the Fritz Thyssen Foundation, with recent work exploring organ-on-a-chip models for Lowe syndrome and gut inflammation.

• Cardiac Electrophysiology
• Molecular Cardiology
• Ion Channels
• +۷ مورد دیگر

Dr. Munir Hussain is an Associate Professor at the University of Bradford, affiliated with the Faculty of Life Sciences and the School of Chemistry & Biosciences . His research focuses on the cellular and molecular mechanisms regulating heart function, particularly ion transport through channels, exchangers, and pumps in cardiac myocytes. Former post-doctoral Research Associate at the Universities of Manchester and Leeds Intermediate British Heart Foundation Research Fellow University Lecturer at the University of Liverpool Research Interests : Dr. Hussain investigates cardiac electrophysiology, including voltage-clamp techniques to study ion channel pharmacology and fluorescence imaging to explore calcium release and re-uptake dynamics in the sarcoplasmic reticulum. His work addresses excitation-contraction coupling and its role in heart rate and contraction regulation. Scientific Awards : Intermediate British Heart Foundation Research Fellow Grants and Funding : His research has been supported by the British Heart Foundation and other institutional grants. He has contributed to understanding the physiological and pharmacological regulation of cardiac ion channels and calcium handling mechanisms. Labs and Teams : Dr. Hussain leads a laboratory at the University of Bradford focused on cardiac electrophysiology, utilizing advanced techniques to study ion transport and intracellular calcium dynamics in cardiac cells.

Nieng Yanمشاهده پروفایل

استاد مهمان

• Structural Biology
• Membrane Protein Structure
• Ion Channel Biophysics
• +۳ مورد دیگر

Professor Nieng Yan is a Visiting Professorial Fellow at the School of Biotechnology & Biomolecular Sciences, Faculty of Science, University of New South Wales (UNSW). She is also a founding Shirley M. Tilghan Professor of Molecular Biology at Princeton University and previously served as a tenured professor at Tsinghua University’s School of Medicine (2007–2017). Her research focuses on structural and functional studies of membrane transport proteins, ion channels, and sterol-sensing mechanisms. B.S. in Biological Sciences & Biotechnology, Tsinghua University (2000) Ph.D. in Molecular Biology, Princeton University (2004, under Prof. Yigong Shi) Her work spans Structural Biology , Membrane Protein Biophysics , and Ion Channel Research , with key contributions to glucose transporters (GLUTs), voltage-gated sodium/calcium channels, and sterol-regulated protein complexes like SCAP-INSIG. She employs cryo-EM and X-ray crystallography to unravel molecular mechanisms of transport, inhibition, and disease-related mutations. Her recent publications highlight structural advances in understanding glucose and monocarboxylate transporters, toxin interactions with ion channels, and cholesterol egress pathways. These studies often intersect with cancer metabolism (Warburg effect), cardiovascular disorders , and infectious disease (malaria). Scientific accolades include the Young Scientist Award (2005), HHMI International Early Career Scientist (2012–2017), Protein Society Young Investigator Award (2015), Beverley & Raymond Sackler International Prize in Biophysics (2015), and election as a Foreign Associate of the US National Academy of Sciences (2019).

• Calcium Signaling
• Muscle Physiology
• Biophysics
• +۵ مورد دیگر

Dr. Eduardo Ríos is a Professor in the Department of Physiology & Biophysics at Rush University Medical Center , where he directs the Section of Cellular Signaling . With academic appointments at both the School of Medicine and Rush Medical College , his work focuses on understanding the molecular mechanisms of calcium signaling in muscle cells , particularly the excitation-contraction coupling in skeletal and cardiac muscle. Education : School of Medicine, Uruguay National University; School of Engineering and School of Sciences, Montevideo, Uruguay. Key Collaborations : Partnered with institutions like the Toronto clinic for muscle disease studies. His research has led to groundbreaking discoveries in calcium release channels (RyR) , calsequestrin's role in calcium buffering, and the couplonopathies —a class of muscle diseases linked to calcium signaling defects. Using advanced techniques like 4-gap voltage clamps , SEER fluorescence , and Snap-TAG methods , his lab has redefined understanding of calcium store dynamics and membrane voltage measurement. With over 35 years of publications on calcium signaling, muscle contraction, and related pathologies, his work has been cited extensively. Notable grants include multiple NIH R01 awards and the Hasterlik Philanthropy Award , supporting studies on calsequestrin's role in health and disease. Scientific Awards : MERIT Award (NIAMS, 1996-2006) Mentor of the Year (Rush University, 2013) Dr. Ríos has mentored 5 senior faculty members , 3 assistant professors , 27 postdocs , 8 graduate students , and 5 physicians through his lab's collaborative environment. His team continues to advance research in muscle physiology and disease mechanisms.

