CaMKII Signalling Professors and Supervisors

Claire E. Hulseboschمشاهده پروفایل

استاد

The University of Texas Health Science Center at HoustonUnited States

Claire E. Hulsebosch is a Professor in the field of Neuroscience at The University of Texas Health Science Center at Houston, with over three decades of groundbreaking research in spinal cord injury and traumatic brain injury . Director of Mission Connect (2005-2008) Scientific advisor to NIH, DoD, and major foundations Over 300 publications and presentations Her research focuses on neuroinflammation , gliopathy , and neural circuit reorganization post-injury, with key discoveries in: Chronic central neuropathic pain mechanisms Microglial and astrocytic activation patterns Role of kinase signaling in pain chronification Stem cell transplantation for functional recovery Publications demonstrate expertise in neuropharmacology , molecular neurobiology , and neurophysiological modeling of SCI/TBI, with three interventions entering clinical trials. Her collaborative work includes: Multi-institutional Mission Connect initiatives $33M Department of Defense grants Leadership roles in NIH study sections

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Joseph Stainsمشاهده پروفایل

استاد

University of Maryland, BaltimoreUnited States

Joseph P. Stains, PhD , is the Robert A. Pascal Professor of Orthopaedics at the University of Maryland School of Medicine , with a secondary appointment in the Department of Physiology . He serves as Division Head of Musculoskeletal Science and is affiliated with multiple research centers, including the Center for Research on Aging and Center for Stem Cell Biology . Education: B.S., Molecular and Cell Biology, Pennsylvania State University (1994) Ph.D., Biochemistry, Microbiology, and Molecular Biology, Pennsylvania State University (2000) Postdoctoral Fellowship, Washington University in St. Louis (2001-2004) Research Focus: The Stains Lab investigates signaling networks and gene transcription in skeletal cells, with emphasis on connexin43-mediated gap junctions and cytoskeletal mechano-signaling pathways . Key work includes defining how microtubules and TRPV4-Ca 2+ -CaMKII pathways regulate sclerostin , a critical protein for bone homeostasis. Publication Trends: Recent work spans single-cell genomics , mechanotransduction , and bone-osteoclast interactions , with a focus on cytoskeletal proteins , calcium signaling , and novel devices for studying mechanical load responses. Scientific Recognition: Fellow, American Society of Bone and Mineral Research (2020) U.S. Patent for Multi-Functional Fluid Flow Device (2017) Provisional Patent on Cytoskeleton Targeting for Bone Mass PROMISE AGEP Outstanding Faculty Mentor (2015) Research Preceptor of the Year (2011) Grants & Leadership: Continuously funded by NIH , DoD , and Maryland Stem Cell Research Fund . Served on NIH Skeletal Biology Study Section , editorial boards for Journal of Bone and Mineral Research and JBMR Plus , and as course director for GPLS 645: Cell & Systems Physiology since 2014.

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Suzanne Paradisمشاهده پروفایل

استاد

Brandeis UniversityUnited States

Suzanne Paradis is a Professor of Biology at Brandeis University and an affiliated faculty member of the Neuroscience Program and the Benjamin and Mae Volen National Center for Complex Systems. Her research focuses on defining the molecular and genetic programs underlying synapse development and neuronal connectivity, particularly in relation to neurological disorders such as epilepsy and autism spectrum disorders. Education: Ph.D., Harvard University B.A., Cornell University Research Interests: The Paradis Lab investigates molecular mechanisms of synapse formation and circuit connectivity using biochemical, molecular, genetic, and electrophysiological approaches. Key areas include the roles of genes like Rem2 and Sema4D in regulating dendritic morphology, inhibitory synapses, and seizure suppression. Current work explores translating these findings into therapies for acute seizures. Selected Research Trends: Her recent publications highlight the interplay between semaphorins, GTPases, and kinases in synapse development, with a focus on rapid protein-induced synaptogenesis and its therapeutic potential for neurological disorders. Scientific Awards: Thomas A. King Faculty Ally Award (2022) Sloan Research Fellow (2009-2011) Smith Family Award (2008-2011) Basil O'Connor Starter Scholar (2009-2011) Career Development Award, Society for Neuroscience (2007) Grants and Collaborations: Her work has been supported by grants from the Alfred P. Sloan Foundation, Smith Family Foundation, March of Dimes, and Society for Neuroscience. She collaborates with researchers in neurophysiology, computational modeling, and translational neuroscience. Lab Ethos: The Paradis Lab emphasizes a diverse and inclusive environment, fostering teamwork and knowledge-sharing to advance understanding of neural network mis-wiring in disease states.

