جست‌وجوی استاد و پژوهشگر

• Neuroscience
• Molecular Biology
• Neurodegenerative Diseases
• +۳ مورد دیگر

Dr. Guido Hermey is a Research Professor at the University Medical Center Hamburg-Eppendorf (UKE), where he leads research at the Institute of Molecular Neurogenetics. His work focuses on molecular mechanisms underlying neuronal plasticity and neurodegeneration, employing multidisciplinary approaches including advanced imaging, biochemistry, and bioinformatics. His research examines: Activity-dependent changes in neuronal gene expression and protein trafficking Role of Vps10p-domain receptors in endosomal transport and synaptic plasticity Molecular pathways linking lysosomal dysfunction to neurodegenerative disorders Disease mechanisms in Alzheimer's, Batten disease, and autism spectrum disorders Hermey's recent publications demonstrate a strong focus on lysosomal storage disorders and synaptic function, with consistent research output exploring neurodegenerative disease mechanisms through molecular and cellular neuroscience approaches. His work frequently investigates protein trafficking pathways and their disruption in disease states. He leads a multidisciplinary research team studying neuronal plasticity using techniques including: Transcriptional profiling of neuronal activity Live-cell imaging of protein trafficking Characterization of disease-linked proteins Bioinformatic analysis of neuronal gene expression

Martin Korteمشاهده پروفایل

استاد

• Synaptic plasticity
• Neuroinflammation
• Neurodegenerative diseases
• +۶ مورد دیگر

Prof. Dr. Martin Korte is a faculty member at the Technische Universität Braunschweig , serving as Professor of Cellular Neurobiology and Director of the Zoological Institute . Since 2012, he has led the Neuroinflammation and Neurodegeneration research group at the Helmholtz Centre for Infection Research , bridging infection biology with neurodegenerative disease mechanisms. PhD in Signaling Systems at Hippocampal Synapses from the Max Planck Institute for Neurobiology Research focus: Synaptic plasticity, neuroinflammation in Alzheimer's disease, and infection-induced neurological impairments Methodological expertise: Neurophysiology, in vivo models, metabolomics, and neuroimaging His work systematically explores how viral infections (e.g., H7N7, H1N1) alter neuroinflammatory states, demonstrating mechanisms like immune challenge effects on noradrenergic systems and protective roles of interventions such as IL-37 expression or influenza vaccination. He investigates metabolite-based therapies (e.g., itaconate, OLT1177) for neuroinflammation and maintains critical contributions to understanding synaptic dysfunction in genetic models (APP/APLP families, Fragile X syndrome). Recent publications highlight his role in: Elucidating BDNF-inflammatory protein interactions via Mendelian randomization Establishing sex-specific neuroinflammatory responses to viral infections Advancing metabolic immunomodulation for Alzheimer's Linking digital media use to brain plasticity in his 2020 Dialogues in Clinical Neuroscience article

Sabine Koningsمشاهده پروفایل

پژوهشگر

• Alzheimer's Disease
• Apolipoprotein E
• Amyloid
• +۵ مورد دیگر

Sabine Konings is a Research Associate at the Faculty of Science, Vrije Universiteit Amsterdam, specializing in Molecular and Cellular Neurobiology with dual affiliation at Amsterdam Neuroscience - Neurodegeneration. Her research profile shows significant contributions to understanding neurodegenerative disease mechanisms through advanced imaging and molecular techniques. Dr. Konings' research interests form a distinctive fingerprint in neuroscience, with primary focus on Alzheimer's Disease (100% prominence), Apolipoprotein E (54%), Amyloid proteins (52%), and Infrared Spectroscopy (48%). Her work extends to Amyloid Precursor Protein (34%), Apolipoprotein E4 (31%), Neuronal Activity (27%), and Astrocyte research (25%), demonstrating a comprehensive approach to neurodegeneration. Her recent publications reveal a sophisticated integration of protein biochemistry with cutting-edge imaging technologies. The research demonstrates how Apolipoprotein E intersects with amyloid-β within neurons, advances in infrared spectroscopy for subcellular protein imaging, and the critical role of APOE genotypes in Alzheimer's disease pathology progression. These works collectively represent significant methodological and conceptual contributions to the field. Amyloid research (100% prominence) Apolipoprotein E mechanisms (100% prominence) Alzheimer's Disease pathology (100% prominence) Infrared Spectroscopy applications (100% prominence) Neuronal hyperexcitability (37% prominence) Synaptic plasticity dysregulation (100% prominence) Dr. Konings maintains an active research profile with multiple high-impact publications in the last two years, including contributions to Life Science Alliance, Journal of Medicinal Chemistry, Journal of the American Chemical Society, and Molecular Neurodegeneration. Her work has received significant attention with hundreds of Mendeley readers and coverage across multiple news outlets and social media platforms, indicating substantial scholarly impact.