• Neuroscience
• Sex Differences in Health
• Decision-Making
• +۳ مورد دیگر

Julia Cox is an Assistant Professor in the Department of Neuroscience at the Feinberg School of Medicine, Northwestern University, where she investigates how sex-based differences impact health outcomes and neural mechanisms of decision-making. Her research focuses on: Sex differences in disease prevalence and treatment response driven by genetic variations Neural substrates of sex-dependent motivation and avoidance learning Dopamine signaling in nucleus accumbens and VTA circuits Decision-making processes influenced by past experiences Neural engineering approaches like wireless optogenetics Dr. Cox's publication record demonstrates a strong neuroscience focus with 13 of 14 recent articles examining sex differences, neural circuits, and behavioral mechanisms. Her Nature Neuroscience publication revealed novel neural mechanisms underlying sex differences in motivation. The sole non-neuroscience publication (2000) in materials science suggests early-career interdisciplinary work, but her current research is exclusively neuroscience-oriented with emphasis on translational implications for personalized medicine.

Janice H. Yackoskiمشاهده پروفایل

دانشیار

• Internal Medicine
• Primary Care
• Geriatrics
• +۲ مورد دیگر

Dr. Janice H. Yackoski is an Associate Professor of Clinical Medicine at the Lewis Katz School of Medicine, Temple University , where she also serves as Director of the Primary Care Track within the Internal Medicine Residency program. A board-certified Internal Medicine physician, her clinical expertise spans primary care, geriatrics, women's health, and preventative care. MD, Lewis Katz School of Medicine at Temple University (Philadelphia, PA) Residency in Internal Medicine at Temple University Hospital Research Focus: Dr. Yackoski's work emphasizes patient-centered approaches to disease prevention and quality-of-life improvement through evidence-based medicine. Her clinical interests align with her academic leadership in primary care education. Scientific Recognition: Selected awards include the Gold Humanism Award (2014) for compassionate care and multiple honors for clinical excellence during residency. Chief Resident, Temple University Hospital (2018-2019) Intern of the Year, Temple University Hospital (2014) Practice Location: Temple General Internal Medicine (3322 N. Broad Street, Philadelphia, PA 19140). Contact: 800-TEMPLE-MED.

Bruno van Swinderenمشاهده پروفایل

استاد

• Consciousness Research
• Drosophila Behavior and Cognition
• Selective Attention
• +۶ مورد دیگر

Professor Bruno van Swinderen is a Professorial Research Fellow and Group Leader at the Queensland Brain Institute, University of Queensland, within the Faculty of Health, Medicine and Behavioural Sciences. With over two decades of neuroscience research experience, he leads a laboratory focused on understanding the neural mechanisms of consciousness using Drosophila (fruit fly) as a model organism. His work bridges molecular, electrophysiological, and behavioral approaches to uncover fundamental principles of brain function related to awareness and consciousness. Professor van Swinderen received his PhD in Evolutionary and Population Biology in 1998 from Washington University in St. Louis, Missouri. His graduate work focused on general anesthesia using Caenorhabditis elegans models, applying both quantitative genetics and molecular genetic approaches. He completed his postdoctoral training at The Neurosciences Institute (NSI) in San Diego, California (1999-2003), where he switched to Drosophila melanogaster to develop methods for studying perception. He established his independent laboratory at the Queensland Brain Institute in February 2008. His research centers on understanding consciousness through three brain states where awareness is lost: selective attention, sleep, and general anesthesia. His laboratory uses Drosophila as a genetic model system to investigate visual perception across different arousal states, with particular focus on how sleep regulates selective attention and predictive processing. The lab employs novel visual paradigms within a Drosophila molecular genetics context, examining how neural circuits process information when consciousness is altered or diminished. A key insight from his work is that fundamental mechanisms of consciousness are conserved across species, challenging assumptions about the uniqueness of human consciousness. Professor van Swinderen has proposed that we dream to first become conscious as babies and then to stay conscious as adults, an adaptive hypothesis linked to predictive processing theory. His recent publications reveal increasingly sophisticated methodologies including whole-brain electrophysiology, calcium imaging, and molecular analyses that have identified specific neural mechanisms underlying sleep homeostasis, anesthesia effects, and attention processes. A notable trend is the integration of computational approaches with traditional neuroscience techniques, allowing for nuanced analysis of complex brain activity patterns. His work demonstrates that flies exhibit surprisingly complex brain functions previously thought to be exclusive to higher organisms, with implications for understanding human consciousness and developing new approaches to anesthesia and sleep disorders. Professor van Swinderen maintains an active research program with numerous collaborations, as evidenced by his extensive publication record. His laboratory continues to push methodological boundaries while maintaining focus on core questions about what makes a brain conscious, contributing significantly to our understanding of brain states where awareness is lost.