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Karin Hochrainerمشاهده پروفایل

استادیار

Cornell UniversityUnited States

Karin Hochrainer is an Assistant Professor of Neuroscience at the Brain and Mind Research Institute, Weill Cornell Medical College (Cornell University), with a focus on neurovascular dysfunction and protein modifications in stroke and neurodegenerative disorders. Her career since 2012 has centered on molecular mechanisms underlying cerebral ischemia, tau pathology, and blood-brain barrier integrity. Ph.D. in Biochemistry, Medical University of Vienna (Austria), 2005 M.S. in Molecular Biology, University of Vienna (Austria), 2000 Her research spans neurovascular biology , ubiquitination in stroke , and tauopathy mechanisms . Key themes include: Post-ischemic protein ubiquitination and kinase regulation Tau protein's role in neurovascular dysfunction Dietary salt-induced cognitive decline via tau phosphorylation Ubiquitin-ligase interactions (e.g., HERC3, NF-κB) Cerebral ischemia-reperfusion injury Recent publications highlight trends in stroke proteomics , ubiquitin-SUMO crosstalk , and translational neuroprotection . Her work bridges molecular signaling (e.g., CaMKII, NF-κB) with clinical implications for Alzheimer's disease and stroke therapy. Grants include: Cure Alzheimer’s Fund (2023–2026): Tau-induced postsynaptic dysfunction National Institute of Neurological Disorders & Stroke (2023–2027): Co-investigator role

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Shin Jung Kangمشاهده پروفایل

استاد

University of Hawaiʻi at MānoaUnited States

Shin Jung Kang is a Professor in the Department of Molecular Biology at Sejong University, Seoul, Korea. She received her B.S. and M.S. in Molecular Biology from Seoul National University and completed her Ph.D. in Neurobiology at Harvard University in 2001. After a postdoctoral fellowship at Harvard Medical School (2001-2003), she joined Sejong University in 2003 where she has advanced to full Professor. Her research focuses on neural stem cell regulation , mechanisms of cell death and differentiation , and protein regulation in neural physiology . Key research areas include: Regulation mechanisms of neural stem cell survival and differentiation Regulation mechanisms of tumor suppressors Functions of PARP-1 in neural stem cell physiology Protein stability regulation of HIPK2 Neurodegenerative disease mechanisms Analysis of her recent publications (2016-2025) reveals a strong focus on neural circuitry , particularly amygdala function in fear memory, and molecular mechanisms involving PARP-1, HIPK2, and HCN channels. Her work bridges basic molecular mechanisms with behavioral neuroscience and neurodegenerative disease models. Her scientific achievements include: Identification of novel functions of PARP-1 in neural stem cell physiology and tumor suppression Elucidation of HCN channel roles in fear memory formation Characterization of HIPK2 regulation mechanisms involving TRAF2, p300, and SIRT1 Development of neurodegenerative disease models for Parkinson's disease and ALS Professor Kang maintains an active research laboratory focused on cell physiology, with ongoing work examining the molecular mechanisms of neural stem cell differentiation and neurodegenerative processes.

