جست‌وجوی استاد و پژوهشگر

Isabella Guidoمشاهده پروفایل

مدرس ارشد

• Synthetic Biology
• Active Bioinspired Systems
• Active Matter
• +۳ مورد دیگر

Isabella Guido is a Senior Lecturer in Experimental Soft Matter Physics at the University of Surrey's School of Mathematics and Physics. She holds a PhD from TU Berlin (2010) and has conducted postdoctoral research at Peking University and the Max Planck Institute for Dynamics and Self-Organization. Her research focuses on synthetic biology, active bioinspired systems, and microtubule-motor protein dynamics. Guido's work bridges active matter physics and synthetic biology, aiming to develop minimal systems mimicking natural cellular structures. Key projects include synthetic beating structures resembling cilia, 3D active nematics, and investigations into cellular symmetry breaking via biomimetic systems. Her education includes a PhD on dielectrophoretic effects in mammalian cells, followed by postdoctoral studies on cell mechanics, microfluidics, and electroporation. Guido's interdisciplinary approach combines experimental biophysics with synthetic biology to uncover principles governing living matter. She leads the Synthetic Active Systems group and collaborates internationally on projects such as light-powered artificial cells and motor-driven microtubule networks. Her work addresses sustainable development goals through bio-inspired material design and active matter applications. Publications highlight contributions to electrotaxis mechanisms, live-cell imaging techniques (e.g., MIET), and microtubule network dynamics under depletion forces. Guido's research has advanced understanding of ciliary beating patterns, synthetic axoneme models, and biopolymer self-organization under mechanical stress.

• Structural Biology
• Molecular Biophysics
• Cryo-Electron Microscopy
• +۹ مورد دیگر

David Agard is a Professor in the Department of Biochemistry and Biophysics at the University of California San Francisco (UCSF), where he leads a research group focused on uncovering the structural basis of biological function at the molecular and cellular levels. His lab specializes in advanced cryo-electron microscopy (cryo-EM) and fluorescence light microscopy, developing novel imaging technologies to study dynamic cellular processes. His research interests span structural biology , molecular chaperone function (particularly Hsp90 and its role in disease), microtubule nucleation , centrosome and cilium structure , and the structure of phage-encoded tubulins . He is deeply involved in methodological innovations in cryo-EM data processing , including deconvolution, heterogeneous reconstruction, and tomography, enabling atomic-level insights into complex biological systems. Recent publications highlight his lab’s work on the structural mechanisms of Hsp90-client regulation, microtubule organization, phage nucleus formation, and high-resolution imaging techniques using functionalized graphene-oxide grids. His work increasingly integrates AI-driven structural modeling and in situ approaches to understand macromolecular complexes in their native cellular context. Dr. Agard has made seminal contributions to understanding the ATPase cycle of Hsp90, the architecture of the gamma-tubulin complex, and the structural dynamics of viral and cellular tubulins. His research bridges biochemistry, biophysics, and cell biology, with implications for cancer, neurodegeneration, and antimicrobial strategies.

Hannah Mitchisonمشاهده پروفایل

استاد

• Genetics
• Genomic Medicine
• Rare Diseases
• +۵ مورد دیگر

Professor Hannah Mitchison is a leading academic at University College London (UCL) , where she serves as Professor of Molecular Medicine in the Genetics & Genomic Medicine Department at the UCL Great Ormond Street Institute of Child Health. She is Head of the department (2022–present) and has held leadership roles in the Ciliopathy Alliance and UK Cilia Network . Her research focuses on ciliopathies and genetic mutations in rare diseases, particularly Primary Ciliary Dyskinesia (PCD) . PhD in Biochemistry (University of Birmingham, 1991) BSc (Hons) in Biochemistry (University of Sussex, 1986) Her research spans genetic discovery , functional studies of ciliary proteins , and translational genetic therapies for PCD and related disorders. Recent work includes large-scale genomic analyses with the 100,000 Genomes Project and developing the CiliaVar database for motile ciliopathy variants. She also explores genotype-phenotype correlations in PCD cohorts across the UK, Finland, and Palestine. Her teaching roles include supervising PhD and MSc students, lecturing on UCL’s MSc Cell & Gene Therapy and Genomic Medicine programs, and leading the module Genomics of Common and Rare Inherited Diseases . She is co-lead for UCL on the Health Education England-supported MSc Genomic Medicine course. Scientific contributions include over 170 journal articles, with recent high-impact publications in Nature , Science , and European Respiratory Journal , emphasizing genomic approaches and novel therapies for ciliopathies. Collaborations with clinical teams and patient advocacy groups like the Ciliopathy Alliance underscore her translational focus. Funding comes from organizations including the Medical Research Council (MRC), Biotechnology and Biological Sciences Research Council (BBSRC), and NIHR Great Ormond Street Hospital Biomedical Research Centre.

