Ullrich Wüllner

Prof. Dr. Ullrich Wüllner is a leading researcher at the German Center for Neurodegenerative Diseases (DZNE) in Bonn, Germany. He heads the Cooperation Unit and previously led the GenBank of the Parkinson's Network, focusing on genetic variants in Parkinson's disease. His work bridges epigenetics with neurodegenerative disorders, particularly Parkinson's and Alzheimer's diseases.

• Specializes in DNA methylation and histone modifications
• Investigates epigenetic regulation of the SNCA gene
• Develops methyl-specific PCR techniques for early diagnosis

Research interests center on epigenetic mechanisms in aging and neurodegeneration. Current projects examine DNA methylation patterns in peripheral blood monocytes as potential biomarkers and explore dopaminergic stimulation's impact on epigenetic modifications. His work has revealed hypomethylation of a hidden SNCA promoter in Parkinson's patients through bisulfite sequencing.

Scientific contributions include:

• Identifying HDAC3's role in polyglutamine diseases
• Characterizing TNF-α promoter methylation in Alzheimer's
• Developing epigenetic tools for neurodegenerative diagnostics

While no explicit advising or grant information appears in the text, his leadership in collaborative networks (like NGFN-Plus) suggests significant institutional support and team coordination efforts.