William J Gradishar

William J Gradishar is a Professor of Medicine (Hematology and Oncology) at Northwestern University's Feinberg School of Medicine, holding the Betsy Bramsen Professor of Breast Oncology chair. His clinical focus centers on breast cancer management and novel therapy development, with affiliations to Northwestern Memorial Hospital and the Robert H. Lurie Comprehensive Cancer Center.

• Education: MD from University of Illinois, Chicago (1982)
• Certifications: Internal Medicine and Medical Oncology (American Board of Internal Medicine)
• Training: Residency at Michael Reese Medical Center (1986), Fellowship at University of Chicago Hospitals (1990)

As a leading breast oncology expert, Gradishar specializes in precision medicine approaches through molecular interrogation of tumors, developmental therapeutics, and clinical trial design incorporating novel agents for early/late-stage breast cancer. His research emphasizes genomic medicine and chemotherapy optimization.

Recent publications highlight advancements in HER2-low metastatic treatment, AI validation in tumor boards, and CD73-mediated immune evasion mechanisms. Key collaborators include institutions across oncology and hematology specialties.

• Scientific Awards (2010–2015):
  • Multiple Best Doctors and Top Doctors recognitions in Oncology
  • Inclusion in Best Doctors in America (various years)
  • Castle Connolly Guide top physician listings

Gradishar leads active clinical trials including:

• ACE-Breast-03 (ARX788 in HER2+ metastatic)
• TOS-358 PI3K-alpha inhibitor trial
• Elacestrant combinations in ER+/HER2- advanced
• DB-1303 in HER2-low, HR+ metastatic