جست‌وجوی استاد و پژوهشگر

Pengbo Zhouمشاهده پروفایل

استاد

• Ubiquitin-Proteasome System
• Cancer Biology
• DNA Damage Response
• +۶ مورد دیگر

Professor Pengbo Zhou is a Professor of Pathology and Laboratory Medicine at Weill Cornell Medical College , where he has been on the faculty since 2010. His research focuses on the ubiquitin-proteasome system and its dysregulation in cancer, with particular emphasis on Cullin-RING E3 ligases, SPOP signaling, and DNA damage response pathways. Education: Ph.D., University of Michigan Medical School , 1993 B.S., Peking University (China) , 1987 Research Interests: Professor Zhou’s laboratory investigates how ubiquitin ligases, notably the CUL4 family and SPOP, orchestrate protein degradation to control genomic stability, hormone signaling, and oncogenesis. His work bridges biochemical mechanisms and translational cancer biology, exploring how disruption of these pathways leads to prostate, breast, and lung malignancies. He has pioneered studies on G3BP1-mediated regulation of SPOP, the role of UBR5 in tumor suppression, and the therapeutic targeting of ubiquitin signaling in metastatic disease. Publication Trends: Across more than 100 peer-reviewed publications, Professor Zhou’s work spans from foundational biochemical analyses of ubiquitin ligase structure-function relationships to large-scale genomic profiling of human tumors. Recent papers emphasize translational applications—engineering degron tools, characterizing cancer-associated mutations, and uncovering vulnerabilities in AR-driven prostate cancer. Scientific Awards & Funding: Principal Investigator, NIH/NCI grant “Upstream and downstream targeting of the SPOP ubiquitin signaling pathway in prostate cancer”, 2024-2029 Co-Principal Investigator, NIH/NCI grant “UBR5’s Mechanisms of Action in Tumorigenesis and Immunoregulation”, 2023-2028 Co-Investigator, NCATS Clinical and Translational Science Center UL1 award, 2022-2027 Advisory & Commercial Relationships: Advisory/Scientific Board Member, Culnexin Therapeutics LLC Ownership stake, Culnexin Therapeutics LLC Proprietary interest, Ship of Theseus LLC Professor Zhou’s team employs cell-based models, mouse genetics, and clinical specimen analyses to advance both mechanistic understanding and therapeutic strategies targeting the ubiquitin system in cancer.

Cynthia Burrowsمشاهده پروفایل

استاد

• Biochemistry
• DNA Damage and Repair
• Epigenetics
• +۵ مورد دیگر

Cynthia Burrows serves as Professor and Thatcher Presidential Endowed Chair of Biological Chemistry at the University of Utah's Department of Chemistry within the College of Science. She also holds membership at the Huntsman Cancer Institute and serves as Editor-in-Chief of Accounts of Chemical Research. Her leadership extends to chairing the Chemistry Department where she spearheaded development of the Thatcher Building, a state-of-the-art biological chemistry research facility. Her educational background includes a Bachelor of Arts in Chemistry from the University of Colorado, Boulder (1975) and a Ph.D. from Cornell University (1982). Postdoctoral work included research with Nobel laureate Jean-Marie Lehn at Université Louis Pasteur. Burrows' research centers on oxidative damage to DNA/RNA molecules and their physiological consequences, particularly cancer development. Her laboratory investigates how oxidation alters nucleic acid structures (especially G-quadruplexes), repair mechanisms for thousands of daily cellular damage events, and the epigenetic implications of oxidative modifications. Recent breakthroughs include nanopore-based detection systems developed with Henry White for identifying DNA damage at single-molecule resolution. Analysis of her 15 most recent publications reveals consistent focus on oxidative DNA damage mechanisms, with particular emphasis on G-quadruplex structures in gene regulation, RNA modification detection via nanopore sequencing, and the dual roles of oxidative lesions as both mutagenic threats and epigenetic regulators. Her work bridges fundamental biochemistry with clinical applications in cancer research. Willard Gibbs Medal (2018) James Flack Norris Award (2018) National Academy of Sciences (2014) Utah Governor's Medal (2016) Rosenblatt Prize for Excellence (2019) AAAS Fellow ACS Fellow Burrows has mentored numerous students reflected in her teaching awards including the Robert W. Parry Teaching Award and Distinguished Teaching Award. She secured funding for five faculty chairs, four named lectureships, and student awards. As a founding leader of the University of Utah Curie Club for Women, she's advanced women in STEM through community building. Her laboratory work continues to explore oxidative damage mechanisms with implications for cancer therapeutics and epigenetic regulation.