Kevin D Sargeمشاهده پروفایل

استاد

• Protein Sumoylation
• Epigenetics
• Gene Bookmarking
• +۸ مورد دیگر

Kevin D. Sarge, PhD, is a Professor in the Department of Molecular and Cellular Biochemistry at the University of Kentucky, with a joint affiliation in the Toxicology Program. His research bridges molecular mechanisms of disease and epigenetic regulation, focusing on post-translational modifications and gene expression memory. Research Interests: Dr. Sarge's work centers on two major areas: (1) Protein sumoylation and its role in diseases such as cardiomyopathy and Alzheimer’s, where he discovered that sumoylation of lamin A and amyloid precursor protein (APP) regulates their function and localization; and (2) Gene bookmarking , an epigenetic process ensuring the inheritance of gene expression states through mitosis, involving HSF2 and TATA-binding protein (TBP). Publication Trends: His recent work (2005–2009) reveals a strong focus on sumoylation, stress response, and epigenetic mechanisms. Publications in journals like Nature Cell Biology and Science highlight his contributions to understanding how transcription factors and chromatin regulators maintain gene expression fidelity during cell division. Scientific Awards: No awards mentioned in the provided text. Advising and Grants: Dr. Sarge has mentored numerous researchers, including H. Xing, D.C. Wilkerson, and Y. Zhang, many of whom are co-authors on key publications. His lab has secured significant research funding, as evidenced by sustained productivity and high-impact publications, though specific grants are not listed. His work has implications for therapeutic development in neurodegenerative and cardiac diseases. Labs and Teams: His laboratory investigates molecular mechanisms using biochemical, genetic, and cell biological approaches, focusing on protein modifications and epigenetic memory. The team collaborates across disciplines, including toxicology and reproductive biology, reflecting the integrative nature of modern molecular biochemistry.

Jonathan Pierceمشاهده پروفایل

دانشیار

• Neuroscience
• Molecular Biology
• Genetics & Genomics
• +۱۱ مورد دیگر

Jonathan Pierce is an Associate Professor in the Department of Neuroscience at The University of Texas at Austin, where he established his lab in 2008. His research focuses on genetic mechanisms governing behaviors and neurological disorders using Caenorhabditis elegans as a model organism. He previously studied at the University of Oregon (PhD in Neuroscience) and University of California, San Francisco (Medical School research). 2008-present: UT Austin Neuroscience Department 2001-2008: University of Oregon graduate training 1997-2001: UCSF Medical School research Research Focus: His lab investigates four core questions: Molecular basis for gait switching mechanisms in Parkinsonian worms Alcohol intoxication/addiction through BK channel modulation Down syndrome gene identification via chromosome 21 overexpression Alzheimer's disease prevention using C. elegans models Humidity and magnetic field sensing mechanisms Publication Trends: Recent works (2018-2025) emphasize alcohol's molecular mechanisms, neurodegenerative disease modeling, and sensory biology. Key themes include ion channel pharmacology, genetic interactions in neurodegeneration, and environmental sensory detection. Scientific Recognition: Notable awards include the NIH Director’s Transformative Research Award (2011), Alzheimer’s Association grant (2010), and multiple awards for Down syndrome advocacy/hiring initiatives ($3k-$10k). His teaching excellence was recognized in 2013 by UT Austin students. Lab Environment: The UT Austin lab (established 2008) focuses on genetic approaches to neurological disorders. They pioneered C. elegans models for Alzheimer’s and Down syndrome research, enabling rapid drug screening and mechanistic studies.

