معرفی
Shuo Lin is a Professor in the Department of Molecular, Cell and Developmental Biology at UCLA since 2001, with a focus on zebrafish genetics to study hematopoietic and vascular development, pancreas organogenesis, and chemical genetics. He earned his Ph.D. in Biological Chemistry from Boston University in 1991, followed by postdoctoral work at MIT. His lab develops zebrafish as a model organism for human disease and drug discovery.
Research interests include:
- Genetic pathways of hematopoiesis and vasculogenesis, emphasizing hemangioblast determination and lineage specification.
- Genetic basis of pancreatic organogenesis, particularly beta cell development for diabetes research.
- Pre-clinical drug discovery using zebrafish models for cancer and neurodegenerative diseases.
His lab pioneered genome-wide mutagenesis via retroviral insertions and BAC transgenesis with GFP/RFP reporters, generating hundreds of transgenic lines for tissue-specific gene expression. Publications span developmental biology, genetics, and nano-EHS studies, often involving high-throughput screening and transgenic zebrafish models.
Graduate students Haishan Zhao and Jason Ear are part of his team. His work integrates biomedical research, transgenesis, and chemical genetics to address fundamental questions in developmental biology and disease modeling.
