جست‌وجوی استاد و پژوهشگر

Ron Drorمشاهده پروفایل

استاد

• Computational Biology
• Machine Learning
• Molecular Dynamics Simulation
• +۶ مورد دیگر

Ron Dror is the Cheriton Family Professor of Computer Science at the Stanford Artificial Intelligence Lab , with courtesy appointments in Structural Biology and Molecular & Cellular Physiology . He also holds affiliations with Bio-X, the Institute for Human-Centered Artificial Intelligence (HAI), the Institute for Computational and Mathematical Engineering (ICME), Sarafan ChEM-H, and the Wu Tsai Neurosciences Institute. Education: PhD in Electrical Engineering and Computer Science, MIT MPhil in Biological Sciences, University of Cambridge (Churchill Scholar) BS in Mathematics and Electrical & Computer Engineering, Rice University (summa cum laude) Ron leads a multidisciplinary research group that combines molecular simulation and machine learning to study biomolecular structure, dynamics, and function. His work focuses on developing computational methods to accelerate drug discovery by predicting molecular interactions and designing more effective therapeutics. Current projects include the PENSA software library for analyzing biomolecular ensembles and FRAME framework for structure-based ligand design. His research has produced groundbreaking work on G-protein-coupled receptors (GPCRs) , RNA structure prediction , and mitochondrial transport mechanisms . Key publications highlight applications of geometric deep learning and molecular dynamics simulations in structural biology. Scientific Awards: Cheriton Family Professorship (2023) Two Gordon Bell Prizes (2014, 2009) Best Paper Awards at NeurIPS (2021), IPDPS (2013), SC11 (2011), SC09 (2009), SC06 (2006) Science Magazine Top 10 Breakthrough (2010) Fulbright Scholarship , NSF Fellowship , DoD Fellowship , Whitaker Foundation Fellowship Ron has advised numerous doctoral and master’s students including EJ Fine , Masha Karelina , and Briana Sobecks . His lab collaborates with experimentalists across academia and industry, applying computational methods to diverse biomedical problems such as RNA structure prediction , GPCR signaling , and mitochondrial metabolism .

Simon Webbمشاهده پروفایل

استاد

• Organic Chemistry
• Biomaterials
• Nanotechnology
• +۷ مورد دیگر

Simon Webb is a Professor of Organic Chemistry at the University of Manchester, leading the Organic Chemistry Group within the School of Chemistry. His research focuses on molecular self-assembly to create biomimetic materials, with key themes including membrane recognition, synthetic ion channels, and magnetically responsive biomaterials. He earned his PhD from the University of Cambridge and has held academic positions since 2002. His work bridges organic chemistry, nanotechnology, and biomedicine, contributing to sustainable development through advanced materials in medicine and biotechnology. Education: B.Sc./M.Sc. Chemistry, Auckland University (1990–1994) PhD, University of Cambridge (1994–1997) Research Interests: Membrane communication via synthetic ion channels Magnetic nanoparticle-vesicle assemblies for drug delivery Peptide-based foldamers for signal transduction His lab develops materials that mimic biological membranes, such as magnetically triggered drug delivery systems (MNPVs) and foldamer-based sensors. Collaborations span advanced materials, biotechnology, and medical research. Current projects include exploring cooperativity in multivalent ligand binding and lipid raft dynamics. Publications highlight innovations in foldamer design, supramolecular arrays, and enzyme-responsive materials. His work is supported by grants and contributes to UN Sustainable Development Goals in health and advanced materials.

Thomas J. D. Jørgensenمشاهده پروفایل

دانشیار

• Mass Spectrometry
• Hydrogen/Deuterium Exchange
• Protein Structural Dynamics
• +۷ مورد دیگر

