جست‌وجوی استاد و پژوهشگر

Chris B. Schafferمشاهده پروفایل

استاد

• Biomedical Imaging and Instrumentation
• Bioengineering
• Neuroscience
• +۳ مورد دیگر

Chris B. Schaffer is a Professor in the Meinig School of Biomedical Engineering at Cornell University, specializing in developing advanced optical techniques to study neurovascular dynamics in neurological diseases. His lab focuses on Alzheimer’s disease mechanisms, leveraging multiphoton microscopy and in vivo imaging to explore capillary stalling, cerebral blood flow deficits, and their cognitive impacts. He holds a Ph.D. in Physics from Harvard University and postdoctoral training in neuroscience at UC San Diego. Research interests include biomedical imaging instrumentation, neurodegenerative disease modeling, and science education innovation. Awards include AAAS Fellowship (2021), AIMBE Fellowship (2019), and multiple teaching accolades. His work bridges engineering and medicine, with contributions to spinal cord injury studies, epilepsy, and vascular contributions to dementia (VCID). Notable discoveries include identifying neutrophil-induced capillary stalls as a key Alzheimer’s disease mechanism and demonstrating cerebral blood flow improvements can restore memory in mouse models. His lab also develops educational tools emphasizing science as a discovery process, used in K-12 and university settings.

• Neuroscience
• Neurobiology
• Retina
• +۴ مورد دیگر

Karl Farrow is a Senior Lecturer at the Faculty of Sciences , KU Leuven , affiliated with the Department of Biology and the Animal Physiology and Neurobiology unit. He is also a member of the VIB-KU Leuven Center for Neuro Electronics Research Flanders (NERF) and the KU Leuven Brain Institute . Dr. Farrow's research focuses on neurobiology and visual processing , particularly the role of retinal ganglion cells and neural circuits in the superior colliculus . His work explores direction selectivity, motion perception, and adaptive mechanisms in visual systems under varying ambient conditions. His recent projects include dissecting the neural basis of threat responses in the superior colliculus, studying evolutionary influences on innate behavior circuits, and developing tools like a single-objective light sheet microscope for 3D tissue analysis. Collaborative efforts involve synaptic transmission studies in amyloid-beta precursor protein interactions.

John Straubمشاهده پروفایل

استاد

• Theoretical Chemistry
• Computational Biophysics
• Protein Dynamics
• +۳ مورد دیگر

John Straub is a Professor of Chemistry at Boston University, affiliated with the Chemistry Department. His research focuses on theoretical and computational studies of protein dynamics, thermodynamics, and phase transitions in molecular systems. He leads efforts to develop advanced algorithms for simulating phase changes in complex systems, including work supported by a National Science Foundation (NSF) grant (CH-1114676) to improve computational methods for phase transition modeling. His group has pioneered generalized simulated tempering and replica exchange algorithms, enabling more accurate simulations of phenomena like vapor-liquid phase changes and peptide aggregation. Dr. Straub also engages in science outreach through collaborations with the Pinhead Institute, supporting K-12 education programs and student internships. His research spans diverse topics such as cholesterol interactions in lipid membranes, amyloid fibril formation mechanisms, and the structural basis of protein aggregation in neurodegenerative diseases. His computational methods have been applied to study membrane proteins, lipid rafts, and the role of environmental factors in protein behavior. Key contributions include modeling amyloid-β aggregation pathways and investigating the impact of membrane composition on protein stability.

