معرفی
Dr. Ting-Yu Lin is an Assistant Professor in the Department of Biosciences at Durham University, UK. Her research focuses on RNA modification mechanisms, particularly pseudouridine synthases (PUS) and their roles in cellular processes. She has held postdoctoral positions at RIKEN Japan and the Max Planck research group in Poland, specializing in structural and biochemical investigations of RNA-modifying enzymes.
Education: B.Sc. in Medical Laboratory Science from Taipei Medical University (2004), Ph.D. in Clinical Laboratory Sciences from National Taiwan University (2009). Completed a PhD exchange program at City of Hope/Bachman Research Institute, USA, focusing on RNA splicing.
- Research Interests: RNA modification, tRNA biology, PUS3 enzyme dysfunction in neurodevelopmental disorders, structural enzymology, and antimalarial drug targets.
- Key Contributions: Defined biochemical mechanisms of human PUS3, cryo-EM structures of Elongator complex, and inhibition of Plasmodium falciparum gyrase B.
Publications span structural biology, enzymology, and molecular biology, with recent work emphasizing RNA modification disorders and antimalarial compounds. Supervises four PhD students and collaborates with international teams in Japan, Poland, and the USA.
Associated with Durham University's Biomolecular Interactions research center, her work bridges fundamental biochemistry with translational applications in disease treatment and diagnostics.