• Neurodegenerative diseases
• Alzheimer's disease
• Molecular chaperones
• +۶ مورد دیگر

Pavel Pavlov is a Researcher affiliated with the Department of Neurobiology, Care Sciences and Society at Karolinska Institutet (KI), working within the Division of Neurogeriatrics under Bengt Winblad's research group. His primary affiliation is with the Department of Neurobiology, Care Sciences and Society, where he serves as a supervisor for research projects focused on molecular mechanisms of neurodegenerative diseases. Dr. Pavlov's research program centers on the molecular chaperone network and its role in neurodegenerative disorders, particularly Alzheimer's disease. His work investigates how molecular chaperones—critical for maintaining intracellular protein homeostasis—can be targeted for therapeutic intervention. Rather than pursuing general inhibition or activation of chaperone function (which could be detrimental for long-term therapy), his research focuses on regulating specific cellular processes by inhibiting protein-protein interactions between molecular chaperones and their co-chaperones. This targeted approach aims to develop novel modulators of the molecular chaperone network with therapeutic potential for Alzheimer's disease. His publication record over the past 16 years demonstrates a consistent and deepening exploration of chaperone-co-chaperone interactions, mitochondrial dysfunction in neurodegeneration, and the development of small molecule therapeutics. The research spans from fundamental molecular mechanisms to preclinical testing in animal models, with several publications describing the development and assessment of lead compounds like GMP-1 that protect mitochondrial function. His work bridges biochemistry, neuroscience, and pharmacology to address the complex protein misfolding pathology characteristic of Alzheimer's and related neurodegenerative diseases. Dr. Pavlov collaborates extensively within Bengt Winblad's research group and with other researchers at Karolinska Institutet, as evidenced by his numerous co-authored publications. His laboratory work involves sophisticated techniques including x-ray crystallography, computational modeling, biochemical characterization of protein interactions, and testing in fly and mouse models of Alzheimer's disease. The research program has evolved from basic investigations of amyloid-beta import into mitochondria to the development of targeted therapeutic approaches for modulating specific aspects of the molecular chaperone network.

Helena Karlströmمشاهده پروفایل

مدرس ارشد

• Neurosciences
• Neurodegenerative Diseases
• Small Vessel Disease
• +۳ مورد دیگر

Helena Karlström is a Senior Lecturer and Docent at Karolinska Institutet's Department of Neurobiology, Care Sciences and Society (NVS). As Head of the Division of Neurogeriatrics, she leads a research group focused on CADASIL (Cerebral Autosomal-Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy), the most common familial small vessel disease leading to strokes and dementia. Her work bridges molecular mechanisms of Notch3 signaling and protein misfolding with therapeutic development, including immunotherapy strategies for CADASIL and Alzheimer's disease. She is actively involved in teaching at master's and doctoral levels, course leadership, and institutional committees for research education and leadership development. Senior Lecturer, Karolinska Institutet (2023–) Doctor of Philosophy, Karolinska Institutet (2002) Docent, Karolinska Institutet (2011) Karlström's research examines molecular pathways in CADASIL and Alzheimer's disease, particularly Notch3 dysfunction, gamma-secretase activity modulation, and protein aggregation mechanisms. Her team investigates how Notch3 mutations cause vascular pathology and explores immune-based clearance strategies for misfolded proteins. Recent work includes developing microvascular isolation methods for neurovascular niche characterization and identifying biomarkers for disease progression. Key projects span from basic molecular studies to translational vaccine development for neurodegenerative disorders. Recent publications highlight her interdisciplinary approach: Active immunotherapy targeting Notch3 deposits in CADASIL mouse models (2023) Molecular chaperone BRICHOS inhibition of NOTCH3 aggregation (2022) Gamma-secretase modulator selectivity studies (2022) Investigations into NOTCH3 mutation effects on signaling (2021) ER-mitochondria contact regulation of amyloid-beta (2016) Scientific awards include: WennerGren postdoctoral fellowship (2004-2005) Soroptimist International Prize (2005) Ostermans postdoctoral fellowship (2006-2007) Riksbankens Jubileumsfond Erik Rönneberg stipend (2009-2012) As a mentor, Karlström has directly supervised four PhD students and co-supervised numerous others, while also teaching over 25 undergraduate and master's students since 2007. She leads leadership development programs for research group leaders and contributes to international educational initiatives. Her grants include €250,000 from the Dutch Brain Foundation and SEK 3.6 million from the European Joint Programme – Rare Diseases (EJP-RD) for CADASIL research. Karlström's laboratory at BioClinicum J9:20 is part of the NVS Department's neurogeriatrics division, which includes 65 employees and 12 research groups. Her team collaborates with international clinicians and researchers through the EJP-RD consortium and maintains expertise in mouse modeling, protein biochemistry, and neurovascular research methods.