Stefan Leutgebمشاهده پروفایل

استاد

• Neurobiology
• Memory Storage
• Neuronal Mechanisms
• +۵ مورد دیگر

Stefan Leutgeb is a Professor in the Department of Neurobiology at the University of California San Diego (UCSD), affiliated with the School of Biological Sciences. His research focuses on the neural mechanisms underlying long-term memory storage, particularly the role of coordinated neuronal activity and synaptic plasticity in hippocampal and cortical networks. His work investigates how spatial and nonspatial information is encoded, how memory systems degrade in aging and neurodegenerative disorders like dementia, and the translational implications of these findings. Key research areas include hippocampal ensemble dynamics, temporal organization of neuronal activity, and the impact of Alzheimer’s-related proteins (e.g., APP) on neural networks. Leutgeb employs multi-electrode recordings, optogenetics, and computational modeling to study these processes. His lab has discovered critical mechanisms such as pattern separation in the dentate gyrus and the role of theta oscillations in memory encoding. Notable recent contributions include studies on how hippocampal network dysfunction due to APP expression disrupts spike timing ( 2022 ), theta oscillation roles in memory phases ( 2021 ), and the necessity of dentate gyrus activity for spatial working memory ( 2018 ). Despite no explicitly listed awards, his prolific publication record reflects significant contributions to systems neuroscience. Leutgeb’s research also explores cognitive aging and cross-species comparisons of neural processes. His lab emphasizes translational research, aiming to bridge basic neuroscience discoveries with clinical applications for neurodegenerative diseases. Current projects include investigating hippocampal ensemble dynamics during memory retention and developing biomarkers for cognitive flexibility.

• Neurochemistry
• Alzheimer's Disease
• Biomarker Research
• +۳ مورد دیگر

Javier Saez Valero is a Professor in the Department of Biochemistry and Molecular Biology at Miguel Hernandez University of Elche, where he also serves as Deputy Vice Rector for Research - Management of Research and Transfer. His academic roles include teaching Biochemistry I in the Bachelor's in Medicine program and courses in the Master's in Neuroscience and Master's in Translational Neuropsychopharmacology, while coordinating the Doctorate in Neuroscience program. His research focuses on neurochemical mechanisms in neurodegenerative disorders, particularly Alzheimer's disease biomarker discovery in cerebrospinal fluid and blood. Key areas include NMDA receptor dynamics, ACE2 fragments, apolipoprotein E interactions, and reelin signaling pathways. His work bridges molecular biochemistry with clinical neurology to develop diagnostic tools and understand disease pathogenesis. Analysis of his 15 most recent publications (2023-2025) reveals a dominant focus on Alzheimer's disease biomarkers, especially CSF protein alterations (nicastrin, ADAM10, ACE2). Significant themes include synaptic vs extrasynaptic receptor distributions, COVID-19 neurological impacts, and nanocarrier drug delivery limitations. His work consistently targets translational applications for early diagnosis and therapeutic development. No scientific awards were documented in the provided information. Professor Saez Valero provides academic guidance through tutorials and course coordination across undergraduate, master's, and doctoral programs. As Doctorate in Neuroscience coordinator, he oversees research training while managing institutional research transfer activities through the Vice Rectorate. His teaching spans biochemistry, neuropathology, and molecular neuroscience with laboratory components. He operates from Laboratory 241 at the Institute of Neurosciences (Campus de San Juan), a joint research center with CSIC. His work integrates with the university's Vice Rectorate for Research and Transfer, facilitating technology transfer and collaborative neuroscience research within the university's research infrastructure.

