معرفی
Chuan-Ju Liu is the Charles W. Ohse Professor of Orthopaedics & Rehabilitation at Yale University School of Medicine, with a joint appointment as Professor in the Graduate School of Arts and Sciences. He serves as Vice Chair of Research in the Department of Orthopaedics & Rehabilitation, a leadership role reflecting his significant contributions to musculoskeletal research. His work spans molecular mechanisms of arthritis, inflammation, and lysosomal storage diseases, with a strong emphasis on translational applications.
His research focuses on:
- Musculoskeletal diseases, especially osteoarthritis and rheumatoid arthritis
- Ion channel biology in chondrocytes and joint degeneration
- Progranulin (PGRN) signaling in inflammation, autoimmunity, and lysosomal disorders
- Therapeutic development for Gaucher Disease and neurodegenerative conditions
Dr. Liu’s recent publications in high-impact journals such as Nature, Cell Research, and PNAS reveal novel pathways involving Nav1.7, TNF receptor complexes, and glucocorticoid signaling in bone and cartilage. His work consistently bridges basic science with clinical translation, identifying repurposed drugs (e.g., digoxin, fexofenadine) and novel biologics as potential therapies.
His scientific achievements have been recognized with major awards:
- Kappa Delta Award (ORS & AAOS)
- Ethelmae Haldan Award (Arthritis National Research Foundation)
- Basic Research Award (American College of Rheumatology)
Dr. Liu has mentored numerous trainees and collaborators and maintains active research grants and partnerships across immunology, neuroscience, and regenerative medicine. He is affiliated with key interdisciplinary programs including the Yale Combined Program in the Biological and Biomedical Sciences (BBS) and the Program in Translational Biomedicine (PTB). His lab continues to pioneer discoveries in musculoskeletal and lysosomal biology, with ongoing work on disease-modifying therapies and molecular mechanisms of degeneration.
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