- Stem Cell Biology
- Neuroscience
- Oncology
- +۶ مورد دیگر
Mark D. Noble is a pioneering Professor (Part-Time) in the Department of Biomedical Genetics at the University of Rochester School of Medicine , with concurrent appointments in Neurology, Neurobiology and Anatomy. He co-discovered the first CNS precursor cell in 1983 and directs the University of Rochester Stem Cell and Regenerative Medicine Institute . His career spans institutions including Stanford University and University College London. Ph.D., Genetics, Stanford University (1977) B.S., Biology & Philosophy, Franklin & Marshall College (1971) Post-doctoral: MRC Neuroimmunology Project, University College London (1977-1981) Research Focus : Dr. Noble's work bridges stem cell biology , neuroscience , and oncology . His lab discovered the redox/Fyn/c-Cbl pathway , revealing how oxidative states regulate stem cell function and cancer progression. Key contributions include chemobrain mechanisms , lysosomal dysfunction therapies , and pharmacological approaches for nerve injuries. His team developed 4-aminopyridine applications for nerve repair and diagnosis. Collaborative Impact : Working with Drs. Chris Proschel and Margot Mayer-Pröschel, he advanced astrocyte transplantation for spinal cord and Parkinson's injury. His work on cancer stem cells in glioblastoma and basal-like breast cancer identified novel therapeutic targets through Cool-1/β-pix inhibition of c-Cbl. Patents & Mentorship : Dr. Noble holds 15 patents and consults for biotech companies. His lab has mentored graduate students like Ludia Pack , Yunpeng Pang , and Neal Shah , while driving research on metabolic regulation of stem cells and translational medicine .