Jennifer E. Phillips-Creminsمشاهده پروفایل

دانشیار

• 3D Genome Organization
• Chromatin Biology
• Neurogenetics
• +۵ مورد دیگر

Jennifer E. Phillips-Cremins, Ph.D. , is an Associate Professor of Genetics and Bioengineering at the University of Pennsylvania, where she leads the Laboratory of Chromatin and Spatial Neurobiology. A member of the Penn Epigenetics Institute and NIH 4D Nucleome Consortium, her research investigates how three-dimensional chromatin organization governs neural specification, synaptic plasticity, and disease pathogenesis. Her lab integrates 3D genome mapping, single-cell imaging, and computational tools to dissect chromatin-synapse communication in Alzheimer's disease, fragile X syndrome, and schizophrenia. Education : B.S. in Chemical Engineering (Clarkson University, 1999), Ph.D. in Biomedical Engineering (Georgia Tech, 2007) Postdoctoral Training : University of Massachusetts (Dekker Lab) and Emory University (Corces Lab, 2008-2013) Her lab has developed groundbreaking technologies including LADL for optogenetic chromatin control, FISHnet for single-cell spatial genomics, and MASTR-seq for repeat expansion analysis. Key discoveries demonstrate that cohesin-mediated loops regulate replication origins and synaptic gene expression, while BREACHes link repeat instability to neurodevelopmental defects. Scientific Recognition : NIH Pioneer Award (2021) NSF CAREER Award (2020) Chan-Zuckerberg Neurodegenerative Disease Awardee (2020) New York Stem Cell Foundation Robertson Investigator (2015-2020) Mentorship : Creator of the SEEDs program for undergraduate/post-baccalaureate training, with 100% of alumni pursuing advanced scientific degrees. Her lab currently trains 3 SEEDs scholars and advises graduate students in Cell and Molecular Biology, Neuroscience, and Bioengineering programs.

• Alzheimer's Disease
• Amyloid-β
• γ-Secretase
• +۳ مورد دیگر

Prof. Dr. Harald Steiner serves as a Group Leader at the German Center for Neurodegenerative Diseases (DZNE) in Munich, Germany, where he directs biochemical research on γ-secretase mechanisms central to Alzheimer's disease pathogenesis. His work focuses on molecular substrate recognition and activity modulation of this critical enzyme complex within the institution's neuroscience research framework. Dr. Steiner's research investigates the proteolytic processing of amyloid-β precursor protein (APP) by the γ-secretase complex—composed of presenilin, nicastrin, APH-1, and PEN-2—which generates amyloid-β peptides that accumulate in senile plaques. His laboratory examines intramembrane cleavage mechanisms to elucidate fundamental biochemical principles underlying Alzheimer's disease progression and identify potential therapeutic intervention points. The research group operates from DZNE's Munich site at Feodor-Lynen-Str. 17, employing biochemical and molecular approaches to dissect γ-secretase function. This work contributes to the broader institutional mission of advancing neurodegenerative disease understanding through basic science research, with implications for developing disease-modifying treatments targeting pathological proteolytic pathways.

Karen D. Parfittمشاهده پروفایل

استاد

• Neuroscience
• Synaptic Physiology
• Synaptic Plasticity
• +۷ مورد دیگر

Karen D. Parfitt is Professor of Neuroscience and Chair of the Neuroscience Department at Pomona College , where she has been a faculty member since 1994. Her research is centered on synaptic transmission and plasticity in the hippocampus, with a focus on the molecular mechanisms of memory and their disruption in neurodegenerative diseases such as Alzheimer’s Disease. She employs both mouse and Drosophila models to investigate these processes. Her educational background includes a Ph.D. from the University of Colorado Health Sciences Center and a Bachelor of Science from Cornell University. She teaches core neuroscience courses such as Neurobiology with Lab, Neuropharmacology, and Senior Experimental Thesis in Neuroscience. Research Interests: Synaptic Physiology and Plasticity Molecular Mechanisms of Neurotransmitter Release Neurobiology of Alzheimer’s Disease Effects of Exercise on Synaptic Plasticity Neurobiology of Aging Her recent publications reveal a strong trend in exploring how secreted amyloid precursor protein-alpha modulates long-term potentiation (LTP), how exercise influences dopaminergic transmission and synaptic plasticity, and how inflammatory pathways contribute to tauopathy. These works span molecular, cellular, and behavioral neuroscience, reflecting a multidisciplinary approach. Scientific Awards and Honors: President, Faculty for Undergraduate Neuroscience (2000–2001) National Institute of Aging Academic Research Enhancement Award (1998) National Science Foundation Instrumentation Grant (1995) Faculty for Undergraduate Neuroscience Service Award (2011) Mellon Partnership Grant (2009) Multiple Pomona College Faculty Grants (1998, 2014, 2018) She has advised numerous undergraduate students, many of whom are co-authors on her publications, highlighting her commitment to mentored research. She has secured sustained funding from the NSF, NIH, NIA, and AFAR, supporting both instrumentation and research. Dr. Parfitt leads an active laboratory in Seaver Biology, focusing on electrophysiological and molecular analyses of synaptic function.

