معرفی
Tiago Dias da Costa is a Senior Lecturer in Bacterial Pathogenesis at the Department of Life Sciences, Faculty of Natural Sciences, Imperial College London. His research focuses on structural mechanisms of bacterial molecular machines, particularly conjugative type IV secretion systems (T4SS) involved in antimicrobial resistance dissemination. He leads the Costa Lab, which employs cryo-electron microscopy, bacterial genetics, and biochemistry to study these systems' assembly, regulation, and function.
He is affiliated with the Centre for Bacterial Resistance Biology, Centre for Structural Biology, and Electron Microscopy Centre. His work addresses the structural basis of conjugation processes, including F-pilus biomechanics and T4SS architecture, aiming to combat AMR through molecular insights.
Key research themes include horizontal gene transfer dynamics, bacterial adaptation strategies, and the development of novel therapeutics targeting conjugation machinery. His lab's recent breakthroughs include high-resolution structures of F-pilus and OMCC complexes, elucidating their roles in AMR spread.
Publications span structural biology, microbiology, and membrane biology, with contributions to Nature, Nature Communications, and Cell. He collaborates widely on projects combining structural analysis with functional studies to understand bacterial pathogenesis mechanisms.
