Mark D. Noble

Mark D. Noble is a pioneering Professor (Part-Time) in the Department of Biomedical Genetics at the University of Rochester School of Medicine, with concurrent appointments in Neurology, Neurobiology and Anatomy. He co-discovered the first CNS precursor cell in 1983 and directs the University of Rochester Stem Cell and Regenerative Medicine Institute. His career spans institutions including Stanford University and University College London.

• Ph.D., Genetics, Stanford University (1977)
• B.S., Biology & Philosophy, Franklin & Marshall College (1971)
• Post-doctoral: MRC Neuroimmunology Project, University College London (1977-1981)

Research Focus:
Dr. Noble's work bridges stem cell biology, neuroscience, and oncology. His lab discovered the redox/Fyn/c-Cbl pathway, revealing how oxidative states regulate stem cell function and cancer progression. Key contributions include chemobrain mechanisms, lysosomal dysfunction therapies, and pharmacological approaches for nerve injuries. His team developed 4-aminopyridine applications for nerve repair and diagnosis.

Collaborative Impact:
Working with Drs. Chris Proschel and Margot Mayer-Pröschel, he advanced astrocyte transplantation for spinal cord and Parkinson's injury. His work on cancer stem cells in glioblastoma and basal-like breast cancer identified novel therapeutic targets through Cool-1/β-pix inhibition of c-Cbl.

Patents & Mentorship:
Dr. Noble holds 15 patents and consults for biotech companies. His lab has mentored graduate students like Ludia Pack, Yunpeng Pang, and Neal Shah, while driving research on metabolic regulation of stem cells and translational medicine.