• Translational Regulation
• RNA/Protein Quality Control
• Protein Misfolding
• +۵ مورد دیگر

Dr. Andrey L. Karamyshev is an Associate Professor in the Department of Cell Biology and Biochemistry at Texas Tech University Health Sciences Center's School of Medicine. His research focuses on molecular mechanisms of translational regulation and protein quality control, with significant contributions to understanding co-translational protein folding and targeting processes. He leads an active laboratory investigating fundamental cellular pathways with direct implications for human diseases. His primary research interests center on translational regulation mechanisms , particularly the RAPP (Regulation of Aberrant Protein Production) pathway discovered by his team, which monitors nascent chain interactions during translation to prevent defective protein synthesis. His work explores protein misfolding in neurodegenerative diseases like Alzheimer's and Parkinson's, investigating how loss of co-translational interactions leads to pathological aggregation. Additional research areas include ribosome specialization, mRNA quality control, and translational adaptations in parasitic organisms like Leishmania. Analysis of his recent publications (2020-2023) reveals consistent focus on protein quality control pathways , with particular emphasis on the Signal Recognition Particle (SRP) system and its intersections with neurodegenerative disease mechanisms. His work increasingly bridges fundamental molecular biology with therapeutic applications, especially in parasitic diseases and neurodegeneration. Faculty of 1000 recommendation (2014) Faculty of 1000 recommendation (2005) Faculty of 1000 recommendation (2003) Editors' Highlights in Microbiology and Infectious Diseases (Nature Communications, 2023) Dr. Karamyshev actively recruits graduate students to his laboratory, where researchers employ advanced techniques including site-specific photo-crosslinking, iPINCH (identification of Proteins Interacting with Nascent Chains), unnatural amino acid incorporation, and ribosome profiling. His lab has secured research funding supporting investigations into translational regulation mechanisms with potential pharmaceutical applications for neurodegenerative and parasitic diseases. Current projects include elucidating the complete RAPP pathway mechanism and exploring co-translational protein interactions in neurodegenerative disease models. His laboratory maintains active collaborations across Texas Tech University and Texas Tech University Health Sciences Center, particularly with parasitology and neuroscience research groups. The team utilizes specialized methodologies for studying nascent chain interactions both in vitro and in human cell culture systems, with growing focus on translational applications for disease treatment.

Hey-Kyoung Leeمشاهده پروفایل

استاد

• Synaptic Plasticity
• Neuroscience
• Memory Formation
• +۵ مورد دیگر

Hey-Kyoung Lee is a Professor of Neuroscience at the Johns Hopkins University School of Medicine , where she serves as Chair of the Undergraduate Neuroscience Program. Her research focuses on synaptic plasticity mechanisms underlying memory formation, cross-modal adaptation, and neurodegenerative disease pathology. Education B.S. in Biology, Yonsei University (1992) Ph.D. in Neuroscience, Brown University (1997) Postdoctoral Training, Johns Hopkins School of Medicine Research Interests center on molecular/cellular bases of memory storage , with emphasis on: Homeostatic synaptic plasticity in sensory cortices Cross-modal adaptation following sensory loss Synaptic dysfunction in Alzheimer's disease models AMPA receptor phosphorylation mechanisms Scientific Achievements Sloan Research Fellow (2004) Junior Faculty Award, University of Maryland (2009) Yonsei 100 Women Leaders (2006) Her laboratory combines electrophysiology, molecular analysis, and imaging to investigate how sensory experience alters neural circuits, with implications for adult brain recovery and neurodegenerative disease interventions.

