جست‌وجوی استاد و پژوهشگر

Kasper Harpsøeمشاهده پروفایل

پژوهشگر

• Computational Chemistry
• Molecular Modeling
• GPCR Research
• +۶ مورد دیگر

Kasper Harpsøe is a Research Consultant and Data and Computing Facility Manager at the Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen. He has extensive expertise in computational medicinal chemistry with over 15 years of experience in molecular modeling techniques, particularly focused on G Protein-Coupled Receptors (GPCRs). Harpsøe earned his Ph.D. in Computational Chemistry from The Danish University of Pharmaceutical Sciences in 2006 with research on "Computational Studies on the Allosteric Modulation of AMPA Receptors." He holds a Master of Science in Pharmacy (Cand. Pharm.) from The Royal Danish School of Pharmacy completed in 2001. His international experience includes a three-month traineeship at Schrödinger Inc. in New York and research collaboration with the Carlson group at the University of Michigan. His research expertise spans structure-based design of peptide and small molecule ligands, binding site identification, docking and binding pose evaluation, protein-ligand interactions, conformational analysis, QSAR, sequence analysis, homology modeling, molecular dynamics, and quantum chemistry calculations. Harpsøe has made significant contributions to understanding GPCR structure-function relationships, ligand recognition mechanisms, and G protein coupling specificity. Analysis of his publication record reveals a consistent focus on GPCR molecular pharmacology, with particular emphasis on serotonin receptors, orphan receptors like GPR139, and GABA receptors. His work integrates computational approaches with experimental validation to identify molecular determinants of receptor selectivity and to design novel ligands for therapeutic applications. The research bridges structural biology, molecular modeling, and medicinal chemistry in the context of drug discovery. Harpsøe currently manages the department's Data and Computing Facility, overseeing a GPU Linux cluster and providing computational support for research groups. Previously, from 2014 to 2021, he served as project manager for computational drug design activities within the Gloriam Group, working on multidisciplinary drug discovery projects in collaboration with medicinal chemists, molecular pharmacologists, structural biologists, and data scientists from both academia and industry.

Roman Manetschمشاهده پروفایل

استاد

• Medicinal Chemistry
• Antimicrobial Agents
• Antiparasitic Drug Development
• +۳ مورد دیگر

Roman Manetsch is a Professor of Chemistry and Chemical Biology at Northeastern University, with a joint appointment in the Bouvé College of Health Sciences. His research focuses on medicinal chemistry, particularly developing novel therapies for neglected parasitic diseases like malaria and leishmaniasis, as well as antibacterial agents targeting drug-resistant pathogens. He leads the Manetsch Lab, which integrates mass spectrometry-based approaches with synthetic chemistry to optimize drug candidates. Expertise includes kinetic target-guided synthesis, protein crosslinking strategies for neurodegenerative diseases, and the discovery of compounds targeting Plasmodium species. Notable contributions include advancements in antimalarial drug design, development of streptothricin F as a novel antibiotic, and synthetic methodologies like sulfo-click and seleno-click amidation. Recipient of the 2023 TIER1 Seed Grant for innovative drug discovery research Leading multidisciplinary projects with the Barnett Institute of Chemical and Biological Analysis Collaborations in both biomedical research and pharmaceutical sciences Research trends emphasize translational applications of synthetic chemistry, with recent work exploring multifragment screening for protein interaction modulators and biocompatible reaction systems for targeted drug delivery. His lab’s publications consistently address critical gaps in treating neglected tropical diseases and antibiotic-resistant infections.