Thomas J. D. Jørgensen is an Associate Professor and Head of the Research Section of Biomedical Mass Spectrometry at the Department of Biochemistry and Molecular Biology, University of Southern Denmark. He leads an active research group focusing on protein structural dynamics using mass spectrometry and hydrogen/deuterium exchange methodologies. His research interests lie at the intersection of biochemistry, structural biology, and systems biology, particularly in understanding how protein dynamics govern function and dysfunction in diseases such as Parkinson’s and metabolic disorders. He employs advanced mass spectrometry techniques to study conformational changes, protein-protein interactions, and enzyme regulation, with a strong emphasis on lipoprotein metabolism and neurodegenerative disease mechanisms. The most recent articles highlight a consistent focus on protein dynamics in lipid metabolism, conformational diseases, and glycoprotein analysis, utilizing hydrogen/deuterium exchange mass spectrometry (HDX-MS) and related techniques. Themes include allosteric regulation of enzymes, protein unfolding, and structural phenotyping of disease-related aggregates. Member of the evaluation committee at the Swedish Research Council (2015) Chairman of multiple PhD evaluation committees (2014) Editorial and peer-review contributions to the scientific community He currently supervises PhD students and is involved in several major research projects funded by organizations such as the Michael J. Fox Foundation and Novo Nordisk Fonden. His lab, the Thomas J. D. Jørgensen Lab, includes postdoctoral researchers, academic staff, and industrial PhD students, fostering a collaborative and interdisciplinary research environment focused on biomedical mass spectrometry and systems biology.

Owen Skinnerمشاهده پروفایل

استادیار

• Mass Spectrometry
• Proteomics
• Metabolomics
• +۶ مورد دیگر

Owen Skinner is an Assistant Professor in the Department of Chemistry and Chemical Biology at Northeastern University, affiliated with the Barnett Institute of Chemical and Biological Analysis. He leads the Skinner Lab, which specializes in high-resolution mass spectrometry to study protein-metabolite interactions in health and disease. Skinner earned his Ph.D. from Northwestern University and conducted postdoctoral research at Massachusetts General Hospital. His research focuses on thiol redox regulation, vitamin cofactor metabolism, and oxidative phosphorylation dynamics. Education: Ph.D. in Chemistry (Northwestern University), Postdoctoral Fellowship in Analytical Chemistry (Massachusetts General Hospital). Research interests include proteomics, metabolomics, mitochondrial dysfunction, and metabolic signaling. The lab actively recruits graduate students, undergraduates, and postdoctoral researchers across Northeastern's scientific community. Affiliations: Barnett Institute, College of Science Lab Members: PhD students Yifan Liu, Michael Xiao, Angela Rojas-Merchan; Undergraduates Helena Rittenhouse, Ridha Shah; High School collaborator Helen Loango Techniques: Native mass spectrometry, proteomics, metabolomics, redox biology Publications span mitochondrial metabolism, metabolic biomarkers in septic shock, and enzyme engineering. The lab emphasizes interdisciplinary collaboration and supports students through Northeastern's experiential learning programs.

Jana Shenمشاهده پروفایل

استاد

• Molecular Simulation
• Data Science
• Kinases
• +۱۲ مورد دیگر

Jana Shen is a Professor in the Department of Pharmaceutical Sciences at the University of Maryland School of Pharmacy, where she leads an interdisciplinary research group at the intersection of chemistry, biology, physics, and computer science. Her lab develops and applies advanced simulation and data science tools to understand biomolecular mechanisms and accelerate drug discovery. Education: Postdoc, The Scripps Research Institute (2003–2007) PhD, University of Minnesota at Twin Cities (1999–2003) MS, University of Calgary, Canada (1996–1999) Diplom-Chemie, Bergische Universität Wuppertal, Germany (1991–1995) Her research focuses on molecular simulation , data science , and computational biophysics , with applications in kinases , GPCRs , transmembrane transporters , and pH-responsive materials . She has pioneered the development of continuous constant pH molecular dynamics (CpHMD) methods and their applications in drug design and biomolecular mechanisms. The recent publications highlight a strong trend in computational drug discovery , particularly in covalent inhibitors , opioid receptor mechanisms , antiviral design , and the integration of machine learning with molecular dynamics . These works span high-impact journals such as eLife , JACS , Nature Communications , and ACS journals. Scientific Awards: National Science Foundation CAREER Award American Chemical Society HP Outstanding Junior Faculty Award Junior Faculty Research Award (University of Oklahoma, 2008, 2009) Phi Kappa Phi, University of Minnesota Louise T. Dosdall Graduate Fellowship Nova Graduate Fellowship Dr. Shen has mentored numerous PhD students and postdoctoral fellows, many of whom have gone on to successful careers in academia and industry. Her research is supported by major agencies including the National Institutes of Health , National Science Foundation , and FDA . She leads the Shen Lab, which actively develops open-source tools such as DeepCys , CpHMD , and PKAD-3 , and maintains databases for covalent ligandability and pKa predictions.

