Matthew Greenblatt

Matthew Greenblatt is an Associate Professor in the Department of Pathology and Laboratory Medicine at Weill Cornell Medicine, where he leads a research program in skeletal stem cell biology. He is affiliated with the Graduate School of Medical Sciences and the Tri-Institutional PhD Program, mentoring students in Cell & Developmental Biology. His research focuses on identifying distinct skeletal stem cells and their roles in bone development, regeneration, and disease.

Research Interests: Dr. Greenblatt’s work centers on developmental biology and stem cells, particularly in the context of bone formation and repair. His lab investigates site-specific skeletal stem cells in the periosteum, skull, and spine, uncovering mechanisms of intramembranous ossification and cranial disorders such as craniosynostosis. He also explores cell signaling pathways in osteoblasts, including SLIT3-mediated angiogenesis, SLITRK5 regulation of hedgehog signaling, and MAPK pathways in neurofibromatosis. His research bridges basic science with clinical pathology, with implications for regenerative medicine and cancer metastasis.

The most recent publications from the Greenblatt lab, all in high-impact journals like Nature and Nature Communications, reveal a strong focus on developmental mechanisms in bone, stem cell lineage specification, and pathological interactions in skeletal diseases. The work integrates lineage tracing, molecular signaling, and disease modeling, with emerging themes in angiogenesis, metastasis, and congenital bone disorders.

Scientific Awards:

• Fuller Albright Award (ASBMR, 2022)
• Elected Member, American Society for Clinical Investigation (2020)
• ASCI Young Investigator Award (2017)
• Harold M. Frost Young Investigator Award (ORS & ASBMR, 2015)
• John Haddad Young Investigator Award (AMM & ASBMR, 2015)
• Paul E. Strandjord Young Investigator Award (ACPS, 2014)
• Leon Reznick Memorial Prize (Harvard, 2012)
• Jeffrey Modell Dissertation Award (Harvard, 2010)
• NIH Director's Early Independence Award
• Burroughs Wellcome Career Award for Medical Scientists

Advising and Grants: Dr. Greenblatt mentors graduate students in the Cell & Developmental Biology program and leads an independently funded research lab. His early independence was enabled by the NIH Director's Early Independence Award and the Burroughs Wellcome Career Award for Medical Scientists, indicating strong institutional and national support. While specific grant details are not listed, these awards represent significant funding for high-risk, high-impact research in skeletal biology.

Labs and Teams: The Greenblatt Lab is part of the Department of Pathology and Laboratory Medicine at Weill Cornell Medicine and collaborates within the broader Tri-Institutional research community. His team combines expertise in stem cell biology, developmental genetics, and molecular signaling to investigate skeletal development and disease. The lab is actively pursuing the discovery of new skeletal cell types and their roles in both local bone pathologies and systemic conditions like cancer metastasis.