معرفی
Thomas J. Meade is the Eileen M. Foell Professor of Cancer Research and Charles Deering McCormick Professor of Teaching Excellence at Northwestern University. He holds appointments across multiple departments including Chemistry, Molecular Biosciences, Neurobiology, and Radiology, and serves as faculty director of The Center for Advanced Molecular Imaging (CAMI). His research program bridges chemistry, molecular imaging, and translational medicine, focusing on developing innovative imaging technologies for biomedical applications.
Meade's research interests center on bioinorganic coordination chemistry with applications in biological molecular imaging, theranostics, and electronic biosensors. His laboratory is organized into three sub-groups working on molecular imaging probes, electronic biosensors for proteins, and inhibitors of transcription factors. The lab specializes in using coordination chemistry to create contrast agents that respond to enzymatic activity, redox status, gene expression, and other cellular signals, enabling dynamic, noninvasive readouts of molecular events in vivo. This work has significant implications for early disease detection, real-time monitoring, and precise disease characterization, particularly in cancer and neuroscience applications.
Analysis of Professor Meade's recent publications reveals a strong focus on gadolinium-based contrast agents for magnetic resonance imaging, with significant work on parashift probes, self-immolative bioresponsive agents, and nanoparticle-based imaging systems. His research increasingly integrates multiple imaging modalities and focuses on translating basic discoveries into clinically relevant applications, particularly for cancer detection and monitoring cellular senescence. The work demonstrates a consistent trajectory toward more sophisticated, responsive imaging agents that provide functional and molecular information beyond traditional anatomical imaging.
- Eileen M. Foell Professor of Cancer Research
- Charles Deering McCormick Professor of Teaching Excellence
Professor Meade maintains close collaborations with clinical and basic science investigators to translate new imaging strategies into meaningful diagnostic and therapeutic applications. His research group provides comprehensive training opportunities for students, covering organic synthesis, inorganic synthesis, X-ray crystallography, HPLC techniques, cell culture, fluorescence imaging, magnetic resonance imaging, and animal studies. The lab actively participates in multiple graduate programs including Chemistry, Interdepartmental Biological Sciences (IBiS), Medical Scientist Training Program, and Biomedical Engineering.
The Meade Group operates within Northwestern University's Chemistry of Life Processes Institute, with facilities in Silverman Hall. The research program maintains three specialized sub-groups focusing on molecular imaging probes, electronic biosensors, and transcription factor inhibitors, with strong connections to clinical applications through collaborations with the Feinberg School of Medicine. Current work emphasizes the development of next-generation imaging agents that respond to specific biological conditions, enabling earlier disease detection and more precise therapeutic monitoring.