Sebastian Hillerمشاهده پروفایل

استاد

• Structural Biology
• NMR Spectroscopy
• Protein Folding
• +۴ مورد دیگر

Professor Sebastian Hiller is a Full Professor at the Biozentrum of the University of Basel, Switzerland, where he leads a research group focused on structural biology and biophysics. His laboratory specializes in using nuclear magnetic resonance (NMR) spectroscopy to elucidate the structures and functions of proteins and their interactions at the atomic level. His research spans several key areas including molecular chaperones and protein folding mechanisms, outer membrane protein biogenesis in bacteria, and kinase signaling pathways. Notably, his group has made significant contributions to understanding how chaperones like trigger factor function, the mechanisms of outer membrane protein assembly through the Bam complex, and dynamic kinase interactions. Their work has direct implications for neurodegenerative diseases and antibiotic development. The Hiller lab's recent publications demonstrate a strong focus on NMR methodology development, protein folding dynamics, and structural mechanisms of antibiotic action. Their research on darobactin's mechanism of action against Gram-negative bacteria represents a significant advance in antibiotic discovery. The group frequently publishes in high-impact journals including Nature, Science, and Nature Communications. ICMRBS Founder's Medal (2018) EMBO Young Investigator (2014) ERC starting grant (2011) SNSF professorship (2010) SNSF scholarship for young researchers (2008) Professor Hiller supervises numerous PhD students and postdoctoral researchers, with many alumni having secured prestigious positions in academia and industry. His laboratory maintains strong collaborations across multiple institutions and has received significant funding through ERC grants and other competitive mechanisms. The Hiller group also operates advanced NMR facilities that serve the broader research community at the University of Basel.

Canan ATILGANمشاهده پروفایل

استاد

• Biophysics
• Structural Biology
• Computational Biology
• +۳ مورد دیگر

Canan ATILGAN is a Professor at the Faculty of Engineering and Natural Sciences, Sabanci University, Istanbul, Turkey. She has held leadership roles including Dean (2018-2020), Director of the Graduate School (2018-2020), and President of the Science Academy (2021-present). Her research focuses on computational tools for protein conformational transitions, allosteric communication, and antibiotic resistance mechanisms. Ph.D. (1996) and B.S. (1991) in Chemical Engineering from Boğaziçi University A pioneer in perturbation-response scanning and network-based protein modeling, her work bridges biophysics, structural biology, and molecular evolution. She has supervised 15 PhD and 17 MS students, emphasizing accessible computational biophysics education through workshops and seminars. Her recent publications highlight allosteric mechanisms in biosensors, β-lactam resistance via TolC dynamics, and evolutionary fitness landscapes. Awards include EMBO and Academia Europaea membership, L’Oréal Turkey Young Women Scientist Fellowship, and TÜBA-GEBİP Distinguished Young Scientist Award. President, Science Academy (2021) EMBO Elected Member (2023) TÜBA-GEBİP Distinguished Young Scientist (2004) She leads the MIDST Lab, contributes to Turkish science communication via sarkac.org, and organizes 'Dialogues in the MIDST' workshops for graduate students. Her work integrates theoretical models with experimental validation in iron transport proteins and resistance mechanisms.

George Stanمشاهده پروفایل

استاد

• Computational Biophysical Chemistry
• Protein Folding and Degradation
• Molecular Dynamics Simulations
• +۳ مورد دیگر

