Simon Brewster

Simon Brewster serves as Senior Research Fellow and Consultant Urological Surgeon at the University of Oxford's Hertford College, where he has been Clinical Tutor since 2002 after serving as Lecturer (2002-2011). His clinical work focuses on prostate cancer at Oxford University Hospitals NHS Trust, delivering exam-focused bedside teaching for Years 4-6 medical students.

Education:

• BSc in Anatomy (1st class), Charing Cross Hospital Medical School, 1983
• MBBS (Hons. Pathology), Charing Cross Hospital Medical School, 1986
• FRCS exams and MD research, Bristol (1988-1998)

Brewster's research program demonstrates sequential evolution from basic science (1998-2007) investigating IGF1R targeting and Wnt signaling in prostate cancer to clinical translation (2011-2022) evaluating multiparametric MRI integration in diagnostic pathways and active surveillance protocols. His work bridges laboratory discoveries with patient-centered outcomes, particularly examining how imaging advancements impact treatment decisions and quality of life. The multidisciplinary nature of his clinical research involves close collaboration between urologists, oncologists, radiologists, and pathologists to optimize prostate cancer management.

Analysis of his 15 most recent publications reveals three dominant themes: (1) MRI-driven diagnostic refinement including pre-biopsy MRI implementation and active surveillance reclassification, (2) comparative treatment efficacy studies evaluating focal therapy versus radical prostatectomy, and (3) national guideline development through NICE recommendations. His work consistently addresses real-world clinical challenges in prostate cancer management, with strong emphasis on patient satisfaction metrics and practical implementation within the UK healthcare system.

Scientific Awards:

• BJUI Article of the Week (November 18, 2018) for MRI impact on active surveillance

As an educator, Brewster has co-supervised four higher research degrees and served as Clinical Supervisor for junior surgical trainees since 1998, including Intercollegiate ISCP Educational Supervisor role since 2009. His grant portfolio includes the UK PART trial (focal therapy vs radical prostatectomy, PI Prof Richard Bryant) and Oxfordshire MRI implementation study (2015-2019). He chairs the Hertford College/Vaughan Williams Prize for Excellence in Clinical Medicine.

He leads a multidisciplinary research consortium including Dr. Val Macaulay (basic science) and Prof. W. Bodmer (Wnt pathway research), while coordinating clinical activities through Oxford University Hospitals NHS Trust. His work directly informs national prostate cancer pathways through British Association of Urological Surgeons committees and NICE guideline development.