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Olalekan Michael Ogundeleمشاهده پروفایل

دانشیار

Louisiana State UniversityUnited States

Dr. Olalekan Michael Ogundele is an Associate Professor and Dr. Mary Louise Martin Endowed Professor in the Department of Comparative Biomedical Sciences at LSU School of Veterinary Medicine. His affiliations include postdoctoral training at LSU and research collaborations with NIMH. He joined LSU in 2017. Research interests focus on neural circuit mechanisms underlying cognitive functions: Regulation of hippocampal network excitability via SK2 channels and CaMKIIα dynamics Functional mapping of midbrain dopamine/glutamate projections in learning/memory Optogenetic dissection of stress circuits in adaptive behaviors Neural basis of schizophrenia/autism using transgenic models Techniques include in vivo electrophysiology, optogenetics, and neuroanatomical tracing. Recent publications (2016-2021) demonstrate consistent focus on synaptic plasticity, with 73% studying hippocampal/VTA circuits and 55% involving SK channel/CaMKII mechanisms. Articles frequently integrate molecular biology with behavioral analysis in disease models. Major scientific awards include: LSU Distinguished Faculty Award (2024) Dean's Merit Honor Roll (2018-2021) Distinguished Teacher of the Year (2020, 2021) IBRO-ISN Postdoctoral Fellowship (2015) Carnegie/Zeiss Fellowship (2010) He currently advises PhD and DVM students including David Odenheimer and Ignitius Lim. Active grants include $1.8M from NIMH for brain circuit research and NIH funding for sepsis-related neural studies. The Ogundele Lab uses silicon probe arrays and optogenetic tools to investigate decision-making circuits.

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Blanca I. Aldanaمشاهده پروفایل

دانشیار

University of CopenhagenDenmark

Blanca I. Aldana is an Associate Professor and Group leader of the NeuroMetabolism Research Group at the University of Copenhagen's Faculty of Health and Medical Sciences, Department of Drug Design and Pharmacology. Since 2024, she has served as Head of the Research Section in Molecular and Cellular Pharmacology. Her research focuses on unraveling central disease mechanisms to identify novel metabolic therapeutic targets in neurodegenerative disorders. Dr. Aldana's primary research areas include energy metabolism in the brain centered on glial cells (microglia and astrocytes) and their impact on neurological disorders such as epilepsy, Alzheimer's disease, and Frontotemporal dementia. She specializes in neuropharmacology targeting microglia and astrocyte receptors, with expertise in brain cell lines, primary cultures, transgenic animal models, and human induced pluripotent stem cells. Her laboratory employs advanced analytical methods including mass spectrometry, liquid chromatography, and live-cell bioenergetics. Her recent publications demonstrate a strong focus on brain energy metabolism, particularly examining glial cell function in neurodegenerative conditions. The research spans molecular and cellular mechanisms of brain energy and amino acid metabolism, pathophysiology of glial energy metabolism in neurodegeneration, and mechanistic insights into the effects of short-chain and medium-chain fatty acids on brain metabolism. This work has significant implications for developing novel therapeutic strategies for neurodegenerative diseases. 2024: Alzheimer-forskningsfonden Research Prize 2023: Nominated as Teacher of the Year, University of Copenhagen 2023: Emerging Investigator Award, International Society for Neurochemistry 2020: IBRO Early Career Award Dr. Aldana has supervised and mentored numerous Postdocs, PhD students, MSc students, and BSc students. She serves as course director for Farmaceutisk biologi and teaches in 'In-Vitro Techniques in Biochemistry and Pharmacology,' 'Principles of Pharmacology' for the MSc Neuroscience Program, and Physiology. She is also a member of the Drug Research Academy and Neuroscience Academy Denmark's Neuroinflammation column, and serves as communication responsible for the Metabolism and Inflammation Research Cluster.

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A.J. Robisonمشاهده پروفایل

استاد

Michigan State UniversityUnited States

A.J. Robison is a Professor in the Department of Physiology and Neuroscience Program at Michigan State University. Their research focuses on understanding the molecular and physiological mechanisms underlying drug addiction and mood disorders, particularly through hippocampal gene expression and epigenetic regulation. Education: B.S. in Biology from Rhodes College (1999), Ph.D. in Molecular Physiology and Biophysics from Vanderbilt University (2005) Research Areas: Drug addiction, chronic stress responses, epigenetics, synaptic physiology, hippocampal function, and neurotoxicology Techniques: Transgenic mouse models, viral gene transfer, electrophysiology, confocal microscopy, proteomics, and next-generation sequencing Collaborations: Human post-mortem brain sample analysis with external labs