Benjamin Wolozinمشاهده پروفایل

استاد

• Neurodegenerative Diseases
• Alzheimer's Disease
• Parkinson's Disease
• +۷ مورد دیگر

Benjamin Wolozin is a Professor at the Boston University Chobanian & Avedisian School of Medicine in the Department of Pharmacology , with an adjunct position in Neurology. He specializes in neurodegenerative diseases, particularly Alzheimer's , Parkinson's , and ALS . MD/PhD, Albert Einstein College of Medicine Past Associate Professor at Loyola University Medical Center (1996-2004) Current affiliations: Alzheimer's Disease Center, Boston University Graduate Program for Neuroscience His research investigates RNA binding proteins (RBPs) , stress granules , and liquid-liquid phase separation in neurodegenerative disease. Key projects include the role of TIA1 and HNRNPA2B1 in tauopathy, m6A RNA methylation in Alzheimer's pathology, and development of 3D iPS-neuron/astrocyte assembloids to model dementia. His lab has identified disease-linked circRNA changes and explores nanobodies targeting stress granule components. Recent awards include the Donald B. Lindsley Prize (Society for Neuroscience) and A. E. Bennett Award . He serves on NIH CDIN study sections and editorial boards for Journal of Biological Chemistry and Neurodegenerative Diseases . Grants include multiple NIH R01 and U01 awards for AD/tauopathy research.

Linda Nicholsonمشاهده پروفایل

استاد

• Molecular Biology
• Protein Dynamics
• Biophysics
• +۴ مورد دیگر

Linda Nicholson is a Professor in the Department of Molecular Biology and Genetics at Cornell University, and the Hays and James M. Clark Director of the Office of Undergraduate Biology. Her research focuses on protein dynamics and function using NMR spectroscopy, with applications to diseases like Alzheimer’s and asthma. She has pioneered studies on proline isomerization switches and the coupling of innate immunity signaling to actin cytoskeleton regulation. Education: While specific academic degrees are not detailed in the provided text, Nicholson joined Cornell’s faculty in 1994, indicating advanced training in molecular biology or related fields. Research Interests: Nicholson’s work integrates biophysics, structural biology, and disease mechanisms. Key areas include protein dynamics in disease contexts (e.g., Src proto-oncoprotein, Lyme disease proteins), and the thermodynamics of protein interactions. Her lab explores how ligand binding propagates through protein structures, informing therapeutic strategies. Awards & Recognition: Nicholson has received multiple accolades, including the 2023 Faculty Award for Excellence in Research, Teaching, and Service through Diversity. Her advising and mentorship efforts, particularly with underrepresented students via the Posse Foundation, have been widely recognized. Scholarly Impact: Over 30+ publications span protein structure-function relationships, antimicrobial peptides, and signaling pathways. Her work bridges basic science and translational research, with implications for drug discovery and immune modulation. Leadership: As Director of Undergraduate Biology, Nicholson oversees curriculum development and student support. She chairs diversity initiatives and collaborates across disciplines to enhance inclusive excellence in STEM education.

Marcus Grimmمشاهده پروفایل

استاد

• Alzheimer's Disease Research
• Lipid Metabolism
• Nutritional Therapy
• +۵ مورد دیگر

