Charlotte Held Gotfredsen is a Professor in the Department of Chemistry at the Technical University of Denmark (DTU). Her research focuses on microbial secondary metabolites, organic chemistry, and metabolomics. She leads the Center for Microbial Secondary Metabolites and is affiliated with DTU Microbes Initiative. Her work contributes to Sustainable Development Goals related to health and innovation. Research interests include natural product discovery, biosynthesis of antibiotics, and development of analytical tools like NMR-based metabolomics. She supervises multiple PhD projects, including studies on endoribonuclease recruiters, bacterial secondary metabolites, and fragment-based drug discovery targeting nucleotide and TNF receptors. Publications span antifungal compounds from Streptomyces, enzymatic fluorination, and genome-driven discovery of bioactive metabolites. Her lab employs cutting-edge techniques in synthetic biology and chemical biology, with a focus on drug discovery and metabolic engineering. Current projects include optimizing metabolomic experiments and expanding biocatalytic methods for fluorine chemistry. She collaborates internationally on topics like RNA-targeted drug design and Alzheimer’s biomarkers.