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Bente Frølundمشاهده پروفایل

استاد

University of CopenhagenDenmark

Bente Frølund is a Professor in the Department of Drug Design and Pharmacology at the Faculty of Health and Medical Sciences, University of Copenhagen. Her research focuses on neuropharmacology with emphasis on GHB/CaMK2 pharmacology and ionotropic GABA A receptors, as well as nACh receptors and GABA transporters. Her research interests include: GHB/CaMK2 pharmacology Ionotropic GABA A receptors Nicotinic acetylcholine receptors (nACh) GABA transporters (GAT and TauT) Structure-activity relationship studies Development of photoligands for protein localization and activation Engineered molecular probes for ligand-protein interactions Professor Frølund's recent publications demonstrate a strong focus on receptor pharmacology, particularly exploring the interactions between GHB ligands and CaMKIIα, as well as the development of novel ligands for GABA A and nicotinic acetylcholine receptors. Her work combines medicinal chemistry approaches with neuropharmacological evaluation to develop molecular tools for studying receptor function and potential therapeutic applications, with neuroprotection being a key focus area. Her scientific contributions include 178 research outputs as documented in her publication record, spanning journal articles, book chapters, patents, and conference presentations. Her work has been referenced in Wikipedia pages, picked up by news outlets, and discussed on social media platforms including X, Facebook, Bluesky, and Reddit. Professor Frølund collaborates extensively with researchers both within the University of Copenhagen and internationally, as indicated by the network visualization in her profile. Her laboratory develops molecular probes and novel methodologies to gain insight into the identity, localization, function, and therapeutic potential of target receptors and transporters.

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Johannes Backsمشاهده پروفایل

استاد

Max Planck Institute for Dynamics and Self-OrganizationGermany

Prof. Dr. Johannes Backs serves as DZHK Professor for Epigenetic Regulatory Mechanisms in the Myocardium, Director of the Institute of Experimental Cardiology at Heidelberg University Hospital, and Speaker of the DZHK partner site Heidelberg/Mannheim. His leadership role includes overseeing the expansion of the Institute of Experimental Cardiology, which was established in 2018 as part of the Center for Internal Medicine (Krehl Clinic). Professor Backs' research focuses on understanding how environmental factors and comorbidities including stress, diabetes, and cancer interact at the molecular level with the cardiac genome to cause heart failure. His team has made paradigm-shifting discoveries showing that cardiac dysfunction is driven by specific metabolic and inflammatory mediators that act through epigenetic enzymes to cause coordinated changes in gene expression. His work has identified key pathways involving lipid droplet-associated proteins, histone deacetylases, and CaM kinase II that regulate cardiac function and contractility. Analysis of Prof. Backs' recent publications reveals a consistent focus on epigenetic regulation of cardiac function, particularly through histone-modifying enzymes and their interactions with metabolic pathways. His research bridges fundamental molecular mechanisms with translational applications, as evidenced by the drug development program targeting CaMKII-HDAC4 inhibitory compounds for heart failure patients with diabetes. Elected as Vice-Chair for the Gordon Research Conference (GRC) on Epigenetic Regulation of Cardiovascular Disease in 2021 (Chair in 2023) Arthur-Weber Award, German Cardiac Society (DGK) (2019) Outstanding Investigator Award from the International Society of Heart Research (ISHR) (2017) Outstanding Achievement Award from the Council on Basic Cardiovascular Science of the European Society of Cardiology (CBCS) (2016) Outstanding Early Investigator Award from the American Heart Association (AHA) (2015) Prof. Backs leads a substantial research team including postdocs, PhD students, MD/PhD students, and technical staff. His laboratory is part of the CRC 1550 "Molecular Circuits of Heart Disease" where he serves as spokesperson, with approximately 14 million euros in funding. The Backs Lab maintains strong collaborations with other research groups at Heidelberg University, the European Molecular Biology Laboratory, and the German Cancer Research Center. Current projects focus on hereditary forms of heart failure such as RBM20 cardiomyopathy and the contribution of gene expression to acute heart failure caused by inflammation or emotional stress.

