Yousin Suh

Yousin Suh, PhD, is an Adjunct Professor in the Department of Genetics and the Department of Medicine (Endocrinology) at Columbia University. Her research focuses on the functional genomics of aging, particularly investigating genetic components of aging and age-related diseases using functional genomic approaches. Key areas of study include DNA repair mechanisms, the GH/IGF-1 pathway in longevity, and genomic instability in cancer and aging. She leads multidisciplinary studies involving population-based association analyses, mouse models, and CRISPR-based epigenome editing.

Her work spans four major projects: population-based studies of BRCA1 haplotypes in breast cancer, genome maintenance mechanisms in aging cohorts, GH/IGF-1 pathway analysis in Ashkenazi centenarians, and mouse models of premature aging. These studies integrate genetic, transcriptomic, and functional assays to dissect aging mechanisms. Recent findings highlight the role of IGF-1R mutations in longevity and the impact of DNA repair pathways on age-related phenotypes.

Dr. Suh has contributed to seminal publications on centenarian genetics, telomere biology, and epigenome editing. Her research bridges population and molecular genetics, aiming to identify therapeutic targets for age-related conditions. Collaborations with institutions like the Albert Einstein College of Medicine and NIH-funded studies underscore her leadership in aging research.