Chee Khoon Lee

Chee Khoon Lee is a Principal Research Fellow at the NHMRC Clinical Trials Centre, University of Sydney's Faculty of Medicine and Health. His research focuses on oncology clinical trials, genomic profiling in cancer, and precision medicine strategies. He advises Janene Dalrymple on a project bridging efficacy and real-world effectiveness in lung cancer treatments.

• Affiliations: NHMRC Clinical Trials Centre, Faculty of Medicine and Health

Research interests include lung and ovarian cancer therapies, biomarker-driven treatment strategies, and optimizing clinical trial designs. His work addresses molecular profiling in metastatic cancers, immune checkpoint inhibitors, and drug efficacy in diverse patient populations. He has contributed to studies on EGFR mutations, PARP inhibitors, and combination immunotherapies.

Publications highlight work in lung cancer treatment resistance mechanisms, biomarker validation (e.g., CA-125 vs RECIST discordance), and therapeutic nomograms for survival prediction. He collaborates on international trials like FLAURA2 (osimertinib in EGFR-positive NSCLC) and the STARLET Collaboration (brain metastases management).

Key contributions include meta-analyses on checkpoint inhibitor efficacy, PD-L1 expression prognostics, and trial endpoint validity. His team explores real-world data applications and systemic therapy optimization for rare cancer subtypes.