Jiricny Josefمشاهده پروفایل

استاد

• Base excision repair
• Mismatch repair
• DNA repair
• +۲ مورد دیگر

Josef Jiricny is a Full Professor at the Swiss Federal Institute of Technology (ETH) Zurich and University of Zurich. Affiliated with the Department of Chemistry and Applied Biosciences at ETH Zurich since 2006, he previously held full professorships at the Department of Biology (2003) and Faculty of Sciences (2001) at University of Zurich, and directed the Institute of Molecular Cancer Research at the Medical Faculty (1996). 1996–Present: Full Professor at University of Zurich and ETH Zurich 1990–1996: Senior Director of Biochemistry at IRBM, Italy 1983–1990: Group Leader at Friedrich Miescher Institute, Basel Research Focus: Specializing in DNA repair mechanisms, his work addresses fundamental processes in base excision repair and mismatch repair, contributing to cancer research and molecular biology advancements. Editorial roles in Biological Chemistry and EMBO publications Scientific advisory positions for Swiss Bridge, IARC, and European Framework programs Awards & Honors: Recipient of the Swiss Bridge Award, Bonizzi-Theler Award, and Ernst-Theophile Jucker Prize, alongside EMBO and Academia Europea memberships.

Wendy Parulekarمشاهده پروفایل

استاد

• Clinical Trial Methodology
• Breast Cancer Treatment
• Genitourinary Oncology
• +۳ مورد دیگر

Dr. Wendy Parulekar is a Senior Investigator at the Canadian Cancer Trials Group and Professor in the Department of Oncology at Queen's University. She completed her MD at the University of Ottawa Medical School, followed by residency in Internal Medicine and Medical Oncology (1996), and a fellowship in Clinical Pharmacology at Toronto Sunnybrook Regional Cancer Centre. Since 1999, she has held a joint clinical/research position at Queen's University. Her research focuses on optimizing clinical trial design and methodology, particularly in breast, head/neck, and genitourinary cancers. She chairs the CCTG Education Committee and participates in national/international initiatives like the SPIRIT protocol standardization effort. Notable contributions include leading trials on SBRT for spinal metastases, ADT duration in prostate cancer, and biomarker-driven therapies for mCRPC. Key awards include Fellow of the Society for Clinical Trials (2011). Current trials include PR21 (Lu-177 PSMA therapy), VU.2 STRIVE (vulvar SCC stratification), and ENZAMET (metastatic prostate cancer therapy).

