معرفی
Yuri Lyubchenko, PhD, DSc is a Professor in the Department of Pharmaceutical Sciences at the University of Nebraska Medical Center (UNMC) College of Pharmacy. He directs the Pharmaceutical Nanoimaging and Nanoengineering Laboratory (PNNL), where his research integrates advanced atomic force microscopy techniques with biophysical approaches to study fundamental molecular mechanisms in health and disease.
His research spans three interconnected areas: (1) Structural genomics related to cancer and chromosome dynamics, where his lab discovered critical properties of centromeric nucleosomes using high-speed AFM; (2) Molecular mechanisms of Alzheimer's and Parkinson's diseases, where his team developed novel approaches revealing how amyloid proteins aggregate at physiological concentrations; and (3) Protein-DNA interactions for HIV restriction, focusing on APOBEC3G mechanisms. His work has been funded by NSF and NIH grants.
Dr. Lyubchenko has pioneered nanoimaging methodologies that enable direct visualization of molecular dynamics, leading to paradigm-shifting discoveries about amyloid aggregation and nucleosome behavior. His research has significantly advanced understanding of how protein misfolding triggers neurodegenerative diseases and how chromatin structure regulates genomic stability.
He has edited significant scholarly works including 'An Introduction to Single Molecule Biophysics' (CRC Press) and a volume in the 'Methods in Molecular Biology' series (Springer Nature), and has organized academic workshops such as the Midwest Single Molecule Workshop.
As an educator, Dr. Lyubchenko teaches multiple courses including PHSC 691: Pharmaceutical Science Applications in Pharmacy, PHSC 520: Pharmaceutical Biochemistry, PHSC-845: Quantitative Pharmaceutical Sciences, and PHSC 848: Bioimaging and Nanoimaging.