Takashi Ishikawaمشاهده پروفایل

استاد

• Structural Biology
• Cryo-electron Tomography
• Flagella/Cilia Research
• +۴ مورد دیگر

Professor Takashi Ishikawa is a distinguished researcher and Group Leader at the Paul Scherrer Institute (PSI) in Switzerland, where he heads the Laboratory for Multiscale Bioimaging within the PSI Center for Life Sciences. His work focuses on the structural biology of eukaryotic flagella and cilia using advanced electron cryo tomography and microscopy techniques. Dr. Ishikawa's research program centers on understanding the 3D molecular architecture and functional mechanisms of flagellar/ciliary components, particularly dynein motor proteins. His laboratory employs cutting-edge cryo-EM methodologies to visualize biological macromolecules and organelles in their native hydrated states, enabling three-dimensional reconstructions at increasingly higher resolutions. The team's work has revealed critical insights into the molecular arrangement of dyneins and other proteins on microtubule doublets, the structural basis of dynein power stroke, and the mechanisms underlying flagellar/ciliary bending motion. His research has significant implications for understanding ciliopathies—diseases caused by defects in flagella/cilia—which affect multiple organ systems including respiratory tracts, reproductive systems, and the brain. The fundamental insights gained from studying these natural nanomachines also inform the development of artificial nanoscale devices and systems. Dr. Ishikawa has established numerous collaborative research projects with groups across various disciplines, including biochemistry, biophysics, and medical research. His laboratory serves as a hub for structural biology research at the intersection of cell biology and nanotechnology, training the next generation of scientists in advanced imaging techniques.

• Cell Biology
• Molecular Biology
• Ciliary Assembly and Motility
• +۴ مورد دیگر

Elizabeth F. Smith is the Paul M. Dauten Jr. Professor of Biological Sciences and Dean of the Faculty of Arts and Sciences at Dartmouth College. She oversees educational policies and faculty development within Dartmouth's largest academic unit. Previously, she served as Associate Dean of the Sciences and Chair of the Department of Biological Sciences. Her research focuses on cilia and flagella biology, exploring their roles in motility, disease, and developmental processes. Smith earned a B.A. in Biology from Agnes Scott College and a Ph.D. in Cell and Developmental Biology from Emory University. Her postdoctoral training was in Genetics and Cell Biology at the University of Minnesota. Her work uses Chlamydomonas reinhardtii as a model system to study ciliary structure, signaling pathways (e.g., calcium-calmodulin), and intraflagellar transport (IFT) mechanisms. Key projects investigate calmodulin's role in dynein regulation and katanin's function in central pair microtubule assembly. Her research addresses diseases linked to ciliary dysfunction, such as polycystic kidney disease, infertility, and respiratory disorders. Supported by grants from NIH, NSF, and other institutions, her lab explores protein complexes (e.g., Pcdp1, PACRG) critical for ciliary motility and assembly. Recent studies highlight structural insights into the ciliary central apparatus and radial spokes. Smith’s publications span high-impact journals like Molecular Biology of the Cell and Journal of Cell Biology . Her lab's interdisciplinary approach integrates biochemistry, genetics, and advanced imaging to unravel ciliary biology. She leads Dartmouth’s efforts in promoting interdisciplinary academic excellence and faculty well-being.

Ryan S. Grayمشاهده پروفایل

دانشیار

• Musculoskeletal Disease
• Developmental Biology
• Genetics
• +۴ مورد دیگر

Ryan S. Gray, Ph.D. is an Associate Professor in the Department of Pediatrics at The University of Texas at Austin , with an adjunct faculty appointment in the Department of Nutritional Sciences within the College of Natural Sciences . Education: Ph.D. in Cellular and Molecular Biology from UT Austin Postdoctoral Training: Washington University School of Medicine Gray's research focuses on musculoskeletal diseases , particularly adolescent idiopathic scoliosis (AIS) and cartilage degeneration . His lab employs a multi-tiered approach combining zebrafish , mouse , and cell culture models informed by human genomics to uncover mechanisms of spine development and disease. Key areas include: Genetic regulation of spine morphogenesis Role of cilia in cerebrospinal fluid dynamics Protein assembly in vertebrate evolution ADGRG6 and SOX9 signaling in cartilage homeostasis His publications highlight novel genetic pathways in AIS, including Kif6 , Inppl1a , and dysregulated dynein genes . Awards include the Early Investigator Podium Award (2017) and Best Poster Award (2015) from leading orthopedic societies. Gray leads the Gray Lab , which emphasizes translational research for musculoskeletal disorders. The lab's work spans from basic science (e.g., kinesin motor proteins) to clinical applications in scoliosis diagnosis and treatment.