• Neurosciences
• Neurodegenerative Diseases
• Alzheimer's Disease
• +۵ مورد دیگر

Professor Selina Wray is a Professor of Molecular Neuroscience in the Department of Neurodegenerative Disease at the UCL Queen Square Institute of Neurology, University College London. She holds an active position as Alzheimer's Research UK Senior Research Fellow and leads a research group focused on understanding the molecular mechanisms of Alzheimer's disease and frontotemporal dementia using patient-derived induced pluripotent stem cell models. PhD, King's College London (2008) MSc, University of Nottingham (2004) Professor Wray's research program centers on cellular and molecular mechanisms of neurodegenerative diseases, with particular emphasis on Alzheimer's disease and frontotemporal dementia. Her laboratory utilizes induced pluripotent stem cell technology to create patient-specific models of these conditions, allowing for detailed investigation of disease pathways at the cellular level. Her work spans multiple aspects of neurodegeneration including tau pathology, amyloid-beta processing, neuroinflammation, and cell-type specific contributions to disease progression. She has made significant contributions to understanding how specific genetic mutations lead to familial forms of dementia. Analysis of Professor Wray's recent publication record (2023-2025) reveals a consistent focus on cellular mechanisms of neurodegeneration, with particular attention to the role of different brain cell types in disease processes. Her work frequently employs advanced stem cell models to investigate Alzheimer's disease mechanisms, biomarker discovery, and potential therapeutic approaches. There is a strong emphasis on understanding the molecular consequences of specific genetic mutations associated with familial dementia. Professor Wray has received significant recognition for her contributions to dementia research: 2018 ARUK David Hague Early Career Investigator of the Year award 2014 Red Magazine Woman of the Year award in the Pioneer category As a principal investigator, Professor Wray leads a research team investigating molecular pathways in neurodegenerative diseases. She has secured substantial funding from Alzheimer's Research UK and participates in multiple collaborative research initiatives. Her work contributes to large-scale stem cell projects and clinical studies aimed at understanding dementia mechanisms and developing new therapeutic approaches. She actively mentors junior researchers and collaborates with clinical scientists to ensure her laboratory findings translate to real-world applications. Professor Wray's laboratory specializes in developing and utilizing induced pluripotent stem cell models to study neurodegenerative diseases. Her team has established protocols for differentiating these cells into various neuronal and glial cell types relevant to dementia research. The lab maintains strong connections with clinical researchers and participates in longitudinal studies of dementia patients, ensuring their cellular models reflect actual disease pathology observed in humans.