Seongmin Leeمشاهده پروفایل

دانشیار

• DNA Damage and Repair
• Mutagenesis
• Translesion Synthesis
• +۶ مورد دیگر

Seongmin Lee is an Associate Professor of Chemical Biology & Medicinal Chemistry and Alan W. Hamm Centennial Fellow at the College of Pharmacy, The University of Texas at Austin. His laboratory investigates molecular mechanisms of DNA damage, repair, and mutagenesis with a focus on developing novel anticancer therapeutics targeting DNA repair pathways. Education: Ph.D. in Chemistry from Purdue University B.S. in Chemistry from Seoul National University, South Korea Dr. Lee's research program centers on oxidative and alkylative DNA lesions induced by environmental mutagens and chemotherapeutic agents. His team employs synthetic chemistry, biochemistry, and structural biology to elucidate how DNA lesions alter replication fidelity, induce mutations, and trigger cancer. Current projects examine platinum-based drug mechanisms, translesion synthesis polymerases, and DNA cross-link repair pathways with direct implications for overcoming chemotherapeutic resistance. Analysis of his 15 most recent publications (2019-2021) reveals consistent focus on structural and mechanistic studies of DNA lesion bypass, with particular emphasis on oxidative adenine lesions (7,8-dihydro-8-oxoadenine), platinum-DNA adducts, and alkylative damage. The work integrates X-ray crystallography, kinetic assays, and synthetic lesion chemistry to map mutagenic pathways and identify therapeutic vulnerabilities in cancer cells. Scientific Awards: Alan W. Hamm Centennial Fellow in Pharmacy Dr. Lee actively mentors 4 current graduate students (Rozelle, Vilas, Schmaltz, Rodriguez) and has supervised 9 PhD graduates including Cheun, Kou, and Ouzon-Shubeita. His laboratory operates with continuous NIH and NSF funding supporting research on DNA-targeting drugs, with recent grants focused on platinum-based agent development and lesion bypass mechanisms. The team maintains collaborations with structural biologists and cancer pharmacologists across multiple institutions. The Laboratory of DNA Damage and Repair and DNA-Targeting Drugs comprises 12 members including research fellows, graduate students, and undergraduates. Current projects involve synthesizing novel DNA lesions, characterizing polymerase bypass mechanisms, and developing next-generation platinum therapeutics with reduced resistance profiles. The lab maintains state-of-the-art facilities for synthetic chemistry, protein purification, and DNA damage analysis.

Shannen Cravensمشاهده پروفایل

استادیار

• Biochemistry
• Biophysics
• Molecular Biology
• +۴ مورد دیگر

Shannen Cravens, Ph.D. , is an Assistant Professor in the Department of Chemistry & Biochemistry at Gonzaga University. Her research integrates biophysical chemistry and molecular biology to investigate fundamental biological processes. Key Research Areas: DNA biophysics, sequence-specific DNA targeting molecules, and biochemical mechanisms of DNA repair enzymes. Recent Expansion: Applied atomic force and confocal microscopy to study tooth decay and enamel erosion. The Cravens Lab focuses on three primary projects: (1) Investigating chemical damage effects on DNAzymes for RNA-targeting therapeutics; (2) Characterizing anti-bacterial/anti-tumor chalcones interacting with DNA; (3) Analyzing calcium leaching from tooth enamel under dietary stressors. Students engage with molecular biology, structural biology, and analytical chemistry techniques. Recent publications highlight her work on ubiquitin ligase regulation (2024), DNA glycosylase dynamics (2017, 2014), and damage search mechanisms (2016). Research aligns with Sustainable Development Goals 3 (Good Health) and 4 (Quality Education).

Evren Gurkan Cavusogluمشاهده پروفایل

دانشیار

• Systems and Control Theory
• Systems Biology
• Computational Biology
• +۳ مورد دیگر

Evren Gurkan Cavusoglu is an Associate Professor in the Department of Electrical, Computer, and Systems Engineering at Case School of Engineering , where he also serves as the Associate Dean of Academics . His academic career bridges engineering and biology through interdisciplinary research. Education MBA, Case Western Reserve University (2016) PhD in Electrical and Electronics Engineering, Middle East Technical University (2003) MSc in Automatic Control and Systems Engineering, University of Sheffield (1997) BSc in Electrical and Electronics Engineering, Middle East Technical University (1996) His research focuses on systems and control theory , systems biology , and computational biology , with applications in biological system modeling and signal processing . He develops in silico models to enhance cancer therapies and study cellular dynamics. Recent publications highlight his work in radiosensitization , DNA repair mechanisms , and fuzzy control systems . His teaching includes signal processing , control systems , and systems biology . Scientific Awards CSE Undergraduate Teaching Award (2017) He is a member of the Institute of Electrical and Electronics Engineers (IEEE) and has contributed to journals like IET Systems Biology , Frontiers in Oncology , and Cancer Research . His work emphasizes translational applications of engineering principles in biomedicine.