Gaia Piginoمشاهده پروفایل

پژوهشگر

• Structural Biology
• Cell Biology
• Molecular Biology
• +۴ مورد دیگر

Dr. Gaia Pigino is a biologist and Associate Head of the Structural Biology Research Centre at Human Technopole , Milan, Italy, following 9 years as a Research Group Leader at the Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG) , Dresden, Germany. She collaborates with Alessandro Vannini to advance structural biology research at Human Technopole. Education: Ph.D. in Evolutionary Biology, University of Siena (2007), supervised by Prof. F. Bernini and Prof. C. Leonzio Diploma in Natural Science (Summa cum laude), University of Siena (2002), supervised by Prof. C. Leonzio and Prof. F. Bernini Her laboratory investigates the molecular mechanisms of ciliary self-organization , focusing on intraflagellar transport (IFT), tubulin post-translational modifications, and axonemal architecture. Key research areas include: Tubulin Code regulation IFT train dynamics Primary and motile cilia in health/disease Microtubule doublet function Cryo-electron tomography Protein sorting and signaling Recent publications highlight advancements in understanding the high-resolution structure of the ciliary glycocalyx , IFT cycle mechanics, and tubulin tyrosination/detyrosination roles in ciliary transport. Her work bridges structural biology and human disease, particularly diabetes and ciliopathies. Scientific Awards: EMBO Member (2022) ERC Consolidator Grant (2018) Keith R. Porter Fellow Award (2018) DFG Grant (2019) Multiple EMBO, HFSP, and Marie Curie Fellowships to advisees Dr. Pigino advises a team of researchers, including Helen Foster , Nikolai Klena , and Adrian Nievergelt , and contributes to structural biology through grants and collaborations. Her lab employs cutting-edge techniques like CRISPR/Cas and MicroSplit to explore ciliary mechanics and cellular ultrastructure.

Jing Wangمشاهده پروفایل

استاد

• Biostatistics
• Epidemiology
• Diabetes Research
• +۶ مورد دیگر

Jing Wang, PhD, is a Professor of Biostatistics and Neurological Surgery at Washington University in St. Louis. She serves as Director of the Biostatistics Consulting Service and holds affiliations with the Institute of Clinical and Translational Sciences (ICTS) and the Center for Biostatistics and Data Science (CBDS). Her research spans biostatistical methodologies, epidemiological studies, and translational medicine with a focus on diabetes, immunology, and endocrine disorders. Dr. Wang’s work integrates statistical innovation with biomedical applications, including machine learning approaches for clustered data analysis and ciliary mechanisms in pancreatic islet function. Her research interests include advanced statistical modeling, public health disparities, and molecular mechanisms underlying chronic diseases. Notable contributions include studies on survival disparities in cancer patients, post-COVID-19 conditions, and the role of primary cilia in glucose regulation and hormone secretion. She has published over 97 peer-reviewed articles, with recent work emphasizing diabetes pathophysiology, heart failure phenotypes, and ciliary signaling pathways in endocrine cells. Dr. Wang leads interdisciplinary teams in designing robust statistical frameworks for clinical research and has pioneered methodologies for analyzing complex biomedical datasets. Her work on pancreatic islet cilia has advanced understanding of cellular signaling in metabolic disorders, while her epidemiological studies address health inequities in vulnerable populations. Collaborations span global institutions, focusing on translational research with clinical impact.