• Regenerative Medicine
• Stem Cell Biology
• Biomaterials
• +۵ مورد دیگر

Dr. Jerran Santos is a Senior Lecturer at the School of Life Sciences, University of Technology Sydney (UTS), and holds an Honorary Professorship in Biomaterials and Tissue Engineering at the University of Toulouse. He leads the Advanced Tissue Engineering and Stem Cell Biology Group at UTS and is an active consultant for the TGA. His research focuses on regenerative and precision medicine, utilizing stem cells and biomaterials to develop translational clinical applications. Key projects address neurodegenerative diseases (e.g., Alzheimer's, Parkinson's), musculoskeletal disorders (e.g., Osteoarthritis), and advanced biomaterials for 3D bioprinting. Dr. Santos has secured over $5 million in research funding and maintains international collaborations. His expertise spans stem cell biology, systems biology, and bioengineering. He has authored over 30 peer-reviewed articles and contributed to book chapters, emphasizing molecular mechanisms in cell differentiation, biomaterial design, and immunotherapy applications. Education: PhD (Macquarie University, 2013), Bachelor of Biotechnology (UTS, 2007) Positions: Biotechnology Course Coordinator (UTS), Stem Cell Futures Fellow (UTS), Visiting Scholar (Cedars-Sinai) Research Themes: Stem cell differentiation, 3D bioprinting, proteomics, and immunomodulatory therapies Scientific achievements include developing patient-specific cell models for degenerative diseases and identifying key molecular pathways in disease progression. His work aligns with UN Sustainable Development Goals 3 (Health), 9 (Infrastructure), and 17 (Partnerships).

• Semantics
• Knowledge Graphs
• Natural Language Processing
• +۴ مورد دیگر

Vanessa Lopez is a Senior Research Scientist and manager of the AI for Health and Social Care team at IBM Research Ireland since 2012. Her work focuses on enhancing AI systems through semantics and knowledge graphs to improve healthcare and scientific discovery. IBM Research Ireland, AI for Health and Social Care team Research interests: Semantics, Knowledge Graphs, NLP, Drug Discovery, Clinical Trials Optimization Her recent publications emphasize multimodal knowledge integration for accelerated discovery, biochemistry model evaluation, and peptide bioactivity prediction frameworks. She has contributed to open-source tools like Zshot and Otter-Knowledge. 2022 IBM Outstanding Technical Achievement Award 2017 US-Ireland Research Innovation Award 2022 IBM Patent Master Inventor Vanessa leads projects like Claims Audit (fraud detection), Cognitive Care Mentor (patient-centric analytics), and BlueLENS (knowledge graph querying). She has co-organized AI/semantic web challenges and served on editorial boards.

Andrew Whiteمشاهده پروفایل

پژوهشگر ارشد

• Peptide Synthesis
• Medicinal Chemistry
• Chemical Biology
• +۵ مورد دیگر

Andrew White is a Research Fellow at the Research School of Chemistry, The Australian National University (ANU), where he has worked since 2021 after completing his PhD at The University of Queensland. His research focuses on developing innovative synthetic methodologies for complex peptides with applications spanning medicinal chemistry, agriculture, and biotechnology, particularly in antimalarial drug development and targeted delivery systems. His academic qualifications include: PhD in Chemistry, The University of Queensland (2020) Bachelor of Marine Studies (Honours) Dr. White's research program centers on peptide synthesis, structure-function relationships, and therapeutic applications. He specializes in disulfide-rich peptides, cyclotides, and cell-penetrating peptides, with significant contributions to antimalarial agent development and protein modification techniques. His work bridges chemical synthesis with biological applications, emphasizing translational potential in drug discovery and agricultural biotechnology. Recent publications (2022-2024) reveal a strong trajectory in peptide engineering, featuring novel umpolung strategies for protein functionalization, synthesis of bioactive peptide conjugates for malaria treatment, and exploration of marine-derived peptide structures. These works demonstrate his interdisciplinary approach combining organic chemistry, chemical biology, and pharmacology to solve complex biomedical challenges. No scientific awards were documented in the available information. Dr. White is registered to supervise research students and collaborates within Professor Lara Malins' research group. While specific grant details weren't provided, his publication record indicates active research funding supporting peptide chemistry innovation. His work shows increasing impact with over 600 citations and an h-index of 14. He operates within Professor Lara Malins' research team at ANU's Research School of Chemistry, contributing to collaborative projects focused on peptide-based drug discovery, structural analysis of bioactive peptides, and development of novel synthetic methodologies for complex biomolecules.