Eyal Maoriمشاهده پروفایل

پژوهشگر ارشد

• RNA Biology
• Social Immunity
• Epigenetic Communication
• +۳ مورد دیگر

Dr. Eyal Maori (University of Cambridge) is a Sir Henry Dale Fellow at the Department of Biochemistry, focusing on RNA communication between organisms. His research explores RNA interconnections in infection, immunity, and genome dynamics, particularly studying RNA transfer between honeybees and its implications for social immunity and epigenetic communication. Key research areas include Establishing methods to study natural RNA transmission in honeybees Characterizing transmissible RNA in recipient honeybees Investigating RNA-primed social immunity across generations Assessing transmissible RNA effects on honeybee physiology and behavior His group employs RNA biochemistry techniques, imaging, and high-throughput sequencing to define RNA transfer mechanisms between cells and organisms. This work aims to develop tools for studying RNA transmission biology across systems, with applications in sustainability, health, and disease control. Publications and patents reveal trends in Plant RNA specificity modification for gene silencing dsRNA applications for pest control CRISPR/Cas9 HIV-1 studies Coffee bean and banana shelf-life enhancements Honeybee-Varroa mite interactions via RNA pathways

Yuri Lyubchenkoمشاهده پروفایل

استاد

• Single Molecule Biophysics
• Atomic Force Microscopy
• Protein-DNA Interactions
• +۷ مورد دیگر

Yuri Lyubchenko, PhD, DSc is a Professor in the Department of Pharmaceutical Sciences at the University of Nebraska Medical Center (UNMC) College of Pharmacy. He directs the Pharmaceutical Nanoimaging and Nanoengineering Laboratory (PNNL), where his research integrates advanced atomic force microscopy techniques with biophysical approaches to study fundamental molecular mechanisms in health and disease. His research spans three interconnected areas: (1) Structural genomics related to cancer and chromosome dynamics, where his lab discovered critical properties of centromeric nucleosomes using high-speed AFM; (2) Molecular mechanisms of Alzheimer's and Parkinson's diseases, where his team developed novel approaches revealing how amyloid proteins aggregate at physiological concentrations; and (3) Protein-DNA interactions for HIV restriction, focusing on APOBEC3G mechanisms. His work has been funded by NSF and NIH grants. Dr. Lyubchenko has pioneered nanoimaging methodologies that enable direct visualization of molecular dynamics, leading to paradigm-shifting discoveries about amyloid aggregation and nucleosome behavior. His research has significantly advanced understanding of how protein misfolding triggers neurodegenerative diseases and how chromatin structure regulates genomic stability. He has edited significant scholarly works including 'An Introduction to Single Molecule Biophysics' (CRC Press) and a volume in the 'Methods in Molecular Biology' series (Springer Nature), and has organized academic workshops such as the Midwest Single Molecule Workshop. As an educator, Dr. Lyubchenko teaches multiple courses including PHSC 691: Pharmaceutical Science Applications in Pharmacy, PHSC 520: Pharmaceutical Biochemistry, PHSC-845: Quantitative Pharmaceutical Sciences, and PHSC 848: Bioimaging and Nanoimaging.

• NMR Spectroscopy
• Solid-state NMR
• Protein Structure
• +۵ مورد دیگر

Dr. Gert Folkers is an Assistant Professor in the Department of Chemistry at Utrecht University's Faculty of Science, specializing in NMR Spectroscopy within the Biomolecular Sciences division. His research focuses on applying advanced NMR techniques to study biological macromolecules in their native environments. He is based in the Nicolaas Bloembergen building and has been actively involved in both research and teaching at the university for many years. Dr. Folkers' research primarily centers on Nuclear Magnetic Resonance spectroscopy with emphasis on solid-state NMR and Dynamic Nuclear Polarization techniques. His work bridges structural biology and biophysics, with significant contributions to understanding protein structures in cellular environments, DNA-protein interactions, and developing novel NMR methodologies for in-cell applications. His research group has pioneered approaches to study proteins inside mammalian cells at atomic resolution, significantly advancing the field of structural biology. Analysis of Dr. Folkers' publication record reveals a strong trajectory in advancing NMR methodology for biological applications, with increasing focus on cellular environments over time. His work spans from fundamental protein-DNA interactions to cutting-edge in-cell structural biology, demonstrating both breadth and depth in structural biology research. Recent publications highlight his leadership in applying DNP-enhanced solid-state NMR to study proteins and nucleic acids in increasingly complex biological contexts. Dr. Folkers has served in various administrative capacities at Utrecht University, including participation in faculty decision-making since 2009 and membership on the University Council since 2012. He has been actively involved in teaching, particularly in life sciences master's and bachelor's information sessions since 2011-2012. His laboratory work extends beyond research to include significant safety responsibilities, having served as a radiation safety officer since 2002 and as an Emergency Response Officer since 2004. Dr. Folkers leads research activities within the NMR Spectroscopy group, working closely with Professor Marc Baldus and other colleagues. His laboratory maintains the radionuclide facility in the Bloembergen building and focuses on developing and applying cutting-edge NMR methodologies to solve challenging problems in structural biology, particularly related to protein structure and function in cellular environments.

