معرفی
Yun-Hee Youm is an Associate Research Scientist in the Department of Pathology at Yale School of Medicine, specializing in immunology, metabolic disorders, and aging. She completed her PhD at Hanyang University and postdoctoral training with Dr. Vishwa Dixit, focusing on metabolic factors in thymic aging and inflammasome pathways in adipose tissue. Her work bridges immunology and metabolism, with notable contributions to understanding obesity-related chronic diseases and age-related inflammaging. She collaborates with the Dixit Lab and co-leads multiple NIH-funded projects. Recent studies include FGF21's role in delaying thymic aging and mechanisms linking cysteine depletion to thermogenesis.
Research Interests: Dr. Youm investigates how metabolic pathways influence immunity and aging, particularly focusing on the inflammasome, adipose tissue inflammation, and thymic involution. Her work highlights therapeutic targets for obesity and age-related immunosenescence, such as NLRP3 inflammasome modulation and FGF21 signaling.
Publications Overview: Her 15 most recent articles span metabolic adaptations, inflammasome regulation, and aging mechanisms. Key themes include FGF21's longevity effects, cysteine's role in thermogenesis, and NLRP3-driven inflammaging. These studies underscore the interplay between metabolism, immunity, and aging.
Awards & Grants: While specific awards are not listed, her NIH grant co-investigator roles and high-impact publications (e.g., Nat Med, Cell Metab) reflect her research excellence. News highlights from Yale Medicine and peer-reviewed journals emphasize her contributions to understanding obesity and aging pathophysiology.
Labs & Teams: Collaborates closely with the Dixit Lab, contributing to interdisciplinary projects on metabolic-immune interactions. Her lab employs mouse models and spatial transcriptomics to study tissue-specific mechanisms of aging and inflammation.