• Alzheimer's Disease Research
• Neurodegenerative Diseases
• Membrane Transport
• +۵ مورد دیگر

Willem Annaert serves as a full Professor at the Faculty of Medicine, KU Leuven, where he leads the Laboratory for Membrane Transport (VIB-KU Leuven). He is also a member of both the VIB-KU Leuven Center for Brain Research and the KU Leuven Brain Institute. His institutional roles include membership on the Faculty Council of Medicine, Departmental Council of Neurosciences, and Department Board of Neuroscience. Annaert's research focuses on the cellular mechanisms underlying neurodegenerative diseases, particularly Alzheimer's disease. His work investigates membrane transport processes, lysosomal biology, organelle communication, and lipid homeostasis in neuronal cells. He examines how dysfunction in these cellular processes contributes to neurodegeneration, with particular attention to amyloid precursor protein processing, presenilin function, and organelle contact sites. His recent publications demonstrate a strong focus on endolysosomal dysfunction in Alzheimer's disease, mitochondrial impairment in neurodegeneration, and the role of membrane contact sites between organelles. The research employs advanced imaging techniques including super-resolution and cryo-electron microscopy to study subcellular dynamics at the nanoscale. Annaert leads multiple significant research projects including 'Impact of genetic risk factors and aging on neuronal organelle and lipid homeostasis in Parkinson's and Alzheimer's disease - GRAN'PA' (2025-2029) and '3D SUper-Resolutie tot cryo-ElectronenMIcroscopie voor de studie van nanoschaal subcellulaire dynamiek en structuur die verandert in Neurodegeneratieve ziekten - 3SURE MIND' (2022-2026). He actively supervises PhD students including S. Gutiérrez Fernández, A. Perdok, and Z.P. Van Acker, and contributes to teaching courses such as 'Advanced Biology of the Cell/Neuron' and 'Advances in Neurodegenerative Diseases.'

Michael S. Wolfeمشاهده پروفایل

استاد

• Intramembrane Proteolysis
• Alzheimer's Disease
• γ-Secretase
• +۳ مورد دیگر

Michael S. Wolfe serves as the Mathias P. Mertes Professor of Medicinal Chemistry within the Department of Medicinal Chemistry at the University of Kansas School of Pharmacy. His research program focuses on intramembrane-cleaving proteases (I-CLiPs) and their critical roles in human disease pathogenesis, particularly Alzheimer's disease and malaria. His educational background includes: Ph.D. in Medicinal Chemistry, University of Kansas M.S. in Medicinal Chemistry, University of Kansas M.A., Harvard University B.S. in Chemistry, Philadelphia College of Pharmacy and Science Dr. Wolfe's research centers on the chemistry and biology of γ-secretase, an aspartyl protease responsible for generating amyloid β-peptide in Alzheimer's disease and mediating Notch signaling in cell differentiation. His lab pioneered transition-state analogue inhibitors to characterize γ-secretase and identified presenilin as its catalytic component. Key discoveries include the enzyme's dual proteolytic functions (endopeptidase and carboxypeptidase activities), the impact of Alzheimer's-causing presenilin mutations on Aβ trimming, and the identification of substrate docking sites. Current work extends to other I-CLiPs like signal peptide peptidase and Rhomboid, with emphasis on developing chemical probes for therapeutic applications in malaria caused by Plasmodium falciparum. Analysis of his 2014-2016 publications reveals consistent focus on γ-secretase mechanism, inhibitor development, and structural biology. His work spans biochemical characterization, substrate processing studies, and therapeutic strategies targeting Alzheimer's disease, with increasing exploration of parasite proteases for malaria treatment. The publications demonstrate interdisciplinary integration of medicinal chemistry, neuroscience, and molecular biology to address fundamental questions in protease biology. Dr. Wolfe leads an active research laboratory investigating membrane-embedded proteases, with emphasis on elucidating catalytic mechanisms, substrate recognition, and developing therapeutic prototypes. His work bridges basic science and translational applications through chemical probe development and inhibitor design.

