John Papaconstantinou

John Papaconstantinou, PhD, is a Professor in the Department of Biochemistry & Molecular Biology at the University of Texas Medical Branch (UTMB). His research focuses on molecular mechanisms of aging, stress response genes, and longevity determination. He investigates how oxidative stress and inflammation contribute to age-related diseases and senescence. Key projects include studying insulin/IGF-1 signaling pathways in aging and the genetic basis of longevity in dwarf mouse models. His work integrates transgenic mice, molecular probes, and genomic analysis to uncover aging-related pathways.

Research Interests:

• Molecular biology of aging and longevity
• Stress response gene regulation
• Oxidative stress and inflammation in age-related diseases
• Insulin/IGF-1 signaling pathways
• Mouse models of aging (Snell/Ames dwarf mice)

Publications: Over 160 peer-reviewed articles, including recent work on senescence mechanisms in cardiovascular disease and lung aging. His research highlights the role of chronic inflammation in aging and the paradoxical effects of DNA repair mechanisms.

Awards and Grants: Not explicitly listed in provided texts, but extensive research productivity with significant citations indicates recognition in his field.

Labs/Teams: Active in UTMB's research community, contributing to strategic pillars on aging and chronic disease research. Collaborates with teams studying exosomes, mitochondrial biology, and stress signaling pathways.