Rawle F. Philbertمشاهده پروفایل

دانشیار

• Oral and Maxillofacial Surgery
• Maxillofacial Trauma Management
• Dental Implantology
• +۴ مورد دیگر

Rawle F. Philbert, D.D.S., FACD, FACS, serves as Associate Professor and Chief of the Division of Oral and Maxillofacial Surgery within the Department of Surgery at UT Southwestern Medical Center's School of Medicine. Certified by the American Board of Oral and Maxillofacial Surgery, he joined the faculty in 2021 after extensive clinical practice and leadership roles. His research focuses on maxillofacial trauma management , dental implantology , and reconstructive techniques , with particular expertise in managing complex cases involving cardiac comorbidities. Clinical innovations include modified bone graft harvesting and specialized osteotomy approaches for dentoalveolar deformities. Analysis of his 15 most recent publications reveals consistent emphasis on trauma reconstruction (32% of works), tumor pathology (20%), and technical innovations (28%), with growing focus on evidence-based practice implementation since 2012. His work bridges surgical technique refinement with practical clinical applications. Lifetime Achievement Award (Lincoln Medical Center Auxiliary, 2009) Doctor of the Year Award (NYC Health System, 2012) American Board Examination Committee Award (2019) Multiple Attending of the Year honors (Harlem Hospital Center, 1994-1996) Dr. Philbert maintains active leadership in national organizations including the American College of Surgeons and American Dental Association, where he serves as a Committee on Dental Education Site Visitor. His clinical practice at the Oral and Maxillofacial Surgery Clinic in Dallas integrates teaching responsibilities with complex case management across trauma, reconstruction, and implant rehabilitation domains.

Gregory Verdineمشاهده پروفایل

استاد

• Chemical Biology
• Epigenetics
• DNA Repair
• +۵ مورد دیگر

Gregory Verdine is the Erving Professor of Chemistry at Harvard University, with primary appointments in the Departments of Stem Cell and Regenerative Biology and Chemistry and Chemical Biology. He is a pioneering figure in chemical biology, DNA repair mechanisms, and therapeutic modality development, particularly known for inventing stapled peptides that target previously "undruggable" proteins. Verdine also serves as Chairman of the Board of Directors at WaVe Life Sciences and President/CEO of FogPharma, while maintaining advisory roles at institutions like Memorial Sloan-Kettering Research Institute and National Cancer Institute. Harvard University (Stem Cell and Regenerative Biology, Chemistry and Chemical Biology) Founder/Co-Founder of 8 biotech companies (Enanta, Gloucester, Tokai, WaVe, Eleven Biotherapeutics, Warp Drive Bio, Aileron, FogPharma) Non-Profit Leadership: Gloucester Marine Genomics Institute and Gloucester Biotechnology Academy Research focuses on chemical biology and genomic stability , with key discoveries in: Molecular mechanisms of epigenetic DNA methylation Genotoxic DNA damage surveillance pathways Design of stapled peptides for protein-protein interaction modulation Applications in oncology (β-catenin, Ras, RAB25 targeting) Advancing nucleotide excision repair systems Antisense oligonucleotide stereochemical optimization His 15 most recent publications (2013-2024) reveal trends in: Covalent enzyme inhibitors Genomic modality discovery Ubiquitin ligase reprogramming Protein structure remodelling Allele-selective genetic therapies DNA lesion recognition mechanisms Awards include the 2024 AACR Award for Excellence in Chemistry in Cancer Research and Nobel Laureate Signature Award . He has translated academic research into clinical applications through multiple FDA-approved drugs (romidepsin, paritaprevir) and currently leads FogPharma's Cell-Penetrating Miniprotein platform. Academic collaborators span Harvard, MIT, and major biomedical research institutions.