• Cryoelectron Tomography
• Cell Biology
• Molecular Biology
• +۶ مورد دیگر

Dr. Jianfeng Lin is a Senior Research Scientist and Managing Director of the Yale CryoEM Resource at Yale University's Department of Molecular Biophysics and Biochemistry. He holds a PhD in Biochemistry and Molecular Biology from Xiamen University (2008) and completed postdoctoral training at Brandeis University and UT Southwestern Medical Center. His research focuses on understanding ciliary motility mechanisms, dynein dynamics, and ciliopathies using cryoelectron tomography and structural biology approaches. He leads the unification of Yale's electron microscopy facilities into the Yale CryoEM Resource, supporting both internal and external research communities. Education: BS in Biological Sciences, Xiamen University (2003) PhD in Biochemistry and Molecular Biology, Xiamen University (2008) Postdoctoral Associate, Brandeis University (2015) Research interests span molecular mechanisms of ciliary dysfunction, structural characterization of axonemal components, and cryoEM applications in biomedical research. His work has revealed structural defects in ciliopathies, dynein regulation pathways, and conserved axonemal architectures across species. Recent studies highlight advancements in cryoEM techniques and their role in resolving complex cellular structures. Advising and Facilities: As Managing Director of the Yale CryoEM Resource, Dr. Lin oversees a state-of-the-art facility supporting structural biology research. His grants and collaborations focus on advancing cryoEM technology and its application to biomedical problems. Labs/Teams: Director of the Yale CryoEM Resource, a centralized facility integrating cryo-electron microscopy capabilities for Yale researchers.

• Structural Biology
• Cellular Structural Biology
• Membrane Proteins
• +۴ مورد دیگر

Dr. Tzviya Zeev-Ben-Mordehai is an Associate Professor in Structural Biochemistry at the Bijvoet Centre for Biomolecular Research , Utrecht University, Netherlands. Her research focuses on integrative structural biology of mammalian gametes and membrane proteins, with significant contributions to herpesvirus nuclear envelope transport mechanisms and sperm cell architecture. Education: PhD (2008) and MSc (2002) in Structural Biology from Weizmann Institute, BSc (2000) in Biochemistry from Technion Research Interests include: Structural biology of mammalian sperm cells Membrane protein structure determination Cryo-EM and cross-linking mass spectrometry Molecular basis of fertilization Herpesvirus nuclear envelope transport Recent Publications (2023-2025) demonstrate expertise in: Cryo-EM structural analysis of sperm flagella Membrane protein organization in viral systems Multi-scale cellular architecture mapping Vaccine platform development for influenza Awards & Grants: Wellcome Trust & Royal Society Sir Henry Dale Fellowship (2015) NWO START-UP Grant (2018) Additional Roles: Member of Utrecht Graduate School Educational Committee, Faculty of Science Diversity Committee, and guest Associate Editor for Cell Growth and Division.

Anne B. Fultonمشاهده پروفایل

استاد

• Retinal Development
• Visual Function
• Retinopathy of Prematurity
• +۴ مورد دیگر

Anne B. Fulton, MD is a distinguished researcher and clinician at Harvard Medical School and Boston Children's Hospital, where she serves as Principal Investigator with continuous NIH funding for over 30 years. She divides her time equally between research and clinical practice, focusing on pediatric ophthalmology and visual development, and leads the Infant Vision Laboratory. Her educational background includes: Undergraduate: Radcliffe College (1962) Medical School: Tufts University School of Medicine (1996) Internship: Grady Memorial Hospital (1967) Residency: Yale University School of Medicine (1976) Dr. Fulton's research focuses on the development of retinal and visual function in infants and children. She pioneered work recognizing rod photoreceptors as a site of critical immaturity for infants' vision and determined the growth curve for the rod visual pigment, rhodopsin. Her laboratory brought first-rate visual electrophysiology and psychophysics to the department, perfected non-invasive assessments of infant and child patients, and related normal developmental changes in retinal and visual function to underlying retinal biochemistry and structure. She demonstrated that rhodopsin content scales the developmental increment in dark-adapted retinal and visual sensitivity. More recently, she introduced adaptive optics imaging to provide non-invasive retinal assessments at a cellular level. Her currently funded research applies these procedures to study retinal disorders, particularly retinopathy of prematurity. Her recent publications demonstrate a continued focus on retinal disorders, particularly retinopathy of prematurity, Stargardt disease, and other inherited retinal conditions. Her work combines clinical research with advanced imaging techniques to better understand disease mechanisms and improve diagnostic and treatment approaches. She has made seminal contributions to understanding photoreceptor development and function in infants and children, with particular emphasis on the role of rhodopsin in visual maturation. Dr. Fulton's research has been continuously funded by the NIH for more than three decades, reflecting the significance and impact of her work in pediatric ophthalmology and visual development. She has established herself as a leading authority in the field of infant vision development and retinal function assessment. She leads the Infant Vision Laboratory at Boston Children's Hospital, where her team conducts cutting-edge research on retinal function and development in infants and children. Her laboratory has been instrumental in developing and perfecting non-invasive assessment techniques for evaluating visual function in pediatric patients, which has significantly advanced the clinical care of children with visual disorders.

