Tae-Hee Lee

Tae-Hee Lee is a Professor of Chemistry at Pennsylvania State University, affiliated with the Huck Institutes of the Life Sciences and the Molecular, Cellular, and Integrative Biosciences program. His research focuses on single-molecule biophysics of nucleosomes, chromatin, and gene regulation, employing advanced techniques like smFRET and super-resolution microscopy. He holds a Ph.D. from Georgia Institute of Technology (2004) and completed postdoctoral training at Stanford University (2007).

His research group investigates nucleosome dynamics, histone modifications, and their roles in epigenetic regulation. Key projects include studying how covalent modifications (e.g., acetylation, ubiquitylation) affect nucleosome stability and transcriptional processes. Techniques developed in his lab bridge physical chemistry, biochemistry, and nanoscale engineering.

• Education: Ph.D., Georgia Tech (2004); Postdoc, Stanford (2007)
• Affiliations: Huck Institutes of the Life Sciences, MCIB Program
• Lab Focus: Single-molecule approaches to chromatin structure and dynamics

He has received prestigious awards including the Searle Scholar (2008) and Camille Dreyfus New Faculty Award (2007). Current openings exist for post-doctoral researchers with expertise in biophysics or molecular spectroscopy.

Publications highlight contributions to understanding nucleosome assembly, histone exchange dynamics, and the interplay between chromatin structure and transcription. Techniques like super-resolution optical lithography and hybrid single-molecule methods are central to his work.