Soichi Wakatsukiمشاهده پروفایل

استاد

• Structural Biology
• Ubiquitin Signaling
• Synchrotron Radiation
• +۷ مورد دیگر

Soichi Wakatsuki is a dual Professor of Photon Science at SLAC National Accelerator Laboratory and Structural Biology at Stanford University School of Medicine. His career spans institutions in Japan (KEK), France (ESRF), and the U.S., with leadership in structural biology and synchrotron instrumentation. B.S./M.S. in Chemical Engineering, University of Tokyo Ph.D. in Chemistry, Stanford University (1991) Research focuses on ubiquitin signaling mechanisms in cellular regulation, multiscale bioimaging (Cryo-EM/XFEL/X-ray tomography), and self-assembly processes in microbial S-layer proteins. Recent work bridges quantum biophysics (RF magnetic field effects) and antiviral therapeutics (SARS-CoV-2 protease inhibition). His lab develops integrative imaging technologies combining X-ray scattering, cryo-tomography, and super-resolution optics. Articles highlight novel structural determination methods and disease-targeted molecular interventions . Scientific Awards Minister of Education Prize (2011) Crystallographic Society of Japan Research Award (2006) Murata Overseas Fellowship (1984-1987) Postdoctoral and graduate advising includes training programs in structural biology, bioengineering, and molecular biophysics. The Wakatsuki Lab collaborates with DOE national labs on XFEL instrumentation and biomedical applications.

Magnar Bjøråsمشاهده پروفایل

پژوهشگر

• DNA Repair Mechanisms
• Epitranscriptomics
• Gene Expression Regulation
• +۳ مورد دیگر

Magnar Bjørås is a Researcher at the Department of Microbiology , University of Oslo. His work spans interdisciplinary research at the intersection of molecular biology, DNA repair, and microbiology, with a particular focus on bacterial pathogenesis and host-virus interactions. Key research themes: DNA repair enzymes, epitranscriptomic modifications, and gene expression dynamics Active collaborations with teams across Norway and international institutions Developed novel methodologies for nucleic acid extraction and antimicrobial peptide design Recent publications highlight his expertise in: DNA glycosylase functions in neurogenesis and metabolic diseases Combinatorial antiviral therapies against coronaviruses and enteroviruses Epigenetic mechanisms in immunodeficiency and cancer His group employs cutting-edge approaches in: Redox biology and oxidative stress responses Computational analysis of regulatory mutations Nanotechnology for biomedical applications

• Pediatric Surgery
• Vascular Malformations
• Lymphatic Malformations
• +۲ مورد دیگر

Dean M. Anselmo serves as an Associate Professor of Clinical Surgery at the Keck School of Medicine, University of Southern California, with clinical practice based at Children's Hospital Los Angeles (CHLA). His expertise centers on complex pediatric surgical conditions, particularly vascular and lymphatic malformations requiring specialized multidisciplinary management. His research focuses on critical areas within pediatric surgery: Vascular Malformations: Investigating hemangiomas, kaposiform hemangioendothelioma, and arteriovenous malformations through surgical excision and sclerotherapy protocols Lymphatic Disorders: Developing evidence-based approaches for abdominal and cervicofacial lymphatic malformations using minimally invasive techniques Neonatal Surgical Outcomes: Analyzing complications in low birth weight infants undergoing enterostomy closure and congenital defect repairs Minimally Invasive Innovation: Pioneering laparoscopic and thoracoscopic methods for cholecystectomy, esophagectomy, and splenic procedures in children His publication trajectory (2016-2025) reveals consistent advancement in vascular anomaly management, emphasizing doxycycline sclerotherapy efficacy, multidisciplinary care models, and surgical outcome optimization for rare conditions like NTRK-rearranged tumors and catastrophic hemangiomas. This work directly informs clinical protocols for complex pediatric cases. No scientific awards were documented in the source material. Information regarding student mentorship, research grants, or laboratory affiliations was not provided in the available text.