Zhen Chenمشاهده پروفایل

استادیار

• Structural Biology
• Cell Biology
• Biophysics
• +۷ مورد دیگر

Zhen Chen is an Assistant Professor of Biology and Biological Engineering at the California Institute of Technology (Caltech). He holds a B.Sc. from Peking University (2009), M.A. from Rice University (2012), and Ph.D. from Rockefeller University (2019). Prior to his current role, he served as a Visiting Associate at Caltech (2023). His research focuses on biophysical principles of cilia biology, cellular cryo-electron tomography (cryoET), and AlphaFold2-assisted modeling to study protein dynamics and cellular structures. Education: B.Sc., Peking University, 2009 M.A., Rice University, 2012 Ph.D., Rockefeller University, 2019 Visiting Associate, Caltech, 2023 Research interests include: Ciliary motion mechanisms and assembly In situ cryoET for cellular imaging AlphaFold2 integration for structural biology Reproductive biology at atomic resolution Development of knockout mouse models Recent funding and recognitions include grants from the Shurl and Kay Curci Foundation (2024), Caltech Center for Evolutionary Science (2024), and Merkin Institute (2024). His lab collaborates on advancing cryoET and AI-driven structural analysis tools. Labs/Teams: Zhen Chen’s lab at Caltech focuses on structural cell biology, combining cryoET, chemical biology, and computational modeling to address fundamental biological questions. The team recently developed the AreTomo software for cryoET data processing.

• Cilia assembly
• Flagellar motility
• Microtubule dynamics
• +۲ مورد دیگر

Elizabeth Smith is Dean of the Faculty of Arts and Sciences and Paul M. Dauten, Jr. Professor of Biological Sciences at Dartmouth College. She researches ciliary assembly and motility mechanisms. Education: PhD from Emory University; BA from Agnes Scott College Research examines molecular mechanisms of cilia/flagella formation and function using Chlamydomonas model system. Her lab investigates microtubule severing proteins, calcium signaling pathways, and intraflagellar transport. Honors include Dauten Professorship and Porter Fellowship. Smith bridges science-art connections through museum collaborations.

Andrew Carterمشاهده پروفایل

پژوهشگر

• Cell Biology
• Structural Biology
• Molecular Motor Proteins
• +۵ مورد دیگر

Andrew Carter is a Researcher at the University of Cambridge , focusing on the structural and mechanistic analysis of dynein, a critical molecular motor protein involved in cellular transport. His work explores dynein's role in organelle positioning, neurodegeneration, and viral infection, utilizing advanced techniques like X-ray crystallography and cryo-electron microscopy. Research interests include: Understanding dynein-dynactin-cargo adaptor activation via JIP3 and LIS1 Mechanisms of long-range axonal transport Structural dynamics of dynein complexes on microtubules Biogenesis of ciliary outer dynein arms Key contributions span structural biology and cell biophysics, with a focus on human cytoplasmic dynein auto-inhibition and activation. His group integrates biophysical and cell biological methods with cutting-edge structural biology to address questions about motor protein regulation and pathogenic hijacking.

• Cell Biology
• Molecular Biology
• Parasitology
• +۷ مورد دیگر

Philippe Bastin is a full Professor and Director of the Trypanosome Cell Biology Unit at Institut Pasteur and INSERM U1201, Paris. He also chairs the Labex IBEID program (Integrative Biology of Emerging Infectious Diseases) and leads multiple international collaborations. University Paris-Descartes (HDR, 2005) Université Catholique de Louvain (PhD, 1993; Degree, 1989) His research focuses on Trypanosoma brucei and Toxoplasma gondii , with specific interests in: Flagellar assembly and intraflagellar transport (IFT) Tubulin post-translational modifications Centrosome and basal body biology Motility mechanisms of vector-borne pathogens Microfluidic tools for parasite imaging Recent work includes Tryp-Chip microfluidic devices for longitudinal parasite imaging, LRRC56 roles in dynein docking, and glutamylation studies in flagellum construction. His 2025 publications explore IFT selectivity and tubulin dynamics. Awards include: Fondation pour la Recherche Médicale Team (2022, 2015) Honorary Christoffel Plantin Award (2021) Pasteur-Vallery-Radot Prize (2013) He has trained 10 PhD students and 13 postdocs, with 1/3 of former trainees in academia, 1/3 in industry (including a startup CEO), and 1/3 in international postdocs.