Philip Williamsمشاهده پروفایل

استادیار

• Natural Products Chemistry
• Marine Natural Products
• Structure Elucidation
• +۲ مورد دیگر

Philip Williams is an Assistant Professor in the Department of Chemistry at the University of Hawaii at Manoa. His research is centered on the discovery and characterization of bioactive natural products from marine organisms, with a focus on developing new methodologies for structure elucidation using advanced NMR techniques. Education: B.Sc., University of Calgary, Canada Ph.D., University of Hawaii at Manoa (2003) Postdoctoral Fellow, Scripps Institution of Oceanography (2003–2006) Research Focus: Williams leads a multidisciplinary program that explores marine natural product chemistry. His group isolates and structurally characterizes small molecules from marine organisms, aiming to identify novel therapeutic leads for cancer and neurodegenerative diseases. A significant part of his work involves refining NMR-based methodologies for stereochemical assignment at sub-micromolar scales. Current Research Directions: Exploring chemical defenses in marine cyanobacteria and sponges Developing NMR strategies for stereochemical determination of trace metabolites Evaluating marine natural products against cancer cell lines and Alzheimer’s disease models Recent Publications: His recent work has uncovered new oxazoline and sesquiterpenoid natural products with promising bioactivities, alongside collaborative studies on flavonoid neuroprotective agents. These publications highlight a consistent theme of integrating innovative spectroscopic approaches with bioassay-guided isolation. Students & Collaborators: Williams supervises a diverse group of graduate and undergraduate researchers, including Cain, Haglund, Hyvl, Kaiser, Kumashiro, Jarrett, Jensen, Raston, Sun, Tius, Zhang, and Sattasathuchana. He is also an active participant in the Natural Products Cancer Biology program at the University of Hawaii.

• Wound Healing
• Pharmacology
• Honey Bioactivity
• +۴ مورد دیگر

Simona MARTINOTTI is a tenured Professor at the Department of Science and Technological Innovation, University of Eastern Piedmont 'Amedeo Avogadro'. Her research focuses on pharmacology, wound healing, and bioactive natural substances like honey and propolis. She leads projects addressing mesothelioma treatment, skin aging, and antioxidant mechanisms. Key collaborations involve interdisciplinary teams studying cancer biology and biomedical applications. Education & Roles: Prof. MARTINOTTI holds a strong academic position with tenured status. Her career includes previous roles as a Researcher at the same institution. Research Interests: Her work bridges pharmacology and natural products science. Major themes include: Development of novel therapeutic agents for malignant neoplasms Optimizing wound healing through honey's bioactive components Elucidating cellular stress pathways in cancer progression Recent Projects: MINDSET: Multiomic analysis for pleural mesothelioma signatures (2023-2025) SAHaRa: Honey-based skin care formulations (2023-2025) Oxidative stress modulation in health (2019-2022) Publications: Over 100 peer-reviewed articles spanning 2009-2025, with recent emphasis on natural product pharmacology and cancer therapeutics. 2024-2025 publications highlight innovations in propolis chemistry and mesothelioma drug discovery. Grants & Funding: Secured funding from the Italian Ministry of Health and institutional grants. Total projects managed: 3 active/complete grants totaling €[unspecified].

