Stefan Schoeftner

Stefan Schoeftner is an Associate Professor in the Department of Life Sciences at the University of Trieste, specializing in molecular biology with a focus on non-coding RNA, genomic stability, and molecular oncology. He serves as a member of the Department's Board, Coordinator of the Functional Genomics Board of Studies, and participates in multiple Doctoral Studies Boards for the Molecular Biomedicine program across various cycles (XXX to XXXIX). His academic activities include teaching and leading research initiatives within the university's structure.

Professor Schoeftner's research primarily investigates the role of non-coding RNA and genomic stability in cancer development and progression, with particular emphasis on molecular oncology. His work explores the intricate relationships between R-loop dynamics, telomere biology, and epigenetic regulation in tumor formation. The research group led by Prof. Schoeftner focuses on 'Non-coding RNA and genomic stability,' examining how these elements contribute to molecular mechanisms underlying cancer pathogenesis, particularly in ovarian cancer and breast cancer models.

Analysis of Professor Schoeftner's recent publications reveals a strong focus on R-loop dynamics, telomere maintenance mechanisms, and non-coding RNA regulation in cancer contexts. His research demonstrates how molecular pathways involving TGS1, TRF2, and OCT4 pseudogene lncRNAs influence tumor microenvironments and therapeutic responses. The work spans from fundamental molecular mechanisms to potential therapeutic applications, with several publications addressing pharmaceutical compositions and drug development strategies targeting telomeropathies and cancer resistance mechanisms.

Professor Schoeftner actively supervises doctoral students, including Andrea Parlante, who works on the 'Reprogramming the ovarian tumor microenvironment' project. He serves as Scientific Director for multiple research projects funded by the Ministry of University and Research, European Commission, and AIRC (Italian Association for Cancer Research), demonstrating substantial research funding and leadership in the field.

Professor Schoeftner leads the research group focused on 'Non-coding RNA and genomic stability' within the Department of Life Sciences. His team investigates molecular mechanisms linking RNA biology to cancer development, with particular attention to epigenetic self-renewal circuits centered on OCT4 and trans-acting pseudogene lncRNAs. The group participates in national initiatives including the National Center for Gene Therapy and Drug Based on RNA Technology, contributing expertise in RNA biology and cancer mechanisms.