Vivek K. Narayan

Vivek K. Narayan, MD, MS is an Associate Professor of Medicine specializing in Hematology-Oncology at the University of Pennsylvania's Perelman School of Medicine. He practices clinically at the Abramson Cancer Center within the Perelman Center for Advanced Medicine in Philadelphia, treating adult patients with genitourinary cancers.

His educational background includes:

• Medical School: University of Virginia
• Residency: Hospital of the University of Pennsylvania
• Fellowship: Hospital of the University of Pennsylvania

Dr. Narayan's research focuses on translational and clinical aspects of prostate cancer and renal cell carcinoma, with particular expertise in immunotherapy and cellular therapies. His laboratory work centers on the Prostate Cancer Cellular Therapy Program where he investigates novel CAR T-cell approaches and combination treatments for advanced disease. Analysis of his recent publications reveals strong emphasis on biomarker-driven therapies, treatment resistance mechanisms, and innovative clinical trial designs for genitourinary malignancies.

Notable scientific contributions include:

• Phase 1 trial of PSMA-targeting TGFβ-insensitive CAR T-cells for metastatic prostate cancer (Nature Medicine 2022)
• Belzutifan for Von Hippel-Lindau disease-associated renal cell carcinoma (NEJM 2021)
• Leadership in the CheckMate 650 immunotherapy trial for prostate cancer (Cancer Cell 2020)

As a clinician-scientist, Dr. Narayan maintains active involvement in patient care with a 5.0 average patient rating across 646 reviews, while directing translational research programs and mentoring through the Perelman School of Medicine. His work bridges basic science discoveries with clinical applications through numerous multi-institutional collaborations and clinical trials.