معرفی
Yuting Liu is a Research Fellow in Neuroscience at Yale School of Medicine. Her research focuses on immunotherapy biomarkers, particularly in non-small cell lung cancer (NSCLC) and other malignancies. She employs advanced techniques like digital spatial profiling (DSP) and quantitative immunohistochemistry to study immune checkpoint molecules (e.g., PD-1/PD-L1, CMTM6, Siglec-15) and their spatial relationships within tumor microenvironments. Her work aims to identify predictive biomarkers for immunotherapy response and elucidate mechanisms underlying tumor-immune interactions.
Key research areas include:
- PD-L1 expression in tumor-associated macrophages vs. tumor cells
- Molecular mechanisms of immune checkpoint inhibitors
- Spatial profiling of immune markers in solid tumors
- Role of miRNA (e.g., miR-21) in tumor-associated macrophage function
Her publications highlight the clinical significance of immune cell co-localization patterns and biomarker expression profiles for predicting therapeutic outcomes in NSCLC and ovarian cancer. Liu collaborates on translational projects leveraging high-plex technologies to advance precision medicine approaches in oncology.