Ben Rossمشاهده پروفایل

مدرس ارشد

• Medicinal Chemistry
• Computer-Aided Drug Design
• Virtual Screening
• +۱۱ مورد دیگر

Dr. Ben Ross is a Senior Lecturer at the School of Pharmacy and Pharmaceutical Sciences , Faculty of Health, Medicine and Behavioural Sciences , University of Queensland. With a background in medicinal chemistry and synthetic chemistry, his research focuses on computer-aided drug design for cancer , viral infections , and neurodegenerative diseases like Alzheimer’s. His team employs biochemical , biophysical , and cell-based assays , alongside animal models , to evaluate novel drug candidates, emphasizing ADMET properties for clinical translation. Education : BSc (First-Class Honours), University of Queensland (1999) PhD in Medicinal Chemistry, University of Queensland (2004) Research Themes include virtual screening, enzyme inhibition, ion channel modulation, and nanoparticle-based drug delivery systems . His work spans computer-aided design of acetylcholinesterase inhibitors , Orai1 calcium channel modulators , and antiviral nanoparticles . Recent projects highlight 3D-printed tablets for personalized prednisone dosing and pH-responsive nanocarriers for colon-targeted therapy. Publications demonstrate expertise in medicinal chemistry (75 total), with high-impact work in Journal of Medicinal Chemistry , ACS Applied Materials & Interfaces , and Nanoscale . Themes include virtual screening , nanoparticle drug delivery , and multi-target inhibitors for neurodegeneration and cancer. Collaborations with local and international researchers enhance translational impact. Supervision & Funding : Actively mentors PhD students in oral drug delivery , Alzheimer’s therapies , and 3D printing , with support from UQ Scholarships , NHMRC , and international programs (MOHE, Saudi Arabia, CSC). Leads the RossChemLab , emphasizing drug-likeness and collaborative discovery .

• Functional Genomics
• Non-coding Genome Analysis
• Developmental Genomics
• +۳ مورد دیگر

Julia Metzger is a Research Group Leader at the Max Planck Institute for Molecular Genetics in Berlin, heading the Heisenberg Research Group Veterinary Functional Genomics . Her group investigates the genetic architecture of mammalian genomes, focusing on non-coding variations and their role in genotype-phenotype relationships , particularly through multi-omics approaches and high-throughput sequencing . Her research integrates computational genomics with experimental biology to study structural variations in pigs and horses, such as body size determination and curly hair phenotypes . Current projects include the Heisenberg-funded MEASURE initiative on regulatory genetics in growth biology. Recent publications highlight her expertise in transcriptome analysis , evolutionary genomics , and veterinary genetics , with co-authorship on studies involving equine , porcine models , and lemur population dynamics . She mentors students like Nima Khaveh (PhD, 2025) and Ward Al Raei (Master’s, 2024), who explore polyploid genomics and tandem repeat genotyping . Awards include the DFG Heisenberg grant .

Albert Berghuisمشاهده پروفایل

استاد

• Structural Biology
• Antibiotic Resistance
• Protein-Drug Interactions
• +۴ مورد دیگر

Albert Berghuis serves as a Professor in the Department of Microbiology and Immunology within McGill University's Faculty of Medicine, holding the prestigious Canada Research Chair in Structural Biology. His laboratory operates from the Bellini Life Sciences Building at McGill Life Sciences Complex, where he leads research at the intersection of structural biology and antimicrobial resistance. Professor Berghuis specializes in elucidating the molecular mechanisms of antibiotic resistance through advanced structural techniques including X-ray diffraction, scattering, and nuclear magnetic resonance spectroscopy. His research particularly focuses on bacterial proteins that confer protection against antibiotics, with significant contributions to understanding aminoglycoside-modifying enzymes and their role in resistance development. His group employs complementary biophysical approaches such as isothermal titration calorimetry to examine protein-drug interactions at atomic resolution, directly informing the development of next-generation antibiotics and resistance-breaking adjuvants. Analysis of his recent publication record reveals consistent expertise in structural mechanisms of antibiotic resistance, with increasing diversification into malaria therapeutics, cancer-related protein studies, and viral resistance mechanisms. His work spans fundamental enzymology of resistance proteins to translational applications in drug design, maintaining strong emphasis on structural characterization of protein-ligand interactions across diverse biological contexts. Scientific Recognition: Canada Research Chair in Structural Biology Professor Berghuis' research program receives substantial support through his Canada Research Chair appointment, enabling his team to maintain cutting-edge structural biology capabilities for investigating antimicrobial resistance mechanisms. His laboratory serves as a key resource for structural insights into protein-drug interactions within McGill's infectious disease research ecosystem. Based at the Bellini Pavilion within McGill's Life Sciences Complex, Berghuis' research group forms part of McGill University's robust structural biology community, collaborating across departments to address critical challenges in antimicrobial resistance through atomic-level structural understanding.

