معرفی
Xiangli Zhao is an Associate Research Scientist in the Department of Orthopaedics & Rehabilitation at Yale School of Medicine, where she conducts advanced research in molecular mechanisms of neurodegenerative and inflammatory diseases. Her work is deeply collaborative, particularly with Dr. Chuan-Ju Liu’s laboratory, and spans lysosomal disorders, osteoarthritis, and immune regulation.
Her research interests include:
- Molecular pathways in Gaucher disease and frontotemporal dementia
- Role of progranulin in neuroprotection and lysosomal function
- Ion channel regulation in chondrocytes and osteoarthritis
- Immunomodulatory roles of CD26 and cPLA2 in autoimmune and inflammatory conditions
- Metabolic contributions to cognitive dysfunction in diabetes
Dr. Zhao’s recent publications, appearing in high-impact journals such as Nature and PNAS, reflect a strong trend toward translational research with therapeutic implications. Her work frequently explores novel drug targets and protective mechanisms in neurodegeneration and inflammation, often using genetically modified mouse models and molecular pharmacology approaches.
Scientific contributions and collaborations include:
- Key contributor to discovery of Nav1.7 as a therapeutic target in osteoarthritis
- Investigated progranulin’s role in autophagy-lysosome fusion in Gaucher disease
- Explored fexofenadine’s anti-inflammatory effects beyond allergy
- Collaborated with experts in neuroscience, immunology, and orthopedics
She advises no formal students listed in the data, but her research likely involves mentoring junior scientists and trainees. Her work is supported by institutional and possibly NIH-level grants, though specific funding is not detailed. She is part of active research teams focusing on neuroimmunology, lysosomal biology, and musculoskeletal disorders at Yale.