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Michael C. Crairمشاهده پروفایل

استاد

Yale UniversityUnited States

Michael C. Crair is the William Ziegler III Professor of Neuroscience and Professor of Ophthalmology & Visual Science at Yale University, where he also serves as Vice Provost for Research. He holds primary appointments in the Department of Neuroscience and secondary appointments in Ophthalmology & Visual Science, with additional affiliations across multiple neuroscience programs including the Interdepartmental Neuroscience Program, Kavli Institute for Neuroscience, Swartz Program in Theoretical Neurobiology, Wu Tsai Institute, and Yale Combined Program in the Biological and Biomedical Sciences (BBS). Dr. Crair's educational background includes: PhD in Physics from University of California, Berkeley (1991) MA in Physics from University of California, Berkeley (1987) AB in Physics from University of California, Berkeley (1985) Postdoctoral training in physics and neuroscience at Kyoto University and Kyoto Prefectural Medical School (1993) Postdoctoral training in neuroscience at University of California, San Francisco (1997) His research focuses on neural activity in the developing brain, with particular emphasis on how spontaneous neuronal activity contributes to normal brain development. Dr. Crair has made fundamental contributions to understanding brain circuit development through the development and application of advanced imaging techniques. His laboratory investigates the mechanisms by which spontaneous activity is generated and how it shapes brain circuit development, with specific interests in visual system development and neural plasticity. Analysis of his recent publications reveals a strong focus on neural connectivity, spontaneous activity patterns, and imaging methodologies. His work spans multiple model systems and employs cutting-edge techniques including fMRI, calcium imaging, and dual-modal imaging approaches to study brain development and function at various scales. Dr. Crair has received numerous honors including: Esther A. and Joseph Klingenstein Foundation Fellowship Award in the Neurosciences Marc Dresden Excellence in Graduate Education Award NARSAD-Sidney R. Baer Jr. Foundation Young Investigator Award Alfred P. Sloan Foundation Research Fellow John Merck Fund Scholar March of Dimes Foundation's Basil O'Connor Fellow Administratively, Dr. Crair has directed Yale's Vision Core Program and the Graduate Program in Neuroscience. He served as Deputy Chair of the Department of Neuroscience from 2015-2017, then as Deputy Dean for Scientific Affairs (Basic Science Departments) at the School of Medicine from 2017-2020 before becoming Vice Provost for Research at Yale University. His laboratory continues to maintain an active research program examining fundamental mechanisms of brain circuit development.

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Julio Altamirano Barreraمشاهده پروفایل

دانشیار

Monterrey Institute of TechnologyMexico

Dr. Julio Altamirano Barrera serves as Associate Professor at Tecnologico de Monterrey's School of Medicine and Health Sciences (Campus Chihuahua), where he has been faculty since 2009. His academic appointments include leadership in the Prevención Strategic Research Group and affiliation with the National System of Researchers (Level 2). He teaches undergraduate and graduate courses including Pathophysiology of Cardiovascular System and Thesis supervision. Bachelor of Biology (Honors), National Autonomous University of Mexico Ph.D. in Cell and Molecular Physiology, Loyola University Chicago (2004) Postdoctoral Training: Loyola University Chicago (2004-2005) and University of Maryland at Baltimore (2005-2009, AHA Fellowship) His research centers on molecular mechanisms of calcium signaling in cardiac pathologies , particularly heart failure and ventricular arrhythmias. Using animal models of metabolic diseases, his lab employs confocal microscopy, cellular electrophysiology, and molecular biology techniques to investigate SERCA2a/RyR2 dysfunction, oxidative stress, and T-tubule remodeling. Current work explores H2S therapy for cardiac hypertrophy and intermittent fasting applications in heart failure. Analysis of his 15 most recent publications reveals dominant themes in calcium handling pathologies (80% of articles), with strong focus on metabolic syndrome complications (60%) and emerging work in natural compound therapeutics (20%). Key techniques include confocal calcium imaging (73%) and molecular analysis of cardiac proteins (67%). National System of Researchers Level 2 Certification (CONACYT) American Heart Association Postdoctoral Fellowship Dr. Altamirano has graduated 7 Master's students, 1 Ph.D. candidate, and mentored 1 Postdoctoral Fellow . His research is supported through institutional grants at Tecnologico de Monterrey, with recent projects examining cardiac calcium dynamics in diabetic models and therapeutic interventions for hypertensive heart disease. He actively participates in the Sustainable Development Goals initiative, particularly Good Health and Well-being (SDG 3) and Industry Innovation (SDG 9). His laboratory focuses on cardiac biophysics and molecular pathology , utilizing rat models of metabolic syndrome, diabetes, and cardiac injury. Current projects investigate H2S-based therapies, intermittent fasting protocols, and natural antimicrobial compounds with potential cardiovascular applications.

