معرفی
Michael Poirier is an Adjunct Professor in the Department of Physics at The Ohio State University. His research focuses on understanding chromatin structure and dynamics, DNA repair mechanisms, and the interplay between histone modifications and gene regulation. He employs interdisciplinary techniques including biochemical assays, single-molecule biophysics (e.g., magnetic tweezers, FRET), and DNA nanotechnology.
Education:
- Ph.D. in Physics, University of Illinois at Chicago, 2002
- M.S. in Physics, University of Illinois at Chicago, 1997
- B.S. in Physics, Truman State University, 1995
Research Interests:
His work investigates nucleosome stability, histone post-translational modifications (PTMs), and DNA mismatch repair in chromatin. Collaborations include the Ottesen Lab (histone engineering), Fishel Lab (DNA repair), and Bundschuh Lab (computational modeling). Recent projects involve DNA origami-based tools to probe chromatin mechanics and design nanoscale devices for biomedical applications.
Lab & Tools:
His lab uses advanced techniques like DNA origami nanocalipers for force measurements, single-molecule FRET, and magnetic tweezers. They also develop hybrid DNA-nanoparticle systems for targeted drug delivery and cellular imaging.
