معرفی
Stephanie Xie serves as a Scientist at Princess Margaret Cancer Centre, University Health Network, and holds an academic appointment in the Temerty Faculty of Medicine at the University of Toronto. Her research focuses on the intersection of stem cell biology and cancer, with particular expertise in hematopoietic stem cells and acute myeloid leukemia.
Dr. Xie's research program investigates the metabolic and proteostatic regulation of hematopoietic stem cell fate decisions, with special emphasis on lipid metabolism (particularly sphingolipids) and quality control programs. Her work explores how these regulatory circuits differ between normal hematopoietic stem cells and leukemia stem cells, aiming to identify therapeutic vulnerabilities in acute myeloid leukemia. She employs multi-omics approaches including proteomics, metabolomics, and single-cell analysis to dissect these mechanisms.
Analysis of Dr. Xie's publication record reveals a strong focus on stem cell metabolism, particularly lipid metabolism's role in stem cell fate determination. Her recent work has increasingly examined the intersection of metabolic regulation with proteostasis and inflammatory signaling in both normal and malignant hematopoiesis. The publications demonstrate a progression from fundamental mechanisms of stem cell regulation toward translational applications for improving stem cell transplantation and targeting leukemia stem cells.
Dr. Xie maintains an active research program with numerous high-impact publications in leading journals including Nature, Cell Stem Cell, and Blood. Her work frequently involves collaborative research with other leading scientists in the field of hematopoiesis and cancer biology.