• Alzheimer's Disease Research
• Peptide Therapeutics
• Amyloid-β Oligomers
• +۴ مورد دیگر

Dr. Janine Kutzsche leads a research group at the Institute of Biological Information Processing - Structural Biochemistry (IBI-7) at Forschungszentrum Jülich, affiliated with Heinrich-Heine-Universität Düsseldorf's Faculty of Mathematics and Natural Sciences. Her research program focuses on developing D-enantiomeric peptide therapeutics for neurodegenerative diseases, particularly Alzheimer's disease. Dr. Kutzsche's primary research interest is in developing D-peptide compounds that specifically target toxic amyloid-β oligomers while sparing monomeric forms that may have neuroprotective functions. Her team identified D3 through mirror image phage display from a library of approximately one billion peptides. This innovative approach has yielded compounds with significant advantages over conventional therapeutic approaches: D-peptides demonstrate greater protease resistance and reduced immunogenicity compared to their L-enantiomeric counterparts. Her research spans from basic molecular mechanisms to preclinical animal studies and clinical translation, with D3 derivatives progressing toward human clinical trials. Analysis of Dr. Kutzsche's publication record reveals a consistent focus on Alzheimer's disease therapeutics, with recent expansion into related neurodegenerative conditions including Parkinson's disease and ALS. Her work demonstrates progression from in vitro characterization to animal models and clinical translation, with increasing focus on drug delivery optimization, pharmacokinetics, and expanding therapeutic applications beyond Alzheimer's disease. The research shows strong interdisciplinary collaboration across biochemistry, neuroscience, and clinical medicine. Dr. Kutzsche leads an active research team comprising current members including Ian Gering, Esther Wollert, and Markus Tusche, along with numerous alumni who have completed doctoral degrees under her supervision. Her work involves significant collaboration with Dr. Willuweit and Prof. Dr. Langen at Forschungszentrum Jülich and Prof. van Groen at the University of Alabama. The research has progressed to the point where a D3 derivative is anticipated for phase I clinical trials in humans, representing successful translation from basic research to potential therapeutic application.

• Alzheimer's Disease
• Neurodegeneration
• Autophagy
• +۳ مورد دیگر

Per Nilsson serves as Principal Researcher and Docent at Karolinska Institute's Department of Neurobiology, Care Sciences and Society. His laboratory investigates the role of autophagy in Aβ metabolism and neurodegeneration in Alzheimer's disease. His research focuses on Alzheimer's disease pathogenesis, with particular emphasis on amyloid-β metabolism, autophagy mechanisms, synaptic dysfunction, and sex-specific differences in neurodegeneration. His work employs advanced transgenic mouse models including App-NL-G-F and App NL-F strains to dissect early pathological events. Analysis of his recent publications reveals consistent themes across multiple high-impact journals: molecular mechanisms of amyloid processing, autophagy-lysosomal dysfunction, synaptic and network impairments, and exploration of therapeutic interventions targeting protein homeostasis. His work frequently bridges basic molecular mechanisms with translational applications. Dr. Nilsson maintains active collaborations across neuroscience disciplines, contributing to major reviews on Alzheimer's modeling and autophagy guidelines. His laboratory participates in international research networks focused on dementia mechanisms and intervention strategies.

Wilma Friedmanمشاهده پروفایل

استاد

• Cellular Neurobiology
• Neurotrophic Factors
• Neuronal Survival and Death Mechanisms
• +۴ مورد دیگر

Wilma Friedman is a Distinguished Professor in the Department of Biological Sciences at Rutgers University–Newark, where she leads the Laboratory of Cellular Neurobiology. Her research focuses on the dual roles of neurotrophic factors in neuronal survival and death, particularly through the p75 neurotrophin receptor (p75NTR), with implications for brain injury, neurodegenerative diseases, and neurodevelopment. Education: B.A., Oberlin College, 1979 Ph.D., The Rockefeller University, 1986 Postdoctoral Training: Karolinska Institute, Stockholm Sweden Dr. Friedman's work investigates context-dependent neurotrophin signaling mechanisms, demonstrating how p75NTR activation can trigger neuronal death or survival based on cellular environment. Her lab employs primary neuronal cultures and in vivo brain injury models to dissect pathways involving proneurotrophins, receptor tyrosine kinases (Trk), and inflammatory mediators. Key discoveries include p75NTR's role in axonal degeneration, cerebellar development, and modulation of astrocyte responses. Analysis of her publications (2014-2024) reveals consistent focus on p75NTR-mediated mechanisms across neurodevelopmental, injury, and disease contexts. Recent work emphasizes cerebellar circuitry, social behavior deficits, oligodendrocyte regulation, and neuroprotective strategies targeting receptor complexes. Her research bridges molecular neuroscience with translational applications for traumatic brain injury and neurodegenerative conditions. Dr. Friedman directs the Laboratory of Cellular Neurobiology, utilizing advanced techniques including in vivo injury models, primary neuronal cultures, and molecular signaling analysis to investigate neurotrophin actions in health and disease.

