معرفی
Prof. Dr. Harald Steiner serves as a Group Leader at the German Center for Neurodegenerative Diseases (DZNE) in Munich, Germany, where he directs biochemical research on γ-secretase mechanisms central to Alzheimer's disease pathogenesis. His work focuses on molecular substrate recognition and activity modulation of this critical enzyme complex within the institution's neuroscience research framework.
Dr. Steiner's research investigates the proteolytic processing of amyloid-β precursor protein (APP) by the γ-secretase complex—composed of presenilin, nicastrin, APH-1, and PEN-2—which generates amyloid-β peptides that accumulate in senile plaques. His laboratory examines intramembrane cleavage mechanisms to elucidate fundamental biochemical principles underlying Alzheimer's disease progression and identify potential therapeutic intervention points.
The research group operates from DZNE's Munich site at Feodor-Lynen-Str. 17, employing biochemical and molecular approaches to dissect γ-secretase function. This work contributes to the broader institutional mission of advancing neurodegenerative disease understanding through basic science research, with implications for developing disease-modifying treatments targeting pathological proteolytic pathways.