George Stan is a Professor of Chemistry at the University of Cincinnati's College of Arts and Sciences. He specializes in computational biophysical chemistry, focusing on protein folding, degradation, and the mechanisms of biological nanomachines like Clp ATPases and chaperonins. Stan received his B.Sc. (1994) from the University of Bucharest and his Ph.D. (1999) from Pennsylvania State University. His postdoctoral work at the University of Maryland and NIH explored protein folding assisted by chaperonins. Research Interests: Stan's work combines molecular dynamics simulations and bioinformatics to study protein-unfolding pathways, substrate recognition by chaperonins, and the dynamics of AAA+ nanomachines. His recent studies investigate how primary sequence and topology influence protein degradation, with applications to knotted proteins and disease-related misfolding. Key Achievements: Stan has secured over $8 million in NSF grants, including a CAREER award for computational modeling of biological nanomachines. His team develops multiscale models of protein translocation and employs machine learning to study allosteric communication in ClpP peptidases. He has published over 80 peer-reviewed articles and reviews. Notable Grants: NSF-BSF (2021-2025), NIH (2024-2029), and multiple XSEDE allocations Service: Co-chaired the 'Molecular Machines' focus session at APS March Meetings (2022-2024) Teaching: Advanced Computational Chemistry, Physical Chemistry, and Big Data in Chemistry Labs/Teams: Leads the Computational Biophysics group at UC, collaborating with Ruxandra Dima and Pietro Strobbia on interdisciplinary projects. Mentors over 20 graduate and undergraduate students since 2006.

Michael Grabeمشاهده پروفایل

استاد

• Ion Channel Function
• Membrane Biology
• Computational Biology
• +۳ مورد دیگر

Michael Grabe is a Professor in the Cardiovascular Research Institute (CVRI) at the University of California San Francisco (UCSF). He holds a joint appointment in the Department of Pharmaceutical Chemistry. His work focuses on computational methods to study biological phenomena, particularly ion transport across membranes and the molecular mechanisms of ion channels/transporters. He has pioneered theoretical approaches to understand membrane protein function and organelle acidity regulation. Education: PhD in Physics, University of California, Berkeley (2002) ScB in Mathematics-Physics, Brown University (1996) Research Interests: Dr. Grabe’s lab investigates ion channel function, membrane remodeling by TMEM16 proteins, lysosomal pH regulation, and computational modeling of membrane-associated processes. Key themes include: Mechanics of ion transport and lipid flipping Protein-induced membrane deformations Simulations of organelle microphysiology Development of computational tools for membrane protein analysis Recent Research Trends: Recent work emphasizes dynamic protein design using AI (e.g., Science 2025), structural studies of K2P channels, and functional insights into TMEM16 scramblases. His team also explores SARS-CoV-2 protein interactions and mitochondrial uncoupling mechanisms. Awards: NSF CAREER Award (2009-2014) Alfred P. Sloan Research Fellowship (2009-2011) Shining Star Community Service Award (2012) Grants & Advising: Principal Investigator of NIH grants studying TMEM16 proteins (R01GM137109) and lysosomal physiology (R21GM100224). His lab trains graduate students and postdocs in computational biophysics and membrane biology. Labs/Teams: Leads the Grabe Lab at UCSF, which collaborates with experimental groups to bridge theory and experiment in membrane systems. Active in developing open-source tools like APBSmem for electrostatic calculations.

Jonathan Weissmanمشاهده پروفایل

استاد

• Protein Folding
• Systems Biology
• Genomics
• +۶ مورد دیگر

Jonathan Weissman is a Professor of Biology at the Massachusetts Institute of Technology (MIT) and a Member of the Whitehead Institute. He is also an Investigator of the Howard Hughes Medical Institute and the Landon T. Clay Professor of Biology. His research spans protein folding mechanisms, ribosome profiling, CRISPR-based tools (CRISPRi/a), and genetic interaction mapping. Whitehead Institute Member MIT Professor HHMI Investigator Co-founder, Maze Therapeutics & KSQ Therapeutics Research Interests focus on: Protein folding in cellular contexts Endoplasmic reticulum (ER) function and stress responses Genome-wide CRISPR screening for gene regulation High-density genetic interaction maps in mammals Mitochondrial protein targeting and quality control Epigenomic engineering with synthetic tools Scientific Awards include: Protein Society Irving Sigal Young Investigator Award (2004) Raymond & Beverly Sackler Prize (2008) National Academy of Sciences election (2009) NAS Award for Scientific Discovery (2015) Genetics Society of America Ira Herskowitz Award (2020) Labs & Collaborations : Leads the Weissman Lab at MIT/Whitehead Institute, co-leads the Laboratory for Genomic Research with GlaxoSmithKline, and chairs the Stowers Institute Scientific Advisory Board.