• Cell Biology
• Membrane Biology
• Lipid Rafts
• +۳ مورد دیگر

Professor Kai Simons serves as a Director at the Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG) in Dresden, Germany, under the Max Planck Society. His research centers on fundamental mechanisms of cellular membrane organization and intracellular transport processes, with significant contributions to understanding lipid raft biology. His core research domains include: Cell Biology Membrane Biology Lipid Rafts Intracellular Transport Protein Trafficking Membrane Microdomains Simons led multiple German Research Foundation (DFG)-funded projects including studies on sphingolipid-cholesterol microdomains in amyloid precursor protein processing, raft-based sorting in post-Golgi transport, and lipid-protein interactions in membrane organization. Though all listed projects are completed, his work established foundational knowledge in membrane domain-induced budding and apical-basolateral transport mechanisms. Current grant activity and student supervision details are not specified in available records. As an MPI-CBG Director, he oversees research in cellular dynamics, but specific lab structure, resources, or collaborative networks beyond historical DFG projects remain undocumented in the source material.

Hedeel Guy-Evansمشاهده پروفایل

استاد

• Alzheimer's Disease Research
• Cancer Biology
• Biochemistry
• +۶ مورد دیگر

Professor Hedeel Guy-Evans is a distinguished faculty member in the Department of Chemistry at Eastern Michigan University, with joint appointments in Neuroscience. Her research bridges the fields of biochemistry, cancer biology, and neurodegenerative diseases, with a particular focus on the intersection between Alzheimer's disease and cancer mechanisms. Education: A-levels, Worthing College, England, 1980 BS, Eastern Michigan University, 1984 MS, Wayne State University Medical School, 1986 Ph.D., Wayne State University Medical School, 1992 Postdoctoral Fellow, Biochemistry, 1992-1994, Université Pierre et Marie CURIE (University of Paris VI), Paris, France Fulbright Research Scholar, 2008-2009, Département de Biologie Cellulaire, Institut Curie, Paris, France Dr. Guy-Evans's research program centers on two major areas: 1) The regulation of Insulin-Like Growth Factor Binding Protein-3 (IGFBP-3) and β-Amyloid by Humanin (HN) in both Alzheimer's disease and cancer, and 2) Pyrimidine biosynthesis. Her work explores how IGFBP-3, β-Amyloid, and Humanin interact in neuronal cell death seen in Alzheimer's disease and in cancer cell proliferation. She investigates the mechanisms by which Humanin protects against neuronal cell death induced by IGFBP-3 and β-Amyloid, with potential applications for new therapeutics. In her pyrimidine biosynthesis research, she studies the structure/function of intrinsically disordered regions on dihydroorotase (DHO) and their order upon association with aspartate transcarbamoylase (ATC). Dr. Guy-Evans has received continuous NIH funding for her research, including her current R15GM131222 grant 'Probing the Role of Insulin-Like Growth Factor-Binding Protein 3 and Humanin in Regulating Hyaluronan Function.' Her publication record shows a clear trend toward increasingly sophisticated investigations of the molecular connections between neurodegenerative processes and cancer biology, with particular emphasis on lung cancer models and the role of neurotransmitter-related pathways. Scientific Awards: 2019 Ronald W. Collins Distinguished Faculty Research Award Dr. Guy-Evans actively mentors numerous undergraduate and graduate students through her research program, with students frequently appearing as co-authors on her publications. Her NIH grants have provided substantial funding for research equipment, student stipends, and collaborative opportunities. She has successfully integrated research into teaching through innovative approaches like team-based learning in biochemistry laboratory courses, as documented in her 2016 Journal of Chemical Education publication.