Véronique Lefebvre

Véronique Lefebvre, PhD, is an Investigator at the Children's Hospital of Philadelphia Research Institute, affiliated with the Department of Surgery and Orthopedic Center. Her research focuses on the genetic mechanisms of cell type specification in the skeleton and brain, emphasizing SOX transcription factors.

• Deciphering SOX protein roles in skeletal progenitor/stem cells, chondrocytes, osteoblasts, and neocortical neurons
• Investigating skeletal malformation diseases (e.g., chondrodysplasias, craniosynostosis) and degenerative diseases (e.g., osteoarthritis, osteoporosis)
• Studying SOXopathies, such as Lamb-Shaffer syndrome and SOX4-associated neurodevelopmental disorders

The Lefebvre Lab employs cutting-edge methodologies like mouse models, cell reprogramming, high-throughput sequencing, and computational analysis to explore both fundamental and translational science. Their work bridges developmental syndromes and adult-onset diseases, seeking novel therapeutic strategies.

• Key projects include SOX8/SOX9 in cartilage development and SOX4/SOX11 in bone homeostasis
• Focus on molecular pathways linking genetic mutations to clinical outcomes

The lab actively investigates the epigenetic regulation of skeletal and neurodevelopmental processes, with implications for rare congenital conditions and common degenerative diseases.