Samuel Fountainمشاهده پروفایل

استاد

• Pharmacology
• Ion Channels
• Cardiometabolic Physiology
• +۱۲ مورد دیگر

Professor Samuel Fountain is a leading academic in pharmacology at the University of East Anglia, where he serves as Chair of Pharmacology within the School of Biological Sciences. He holds additional leadership roles as Associate Pro-Vice-Chancellor of the UEA Doctoral College and has previously served as Associate Dean for Postgraduate Research and Director of the Biomedical Research Centre. He is actively supervising multiple PhD students and securing major research funding. BSc (Hons) Pharmacology, University of Leeds (1997–2000) MRC-funded PhD, University of Leeds (2000–2004) Wellcome Trust Research Associate, University of Manchester (2004–2008) BBSRC David Phillips Fellow, University of Leeds (2008–2010) Lecturer to Professor of Pharmacology, University of East Anglia (2010–present) His research focuses on the role of ion channels—particularly P2X receptors—in vascular and adipose tissues, with implications for cardiometabolic diseases. His work integrates pharmacology, physiology, and molecular biology to understand neurovascular and neuroadipose communication, receptor-ligand interactions, and drug discovery. He employs techniques such as pressure myography, patch-clamp electrophysiology, calcium imaging, and molecular modelling. The analysis of his recent publications reveals a strong emphasis on purinergic signalling, ion channel pharmacology, and autonomic control of blood vessels and fat tissue. His work bridges basic science with translational applications, particularly in hypertension, obesity, and metabolic syndrome. Collaborations with AstraZeneca, Merck, and the British Heart Foundation underscore the clinical and pharmaceutical relevance of his research. Notable scientific recognition includes the prestigious BBSRC David Phillips Fellowship. He also contributes to the academic community through editorial roles, including as Editor of Purinergic Signalling , and as a member of the British Pharmacological Society and The Physiological Society. Professor Fountain actively mentors postdoctoral researchers and PhD students, several of whom are funded by BBSRC, BHF, and AstraZeneca iCASE awards. His lab is supported by significant grants from the British Heart Foundation, BBSRC, and industry partners, enabling cutting-edge research in vascular and metabolic pharmacology. He leads multiple active projects on neurovascular transmission, purinergic control, and drug discovery for P2X receptors. His research group operates within the Cells and Tissues research theme at UEA and utilizes advanced experimental platforms including human tissue studies, high-throughput screening, and computational ligand docking. The lab fosters interdisciplinary collaboration between pharmacologists, physiologists, and clinicians, positioning it at the forefront of autonomic and metabolic research.

Reinhard Wimmerمشاهده پروفایل

استاد

• Nuclear Magnetic Resonance (NMR) Spectroscopy
• Protein Structure Analysis
• Antimicrobial Peptides
• +۵ مورد دیگر

Reinhard Wimmer is a Professor at Aalborg University's Department of Chemistry and Bioscience, affiliated with The Faculty of Engineering and Science and the Medical Biotechnology Center for Microbial Communities. His research focuses on NMR spectroscopy, protein structure analysis, and bioprocess engineering. He leads projects such as SEAMARK (Horizon Europe) and collaborates on initiatives like INNO-H2S for H2S scavenger recovery. Education: No explicit details provided Key research interests include antimicrobial peptides, metabolomics, and biodegradable polymer processing. Recent work addresses PET waste depolymerization and calmodulin dynamics. Active in interdisciplinary projects combining biotechnology with environmental engineering. His 217+ publications span NMR-based metabolomics, enzyme engineering, and microbial metabolite analysis. Awards and grants include funding from the Novo Nordisk Foundation and Horizon Europe.