• Medical Chemistry
• Synthetic Organic Chemistry
• Pharmacology
• +۶ مورد دیگر

David A. Spiegel is a Professor of Chemistry at Yale University, with secondary appointments in Pharmacology and Molecular Medicine. His research focuses on the intersection of organic chemistry, pharmacology, and synthetic immunology, developing novel small molecules for biomedical applications. Yale School of Medicine Chemistry Pharmacology Molecular Medicine Global Health Studies Yale Cancer Center Research Interests: Dr. Spiegel’s work spans medical chemistry, synthetic immunology, and chemical biology. He explores methods for targeted protein degradation, antibody recruitment, and metabolic disease mechanisms. His lab designs bioactive compounds for cancer, infectious diseases, and neurodegenerative conditions. Recent Publications: His recent studies address tumor growth via YAP signaling, brain-targeted drug delivery, and synthetic strategies for immunomodulation. Key themes include glycation, transcytosis, and small molecule-based therapies. Scientific Awards: Alfred P. Sloan Foundation Fellowship NIH Director’s New Innovator Award Camille and Henry Dreyfus New Faculty Award Ellison Foundation New Scholar Award Bill and Melinda Gates Foundation Grand Challenges Explorations Award Labs & Collaborations: Dr. Spiegel leads the Spiegel Research Group at Yale, collaborating with institutions like the Yale Cancer Center and Yale Ventures. His work integrates interdisciplinary approaches in chemical biology and translational medicine.

Viranga Tillekeratneمشاهده پروفایل

استاد

• Drug Design
• Natural Product Synthesis
• Anticancer Therapeutics
• +۴ مورد دیگر

Viranga Tillekeratne is a Professor at the University of Toledo's College of Pharmacy and Pharmaceutical Sciences, specializing in the Department of Medicinal and Biological Chemistry. His lab pioneers the development of small-molecule probes for drug design, focusing on natural product derivatives (e.g., epothilones and largazole) and redox-active electrocatalysts for electrochemical sensors. Research emphasizes anticancer agents, neurodegenerative therapeutics, and epigenetic modulators targeting histone deacetylases (HDACs). Education includes a D.Phil. from the University of Oxford (1975) and a B.S. from the University of Colombo, Sri Lanka (1969). Research Interests: Tillekeratne's work spans three core areas: Drug Design & Natural Products : Structural optimization of bioactive compounds (e.g., largazole analogues for HDAC inhibition, epothilones for microtubule targeting). Electrochemical Sensors : Development of quinone-capped electrocatalysts for thiol/neurotoxin detection. Mechanistic Therapeutics : Ferroptosis induction, neuroinflammation suppression, and isoform-selective enzyme inhibitors. Publication Trends (2018–2024): Recent articles highlight ferroptosis induction, HDAC inhibitor hybrids, microtubule-targeting agents, and neuroprotective strategies. Dominant themes include covalent probe design, structure-activity relationships, and translational applications in cancer/neurodegeneration. Labs & Collaborations: Leads an active research group at UToledo and collaborates with Dr. Jon R. Kirchhoff (Chemistry) on sensor development. Patents cover cofilin inhibitors for neuroinflammation and imidazole-based anticancer agents.

• Medicinal Chemistry
• Organic Synthesis
• Drug Discovery
• +۴ مورد دیگر

Keng Yoon Yeong is a Senior Lecturer in the School of Science at Monash University, specializing in Medicinal Chemistry and Advanced Organic Chemistry. His research focuses on small molecule and short peptide drug discovery targeting cancers, infectious diseases, and neurological disorders. Prior to academia, he spent 11 years as a research scientist in industry, focusing on organic synthesis and immunoassays. His work is supported by international and national funders like the Royal Society of Chemistry UK and Malaysian Ministry of Science, Technology and Innovation (MOSTI). He has co-authored over 60 publications and holds several awards, including the Faculty of Science Dean's Awards for Excellence in Teaching (2020) and Honours Supervision (2023). His research group employs parallel synthesis for compound libraries and explores strategies like computer-aided drug design and bioisosteric replacements. Recent projects include developing ADAR1 inhibitors for oral cancers and isolating bioactive compounds from Myristica fragrans for Alzheimer’s treatment. He actively collaborates internationally and has visited institutions like the University of Northern British Columbia (2024) and Petru Poni Institute of Macromolecular Chemistry (2024). Awards include the Golden Pavilion Award for Best Research Project and Thesis from University Science Malaysia (2015–2016), and recognition for sustainable drug discovery initiatives. His media engagements include TEDx talks and features on drug discovery trends.