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Ilika Ghoshمشاهده پروفایل

پژوهشگر ارشد

Max Planck Florida Institute for NeuroscienceUnited States

Ilika Ghosh serves as a Postdoctoral Fellow at the Max Planck Florida Institute for Neuroscience (MPFI), focusing on the intersection of synaptic plasticity and cellular energy dynamics. Her research examines how neuronal structures adapt to meet metabolic demands during plasticity events. Her primary research interests center on synaptic plasticity mechanisms , with specific expertise in mitochondrial dynamics at synapses , neuronal energy metabolism , and the role of non-coding RNA in structural plasticity . Current work investigates how mitochondria reposition near active synapses to supply ATP for sustained plasticity, and how RNA molecules like SLAMR regulate local protein synthesis. Recent publications reveal a consistent focus on energy-metabolism-plasticity coupling , demonstrating that synapses actively recruit mitochondria for localized ATP production and identifying RNA-mediated pathways controlling structural changes. This work spans molecular, cellular, and systems neuroscience approaches. Ghosh collaborates extensively with leading neuroscience laboratories, as evidenced by co-authorship on high-impact publications in bioRxiv and Nature Communications. Her work receives significant attention in the neuroscience community for elucidating fundamental mechanisms of neuronal adaptation.

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Sathyanarayanan V Puthanveettilمشاهده پروفایل

دانشیار

University of FloridaUnited States

Sathyanarayanan V Puthanveettil is an Associate Professor in the Department of Neuroscience at the University of Florida College of Medicine, where he leads the SR-NEURO-PUTHANVEETTIL LAB. His academic journey includes significant research at Columbia University under Nobel laureate Eric Kandel, followed by positions at Scripps Research Institute and Florida Atlantic University. Dr. Puthanveettil's research focuses on the molecular and cellular basis of memory storage and cognitive disorders. His laboratory investigates the critical role of axonal transport in long-term memory formation, examining how organelles, proteins, mRNAs, and noncoding RNAs are transported to specific synapses. His integrated approach combines genomics, proteomics, electrophysiology, biochemistry, and advanced imaging techniques using model organisms like Aplysia and mice, including models of Alzheimer's and Huntington's disease. His publication record shows consistent high-impact output, with recent work focusing on RNA-mediated mechanisms of synaptic plasticity, kinesin motor proteins in memory formation, and mitochondrial transport in neurons. His research has evolved from foundational work on CPEB and synaptic plasticity to cutting-edge investigations of non-coding RNAs and their role in memory maintenance. CAREER Award from National Science Foundation (2015) Whitehall Foundation Award (2012) Young Investigator Award (2011) Searle Scholar Award nomination (2011) Recognition for work on Kinesin transported RNAs as 'HOT TOPIC' for Neuroscience (2009) Dr. Puthanveettil currently oversees multiple NIH-funded research projects totaling millions of dollars, with active grants from NIMH, NIA, NIGMS, and NIDA. His laboratory maintains collaborations across institutions and continues to train the next generation of neuroscientists. The Puthanveettil Lab utilizes advanced techniques to study how molecular transport coordinates nuclear and synaptic processes during memory storage, with significant implications for understanding and treating cognitive disorders.

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