Tina Pericaمشاهده پروفایل

استادیار

• Biochemistry
• Systems Biology
• Protein Biochemistry
• +۵ مورد دیگر

Prof. Tina Perica is an Assistant Professor (tenure-track) in the Department of Biochemistry at the University of Zurich, joining in July 2021. Her research focuses on understanding how biochemical properties of proteins encode systems-level functions in signal transduction and gene regulation. Her lab integrates protein biochemistry, biophysics, functional genomics, and computational biology to study cellular regulation mechanisms. Education: B.Sc. in Biology, University of Zagreb (2008) Ph.D. in Biochemistry, University of Cambridge (2013) Postdoctoral training at University of California, San Francisco (2013–2021) Research Interests: Systems Biochemistry Allosteric Regulation in GTPases and Kinases Genotype-to-Phenotype Mapping Functional Genomics and Computational Biology Her team explores how molecular mechanisms of proteins interact within cellular networks to regulate complex processes, aiming to predict therapeutic effects and disease mutations. Lab Activities: Develops experimental and computational tools to map functional interactions in signaling pathways Focuses on targeted perturbations of proteins to study systems-level effects Emphasizes interdisciplinary approaches blending biochemistry with systems biology

Timothy Grantمشاهده پروفایل

استادیار

• Cryo-electron microscopy (cryo-EM)
• Structural biology
• Computational imaging
• +۴ مورد دیگر

Timothy Grant is an Assistant Professor of Biochemistry at the University of Wisconsin–Madison and an Investigator at the Morgridge Institute for Research , embedded within the John W. and Jeanne M. Rowe Center for Research in Virology . His laboratory, the Grant Lab , focuses on pushing the limits of cryo-electron microscopy (cryo-EM) to visualize ever-smaller and more dynamic biological macromolecules. Education & Academic Home: Faculty appointment: Assistant Professor, Department of Biochemistry, UW–Madison College of Agricultural and Life Sciences. Concurrent appointment: Morgridge Institute Investigator, Rowe Center for Research in Virology. Research Interests: The Grant group develops computational and experimental methods that extend cryo-EM into two major frontiers: size —capturing structures of very small proteins previously invisible to cryo-EM—and motion —resolving conformational changes of molecular machines in real time. These advances are integrated into the open-source software package cisTEM , which provides a user-friendly workflow for single-particle image processing. Publication Trends: Across the 15 most recent papers (2021-2025), Grant’s work spans method-centric algorithmic innovation, high-resolution structural studies of bacterial DNA replication-restart machinery, and integrative technologies that couple native mass spectrometry with cryo-EM. A clear trajectory emerges from tool development toward application in virology and antibiotic-target validation. Scientific Awards: None explicitly mentioned in the provided text. Students & Research Team: Grant currently mentors six graduate students (Colin Hemme, Gan Li, Heidy Elkhaligy, Peter Ducos, Roma Broadberry, Shashwat Shastri) and several postdoctoral researchers and staff, including Alex Duckworth, Raison Dsouza, and Tim Wagner. Laboratory & Collaborations: The Grant Lab is physically located within UW–Madison’s Biochemistry Building and leverages the Center for High-Throughput Computing shared between UW–Madison and Morgridge to perform large-scale cryo-EM data processing.

Gerhard Wolberمشاهده پروفایل

استاد

• Computational Drug Design
• G-Protein Coupled Receptors (GPCRs)
• Cytochrome P450 Enzymes
• +۳ مورد دیگر

Professor Gerhard Wolber leads the Molecular Drug Design research group at the Institute of Pharmacy , Freie Universitaet Berlin. His work focuses on computational approaches to drug discovery, with expertise in G-protein coupled receptors (GPCRs) , cytochrome P450 enzymes , Toll-like receptors , and viral protease inhibitors . He supervises a team of 13 PhD candidates 3 researchers 2 Master's students engaged in projects ranging from calcium channel blockers to CYP enzyme modulators for cancer therapy. Recent publications highlight his lab's contributions to pan-coronavirus drug discovery, TLR8 antagonism, and calcium channel inhibition. The team employs advanced methodologies including Molecular dynamics simulations Fragment-based de novo design Bayesian neural networks DFT calculations 3D pharmacophore modeling to bridge computational predictions with experimental validation. Notable projects include Virtual screening for TREM2-targeted glioblastoma therapeutics Allosteric communication path analysis via MDPath Immune checkpoint inhibitors for cancer immunotherapy Biased GPCR ligand development demonstrating a multidisciplinary approach to contemporary drug design challenges.