Dmitry Katayevمشاهده پروفایل

استادیار

• Organic Synthesis
• Catalysis
• Photocatalysis
• +۴ مورد دیگر

Prof. Dmitry Katayev serves as Tenure Track Assistant Professor in Organic Chemistry at the University of Bern's Department of Chemistry, Biochemistry and Pharmacy, where he leads an active research group focused on innovative catalytic methodologies. His work bridges fundamental mechanistic studies with practical applications in sustainable synthesis. His educational trajectory includes: MSc in Chemistry and Chemical Engineering, Russian Academy of Sciences, Moscow (2008) PhD in Organic Chemistry, University of Geneva under EP Küng (2012) Postdoctoral research at Technical University Kaiserslauten with L. Goossen (2013-2015) Postdoctoral research at ETH Zurich with A. Togni (2015-2016) Research efforts center on light- and electricity-driven C-H functionalization , with emphasis on developing photocatalytic, electrochemical, and mechanochemical strategies for forming C-C, C-N, and C-O bonds. The group pioneers bench-stable reagents for radical transformations while integrating physical organic chemistry and computational studies to elucidate reaction mechanisms. Key innovations include anti-Markovnikov hydronitration protocols and dual-functional group transfer reagents for sustainable synthesis. Analysis of recent publications (2024-2025) reveals a dominant trend toward radical chemistry and green methodology development , featuring photoredox catalysis for fluorinated radical generation, iron-mediated ligand transfer, and mechanochemical nitration. These works consistently address scalability challenges through flow chemistry integration while expanding the toolbox for bioactive molecule synthesis. His recognition includes: SNSF Ambizione Fellowship (2017-2020) SNSF Eccellenza Grant (2021-present) Prof. Katayev mentors a multidisciplinary team of postdocs and graduate students, securing competitive funding for projects that bridge academic discovery and industrial application. His group actively collaborates on translating fundamental catalytic concepts into scalable fine chemical production processes. The Katayev Lab operates specialized facilities for photoredox, electrochemical, and mechanochemical synthesis at the University of Bern, contributing to the department's prominence in sustainable chemistry. The group regularly participates in public outreach initiatives like the BioChemistry on Saturday lecture series, demonstrating commitment to science communication.

Shuo Linمشاهده پروفایل

استاد

• Developmental Biology
• Genetics
• Molecular Biology
• +۹ مورد دیگر

Shuo Lin is a Professor in the Department of Molecular, Cell and Developmental Biology at UCLA since 2001, with a focus on zebrafish genetics to study hematopoietic and vascular development , pancreas organogenesis , and chemical genetics . He earned his Ph.D. in Biological Chemistry from Boston University in 1991, followed by postdoctoral work at MIT. His lab develops zebrafish as a model organism for human disease and drug discovery. Research interests include: Genetic pathways of hematopoiesis and vasculogenesis , emphasizing hemangioblast determination and lineage specification . Genetic basis of pancreatic organogenesis , particularly beta cell development for diabetes research. Pre-clinical drug discovery using zebrafish models for cancer and neurodegenerative diseases . His lab pioneered genome-wide mutagenesis via retroviral insertions and BAC transgenesis with GFP/RFP reporters , generating hundreds of transgenic lines for tissue-specific gene expression. Publications span developmental biology , genetics , and nano-EHS studies , often involving high-throughput screening and transgenic zebrafish models . Graduate students Haishan Zhao and Jason Ear are part of his team. His work integrates biomedical research , transgenesis , and chemical genetics to address fundamental questions in developmental biology and disease modeling.

Nick Barlowمشاهده پروفایل

پژوهشگر ارشد

• Peptide Chemistry
• Small Molecule Drug Discovery
• Drug Targets (Peptidases, Proteases, GPCRs)
• +۴ مورد دیگر

Nick Barlow is a Research Fellow in Medicinal Chemistry at Monash University, leading a drug discovery group focused on peptide chemistry and small molecule drug development. His work bridges fundamental and translational research, targeting drug mechanisms involving peptidases, proteases, and GPCRs. He currently oversees diabetes research programs investigating melanocortin receptors' role in glucose control and has developed technologies enhancing membrane permeability of chemical tools and bioactive peptides. Barlow's team has advanced three peptide drug candidates to preclinical stages over the past five years, establishing startup companies for commercialization. His research contributes to UN Sustainable Development Goals addressing good health and well-being (SDG 3). Recent collaborations include projects on HIV-1 reverse transcriptase inhibition and cardiovascular disease mechanisms. Key projects include the 2021-2023 'Lead optimisation of novel inhibitors of IRAP' funded by Australian Research Council. His publications span peptide design, enzyme inhibition, and immunomodulatory mechanisms, reflecting expertise in drug delivery systems and fragment-based approaches.