Professor Marcus Grimm serves as Academic Head of Centre of Research and Funding and Professor and Programme Director for the Bachelor's Programme in Nutritional Therapy and Counselling at the Cologne Campus of SRH University of Health since October 1, 2021. With a distinguished career spanning over two decades in Alzheimer's disease research, Prof. Grimm has established himself as a leading expert in the intersection of lipid metabolism and neurodegenerative disorders. Prof. Grimm completed his biochemistry studies at the Johann Wolfgang Goethe University in Frankfurt with support from the German Academic Scholarship Foundation. He earned his PhD summa cum laude from the Center for Molecular Biology (ZMBH) at Heidelberg University, where he demonstrated the bidirectional interaction between Alzheimer's disease and lipid homeostasis, publishing findings in high-impact journals including Nature Cell Biology. During his doctoral studies, he concurrently completed an MBA through distance learning. He later habilitated at Saarland University in the field of Alzheimer's disease prevention, receiving a research prize in 2010. Prof. Grimm's research program has consistently focused on understanding the molecular mechanisms linking lipid metabolism to Alzheimer's disease pathogenesis. His work has established critical connections between dietary components, lipid homeostasis, and amyloid-beta processing. With an h-index of 36 and over 3,500 total citations, his research has significantly advanced understanding of how nutritional interventions might prevent or mitigate Alzheimer's disease progression. Key areas of investigation include fatty acid metabolism, vitamin effects on neurodegeneration, and lipidomics approaches to understanding Alzheimer's disease mechanisms. His most recent publications demonstrate a continued focus on lipidomics, fatty acid metabolism, and nutritional interventions in Alzheimer's disease. The research shows promising connections between specific dietary components and amyloid-beta degradation pathways, with potential implications for therapeutic development. His work on the LipiDiDiet clinical trial represents a significant contribution to understanding how multinutrient formulations might affect cognitive decline in prodromal Alzheimer's disease. Research prize in 2010 Summa cum laude for PhD Multiple patents related to Alzheimer's disease treatment Extensive publication record with over 3500 citations Beyond his research and teaching responsibilities, Prof. Grimm provides advisory services in nutritional counseling and therapy and is involved in establishing a nutritional counseling center. He maintains an active research laboratory that operates as part of the German Institute for Dementia Prevention, providing opportunities for student involvement and continuing his groundbreaking work at the intersection of nutrition and neurodegenerative disease.

• Computational Biophysics
• Membrane Biophysics
• Molecular Dynamics Simulations
• +۵ مورد دیگر

Weria Pezeshkian is an Assistant Professor in the Biocomplexity research group at the Niels Bohr Institute, University of Copenhagen. With expertise spanning computational biophysics and membrane dynamics, Dr. Pezeshkian leads research that bridges physics, biology, and computational science to address fundamental questions in cellular mechanics. Dr. Pezeshkian's research focuses on: Computational modeling of cellular membranes and their dynamic properties Molecular dynamics simulations of protein-lipid interactions Membrane mechanics and curvature generation mechanisms Plasma membrane repair processes Development of computational methodologies for multiscale biological modeling Analysis of recent publications reveals a strong emphasis on membrane biophysics, particularly in understanding how proteins interact with and shape cellular membranes. The research combines advanced computational techniques with experimental data to model complex cellular processes across multiple scales. Key contributions include elucidating mechanisms of membrane repair, protein-induced membrane curvature, and innovative simulation methodologies like FreeDTS and TS2CG. Scientific recognition includes: MGMS Frank Blaney Award (2024) Dr. Pezeshkian maintains an extensive collaborative network across institutions and disciplines, focusing on integrative approaches to complex biological questions. The research has significant implications for understanding fundamental cellular processes and potential applications in disease mechanisms related to membrane dysfunction.

Domenico Praticòمشاهده پروفایل

استاد

• Clinical Pharmacology
• Oxidative Biology
• Alzheimer's Disease
• +۴ مورد دیگر

Domenico Praticò, MD, FCPP is a Professor in the Department of Neural Sciences at Lewis Katz School of Medicine, Temple University, and the Founding Director of the Alzheimer's Center at Temple. His research focuses on clinical pharmacology, oxidative biology, and neurodegeneration. MD, University of Rome "La Sapienza" (1986) Internship, Residency, and Fellowship at University of Rome "La Sapienza" Cardiovascular Science Fellowship, University of Dublin (1994) Dr. Praticò investigates the role of bioactive oxidized lipids, oxidative stress, and neuroinflammation in aging, Alzheimer's disease, and cardiovascular disorders. His lab employs cellular and animal models to translate findings into human disease understanding. Recent publications highlight his work on Alzheimer's disease mechanisms involving non-coding RNAs, endosomal trafficking, lipid metabolism, autophagy, and vascular contributions. His studies bridge neurobiology, cardiovascular research, and translational medicine. Fellow of the Center for Clinical Pharmacology (FCPP) His lab integrates in vitro systems and transgenic mouse models to study APP processing, Aβ metabolism, tau pathology, and synaptic dysfunction. The Pratico Lab emphasizes drug discovery for neurotherapeutics and biomarker identification.