معرفی
Simon Sharpe is a Professor in the Department of Biochemistry at the University of Toronto and a Senior Scientist at The Hospital for Sick Children. His research focuses on the structural and dynamic properties of self-assembling proteins, particularly those involved in degenerative diseases, elastomeric proteins, and biological phase separation. The Sharpe Lab utilizes advanced biophysical techniques such as NMR spectroscopy, X-ray scattering, and electron microscopy to investigate these phenomena.
- BSc: Memorial University of Newfoundland (Cell Biology and Biochemistry, 1997)
- PhD: University of Western Ontario (Biochemistry, 2002)
- Postdoctoral Training: NIH (Solid-State NMR, 2002-2006)
Research interests include:
- Protein self-assembly mechanisms
- Amyloid formation in neurodegenerative diseases
- Elastin and resilin biophysics
- Lipid-protein interactions
- Biological phase separation
- Structure-function relationships
Lab members include Research Associate Dr. Sean Reichheld and PhD students James Otis, Asal Nady, and Robert Lu. The lab has dedicated access to 600 and 700 MHz NMR spectrometers and collaborates with SickKids facilities including the SBC Facility and Imaging Facility.
Scientific awards:
- Canada Research Chair (2006-2016)
- Ontario Early Researcher Award (2010)
Dr. Sharpe has taught courses including BCH374Y1 (Research Project in Biochemistry) and BCH425H (Structural Biology: Principles and Practice). His recent publications examine topics ranging from serum amyloid A structure to bacterial phase separation defenses, with methodologies combining solid-state NMR, fluorescence microscopy, and computational approaches.