Albrecht Schwabمشاهده پروفایل

استاد

• Physiology
• Biochemistry
• Cancer Biology
• +۷ مورد دیگر

Prof. Dr. Albrecht Schwab is a faculty member at the Institute of Physiology II , affiliated with the Medical Faculty of Münster University . He leads the Cell Migration Group , focusing on the role of ion channels and ion transporters in tumor and immune cell migration. Key research areas include calcium signaling , pH regulation , and mechanosensitivity in cancer progression and neutrophil function. Department: Institute of Physiology II University: University of Münster Research Networks: Cells in Motion, pHioniC (2018-2023), IonTraC (2011-2015) His work investigates how ion transport proteins like KCa3.1 , TRP channels , and the Na+/H+ exchanger (NHE1) drive cancer metastasis and immune cell chemotaxis. Projects include mechanosignaling in pancreatic stellate cells, TRP channel roles in neutrophil activation, and epigenetic dysregulation of ion channels in lung cancer. Techniques employed include time-lapse videomicroscopy , live-cell fluorescence , and atomic force microscopy . Articles highlight trends in ion channel imaging (PET/fluorescent probes), mechanotransduction in fibrosis, and calcium/pH signaling in melanoma and pancreatic cancer. The lab collaborates with technical staff (Ilka Neumann, Sarah Sargin, Sandra Schimmelpfennig) and participates in European research consortia.

Appu Kumar Singhمشاهده پروفایل

استادیار

• Calcium signaling
• Ion channels
• Structural biology
• +۷ مورد دیگر

Appu Kumar Singh is an Assistant Professor at the Department of Biological Sciences and Bioengineering, Indian Institute of Technology Kanpur. His research focuses on membrane-spanning calcium ion channels (including TRP channels) and their role in physiological functions such as sensory modalities, neuronal excitability, bone formation, and apoptosis. His lab employs structural biology techniques like x-ray crystallography and cryo-electron microscopy, complemented by functional approaches including electrophysiology and mutagenesis. Notably, his collaborative study with Kirill's lab at Scripps (published in Science ) resolved the molecular architecture of GPR158 and its role in depression/anxiety, alongside discoveries about auxin-cholesterol signaling in lysosomes via GPR155 (LYCHOS).

Veronika Harmatمشاهده پروفایل

مدرس

• Structural Biology
• Biochemistry
• Enzymology
• +۵ مورد دیگر

Veronika Harmat is a Lecturer at the Institute of Chemistry , Eötvös Loránd University, affiliated with the Department of Inorganic Chemistry. Her research bridges biochemistry, structural biology, and enzymology, with a focus on protease inhibition mechanisms, amyloid peptide dynamics, and carbohydrate chemistry. Institution : Eötvös Loránd University Role : Lecturer Department : Department of Inorganic Chemistry Contact : veronika.harmat@ttk.elte.hu Research interests include structural analysis of protein complexes, enzyme-substrate interactions, and molecular mechanisms in the complement system. Recent work explores: Conformer dynamics in carbohydrates via ion mobility mass spectrometry Mechanisms of protease inhibition (MASP enzymes, ecotin) Amyloid peptide interface packing and aggregation Metal coordination in enzyme activity (e.g., dUTPase, calmodulin) Substrate specificity in serine proteases and oligopeptidases Publications highlight interdisciplinary approaches combining X-ray crystallography, cryo-EM, and computational modeling to study: Thermodynamic and structural factors in redox reactions Role of dimerization in enzyme regulation Calcium signaling through calmodulin interactions Antibiotic targeting of mammalian proteases Self-compartmentalization in hyperthermophilic enzymes Current affiliations involve structural studies of proteins relevant to immunology, neurodegeneration, and inorganic chemistry applications.