• Synthetic Organic Chemistry
• Biological Chemistry
• Enzymology
• +۵ مورد دیگر

Dr. David Miller is a Senior Lecturer in Biological Chemistry and Director of Postgraduate Taught (PGT) Programmes at the School of Chemistry, Cardiff University. With over two decades of academic experience, he leads research at the intersection of synthetic organic chemistry and biological systems, focusing on enzyme mechanisms and applications in drug discovery. MA in Chemistry with Supplementary Quantum Chemistry, Oriel College Oxford (1989-1993) PhD, Southampton University under Prof. T. D. H. Bugg (1993-1997) Dr. Miller's research centers on applying synthetic organic chemistry to solve biological problems and vice versa. His work explores how small organic molecules can probe the function of biological macromolecules like proteins and DNA. His primary research areas include: Inositol monophosphatase : Studying this enzyme's mechanism as a target for bipolar disorder treatments mu-Calpain research : Developing inhibitors for autoimmune diseases like rheumatoid arthritis and osteoarthritis Terpenoid biosynthesis : Investigating how terpene cyclases generate diverse natural products from common precursors Analysis of Dr. Miller's recent publications reveals a strong focus on enzyme engineering, particularly with terpene synthases. His work combines computational modeling, structural biology, and synthetic chemistry to manipulate enzyme function. A significant trend is the exploration of enzyme plasticity to create novel catalytic activities and non-natural products. His research bridges fundamental enzymology with practical applications in drug discovery and biocatalysis. Dr. Miller is a Member of the Royal Society of Chemistry (MRSC), reflecting his contributions to the field of chemical sciences. As Director of Postgraduate Taught Programmes, Dr. Miller oversees curriculum development and student supervision. He teaches across multiple levels, from foundational organic chemistry to specialized courses in biocatalysis and drug development. His research group receives funding for projects exploring enzyme mechanisms and their applications in therapeutic development. Dr. Miller's laboratory focuses on the structural and mechanistic aspects of enzyme catalysis, with particular emphasis on terpene synthases and calpain proteases. His team combines synthetic organic chemistry, protein engineering, and structural biology approaches to unravel complex biochemical processes.

• Natural Products Chemistry
• Bioactive Substance Isolation and Modification
• Computer-Aided Molecular Modeling (CAMM/CADD)
• +۵ مورد دیگر

Mario V. Zlatovic is a Full Professor at the Faculty of Chemistry, University of Belgrade , specializing in Natural Products Chemistry, Computational Chemistry, and Medical Chemistry. He has held various academic roles since 1988 and currently teaches courses on Chemical Bonding, Molecular Modeling, and Organic Chemistry. Born: 7 April 1963, Šibenik, Croatia Languages: Serbian (native), English, Russian, Croatian Research Focus: His work explores non-covalent interactions in proteins and small molecules, particularly in superoxide dismutases and anion-π systems . He designs antimicrobial and antimalarial agents, emphasizing structure-based drug design and 3D-QSAR analysis . Scientific Contributions: Over 15 years, his publications span materials science (DFT calculations), enzyme inhibition (α-glucosidase), and marine bioconjugates. He combines computational methods with experimental validation in drug discovery. Fulbright Fellow (2009-2010) at National Cancer Institute, USA Supervisor of HemNet (2020-present) Member of Faculty Council and Examination Recognition Commission Teaching: Offers courses on Molecular Modeling, Chemical Informatics, and Project Management. His educational work includes a 2015 publication on homology modeling pedagogy.